Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2 (original) (raw)

References

1. Easton, D.F. et al. Genome-wide association study identifies novel breast cancer susceptibility loci. Nature 447, 1087–1093 (2007).
   Article CAS Google Scholar
2. Hunter, D.J. et al. A genome-wide association study identifies alleles in FGFR2 associated with risk of sporadic postmenopausal breast cancer. Nat. Genet. 39, 870–874 (2007).
   Article CAS Google Scholar
3. Stacey, S.N. et al. Common variants on chromosomes 2q35 and 16q12 confer susceptibility to estrogen receptor-positive breast cancer. Nat. Genet. 39, 865–869 (2007).
   Article CAS Google Scholar
4. Stacey, S.N. et al. Common variants on chromosome 5p12 confer susceptibility to estrogen receptor-positive breast cancer. Nat. Genet. 40, 703–706 (2008).
   Article CAS Google Scholar
5. Zheng, W. et al. Genome-wide association study identifies a new breast cancer susceptibility locus at 6q25.1. Nat. Genet. 41, 324–328 (2009).
   Article CAS Google Scholar
6. Garcia-Closas, M. et al. Heterogeneity of breast cancer associations with five susceptibility loci by clinical and pathological characteristics. PLoS Genet. 4, e1000054 (2008).
   Article Google Scholar
7. Yin, M.J., Shao, L., Voehringer, D., Smeal, T. & Jallal, B. The serine/threonine kinase Nek6 is required for cell cycle progression through mitosis. J. Biol. Chem. 278, 52454–52460 (2003).
   Article CAS Google Scholar
8. Quarmby, L.M. & Mahjoub, M.R. Caught Nek-ing: cilia and centrioles. J. Cell Sci. 118, 5161–5169 (2005).
   Article CAS Google Scholar
9. Chen, Y . et al. Differential expression of novel tyrosine kinase substrates during breast cancer development. Mol. Cell. Proteomics 6, 2072–2087 (2007).
   Article CAS Google Scholar
10. Min, J . et al. Synip: a novel insulin-regulated syntaxin 4-binding protein mediating GLUT4 translocation in adipocytes. Mol. Cell 3, 751–760 (1999).
    Article CAS Google Scholar
11. Stranger, B.E. et al. Population genomics of human gene expression. Nat. Genet. 39, 1217–1224 (2007).
    Article CAS Google Scholar

Download references

Acknowledgements

The initial GWAS, SEARCH, the replication genotyping through BCAC and the main analysis of this study were supported by Cancer Research UK grants C1287/A7497, C490/A11021, C1287/A10118 and C1287/A5260. D.F.E. and P.D.P.P. are supported by Cancer Research UK. Meetings of BCAC have been supported in part by ESF COST action BM0606.

The Nurses' Health Studies are supported by US National Institutes of Health grants CA65725, CA87969, CA49449, CA67262, CA50385 and 5UO1CA098233. The WHI program is supported by contracts from the National Heart, Lung, and Blood Institute, NIH. We thank the WHI investigators and staff for their dedication and the study participants for making the program possible. A full listing of WHI investigators can be found at http://www.whiscience.org/publications/WHI_investigators_shortlist.pdf. The ACS study is supported by UO1 CA098710. We thank C. Lichtman for data management and the participants on the CPS-II. The PLCO study is supported by the Intramural Research Program of the Division of Cancer Epidemiology and Genetics and contracts from the Division of Cancer Prevention, National Cancer Institute, NIH and DHHS. We thank P. Prorok, Division of Cancer Prevention, National Cancer Institute, the Screening Center investigators and staff of the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial (PLCO) and T. Sheehy and staff at SAIC-Frederick. We acknowledge the study participants for their contributions to making this study possible. The ABCFS was supported by the National Health and Medical Research Council (NHMRC) of Australia (#145604), the US NIH (RO1 CA102740-01A2) and by the National Cancer Institute, NIH under RFA #CA-95-011 through cooperative agreements with members of the Breast Cancer Family Registry (Breast CFR) and principal investigators from Cancer Care Ontario (UO1 CA69467), Columbia University (U01 CA69398), Fox Chase Cancer Center (U01 CA69631), Huntsman Cancer Institute (U01 CA69446), Northern California Cancer Center (U01 CA69417) and University of Melbourne (U01 CA69638). The content of this manuscript does not necessarily reflect the views or policies of the National Cancer Institute or any of collaborating centers in the Breast CFR, nor does mention of trade names, commercial products or organizations imply endorsement by the US government or the Breast CFR. The ABCFS was initially supported by the NHMRC, the New South Wales Cancer Council and the Victorian Health Promotion Foundation. J.L.H. and M.C.S. are supported by NHMRC. We thank M. Angelakos, J. Maskiell and G. Dite. We thank X. Chen for genotyping the ABCFS, kConFab and AOCS samples, and H. Thorne, E. Niedermayr, all the kConFab research nurses and staff, the heads and staff of the Family Cancer Clinics and the Clinical Follow Up Study (funded by NHMRC grants 145684, 288704 and 454508) for their contributions to this resource, and the many families who contribute to kConFab. kConFab is supported by grants from the National Breast Cancer Foundation, the National Health and Medical Research Council (NHMRC) and by the Queensland Cancer Fund, the Cancer Councils of New South Wales, Victoria, Tasmania and South Australia, and the Cancer Foundation of Western Australia. The AOCS Management Group (D. Bowtell, G.C.-T., A. deFazio, D. Gertig, A. Green and P. Webb) gratefully acknowledges the contribution of all the clinical and scientific collaborators (see http://www.aocstudy.org/). The ACS Management Group (A. Green, P. Parsons, N. Hayward, P. Webb, D. Whiteman) thank all of the project staff, collaborating institutions and study participants. Financial support was provided by US Army Medical Research and Materiel Command under DAMD17-01-1-0729, the Cancer Council Tasmania and Cancer Foundation of Western Australia (AOCS study) and The National Health and Medical Research Council of Australia (199600) (ACS study). G.C.-T. is supported by NHMRC. Funding of the ABCS study was provided by the Dutch Cancer Society (grants NKI 2001-2423; 2007-3839) and the Dutch National Genomics Initiative. ABCS acknowledges L. Braaf, L. Van't Veer, F. Van Leeuwen, R. Tollenaar and other contributors to the 'BOSOM' study and the support of H.B. Bueno-de-Mesquita for organizing the release of control DNA. The British Breast Cancer Study is funded by Cancer Research UK and Breakthrough Breast Cancer. We acknowledge NHS funding to the NIHR Biomedical Research Centre, and the National Cancer Research Network (NCRN). The CGPS was supported by the Danish Medical Research Council and Copenhagen County. The CNIO-BCS was supported by the Genome Spain Foundation and grants from the Asociación Española Contra Cáncer and the Fondo de Investigación Sanitario (PI081120 and PI081583). We thank J.I. Arias from the Hospital Monte Naranco, P. Zamora from the Hospital La Paz and C. Alonso and T. Moreno from the CNIO. The GENICA study was supported by the German Human Genome Project and funded by the Federal Ministry of Education and Research (BMBF) Germany grants 01KW9975/5, 01KW9976/8, 01KW9977/0 and 01KW0114. Genotyping analysis was supported by the Robert Bosch Foundation of Medical Research. B. Pesch, V. Harth and T. Brüning were involved in the recruitment of study subjects and responsible for the collection of epidemiological data. The Genetic Epidemiology Study of Breast Cancer by Age 50 (GESBC) was supported by the Deutsche Krebshilfe e.V. (project number 70492) and the genotyping in part by the state of Baden-Württemberg through Medical Faculty of the University of Ulm (P.685). We thank U. Eilber and T. Koehler for their technical support. We cordially thank M. Bremer, A. Scharf and C. Sohn for their support of the breast cancer studies in Hannover. HABCS and HMBCS received funding through a Hannelore-Munke stipend to N.V.B. HUBCS was supported by a grant from the German Federal Ministry of Education and Research (RUS 08/017). HEBCS wishes to thank H. Jäntti and K. Aaltonen for help with the subject data. The Finnish Cancer registry is gratefully acknowledged for the cancer data. The HEBCS study has been financially supported by the Helsinki University Central Hospital Research Fund, Academy of Finland (110663), Finnish Cancer Society and the Sigrid Juselius Foundation. KARBAC was supported by The Swedish Cancer Foundation, The Gustav V Jubilee Foundation and the Bert von Kantzow Foundation. KBCP is grateful to E. Myöhänen for her assistance. KBCP was supported by special Government Funding (EVO) of Kuopio University Hospital, The Finnish Cancer Society, University of Kuopio and by the Northern Savo Cancer Society. MCBCS was supported by grants from the NIH (P50 CA116201 and R01 CA122340). We thank all the participants in the MCCS and the team of investigators, project and data managers and project assistants. The MCCS is supported by the Australian National Health and Medical Research Council (grants 209057, 251533, 396414 and 504711). Cohort recruitment and follow up is funded by The Cancer Council Victoria. The OFBCR was supported by the National Cancer Institute, NIH under RFA #CA-06-503 and through cooperative agreements with members of the Breast Cancer Family Registry and Cancer Care Ontario (U01 CA69467). We thank N. Weerasooriya, M. Gill, L. Collins and N. Gokgoz for their assistance. The ORIGO study was supported by the Dutch Cancer Society; we thank P.E.A. Huijts, E. Krol-Warmerdam and J. Blom for recruiting subjects, administering questionnaires and managing clinical information. RBCS was supported by the Dutch Cancer Society. SASBAC study was supported by funding from the Agency for Science, Technology and Research of Singapore (A*STAR), the US NIH and the Susan G. Komen Breast Cancer Foundation. The SBCS was supported by Yorkshire Cancer Research and the Breast Cancer Campaign. We thank S. Higham, H. Cramp, D. Connley and S. Balasubramanian for their contribution to the SBCS. The PBCS was funded by Intramural Research Funds of the US National Cancer Institute, DHHS. The PBCS thanks N. Szeszenia-Dabrowska, B. Peplonska, W. Zatonski, M. Sherman and P. Chao for their valuable contributions to the study. SEBCS was supported by a grant of the Korea Health 21 R&D Project, Ministry of Health & Welfare (R.O.K.) (AO30001) and by a grant from the National R&D program for Cancer Control, Ministry of Health & Welfare, Republic of Korea (0620410-1). The UCIBCS component of this research was supported by the US NIH, National Cancer Institute grants CA-58860 and CA-92044 and the Lon V. Smith Foundation grant LVS-39420.

Author information

Author notes

1. Shahana Ahmed, Gilles Thomas, Maya Ghoussaini, Catherine S Healey and Manjeet K Humphreys: These authors contributed equally to this work.

Authors and Affiliations

1. Department of Oncology, University of Cambridge, Cambridge, UK
   Shahana Ahmed, Maya Ghoussaini, Catherine S Healey, Radka Platte, Melanie Maranian, Bruce A J Ponder, Paul D P Pharoah & Alison M Dunning
2. Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
   Gilles Thomas, Kevin Jacobs, Regina G Ziegler, Montserrat Garcia-Closas, Alice Sigurdson, Michele Doody, Parveen Bhatti & Robert N Hoover
3. Department of Public Health and Primary Care, CR-UK Genetic Epidemiology Unit, University of Cambridge, Cambridge, UK
   Manjeet K Humphreys, Jonathan Morrison, Karen A Pooley, Paul D P Pharoah & Douglas F Easton
4. Department of Public Health and Primary Care, EPIC, University of Cambridge, Cambridge, UK
   Robert Luben
5. Wessex Clinical Genetics Service, Princess Ann Hospital, Southampton, UK
   Diana Eccles
6. Regional Genetic Service, St. Mary's Hospital, Manchester, UK
   D Gareth Evans
7. Breakthrough Breast Cancer Research Centre, Institute of Cancer Research, London, UK
   Olivia Fletcher & Nichola Johnson
8. London School of Hygiene and Tropical Medicine and Institute of Cancer Research, London, UK.,
   Olivia Fletcher, Isabel dos Santos Silva & Julian Peto
9. Institute of Cancer Research, Sutton, Surrey, UK
   Julian Peto
10. Cancer Genome Project, Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Hinxton, Cambridge, UK
    Michael R Stratton
11. Section of Cancer Genetics, Institute of Cancer Research, Sutton, Surrey, UK
    Nazneen Rahman
12. Bioinformed Consulting Services, Gaithersburg, Maryland, USA
    Kevin Jacobs
13. Core Genotyping Facility, Advanced Technology Program, SAIC-Frederick Inc., NCI-Frederick, Frederick, Maryland, USA
    Kevin Jacobs
14. Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Ross Prentice & Garnet L Anderson
15. Department of Obstetrics and Gynecology, Baylor College of Medicine, Houston, Texas, USA
    Aleksandar Rajkovic
16. Department of Geriatric Medicine, John A. Burns School of Medicine, University of Hawaii/Pacific Health Research Institute, Honolulu, Hawaii, USA
    J David Curb
17. Division of Cancer Prevention, NCI, NIH, DHHS, Bethesda, Maryland, USA
    Christine D Berg
18. Department of Internal Medicine, University of Utah, Salt Lake City, Utah, USA
    Saundra S Buys
19. The Center for Human Genetics, Marshfield Clinic Research Foundation, Marshfield, Wisconsin, USA
    Catherine A McCarty
20. Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, Georgia, USA
    Heather Spencer Feigelson, Eugenia E Calle, Michael J Thun & W Ryan Diver
21. Department of Clinical Biochemistry, Copenhagen University Hospital, Herlev, Denmark
    Stig Bojesen & Børge G Nordestgaard
22. Copenhagen General Population Study, Copenhagen University Hospital, Herlev, Denmark
    Stig Bojesen & Børge G Nordestgaard
23. Department of Breast Surgery, Copenhagen University Hospital, Herlev, Denmark
    Henrik Flyger
24. Departments of Obstetrics and Gynaecology,
    Thilo Dörk, Peter Schürmann, Peter Hillemanns, Natalia V Bogdanova & Marina Bermisheva
25. Radiation Oncology, Hannover Medical School, Hannover, Germany
    Johann H Karstens & Natalia V Bogdanova
26. N.N. Alexandrov Research Institute of Oncology and Medical Radiology, Minsk, Belarus
    Natalia V Bogdanova, Natalia N Antonenkova & Iosif V Zalutsky
27. Institute of Biochemistry and Genetics, Ufa Scientific Center of Russian Academy of Sciences, Ufa, Russia
    Marina Bermisheva & Elza Khusnutdinova
28. Department of Medical Genetics, Yakut Research Center of Russian Academy of Medical Sciences, Yakutsk, Russia
    Sardana Fedorova
29. Seoul National University College of Medicine, Seoul, Korea
    Daehee Kang, Keun-Young Yoo, Dong Young Noh & Sei-Hyun Ahn
30. Departments of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Peter Devilee
31. Department of Pathology, Leiden University Medical Center, Leiden, The Netherlands
    Peter Devilee
32. Department of Clinical Genetics, Leiden University Medical Center, Leiden, The Netherlands
    Christi J van Asperen
33. Surgical Oncology, Leiden University Medical Center, Leiden, The Netherlands
    R A E M Tollenaar
34. Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus MC-Daniel den Hoed Cancer Center, Rotterdam, The Netherlands
    Caroline Seynaeve
35. Department of Epidemiology and Cancer Prevention, The M. Sklodowska-Curie Cancer Center and Institute of Oncology, Warsaw, Poland
    Jolanta Lissowska
36. Hormonal and Reproductive Epidemiology Branch, National Cancer Institute, Rockville, Maryland, USA
    Louise Brinton
37. Department of Occupational & Environmental Epidemiology, Nofer Institute of Occupational Medicine, Lodz, Poland
    Beata Peplonska
38. Departments of Obstetrics and Gynaecology, Helsinki University Central Hospital, Helsinki, Finland
    Heli Nevanlinna & Tuomas Heikkinen
39. Department of Clinical Genetics, Helsinki University Central Hospital, Helsinki, Finland
    Kristiina Aittomäki
40. Departments of Oncology, Helsinki University Central Hospital, Helsinki, Finland
    Carl Blomqvist
41. Centre for Molecular, Environmental, Genetic and Analytic Epidemiology, University of Melbourne, Melbourne, Australia
    John L Hopper, Graham G Giles, Gianluca Severi, Laura Baglietto & Dallas R English
42. Department of Pathology, University of Melbourne, Melbourne, Australia
    Melissa C Southey
43. Queensland Institute for Medical Research, Brisbane, Australia
    Letitia Smith, Amanda B Spurdle, Jonathan Beesley & Georgia Chenevix-Trench
44. Netherlands Cancer Institute, Amsterdam, The Netherlands
    Marjanka K Schmidt, Annegien Broeks, Richard R van Hien & Sten Cornelissen
45. Genetic and Molecular Epidemiology Group,
    Roger L Milne
46. Human Genetics Group,
    Gloria Ribas & Javier Benitez
47. National Genotyping Centre (CEGEN), Human Cancer Genetics Program, Spanish National Cancer Research Centre (CNIO), Madrid, Spain
    Anna González-Neira & Javier Benitez
48. Department of Gynaecology and Obstetrics, Clinical Center University of Cologne, Köln, Germany
    Rita K Schmutzler
49. Molecular Epidemiology Group, German Cancer Research Center (DKFZ), Heidelberg, Germany
    Barbara Burwinkel
50. Department of Obstetrics and Gynecology, University of Heidelberg, Heidelberg, Germany
    Barbara Burwinkel
51. Institute of Human Genetics, University of Heidelberg, Heidelberg, Germany
    Claus R Bartram
52. Department of Gynaecology and Obstetrics, Technical University of Munich, Munich, Germany
    Alfons Meindl
53. Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology, Stuttgart, Germany
    Hiltrud Brauch & Christina Justenhoven
54. University of Tuebingen, Tuebingen, Germany
    Hiltrud Brauch & Christina Justenhoven
55. Molecular Genetics of Breast Cancer, Deutsches Krebsforschungszentrum (DKFZ), Heidelberg, Germany
    Ute Hamann
56. Division of Cancer Epidemiology, German Cancer Research Center (DFKZ), Heidelberg, Germany
    Jenny Chang-Claude & Rebecca Hein
57. Women's Hospital of University of Ulm, Ulm, Germany
    Shan Wang-Gohrke
58. Department of Molecular Medicine and Surgery, Karolinska Institutet, Stockholm, S17176, Sweden
    Annika Lindblom
59. Department of Oncology and Pathology, Karolinska Institutet, Stockholm, S17176, Sweden
    Sara Margolin
60. Institute of Clinical Medicine, Pathology and Forensic Medicine and Biocenter Kuopio, University of Kuopio, Kuopio, Finland
    Arto Mannermaa & Veli-Matti Kosma
61. Departments of Pathology, Kuopio University Hospital, Kuopio, Finland
    Arto Mannermaa & Veli-Matti Kosma
62. Department of Oncology, Kuopio University Hospital, Kuopio, Finland
    Vesa Kataja
63. Department of Oncology, Vaasa Central Hospital, Vaasa, Finland
    Vesa Kataja
64. Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Janet E Olson, Xianshu Wang, Zachary Fredericksen, Ellen L Goode & Fergus Couch
65. Cancer Epidemiology Centre, Cancer Council Victoria, Melbourne, Australia
    Graham G Giles, Gianluca Severi, Laura Baglietto & Dallas R English
66. Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
    Susan E Hankinson, David G Cox & David J Hunter
67. Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Peter Kraft & David J Hunter
68. Department of Public Health, Norwegian University of Science and Technology, Trondheim, Norway
    Lars J Vatten & Kristian Hveem
69. Institute of Community Medicine, University of Tromso, Tromso, Norway
    Merethe Kumle
70. Division of Environmental Health Science, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
    Bruce H Alexander
71. Department of Medical Oncology, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands
    Maartje J Hooning & Mieke Schutte
72. Department of Clinical Genetics, Rotterdam Family Cancer Clinic, Erasmus University Medical Center, Rotterdam, The Netherlands
    Ans M W van den Ouweland & Rogier A Oldenburg
73. Department of Medical Epidemiology and Biostatistics, Karolinska Institute, Stockholm, Sweden
    Per Hall & Kamila Czene
74. Population Genetics, Genome Institute of Singapore, Singapore
    Jianjun Liu & Yuqing Li
75. Institute for Cancer Studies, University of Sheffield School of Medicine and Biomedical Sciences, Sheffield, UK
    Angela Cox, Graeme Elliott & Ian Brock
76. Academic Unit of Surgical Oncology, University of Sheffield School of Medicine and Biomedical Sciences, Sheffield, UK
    Malcolm W R Reed
77. Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan
    Chen-Yang Shen
78. Graduate Institute of Environmental Science, China Medical University, Taichong, Taiwan
    Chen-Yang Shen
79. Tri-Service General Hospital, Taipei, Taiwan
    Jyh-Cherng Yu & Giu-Cheng Hsu
80. Changhua Christian Hospital, Changhua, Taiwan
    Shou-Tung Chen
81. Department of Epidemiology, University of California Irvine, Irvine, California, USA
    Hoda Anton-Culver & Argyrios Ziogas
82. Samuel Lunenfeld Research Institute, Mount Sinai Hospital, Toronto, Ontario, Canada
    Irene L Andrulis & Julia A Knight
83. Ontario Familial Breast Cancer Registry, Cancer Care Ontario, Toronto, Ontario, Canada
    Irene L Andrulis
84. Cancer Research UK Cambridge Cancer Research Institute, Cambridge, UK
    Bruce A J Ponder
85. Advanced Technology Center, National Cancer Institute, Gaithersburg, Maryland, USA
    Stephen J Chanock

Authors

1. Shahana Ahmed
2. Gilles Thomas
3. Maya Ghoussaini
4. Catherine S Healey
5. Manjeet K Humphreys
6. Radka Platte
7. Jonathan Morrison
8. Melanie Maranian
9. Karen A Pooley
10. Robert Luben
11. Diana Eccles
12. D Gareth Evans
13. Olivia Fletcher
14. Nichola Johnson
15. Isabel dos Santos Silva
16. Julian Peto
17. Michael R Stratton
18. Nazneen Rahman
19. Kevin Jacobs
20. Ross Prentice
21. Garnet L Anderson
22. Aleksandar Rajkovic
23. J David Curb
24. Regina G Ziegler
25. Christine D Berg
26. Saundra S Buys
27. Catherine A McCarty
28. Heather Spencer Feigelson
29. Eugenia E Calle
30. Michael J Thun
31. W Ryan Diver
32. Stig Bojesen
33. Børge G Nordestgaard
34. Henrik Flyger
35. Thilo Dörk
36. Peter Schürmann
37. Peter Hillemanns
38. Johann H Karstens
39. Natalia V Bogdanova
40. Natalia N Antonenkova
41. Iosif V Zalutsky
42. Marina Bermisheva
43. Sardana Fedorova
44. Elza Khusnutdinova
45. Daehee Kang
46. Keun-Young Yoo
47. Dong Young Noh
48. Sei-Hyun Ahn
49. Peter Devilee
50. Christi J van Asperen
51. R A E M Tollenaar
52. Caroline Seynaeve
53. Montserrat Garcia-Closas
54. Jolanta Lissowska
55. Louise Brinton
56. Beata Peplonska
57. Heli Nevanlinna
58. Tuomas Heikkinen
59. Kristiina Aittomäki
60. Carl Blomqvist
61. John L Hopper
62. Melissa C Southey
63. Letitia Smith
64. Amanda B Spurdle
65. Marjanka K Schmidt
66. Annegien Broeks
67. Richard R van Hien
68. Sten Cornelissen
69. Roger L Milne
70. Gloria Ribas
71. Anna González-Neira
72. Javier Benitez
73. Rita K Schmutzler
74. Barbara Burwinkel
75. Claus R Bartram
76. Alfons Meindl
77. Hiltrud Brauch
78. Christina Justenhoven
79. Ute Hamann
80. Jenny Chang-Claude
81. Rebecca Hein
82. Shan Wang-Gohrke
83. Annika Lindblom
84. Sara Margolin
85. Arto Mannermaa
86. Veli-Matti Kosma
87. Vesa Kataja
88. Janet E Olson
89. Xianshu Wang
90. Zachary Fredericksen
91. Graham G Giles
92. Gianluca Severi
93. Laura Baglietto
94. Dallas R English
95. Susan E Hankinson
96. David G Cox
97. Peter Kraft
98. Lars J Vatten
99. Kristian Hveem
100. Merethe Kumle
101. Alice Sigurdson
102. Michele Doody
103. Parveen Bhatti
104. Bruce H Alexander
105. Maartje J Hooning
106. Ans M W van den Ouweland
107. Rogier A Oldenburg
108. Mieke Schutte
109. Per Hall
110. Kamila Czene
111. Jianjun Liu
112. Yuqing Li
113. Angela Cox
114. Graeme Elliott
115. Ian Brock
116. Malcolm W R Reed
117. Chen-Yang Shen
118. Jyh-Cherng Yu
119. Giu-Cheng Hsu
120. Shou-Tung Chen
121. Hoda Anton-Culver
122. Argyrios Ziogas
123. Irene L Andrulis
124. Julia A Knight
125. Jonathan Beesley
126. Ellen L Goode
127. Fergus Couch
128. Georgia Chenevix-Trench
129. Robert N Hoover
130. Bruce A J Ponder
131. David J Hunter
132. Paul D P Pharoah
133. Alison M Dunning
134. Stephen J Chanock
135. Douglas F Easton

Consortia

SEARCH

The GENICA Consortium

kConFab

Australian Ovarian Cancer Study Group

Contributions

D.F.E., A.M.D., P.D.P.P. and B.A.J.P. designed the study and obtained financial support. D.F.E. and P.D.P.P. conducted the statistical analysis. G.T., R.N.H., D.J.H. and S.J.C. directed the CGEMS study and designed and conducted the stage 3 experiment with D.F.E., S.A., M.G., C.S.H. and M.M. conducting the fine-scale mapping. M.K.H., J.M. and R.L. provided bioinformatics support. D.E., D.G.E., O.F., N.J., I.d.S.S., J.P., M.R.S. and N.R. co-ordinated the studies used in stage 1. The remaining authors coordinated the studies in stage 4 and/or undertook genotyping in those studies. D.F.E. drafted the manuscript, with substantial input from other authors. All authors contributed to the final paper.

Corresponding author

Correspondence toDouglas F Easton.

Supplementary information

Rights and permissions

About this article

Cite this article

Ahmed, S., Thomas, G., Ghoussaini, M. et al. Newly discovered breast cancer susceptibility loci on 3p24 and 17q23.2.Nat Genet 41, 585–590 (2009). https://doi.org/10.1038/ng.354

Download citation

• Received: 05 December 2008
• Accepted: 03 February 2009
• Published: 29 March 2009
• Issue date: May 2009
• DOI: https://doi.org/10.1038/ng.354