Genetic variation in LIN28B is associated with the timing of puberty (original) (raw)

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Acknowledgements

We are grateful to all of the participants in each of the studies contributing to this effort. Full acknowledgments can be found in the Supplementary Note.

Support for this research was provided by: the UK Medical Research Council; the Wellcome Trust; University of Bristol; the Faculty of Biology and Medicine of Lausanne, Switzerland; and GlaxoSmithKline.

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Author notes

1. ken.ong@mrc-epid.cam.ac.uk

Authors and Affiliations

1. Medical Research Council (MRC) Epidemiology Unit, Addenbrooke's Hospital, Cambridge, UK
   Ken K Ong, Cathy E Elks, Shengxu Li, Jing Hua Zhao, Jian'an Luan, Soren Brage, Ulf Ekelund, Christopher J Gillson, Matthew A Sims, Ruth J Loos & Nicholas J Wareham
2. Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
   Ken K Ong, Cathy E Elks, Shengxu Li, Jing Hua Zhao, Jian'an Luan, Soren Brage, Ulf Ekelund, Christopher J Gillson, Matthew A Sims, Ruth J Loos & Nicholas J Wareham
3. Department of Paediatrics, University of Cambridge, Cambridge, UK
   Ken K Ong
4. Institute of Sport Science and Clinical Biomechanics, University of Southern Denmark, Odense, Denmark
   Lars B Andersen
5. MRC Dunn Human Nutrition Unit, Wellcome Trust/MRC Building, Cambridge, UK
   Sheila A Bingham
6. MRC Centre for Nutritional Epidemiology in Cancer Prevention and Survival, Cambridge, UK
   Sheila A Bingham
7. Department of Social Medicine, MRC Centre for Causal Analyses in Translational Epidemiology, University of Bristol, UK
   George Davey Smith & Beate Glaser
8. School of Health and Medical Sciences, Örebro University, Örebro, Sweden
   Ulf Ekelund
9. Department of Community Based Medicine, Avon Longitudinal Study of Parents and Children (ALSPAC), University of Bristol, Bristol, UK
   Jean Golding
10. MRC Unit for Lifelong Health and Ageing, London, UK
    Rebecca Hardy, Diana Kuh & Andrew Wong
11. Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
    Kay-Tee Khaw & Robert Luben
12. National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Georgia, USA
    Michele Marcus, Michael A McGeehin & Carol Rubin
13. Department of Epidemiology, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Michele Marcus
14. Departments of Environmental and Occupational Health, Rollins School of Public Health, Emory University, Atlanta, Georgia, USA
    Michele Marcus
15. Department of Oral and Dental Science, University of Bristol, Bristol, UK
    Andrew R Ness
16. Department of Social Medicine, ALSPAC, University of Bristol, Bristol, UK
    Kate Northstone & Susan M Ring
17. Genetics Division, GlaxoSmithKline, King of Prussia, Pennsylvania, USA
    Kijoung Song, Dawn M Waterworth & Vincent Mooser
18. Division of Community Health Sciences, St. George's, University of London, London, UK
    David P Strachan
19. Department of Internal Medicine, BH-10 Centre Hospitalier Universitaire Vaudois (CHUV), Lausanne, Switzerland
    Peter Vollenweider & Gerard Waeber
20. Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
    Panagiotis Deloukas & Inês Barroso

Authors

1. Ken K Ong
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2. Cathy E Elks
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3. Shengxu Li
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4. Jing Hua Zhao
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5. Jian'an Luan
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6. Lars B Andersen
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7. Sheila A Bingham
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8. Soren Brage
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9. George Davey Smith
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10. Ulf Ekelund
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11. Christopher J Gillson
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12. Beate Glaser
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13. Jean Golding
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14. Rebecca Hardy
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15. Kay-Tee Khaw
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16. Diana Kuh
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17. Robert Luben
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18. Michele Marcus
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19. Michael A McGeehin
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20. Andrew R Ness
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21. Kate Northstone
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22. Susan M Ring
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23. Carol Rubin
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24. Matthew A Sims
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25. Kijoung Song
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26. David P Strachan
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27. Peter Vollenweider
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28. Gerard Waeber
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29. Dawn M Waterworth
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30. Andrew Wong
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31. Panagiotis Deloukas
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32. Inês Barroso
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33. Vincent Mooser
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34. Ruth J Loos
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35. Nicholas J Wareham
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Contributions

Writing group: C.E.E., R.J.L., S.L., K.K.O., N.J.W.

Genome-wide association analyses and meta-analyses: I.B., P.D., C.E.E., S.L., R.J.L., V.M., K.K.O., N.J.W., J.H.Z.

Oversight of contributing cohorts: L.B.A., S.B., U.E., J.G., D.K., K.-T.K., S.A.B., V.M., A.R.N., D.P.S., G.D.S., P.V., N.J.W.

Phenotype preparation and analyses in contributing cohorts: S.B., U.E., B.G., J.G., R.H., S.L., J.L., R.L., R.J.L., M.M., M.A.M., A.R.N., K.N., K.K.O., C.R., D.P.S., K.S., G.W., D.M.W., J.H.Z.

Generating new genotype data: C.J.G., S.M.R., M.A.S., A.W.

Corresponding authors

Correspondence toKen K Ong or Ruth J Loos.

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Competing interests

Vincent Mooser, Dawn Waterworth and Kijoung Song are full-time employees of GlaxoSmithKline. Peter Vollenweider and Gérard Waeber received financial support from GlaxoSmithKline to build the CoLaus study. Inês Barroso owns stock in the companies GlaxoSmithKline (GSK) and Incyte (INCY).

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Ong, K., Elks, C., Li, S. et al. Genetic variation in LIN28B is associated with the timing of puberty.Nat Genet 41, 729–733 (2009). https://doi.org/10.1038/ng.382

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• Received: 27 October 2008
• Accepted: 21 April 2009
• Published: 17 May 2009
• Issue Date: June 2009
• DOI: https://doi.org/10.1038/ng.382