Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32 (original) (raw)

References

  1. Skibola, C.F., Curry, J.D. & Nieters, A. Haematologica 92, 960–969 (2007).
    Article CAS Google Scholar
  2. Skibola, C.F. et al. Nat. Genet. 41, 873–875 (2009).
    Article CAS Google Scholar
  3. Skibola, C.F. et al. PLoS One 3, e2816 (2008).
    Article Google Scholar
  4. Smedby, K.E. et al. J. Natl. Cancer Inst. 97, 199–209 (2005).
    Article Google Scholar
  5. Cerhan, J.R. et al. Blood 110, 4455–4463 (2007).
    Article CAS Google Scholar
  6. Di Bernardo, M.C. et al. Nat. Genet. 40, 1204–1210 (2008).
    Article CAS Google Scholar
  7. de Bakker, P.I. et al. Nat. Genet. 38, 1166–1172 (2006).
    Article CAS Google Scholar
  8. Klitz, W. et al. Tissue Antigens 62, 296–307 (2003).
    Article CAS Google Scholar
  9. Al-Tonbary, Y. et al. Hematology 9, 139–145 (2004).
    Article CAS Google Scholar
  10. Nathalang, O. et al. Eur. J. Immunogenet. 26, 389–392 (1999).
    Article CAS Google Scholar
  11. Choi, H.B. et al. Int. J. Hematol. 87, 203–209 (2008).
    Article Google Scholar
  12. Skibola, C.F. et al. Am. J. Epidemiol. 171, 267–276 (2010).
    Article Google Scholar
  13. Abdou, A.M. et al. Leukemia 24, 1055–1058 (2010).
    Article CAS Google Scholar

Download references

Acknowledgements

This work was supported by grants CA122663 and CA104682 from the National Cancer Institute (NCI), US National Institutes of Health (NIH) (C.F.S.); grants CA45614 and CA89745 from the NCI, NIH (E.A.H.); the American Cancer Society (IRG-07-06401) and a charitable donation by S. Chase (K.B.). E.H. is a faculty fellow of the Edmond J. Safra Bioinformatics program at Tel-Aviv University. SCALE study: We thank X.Y. Chen, H.B. Toh, K.K. Heng and W.Y. Meah from Genome Institute of Singapore for their support in genotyping analyses. We are also grateful to L. Klareskog, Center for Molecular Medicine, and L. Alfredsson, Institute of Environmental Medicine at the Karolinska Institute, Stockholm, Sweden, for sharing DNA from their EIRA study control population and to E. Rehnberg for help with imputing genotypes in the SCALE study. The following agencies contributed funding to SCALE that facilitated the present project: Agency for Science and Technology and Research of Singapore (A*STAR), NCI, the Swedish Cancer Society, the Swedish Research Council and the Danish Medical Research Council. GEC-Mayo Study: This study is supported by grants R01 CA91253 and R01 CA118444 from the NCI. NCI-SEER study: We thank P. Hui of the Information Management Services, Inc. for programming support, and we acknowledge the contributions of the staff and scientists at the SEER centers of Iowa, Los Angeles, Detroit and Seattle for conducting the study's field effort. We especially acknowledge the contributions of study site principal investigator L. Bernstein (Los Angeles). The NCI-SEER study was supported by the Intramural Research Program of the NIH (NCI) and by US Public Health Service (PHS) contracts N01-PC-65064, N01-PC-67008, N01-PC-67009, N01-PC-67010 and N02-PC-71105. Yale study: This study is supported by grant CA62006 from the NCI and the Intramural Research Program of the NIH (NCI). NSW study: The NSW study was supported by a National Health and Medical Research Council of Australia project grant, Cancer Council NSW, a University of Sydney Medical Foundation Program Grant and the Intramural Research Program of the NIH (NCI). BC study: Funding for the British Columbia study was from the Canadian Cancer Society and the Canadian Institutes of Health Research. A.B.-W. is a Senior Scholar of the Michael Smith Foundation for Health Research. EpiLymph study: Funding was available from the German José Carreras Leukemia Foundation (DJCLS_R04/08 and R07/26f) (A.N.), the EC 5th Framework Program Quality of Life grant No. QLK4-CT-2000-00422 (P. Boffetta, P. Brennan), the Federal Office for Radiation Protection grants No. StSch4261 and StSch4420 (Germany), the Spanish Ministry of Health grants Centro de Investigación Biomédica en Red de Epidemiología y Salud Pública (CIBERESP) (06/02/0073), FIS 08-1555 and Marato TV3 (051210) (Spain), La Fondation de France, no. 1999 0084 71 (M. Maynadié), Compagnia di San Paolo di Torino, Programma Oncologia 2001 (P.C.), the Health Research Board, Ireland, and the Ministry of Health of the Czech Republic, MZ0 MOU 2005 (L.F.).

Author information

Authors and Affiliations

  1. Division of Environmental Health Sciences, School of Public Health, University of California, Berkeley, Berkeley, California, USA
    Lucia Conde, Nicholas K Akers, Luz Agana, Jacques Riby, Martyn T Smith & Christine F Skibola
  2. Molecular Microbiology and Biotechnology Department, Tel-Aviv University, Tel-Aviv, Israel
    Eran Halperin
  3. International Computer Science Institute, Berkeley, California, USA
    Eran Halperin
  4. Integrative Cancer Genomics Division, Translational Genomics Research Institute (TGen), Phoenix, Arizona, USA
    Kevin M Brown
  5. Department of Medicine, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden
    Karin E Smedby
  6. Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
    Nathaniel Rothman, Patricia Hartge, Lindsay M Morton, Sophia S Wang, Mark P Purdue, Qing Lan, Shelia H Zahm, Neil E Caporaso, Lynn R Goldin & Stephen Chanock
  7. Cancer Epidemiology, German Cancer Research Center, Heidelberg, Germany
    Alexandra Nieters, Nikolaus Becker & Katja Butterbach
  8. Molecular Epidemiology, Centre of Chronic Immunodeficiency, University of Freiburg Medical Centre, Freiburg, Germany
    Alexandra Nieters
  9. Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Susan L Slager, Sara J Achenbach, Timothy G Call, James R Cerhan, Julie M Cunningham, Curtis A Hanson, Neil E Kay, Jose F Leis, Kari G Rabe & Celine M Vachon
  10. British Columbia Cancer Research Center, British Columbia Cancer Agency, Vancouver, British Columbia, Canada
    Angela Brooks-Wilson & John J Spinelli
  11. Department of Biomedical Physiology and Kinesiology, Simon Fraser University, Vancouver, British Columbia, Canada
    Angela Brooks-Wilson
  12. Human Genetics, Genome Institute of Singapore, A*STAR, Singapore
    Jianjun Liu & Hui-Qi Low
  13. Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
    Hans-Olov Adami, Hatef Darabi & Keith Humphreys
  14. Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
    Hans-Olov Adami
  15. Department of Epidemiology Research, Statens Serum Institut, Copenhagen, Denmark
    Henrik Hjalgrim & Mads Melbye
  16. Cancer Prevention Institute of California (formerly the Northern California Cancer Center), Fremont, California, USA
    Ellen T Chang
  17. Division of Epidemiology, Department of Health Research and Policy, Stanford University School of Medicine, Stanford, California, USA
    Ellen T Chang
  18. Department of Oncology and Pathology, Karolinska University Hospital, Karolinska Institutet, Stockholm, Sweden
    Bengt Glimelius
  19. Department of Oncology, Radiology and Clinical Immunology, Akademiska Hospital, Uppsala University, Uppsala, Sweden
    Bengt Glimelius
  20. Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
    Wendy Cozen
  21. Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA
    Scott Davis
  22. Department of Family Medicine and Public Health Sciences, Wayne State University, Detroit, Michigan, USA
    Maryjean Schenk
  23. Division of Etiology, Beckman Research Institute and the City of Hope, Duarte, California, USA
    Sophia S Wang
  24. Sydney School of Public Health, The University of Sydney, Sydney, Australia
    Bruce Armstrong & Anne Kricker
  25. Department of Haematology, St. Vincent's Hospital, Sydney, Australia
    Sam Milliken
  26. University of New South Wales Cancer Research Center, Prince of Wales Clinical School, Sydney, Australia
    Claire M Vajdic
  27. International Prevention Research Institute, Lyon, France
    Peter Boyle & Paolo Boffetta
  28. School of Public Health, Yale University, New Haven, Connecticut, USA
    Yawei Zhang & Tongzhang Zheng
  29. Unit of Infections and Cancer (UNIC), Cancer Epidemiology Research Programme, Catalan Institute of Oncology, Barcelona, Spain
    Yolanda Benavente & Silvia de Sanjosé
  30. The Tisch Cancer Institute, Mount Sinai School of Medicine, New York, New York, USA
    Paolo Boffetta
  31. International Agency for Research on Cancer, Lyon, France
    Paul Brennan
  32. Department of Public Health, Occupational Health Section, University of Cagliari, Cagliari, Italy
    Pierluigi Cocco
  33. Masaryk Memorial Cancer Institute, Brno, Czech Republic
    Lenka Foretova
  34. Registry of Hematological Malignancies, EA4184, University of Burgundy, University Hospital of Dijon, Dijon, France
    Marc Maynadié
  35. School of Public Health and Population Science, University College Dublin, Dublin, Ireland
    Anthony Staines
  36. School of Population and Public Health, University of British Columbia, Vancouver, British Columbia, Canada
    John J Spinelli
  37. Department of Biomedical Informatics, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Nicola J Camp & Martha Glenn
  38. Department of Medicine, Duke University Medical Center, Durham, North Carolina, USA
    Mark C Lanasa & J Brice Weinberg
  39. Division of Cell and Gene Therapies, Office of Cellular, Tissues and Gene Therapies, US Food and Drug Administration, US National Institutes of Health, Bethesda, Maryland, USA
    Gerald E Marti
  40. Moores Cancer Center, University of California, San Diego, La Jolla, California, USA
    Laura Z Rassenti
  41. Prevention and Etiology Research Program, Masonic Cancer Center, University of Minnesota, Minneapolis, Minnesota, USA
    Logan G Spector
  42. Department of Epidemiology, The University of Texas M.D. Anderson Cancer Center, Houston, Texas, USA
    Sara S Strom
  43. Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA
    Elizabeth A Holly & Paige M Bracci

Authors

  1. Lucia Conde
  2. Eran Halperin
  3. Nicholas K Akers
  4. Kevin M Brown
  5. Karin E Smedby
  6. Nathaniel Rothman
  7. Alexandra Nieters
  8. Susan L Slager
  9. Angela Brooks-Wilson
  10. Luz Agana
  11. Jacques Riby
  12. Jianjun Liu
  13. Hans-Olov Adami
  14. Hatef Darabi
  15. Henrik Hjalgrim
  16. Hui-Qi Low
  17. Keith Humphreys
  18. Mads Melbye
  19. Ellen T Chang
  20. Bengt Glimelius
  21. Wendy Cozen
  22. Scott Davis
  23. Patricia Hartge
  24. Lindsay M Morton
  25. Maryjean Schenk
  26. Sophia S Wang
  27. Bruce Armstrong
  28. Anne Kricker
  29. Sam Milliken
  30. Mark P Purdue
  31. Claire M Vajdic
  32. Peter Boyle
  33. Qing Lan
  34. Shelia H Zahm
  35. Yawei Zhang
  36. Tongzhang Zheng
  37. Nikolaus Becker
  38. Yolanda Benavente
  39. Paolo Boffetta
  40. Paul Brennan
  41. Katja Butterbach
  42. Pierluigi Cocco
  43. Lenka Foretova
  44. Marc Maynadié
  45. Silvia de Sanjosé
  46. Anthony Staines
  47. John J Spinelli
  48. Sara J Achenbach
  49. Timothy G Call
  50. Nicola J Camp
  51. Martha Glenn
  52. Neil E Caporaso
  53. James R Cerhan
  54. Julie M Cunningham
  55. Lynn R Goldin
  56. Curtis A Hanson
  57. Neil E Kay
  58. Mark C Lanasa
  59. Jose F Leis
  60. Gerald E Marti
  61. Kari G Rabe
  62. Laura Z Rassenti
  63. Logan G Spector
  64. Sara S Strom
  65. Celine M Vachon
  66. J Brice Weinberg
  67. Elizabeth A Holly
  68. Stephen Chanock
  69. Martyn T Smith
  70. Paige M Bracci
  71. Christine F Skibola

Contributions

Design and interpretation of overall study: C.F.S., E.H., K.M.B., M.T.S., P.M.B. Primary data analysis: L.C., E.H. Drafting of manuscript: L.C., C.F.S. Critical revision of manuscript: E.H., K.M.B., A.B.-W., B.A., C.M. Vajdic., S.C., M.T.S., P.M.B. Study design, genotyping and statistical analysis of individual studies: SF1, SF1B and SF2: L.C., E.H., J.R., N.K.A., L.A., E.A.H., M.T.S., P.M.B., C.F.S. SCALE: K.E.S., J.L., H.-O.A., H.D., H.H., H.-Q.L., K.H., M. Melbye, E.T.C., B.G. NCI-SEER: N.R., W.C., S.D., P.H., L.M.M., M.S., S.S.W., S.C., J.R.C. NSW: B.A., A.K., S.M., M.P.P., C.M. Vajdic. Yale: P. Boyle, Q.L., S.H.Z., Y.Z., T.Z. EpiLymph: A.N., N.B., Y.B., P. Boffetta, P. Brennan, K.B., P.C., L.F., M. Maynadié, S.de.S., A.S. BC: A.B.-W., J.J.S. Mayo-GEC: S.L.S., S.J.A., T.G.C., M.G., N.J.C., N.E.C., J.R.C., J.M.C., L.R.G., C.A.H., N.E.K., M.C.L., J.F.L., G.E.M., K.G.R., L.Z.R., L.G.S., S.S.S., C.M. Vachon, J.B.W. All authors contributed to the final manuscript and approved its content.

Corresponding author

Correspondence toChristine F Skibola.

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The authors declare no competing financial interests.

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Conde, L., Halperin, E., Akers, N. et al. Genome-wide association study of follicular lymphoma identifies a risk locus at 6p21.32.Nat Genet 42, 661–664 (2010). https://doi.org/10.1038/ng.626

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