Copy number alterations unmasked as enhancer hijackers (original) (raw)

Nature Genetics volume 49, pages 5–6 (2017)Cite this article

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Our understanding of how DNA copy number changes contribute to disease, including cancer, has to a large degree been focused on the changes in gene dosage that they generate and has neglected the effects of the DNA rearrangements that lead to their formation. A new study reports an innovative analytical framework for copy number alterations that are oncogenic primarily owing to the genomic rearrangements that underlie them.

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Figure 1: Oncogenic rearrangement topologies that rely on changes in relative placement of genes near regulatory elements rather than simple changes in gene dosage.

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Authors and Affiliations

  1. Rameen Beroukhim, Xiaoyang Zhang and Matthew Meyerson are at the Dana-Farber Cancer Institute, the Broad Institute of Harvard and MIT, and Harvard Medical School, Boston, Massachusetts, USA.,
    Rameen Beroukhim, Xiaoyang Zhang & Matthew Meyerson

Authors

  1. Rameen Beroukhim
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  2. Xiaoyang Zhang
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  3. Matthew Meyerson
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Corresponding author

Correspondence toMatthew Meyerson.

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Competing interests

R.B. receives research support from and is a consultant for Novartis. M.M. receives research support from Bayer and is a founding advisor of Foundation Medicine, for which he was previously a consultant and in which he previously held equity.

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Beroukhim, R., Zhang, X. & Meyerson, M. Copy number alterations unmasked as enhancer hijackers.Nat Genet 49, 5–6 (2017). https://doi.org/10.1038/ng.3754

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