Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics (original) (raw)

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In the version of this article initially published online, the authors neglected to acknowledge one of the funding sources for their study. The acknowledgements should have recognized support from the Medical Research Council under project number MC_U142684172. The error has been corrected for the print, PDF and HTML versions of this article.

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Acknowledgements

The EUMODIC project was funded by European Commission contract number LSHG-CT-2006-037188. The work at MRC-Harwell was funded by the Medical Research Council under project MC_U142684172. The work at the Toronto Centre for Phenogenomics (TCP) was funded under the NorCOMM project by the government of Canada through Genome Canada and Genome Prairie. The Institut Clinique de la Souris (ICS) has been supported by French state funds through the Agence Nationale de la Recherche under the framework program Investissements d'Avenir by ANR-10-IDEX-0002-02, ANR-10-LABX-0030-INRT and ANR-10-INBS-07 PHENOMIN. A full list of members of the EUMODIC consortium who contributed to the goals of the project is available in the Supplementary Note, and a list of partners is available at http://www.eumodic.org/partners.html.

Author information

Author notes

  1. Martin Hrabě de Angelis, George Nicholson, Mohammed Selloum, Jacqueline K White, Hugh Morgan, Ramiro Ramirez-Solis, Tania Sorg, Sara Wells, Helmut Fuchs, Martin Fray, Chris Holmes, Karen P Steel, Yann Herault, Valérie Gailus-Durner, Ann-Marie Mallon and Steve D M Brown: These authors contributed equally to this work.

Authors and Affiliations

  1. German Mouse Clinic, Institute of Experimental Genetics, Helmholtz Zentrum München–German Research Center for Environmental Health, München/Neuherberg, Germany
    Martin Hrabě de Angelis, Helmut Fuchs, Thure Adler, Antonio Aguilar-Pimentel, Lore Becker, Raffi Bekeredjian, Wolfgang Hans, Anja Hurt, Boris Ivandic, Hugo A Katus, Martin Klingenspor, Thomas Klopstock, Christoph Lengger, Tonia Ludwig, Holger Maier, Susan Marschall, Kateryna Micklich, Beatrix Naton, Markus Ollert, Ildiko Racz, Birgit Rathkolb, Jan Rozman, Karl-Heinz Schäble, Evelyn Schiller, Anja Schrewe, Ralf Steinkamp, Claudia Stöger, Irina Treise, Monja Willershäuser, Eckhard Wolf, Ramona Zeh, Andreas Zimmer & Valérie Gailus-Durner
  2. Experimental Genetics, Centre of Life and Food Sciences Weihenstephan, Technische Universität München, Freising, Germany
    Martin Hrabě de Angelis
  3. German Center for Diabetes Research (DZD), Neuherberg, Germany
    Martin Hrabě de Angelis
  4. Department of Statistics, University of Oxford, Oxford, UK
    George Nicholson & Chris Holmes
  5. Institut Clinique de la Souris, PHENOMIN, Centre Européan de Recherche en Biologie et Médecine GIE (Groupement d'Intérêt Economique), Illkirch, France
    Mohammed Selloum, Tania Sorg, Dalila Ali-Hadji, Gregory Amann, Philippe André, Aurelie Auburtin, Abdel Ayadi, Julien Becker, Elodie Bedu, Marie-Christine Birling, Marie-France Champy, Philippe Charles, Roy Combe, André Dierich, Lahcen El Fertak, Patrice Goetz, Isabelle Goncalves Da Cruz, Alain Guimond, Hughes Jacobs, Sylvie Jacquot, Valerie Lalanne, Sophie Leblanc, Elise le Marchand, Aline Lux, Jean-Louis Mandel, Manuel Mark, Hamid Meziane, Christophe Mittelhauser, Laurent Monassier, David Moulaert, Stéphanie Muller, Guillaume Pavlovic, Emilie Peter, Benoit Petit-Demoulière, Laurent Pouilly, Stephane Rousseau, Fabrice Riet, Michel Roux, Isabelle Tilly, Laurent Vasseur, Christelle Wagner, Marie Wattenhofer-Donze, Bruno Weber, Olivia Wendling, Anne Wolter & Yann Herault
  6. CNRS UMR 7104, Illkirch, France
    Mohammed Selloum, Tania Sorg, Dalila Ali-Hadji, Gregory Amann, Philippe André, Aurelie Auburtin, Abdel Ayadi, Julien Becker, Elodie Bedu, Marie-Christine Birling, Véronique Brault, Marie-France Champy, Philippe Charles, Claire Chevalier, Roy Combe, Emilie Dalloneau, André Dierich, Arnaud Duchon, Lahcen El Fertak, Patrice Goetz, Isabelle Goncalves Da Cruz, Alain Guimond, Hughes Jacobs, Sylvie Jacquot, Valerie Lalanne, Sophie Leblanc, Elise le Marchand, Aline Lux, Jean-Louis Mandel, Manuel Mark, Hamid Meziane, Christophe Mittelhauser, Laurent Monassier, David Moulaert, Stéphanie Muller, Guillaume Pavlovic, Emilie Peter, Benoit Petit-Demoulière, Laurent Pouilly, Stephane Rousseau, Fabrice Riet, Michel Roux, Isabelle Tilly, Laurent Vasseur, Emilie Velot, Christelle Wagner, Marie Wattenhofer-Donze, Bruno Weber, Olivia Wendling, Anne Wolter & Yann Herault
  7. INSERM U964, Illkirch, France
    Mohammed Selloum, Tania Sorg, Dalila Ali-Hadji, Gregory Amann, Philippe André, Aurelie Auburtin, Abdel Ayadi, Julien Becker, Elodie Bedu, Marie-Christine Birling, Véronique Brault, Marie-France Champy, Philippe Charles, Claire Chevalier, Roy Combe, Emilie Dalloneau, André Dierich, Arnaud Duchon, Lahcen El Fertak, Patrice Goetz, Isabelle Goncalves Da Cruz, Alain Guimond, Hughes Jacobs, Sylvie Jacquot, Valerie Lalanne, Sophie Leblanc, Elise le Marchand, Aline Lux, Jean-Louis Mandel, Manuel Mark, Hamid Meziane, Christophe Mittelhauser, Laurent Monassier, David Moulaert, Stéphanie Muller, Guillaume Pavlovic, Emilie Peter, Benoit Petit-Demoulière, Laurent Pouilly, Stephane Rousseau, Fabrice Riet, Michel Roux, Isabelle Tilly, Laurent Vasseur, Emilie Velot, Christelle Wagner, Marie Wattenhofer-Donze, Bruno Weber, Olivia Wendling, Anne Wolter & Yann Herault
  8. Université de Strasbourg, Illkirch, France
    Mohammed Selloum, Tania Sorg, Dalila Ali-Hadji, Gregory Amann, Philippe André, Aurelie Auburtin, Abdel Ayadi, Julien Becker, Elodie Bedu, Marie-Christine Birling, Véronique Brault, Marie-France Champy, Philippe Charles, Claire Chevalier, Roy Combe, Emilie Dalloneau, André Dierich, Arnaud Duchon, Lahcen El Fertak, Patrice Goetz, Isabelle Goncalves Da Cruz, Alain Guimond, Hughes Jacobs, Sylvie Jacquot, Valerie Lalanne, Sophie Leblanc, Elise le Marchand, Aline Lux, Jean-Louis Mandel, Manuel Mark, Hamid Meziane, Christophe Mittelhauser, Laurent Monassier, David Moulaert, Stéphanie Muller, Guillaume Pavlovic, Emilie Peter, Benoit Petit-Demoulière, Laurent Pouilly, Stephane Rousseau, Fabrice Riet, Michel Roux, Isabelle Tilly, Laurent Vasseur, Emilie Velot, Christelle Wagner, Marie Wattenhofer-Donze, Bruno Weber, Olivia Wendling, Anne Wolter & Yann Herault
  9. Wellcome Trust Sanger Institute, Hinxton, UK
    Jacqueline K White, Ramiro Ramirez-Solis, David J Adams, Niels C Adams, Joanna Bottomley, James N Bussell, Jeanne Estabel, Anna-Karin Gerdin, Richard Houghton, Natasha A Karp, David G Melvin, Christine Podrini, David Richardson, Edward Ryder, Jennifer Salisbury, David Sunter & Karen P Steel
  10. Medical Research Council, MRC-Harwell, Harwell, UK
    Hugh Morgan, Sara Wells, Martin Fray, Sarah Atkins, Andrew Blake, Michael R Bowl, Heather Cater, Gemma F Codner, Roger Cox, Armida Di Fenza, Chris T Esapa, Tanja Feigel, Irina Emelyanova, Hilary Gates, Simon Greenaway, John M Hancock, Tertius Hough, Sharon Kitchen, Patrick M Nolan, Amanda Pickard, Paul Potter, Mohamed M Quwailid, Luis Santos, Michelle Simon, Michelle Stewart, Lydia Teboul, Alison Walling, Henrik Westerberg, Joe Wood, Ann-Marie Mallon & Steve D M Brown
  11. Institute for Medical Microbiology, Immunology and Hygiene, Technische Universität München, Munich, Germany
    Thure Adler & Dirk H Busch
  12. Division of Environmental Dermatology and Allergy (UDA), Helmholtz Zentrum München–German Research Center for Environmental Health, Munich, Germany
    Antonio Aguilar-Pimentel & Markus Ollert
  13. Department of Dermatology and Allergy, Clinical Research Division of Molecular and Clinical Allergotoxicology, Technische Universität München, Munich, Germany
    Antonio Aguilar-Pimentel & Markus Ollert
  14. Deptartment of Neurology, Klinikum der Ludwig Maximilians Universität München, Munich, Germany
    Lore Becker, Heinz Höfler & Thomas Klopstock
  15. Department of Cardiology, Angiology and Pneumology, Heidelberg University Hospital, Heidelberg, Germany
    Raffi Bekeredjian, Boris Ivandic & Hugo A Katus
  16. Institut de Génétique et de Biologie Moléculaire et Cellulaire, Illkirch, France
    Véronique Brault, Claire Chevalier, Emilie Dalloneau, Arnaud Duchon, Jean-Louis Mandel, Manuel Mark, Michel Roux, Emilie Velot, Christelle Wagner, Olivia Wendling & Yann Herault
  17. Institute of Pathology, Helmholtz Zentrum München–German Research Center for Environmental Health, München/Neuherberg, Germany
    Julia Calzada-Wack, Tanja Klein-Rodewald, Frauke Neff, Natalia S Pellegata, Leticia Quintanilla-Fend & Monica Tost
  18. Institute of Cell Biology and Neurology, CNR (National Research Council), Rome, Italy
    Francesco Chiani, Brendan Doe, Alessia Gambadoro & Glauco P Tocchini-Valentini
  19. Institute of Lung Biology and Disease, Helmholtz Zentrum München–German Research Center for Environmental Health, München/Neuherberg, Germany
    Oliver Eickelberg, Alexander Götz, Holger Schulz, Tobias Stöger & Ali Önder Yildirim
  20. Institute of Human Genetics, Helmholtz Zentrum München–German Research Center for Environmental Health, München/Neuherberg, Germany
    Jack Favor
  21. Lunenfeld-Tanenbaum Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Ann Flenniken & Nora Jones
  22. Institute of Developmental Genetics, Helmholtz Zentrum München–German Research Center for Environmental Health, München/Neuherberg, Germany
    Lilian Garrett, Lisa Glasl, Jochen Graw, Sabine M Hölter, Oliver Puk, Minxuan Sun, Daniela Vogt-Weisenhorn, Wolfgang Wurst & Annemarie Zimprich
  23. Department of Computer Science, University of Aberystwyth, Aberystwyth, UK
    George Gkoutos
  24. Manitoba Institute of Cell Biology, University of Manitoba, Winnipeg, Manitoba, Canada
    Geoff Hicks
  25. Computational Bioscience Research Center, King Abdullah University of Science and Technology, Thuwal, Saudi Arabia
    Robert Hoehndorf
  26. Else Kröner-Fresenius Center for Nutritional Medicine, Technische Universität München, Freising-Weihenstephan, Germany
    Martin Klingenspor & Jan Rozman
  27. Toronto Centre for Phenogenomics, Toronto, Ontario, Canada
    Colin McKerlie
  28. Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Toronto, Ontario, Canada
    Colin McKerlie, Lauryl M J Nutter & Janet Rossant
  29. Institute of Molecular Psychiatry, University of Bonn, Bonn, Germany
    Ildiko Racz & Andreas Zimmer
  30. Institute of Molecular Animal Breeding and Biotechnology, Ludwig Maximilians Universität München, Munich, Germany
    Birgit Rathkolb & Eckhard Wolf
  31. Max Planck Institute of Psychiatry, Munich, Germany
    Wolfgang Wurst
  32. Deutsches Zentrum für Neurodegenerative Erkrankungen, Munich, Germany
    Wolfgang Wurst
  33. Development Genetics, Centre of Life and Food Sciences Weihenstephan, Technische Universität München, Freising, Germany
    Wolfgang Wurst

Authors

  1. Martin Hrabě de Angelis
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  2. George Nicholson
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  3. Mohammed Selloum
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  4. Jacqueline K White
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  5. Hugh Morgan
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  6. Ramiro Ramirez-Solis
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  7. Tania Sorg
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  8. Sara Wells
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  9. Helmut Fuchs
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  10. Martin Fray
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  11. David J Adams
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  12. Niels C Adams
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  13. Thure Adler
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  14. Antonio Aguilar-Pimentel
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  15. Dalila Ali-Hadji
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  16. Gregory Amann
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  17. Philippe André
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  18. Sarah Atkins
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  19. Aurelie Auburtin
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  20. Abdel Ayadi
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  21. Julien Becker
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  22. Lore Becker
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  23. Elodie Bedu
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  24. Raffi Bekeredjian
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  25. Marie-Christine Birling
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  26. Andrew Blake
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  27. Joanna Bottomley
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  28. Michael R Bowl
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  29. Véronique Brault
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  30. Dirk H Busch
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  32. Julia Calzada-Wack
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  33. Heather Cater
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  34. Marie-France Champy
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  45. Arnaud Duchon
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  46. Oliver Eickelberg
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  47. Chris T Esapa
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  48. Lahcen El Fertak
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Consortia

EUMODIC Consortium

Contributions

M.H.d.A., K.P.S., Y.H. and S.D.M.B. conceived the study and directed the research. G.N., H. Morgan, A.-M.M. and S.D.M.B. wrote the manuscript. M. Selloum, J.K.W., R.R.-S., T. Sorg, S.W., H.F., M.F., D.J.A., N.C.A., T.A., A.A.-P., D.A.-H., G.A., P.A., S.A., A. Auburtin, A. Ayadi, J. Becker, L.B., E.B., R.B., M.-C.B., J. Bottomley, M.R.B., V.B., D.H.B., J.N.B., J.C.-W., H.C., M.-F.C., P.C., C.C., F.C., G.F.C., R. Combe, R. Cox, E.D., A. Dierich, B.D., A. Duchon, O.E., C.T.E., L.E.F., I.E., J.E., J.F., A.F., A. Gambadoro, L. Garrett, H.G., A.-K.G., L. Glasl, P.G., I.G.D.C., A. Götz, J.G., A. Guimond, W.H., G.H., S.M.H., H.H., T.H., R. Houghton, A.H., B.I., H.J., S.J., H.A.K., S.K., T.K.-R., M.K., T.K., V.L., E.l.M., T.L., A.L., C. McKerlie, J.-L.M., S. Marschall, M.M., H. Meziane, K.M., C. Mittelhauser, L.M., D.M., S. Muller, B.N., F.N., P.M.N., L.M.J.N., M.O., G.P., N.S.P., E.P., B.P.-D., A.P., C.P., P.P., L.P., O.P., D.R., S.R., L.Q.-F., M.M.Q., I.R., B.R., F.R., J. Rossant, M.R., J. Rozman, E.R., J.S., K.-H.S., E.S., A.S., H.S., R.S., M. Stewart, C.S., T. Stöger, M. Sun, D.S., L.T., I. Tilly, G.P.T.-V., M.T., I. Treise, E.V., D.V.-W., C.W., B.W., O.W., M.W., E.W., A. Wolter, W.W., A.Ö.Y., R.Z., A. Zimmer, A. Zimprich and V.G.-D. undertook mouse generation, phenotyping, and data acquisition and assessment from the phenotyping pipelines. G.N., H. Morgan, A.B., A.D.F., T.F., G.G., S.G., J.M.H., R. Hoehndorf, N.J., N.A.K., S.L., C.L., H. Maier, D.G.M., L.S., M. Simon, L.V., A. Walling, M.W.-D., H.W., J.W., C.H. and A.-M.M. developed data tools and databases, and carried out data and statistical analyses.

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Correspondence toSteve D M Brown.

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The authors declare no competing financial interests.

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A list of members and affiliations is provided in the Supplementary Note.

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Hrabě de Angelis, M., Nicholson, G., Selloum, M. et al. Analysis of mammalian gene function through broad-based phenotypic screens across a consortium of mouse clinics.Nat Genet 47, 969–978 (2015). https://doi.org/10.1038/ng.3360

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