Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction (original) (raw)

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References

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Acknowledgements

The genotyping of some of the myocardial infarction sample sets was funded in part through a grant from the US National Heart, Lung, and Blood Institute (SR01HL089650-01). The New Zealand cohort study was supported by a programme grant from the Health Research Council of New Zealand. The Korean study was supported by a grant from the Korean Health 21 R&D project, Ministry of Health & Welfare, Republic of Korea (A010249).

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Authors and Affiliations

1. deCODE Genetics, Sturlugata 8, Reykjavik, 101, Iceland
   Daniel F Gudbjartsson, Unnur S Bjornsdottir, Eva Halapi, Anna Helgadottir, Patrick Sulem, Gudrun M Jonsdottir, Gudmar Thorleifsson, Hafdis Helgadottir, Valgerdur Steinthorsdottir, Hreinn Stefansson, Jeffrey Gulcher, Augustine Kong, Ingileif Jonsdottir, Unnur Thorsteinsdottir & Kari Stefansson
2. Faculty of Medicine, University of Iceland, Reykjavik, 101, Iceland
   Unnur S Bjornsdottir, Bjorn R Ludviksson, David Arnar, Gudmundur Thorgeirsson, Thorarinn Gislason, Ingileif Jonsdottir, Unnur Thorsteinsdottir & Kari Stefansson
3. The Lung Institute of Western Australia, Nedlands, 6006, WA, Australia
   Carolyn Williams & Philip J Thompson
4. The Western Australian Institute of Medical Research, Perth, 6000, WA, Australia
   Carolyn Williams & Philip J Thompson
5. The Centre for Asthma, Allergy and Respiratory Research, University of Western Australia, Perth, 6009, WA, Australia
   Carolyn Williams & Philip J Thompson
6. Department of Molecular Genetics, PathWest Laboratory Medicine of Western Australia, QEII Medical Centre, Nedlands, 6009, WA, Australia
   Jennie Hui & John Beilby
7. Western Australian Institute for Medical Research, B Block, QEII Medical Centre, The University of Western Australia, Nedlands, 6009, WA, Australia
   Jennie Hui
8. School of Surgery and Pathology, University of Western Australia, Perth, 6009, WA, Australia
   John Beilby
9. Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Perth, 6009, WA, Australia
   Nicole M Warrington & Lyle J Palmer
10. Department of Pulmonary Physiology, West Australian Sleep Disorders Research Institute, Sir Charles Gairdner Hospital, Nedlands, 6009, WA, Australia
    Alan James
11. School of Medicine and Pharmacology, The University of Western Australia, Nedlands, 6009, WA, Australia
    Alan James
12. Department of Pediatric Pulmonology and Pediatric Allergology, Beatrix Children's Hospital, University Medical Center Groningen, University of Groningen, Groningen, 9700, RB, The Netherlands
    Gerard H Koppelman
13. Centre of Pediatrics and Adolescent Medicine, University of Freiburg, Freiburg, 79085, Germany
    Andrea Heinzmann, Marcus Krueger & Klaus Deichmann
14. Department of Epidemiology, University Medical Center, University of Groningen, Groningen, 9700, RB, The Netherlands
    H Marike Boezen
15. Division of Therapeutics, University Hospital of Nottingham, Queen's Medical Centre, Nottingham, NG7 2UH, UK
    Amanda Wheatley
16. Cologne Center for Genomics, University of Cologne, Cologne, 50923, Germany
    Janine Altmuller & Ian P Hall
17. Department of Life Science, Laboratory of Genomic Diversity, Sogang University, Seoul, 121-742, Republic of Korea
    Hyoung Doo Shin
18. Department of Genetic Epidemiology, SNP Genetics, Inc., Seoul, 153-803, Republic of Korea
    Hyoung Doo Shin
19. Division of Allergy and Respiratory Medicine, Soonchunhyang University Seoul Hospital, 140-210, Seoul, Republic of Korea
    Soo-Taek Uh & Hyun Sub Cheong
20. Landspitali University Hospital, Reykjavik, 101, Iceland
    Brynja Jonsdottir, David Gislason, Bjorn R Ludviksson, Dora Ludviksdottir, David Arnar, Gudmundur Thorgeirsson, Thorarinn Gislason & Ingileif Jonsdottir
21. Division of Allergy and Respiratory Medicine, Soonchunhyang University, Bucheon Hospital, Puchon, 420-031, Republic of Korea
    Choon-Sik Park
22. Department of Respitory Medicine, Bispebjerg Hospital, Copenhagen University Hospital, Copenhagen, DK-2400, Denmark
    Linda M Rasmussen, Celeste Porsbjerg, Jakob W Hansen & Vibeke Backer
23. Research Institute of Biological Psychiatry, Sct. Hans Hospital, Boserupvej 2, Roskilde, DK-4000, Denmark
    Thomas Werge
24. Department of Medical Sciences: Inflammation, Uppsala University, Uppsala, 75105, Sweden
    Christer Janson & Ulla-Britt Jönsson
25. Department of Medicine and Therapeutics, Prince of Wales Hospital, Chinese University of Hong Kong, Shatin, Hong Kong
    Maggie C Y Ng, Juliana Chan, Wing Yee So & Ronald Ma
26. Duke University School of Medicine, Durham, 27710, North Carolina, USA
    Svati H Shah & Christopher B Granger
27. Emory University School of Medicine, Atlanta, 30322, Georgia, USA
    Arshed A Quyyumi, Allan I Levey & Viola Vaccarino
28. University of Pennsylvania School of Medicine, Philadelphia, 19104, Pennsylvania, USA
    Muredach P Reilly & Daniel J Rader
29. Vascular Research Group, Otago Medical School, PO Box 913, Dunedin, 9054, New Zealand
    Michael J A Williams, Andre M van Rij & Gregory T Jones
30. Department of Mother and Child, Section of Biology and Genetics, Biology and Genetics, University of Verona, Verona, 37129, Italy
    Elisabetta Trabetti, Giovanni Malerba & Pier Franco Pignatti
31. Department of Mother and Child, Section of Pediatrics, University of Verona, Verona, 37129, Italy
    Attilio Boner
32. Department of Pediatrics, Bolzano Hospital, Bolzano, 39100, Italy
    Lydia Pescollderungg
33. Department of Clinical and Experimental Medicine, Section of Internal Medicine, University of Verona, Verona, 37129, Italy
    Domenico Girelli, Oliviero Olivieri & Nicola Martinelli
34. The Laboratory in Mjodd, RAM, Reykjavik, 109, Iceland
    Gudmundur I Eyjolfsson
35. Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg, 85764, Germany
    Matthias Wjst
36. Institute of Genetic Medicine, EURAC Research, Bozen, 39100, Germany
    Matthias Wjst
37. Department of Pulmonology, University Medical Center, University of Groningen, Groningen, 9700, RB, The Netherlands
    Dirkje S Postma

Authors

1. Daniel F Gudbjartsson
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2. Unnur S Bjornsdottir
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3. Eva Halapi
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4. Anna Helgadottir
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5. Patrick Sulem
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6. Gudrun M Jonsdottir
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7. Gudmar Thorleifsson
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8. Hafdis Helgadottir
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9. Valgerdur Steinthorsdottir
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10. Hreinn Stefansson
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11. Carolyn Williams
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12. Jennie Hui
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13. John Beilby
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14. Nicole M Warrington
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15. Alan James
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16. Lyle J Palmer
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17. Gerard H Koppelman
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18. Andrea Heinzmann
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19. Marcus Krueger
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20. H Marike Boezen
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21. Amanda Wheatley
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22. Janine Altmuller
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23. Hyoung Doo Shin
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24. Soo-Taek Uh
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25. Hyun Sub Cheong
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26. Brynja Jonsdottir
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27. David Gislason
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28. Choon-Sik Park
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29. Linda M Rasmussen
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30. Celeste Porsbjerg
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31. Jakob W Hansen
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32. Vibeke Backer
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33. Thomas Werge
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34. Christer Janson
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35. Ulla-Britt Jönsson
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36. Maggie C Y Ng
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37. Juliana Chan
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38. Wing Yee So
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39. Ronald Ma
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40. Svati H Shah
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41. Christopher B Granger
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42. Arshed A Quyyumi
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43. Allan I Levey
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44. Viola Vaccarino
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45. Muredach P Reilly
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46. Daniel J Rader
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47. Michael J A Williams
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48. Andre M van Rij
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49. Gregory T Jones
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50. Elisabetta Trabetti
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51. Giovanni Malerba
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52. Pier Franco Pignatti
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53. Attilio Boner
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54. Lydia Pescollderungg
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55. Domenico Girelli
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56. Oliviero Olivieri
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57. Nicola Martinelli
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58. Bjorn R Ludviksson
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59. Dora Ludviksdottir
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60. Gudmundur I Eyjolfsson
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61. David Arnar
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62. Klaus Deichmann
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63. Philip J Thompson
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64. Matthias Wjst
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65. Ian P Hall
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66. Dirkje S Postma
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67. Thorarinn Gislason
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68. Jeffrey Gulcher
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69. Augustine Kong
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70. Ingileif Jonsdottir
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71. Unnur Thorsteinsdottir
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72. Kari Stefansson
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Contributions

D.F.G., U.S.B., M.W., I.P.H., D.S.P., I.J., U.T. and K.S. wrote the first draft of the paper. U.S.B., E.H., A. Helgadottir, B.J., D. Gislason, B.R.L., D.L., G.I.E., D.A. and G. Thorgeirsson participated in the collection of the Icelandic data. C.W., J.H., J.B., N.M.W., A.J., L.J.P. and P.J.T. collected the Australian data. G.H.K., H.M.B. and D.S.P. collected the Dutch data. A. Heinzmann, M.K., J.A.,K.D. and M.W. collected the German data. A.W. and I.P.H. collected the UK data. H.D.S., S.-T.U., H.S.C. and C.-S.P. collected the Korean data. L.M.R., C.P., J.W.H., V.B. and T.W. collected the Danish data. C.J. and U.-B.J. collected the Swedish data. M.C.Y.N., J.C., W.Y.S. and R.M. collected the Hong Kong data. S.H.S., C.B.G, A.A.Q., A.I.L., V.V., M.P.R. and D.J.R. collected the US data. M.J.A.W., A.M.V.R. and G.T.J. collected the New Zealand data. E.T., G.M., P.F.P., A.B., L.P., D. Girelli, O.O. and N.M. collected the Italian data. E.H., A. Helgadottir, H.H., V.S. and U.T. carried out the genotyping. D.F.G., P.S., G.M.J., G. Thorleifsson, H.S. and A.K. analyzed the data. D.F.G., U.S.B., K.D., P.J.T., M.W., I.P.H., D.S.P., T.G., J.G., I.J., U.T. and K.S. planned and supervised the work. All authors contributed to the final version of the paper.

Corresponding authors

Correspondence toDaniel F Gudbjartsson or Kari Stefansson.

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The authors from deCODE own stocks and stock options in the company.

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Gudbjartsson, D., Bjornsdottir, U., Halapi, E. et al. Sequence variants affecting eosinophil numbers associate with asthma and myocardial infarction.Nat Genet 41, 342–347 (2009). https://doi.org/10.1038/ng.323

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• Received: 28 July 2008
• Accepted: 05 January 2009
• Published: 08 February 2009
• Issue Date: March 2009
• DOI: https://doi.org/10.1038/ng.323