The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer (original) (raw)

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Acknowledgements

M.L.F. is a Howard Hughes Medical Institute Physician-Scientist Early Career Awardee and is a recipient of a 2006 Doris Duke Clinical Scientist Development Award. This work was supported by grants from the US National Institutes of Health (R01 CA129435 to M.L.F. and R01 CA109147 to G.A.C.), the Mayer Foundation (to M.L.F.), the H.L. Snyder Medical Foundation (to M.L.F.), the Dana-Farber/Harvard Cancer Center Prostate Cancer SPORE (National Cancer Institute Grant No. 5P50CA90381), the Prostate Cancer Foundation (to G.A.C. and to M.M.P.), the Whittier Foundation (to G.A.C.), the American Cancer Society Institutional Research Grant (IRG – 58-007-48 to L.J.) and the American Society of Clinical Oncology (to M.M.P.). We also acknowledge M.A. Brown for his support and guidance.

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1. Mark M Pomerantz and Nasim Ahmadiyeh: These authors contributed equally to this work.

Authors and Affiliations

1. Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
   Mark M Pomerantz, Nasim Ahmadiyeh, Paula Herman, Michael P Verzi, Christine A Beckwith, Adam Hills, Matt Davis, Keluo Yao, Sarah M Kehoe, Jordi Barretina, Adam Bass, Ramesh Shivdasani & Matthew L Freedman
2. Department of Surgery, Brigham and Women's Hospital, Boston, Massachusetts, USA
   Nasim Ahmadiyeh
3. Department of Urology, Keck School of Medicine of USC, Los Angeles, California, USA
   Li Jia, Chunli Yan & Gerhard A Coetzee
4. Department of Biology and the Roy J. Carver Center for Genomics, University of Iowa, Iowa City, Iowa, USA
   Harshavardhan Doddapaneni & J Robert Manak
5. Department of Pathology and Laboratory Medicine, University of Calgary, Alberta, Canada
   Jennifer A Chan
6. Department of Preventive Medicine, Keck School of Medicine, Los Angeles, California, USA
   Heinz-Josef Lenz, Christopher A Haiman & Brian E Henderson
7. Institute for Genetic Medicine, Keck School of Medicine, Los Angeles, California, USA
   Baruch Frenkel
8. Vall d'Hebron Institute of Oncology, Vall d'Hebron University Hospital, Catalonia, Spain
   Josep Tabernero & José Baselga
9. Department of Biostatistics and Computational Biology, Dana-Farber Cancer Institute, Boston, Massachusetts, USA
   Meredith M Regan
10. The Broad Institute of Harvard and MIT, Cambridge, Massachusetts, USA
    Matthew L Freedman

Authors

1. Mark M Pomerantz
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2. Nasim Ahmadiyeh
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3. Li Jia
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4. Paula Herman
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5. Michael P Verzi
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6. Harshavardhan Doddapaneni
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7. Christine A Beckwith
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8. Jennifer A Chan
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9. Adam Hills
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10. Matt Davis
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11. Keluo Yao
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12. Sarah M Kehoe
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13. Heinz-Josef Lenz
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14. Christopher A Haiman
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15. Chunli Yan
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16. Brian E Henderson
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17. Baruch Frenkel
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18. Jordi Barretina
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19. Adam Bass
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20. Josep Tabernero
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21. José Baselga
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22. Meredith M Regan
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23. J Robert Manak
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24. Ramesh Shivdasani
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25. Gerhard A Coetzee
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26. Matthew L Freedman
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Contributions

M.M.P., N.A. and M.L.F. designed the study, analyzed all genetic and epigenetic data and wrote the manuscript. L.J., C.A.H., C.Y., B.E.H., B.F. and G.A.C. performed and analyzed ChIP and luciferase assays. M.M.P., N.A., P.H. and A.H. performed 3C experiments. M.P.V. and R.S. performed and analyzed ChIP experiments. H.D. and J.R.M. performed analysis of expression array. C.A.B. performed expression analysis of colon samples. J.A.C. analyzed colon samples and isolated nucleic acid. M.D., K.Y. and S.M.K. performed mass array assays. H.-J.L., J.Bar., A.B., J.T. and J.Bas. collected and supplied colon samples. M.M.R. contributed statistical analysis. M.L.F. conceived and directed the study.

Corresponding author

Correspondence toMatthew L Freedman.

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Competing interests

Dr. Manak and his group generated the expression tiling array data while he was employed at Roche NimbleGen. Dr. Manak is currently employed at the University of Iowa and has no competing financial interests with Roche NimbleGen.

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Pomerantz, M., Ahmadiyeh, N., Jia, L. et al. The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer.Nat Genet 41, 882–884 (2009). https://doi.org/10.1038/ng.403

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• Received: 09 January 2009
• Accepted: 22 May 2009
• Published: 28 June 2009
• Issue Date: August 2009
• DOI: https://doi.org/10.1038/ng.403