Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis (original) (raw)
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Acknowledgements
This study was supported by the Fondazione Italiana Sclerosi Multipla (FISM) Cod. 2008/R/7 to F.C., by the Italian Ministry of Scientific Research (MIUR grant 2007KXNKNP) and by US National Institutes of Health contract NO1-AG-1-2109 from National Institute of Aging (NIA) to the SardiNIA ('ProgeNIA') team. The contributions of G.R.A., Y.L. and L.L. were supported in part by NIH grants HG002651, HG005214 and MH084698.
We thank all the cases and controls who made this research possible; J. Todd for a critical revision of the manuscript and helpful suggestions; A. Cao for his continuous help and support; D. Longo, D. Taub, S. Naitza, L. Crisponi, M. Congia, C. Jones, P. Zanella, R. Tirler, L. Leoni, R. Cusano, R. Lampis, V. Orrù, F. Coraddu, J. Foster, M. Luiu, L. Davolio Marani, S. Solveig Fois and M. Arru for help and advice; J. Frau, L. Lorefice, G. Coghe, G. Fenu, L. Mannu, P. Cossu, W. Satta, I. Pirastru, S. Leoni and C. Buscarinu for collaboration in the collection of MS cases; and W. Garau and F. Virdis, along with the personnel of the blood donor centers of Cagliari and Sassari, for their help in the collection of the controls. We are grateful for the important computing resources made available for the imputation and analysis by the CRS4 Computing Cluster in Pula (Cagliari, Italy).
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Author notes
- Serena Sanna, Maristella Pitzalis and Magdalena Zoledziewska: These authors contributed equally to this work.
Authors and Affiliations
- Istituto di Neurogenetica e Neurofarmacologia, Consiglio Nazionale delle Ricerche (CNR), Monserrato, Italy
Serena Sanna, Carlo Sidore, Fabio Busonero, Andrea Maschio, Mariano Dei, Sandra Lai, Antonella Mulas, Gianmauro Cuccuru, Eleonora Porcu, Manuela Uda & Francesco Cucca - Dipartimento di Scienze Biomediche, Università di Sassari, Sassari, Italy
Maristella Pitzalis, Magdalena Zoledziewska, Francesca Deidda, Fausto Poddie, Laura Morelli, Elisa Deriu & Francesco Cucca - Center for Advanced Studies, Research and Development in Sardinia (CRS4), Laboratorio di Bioinformatica, Parco tecnologico della Sardegna, Pula, Italy
Ilenia Zara - CRS4, Laboratorio di Genomica, Parco tecnologico della Sardegna, Pula, Italy
Carlo Sidore, Michael B Whalen, M Francesca Urru & Andrea Angius - Dipartimento di Scienze Neurologiche e Cardiovascolari, Centro Sclerosi Multipla, Università di Cagliari, Cagliari, Italy
Raffaele Murru, Gianna Costa, Maria Cristina Melis, Loredana Moi, Eleonora Cocco & Maria Giovanna Marrosu - Istituto di Neurologia Clinica, Università di Sassari, Sassari, Italy
Gabriele Farina, Stefano Sotgiu, Maura Pugliatti & Giulio Rosati - Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
Yun Li, Liming Liang & Gonçalo R Abecasis - Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
Yun Li - Department of Biostatistics, University of North Carolina, Chapel Hill, North Carolina, USA
Yun Li - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Liming Liang - Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
Liming Liang - Dipartimento di Scienze Biomediche e biotecnologie, Università di Cagliari, Cagliari, Italy
Patrizia Zavattari - Azienda Ospedaliera Brotzu, Centro Trasfusionale, Cagliari, Italy
Michele Bajorek - Azienda Sanitaria Locale 1, Sassari, Italy
Maria Anna Satta - Divisione di Neurologia, Azienda Ospedaliera Brotzu, Cagliari, Italy
Paola Ferrigno & Maurizio Melis - Divisione Neurologia, Presidio Ospedaliero, Ozieri, Italy
Sebastiano Traccis - Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA
David Schlessinger
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Sanna, S., Pitzalis, M., Zoledziewska, M. et al. Variants within the immunoregulatory CBLB gene are associated with multiple sclerosis.Nat Genet 42, 495–497 (2010). https://doi.org/10.1038/ng.584
- Received: 21 December 2009
- Accepted: 13 April 2010
- Published: 09 May 2010
- Issue Date: June 2010
- DOI: https://doi.org/10.1038/ng.584