Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index (original) (raw)
Change history
12 October 2011
In the version of this supplementary file originally posted online, there was an error in the equation shown on page 36. The error has been corrected in this file as of 12 October 2011.
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Acknowledgements
A full list of acknowledgments appears in the Supplementary Note.
Funding was provided by Academy of Finland (10404, 77299, 104781, 114382, 117797, 120315, 121584, 124243, 126775, 126925, 127437, 129255, 129269, 129306, 129494, 129680, 130326, 209072, 210595, 213225, 213506 and 216374); ADA Mentor-Based Postdoctoral Fellowship; Amgen; Agency for Science, Technology and Research of Singapore (A*STAR); ALF/LUA research grant in Gothenburg; Althingi (the Icelandic Parliament); AstraZeneca; Augustinus Foundation; Australian National Health and Medical Research Council (241944, 389875, 389891, 389892, 389938, 442915, 442981, 496739, 496688, 552485 and 613672); Australian Research Council (ARC grant DP0770096); Becket Foundation; Biocenter (Finland); Biomedicum Helsinki Foundation; Boston Obesity Nutrition Research Center; British Diabetes Association (1192); British Heart Foundation (97020; PG/02/128); Busselton Population Medical Research Foundation; Cambridge Institute for Medical Research; Cambridge National Institute of Health Research (NIHR) Comprehensive Biomedical Research Centre; CamStrad (UK); Cancer Research UK; Centre for Medical Systems Biology (The Netherlands); Centre for Neurogenomics and Cognitive Research (The Netherlands); Chief Scientist Office of the Scottish Government; Contrat Plan Etat Région (France); Danish Centre for Health Technology Assessment; Danish Diabetes Association; Danish Heart Foundation; Danish Pharmaceutical Association; Danish Research Council; Deutsche Forschungsgemeinschaft (DFG; HE 1446/4-1); Department of Health (UK); Diabetes UK; Diabetes and Inflammation Laboratory; Donald W. Reynolds Foundation; Dresden University of Technology Funding Grant; Emil and Vera Cornell Foundation; Erasmus Medical Center (Rotterdam); Erasmus University (Rotterdam); European Commission (DG XII; QLG1-CT-2000-01643, QLG2-CT-2002-01254, LSHC-CT-2005, LSHG-CT-2006-018947, LSHG-CT-2004-518153, LSH-2006-037593, LSHM-CT-2007-037273, HEALTH-F2-2008-ENGAGE, HEALTH-F4-2007-201413, HEALTH-F4-2007-201550, FP7/2007-2013, 205419, 212111, 245536, SOC 95201408 05F02 and WLRT-2001-01254); Federal Ministry of Education and Research (Germany) (01AK803, 01EA9401, 01GI0823, 01GI0826, 01GP0209, 01GP0259, 01GS0820, 01GS0823, 01GS0824, 01GS0825, 01GS0830, 01GS0831, 01IG07015, 01KU0903, 01ZZ9603, 01ZZ0103, 01ZZ0403 and 03ZIK012); Federal State of Mecklenburg-West Pomerania; European Social Fund; Eve Appeal; Finnish Diabetes Research Foundation; Finnish Foundation for Cardiovascular Research; Finnish Foundation for Pediatric Research, Finnish Medical Society; Finska Läkaresällskapet, Päivikki and Sakari Sohlberg Foundation, Folkhälsan Research Foundation; Fond Européen pour le Développement Régional (France); Fondation LeDucq (Paris, France); Foundation for Life and Health in Finland; Foundation for Strategic Research (Sweden); Genetic Association Information Network; German Research Council (KFO-152); German National Genome Research Net 'NGFNplus' (FKZ 01GS0823); German Research Center for Environmental Health; Giorgi-Cavaglieri Foundation; GlaxoSmithKline; Göteborg Medical Society; Great Wine Estates Auctions; Gyllenberg Foundation; Health Care Centers in Vasa, Närpes and Korsholm; Healthway, Western Australia; Helmholtz Center Munich; Helsinki University Central Hospital, Hjartavernd (the Icelandic Heart Association); INSERM (France); Ib Henriksen Foundation; Interdisziplinäres Zentrum für Klinische Forschung (IZKF) (B27); Jalmari and Rauha Ahokas Foundation; Juho Vainio Foundation; Juvenile Diabetes Research Foundation International (JDRF); Karolinska Institute; Knut and Alice Wallenberg Foundation; Leenaards Foundation; Lundbeck Foundation Centre of Applied Medical Genomics for Personalized Disease Prediction, Prevention and Care (LUCAMP); Lundberg Foundation; Marie Curie Intra-European Fellowship; Medical Research Council (UK) (G0000649, G0000934, G9521010D, G0500539, G0600331 and G0601261, PrevMetSyn); Ministry of Cultural Affairs and Social Ministry of the Federal State of Mecklenburg-West Pomerania; Ministry for Health, Welfare and Sports (The Netherlands); Ministry of Education (Finland); Ministry of Education, Culture and Science (The Netherlands); Ministry of Internal Affairs and Health (Denmark); Ministry of Science, Education and Sport of the Republic of Croatia (216-1080315-0302); Ministry of Science, Research and the Arts Baden-Württemberg; Montreal Heart Institute Foundation; Municipal Health Care Center and Hospital in Jakobstad; Municipality of Rotterdam; Närpes Health Care Foundation; National Cancer Institute; National Health and Medical Research Council of Australia; National Institute for Health Research Cambridge Biomedical Research Centre; National Institute for Health Research Oxford Biomedical Research Centre; National Institute for Health Research comprehensive Biomedical Research Centre; US National Institutes of Health (263-MA-410953, AA07535, AA10248, AA014041, AA13320, AA13321, AA13326, CA047988, CA65725, CA87969, CA49449, CA67262, CA50385, DA12854, DK58845, DK46200, DK062370, DK063491, DK072193, HG002651, HL084729, HHSN268200625226C, HL71981, K23-DK080145, K99-HL094535, M01-RR00425, MH084698, N01-AG12100, NO1-AG12109, N01-HC15103, N01-HC25195, N01-HC35129, N01-HC45133, N01-HC55015, N01-HC55016, N01-HC55018, N01-HC55019, N01-HC55020, N01-N01HC-55021, N01-HC55022, N01-HC55222, N01-HC75150, N01-HC85079, N01-HC85080, N01-HG-65403, N01-HC85081, N01-HC85082, N01-HC85083, N01-HC85084, N01-HC85085, N01-HC85086, N02-HL64278, P30-DK072488, R01-AG031890, R01-DK073490, R01-DK075787, R01DK068336, R01DK075681, R01-HL59367, R01-HL086694, R01-HL087641, R01-HL087647, R01-HL087652, R01-HL087676, R01-HL087679, R01-HL087700, R01-HL088119, R01-MH59160, R01-MH59565, R01-MH59566, R01-MH59571, R01-MH59586, R01-MH59587, R01-MH59588, R01-MH60870, R01-MH60879, R01-MH61675, R01-MH63706, R01-MH67257, R01-MH79469, R01-MH79470, R01-MH81800, RL1-MH083268, UO1-CA098233, U01-DK062418, U01-GM074518, U01-HG004402, U01-HG004399, U01-HL72515, U01-HL080295, U01-HL084756, U54-RR020278, T32-HG00040, UL1-RR025005 and Z01-HG000024); National Alliance for Research on Schizophrenia and Depression (NARSAD); Netherlands Genomics Initiative/Netherlands Consortium for Healthy Aging (050-060-810); Netherlands Organisation for Scientific Research (NWO) (904-61-090, 904-61-193, 480-04-004, 400-05-717, SPI 56-464-1419, 175.010.2005.011 and 911-03-012); Nord-Trøndelag County Council; Nordic Center of Excellence in Disease Genetics; Novo Nordisk Foundation; Norwegian Institute of Public Health; Ollqvist Foundation; Oxford NIHR Biomedical Research Centre; Organization for the Health Research and Development (10-000-1002); Paavo Nurmi Foundation; Paul Michael Donovan Charitable Foundation; Perklén Foundation; Petrus and Augusta Hedlunds Foundation; Pew Scholar for the Biomedical Sciences; Public Health and Risk Assessment, Health and Consumer Protection (2004310); Research Foundation of Copenhagen County; Research Institute for Diseases in the Elderly (014-93-015; RIDE2); Robert Dawson Evans Endowment; Royal Society (UK); Royal Swedish Academy of Science; Sahlgrenska Center for Cardiovascular and Metabolic Research (CMR, no. A305: 188); Siemens Healthcare, Erlangen, Germany; Sigrid Juselius Foundation; Signe and Ane Gyllenberg Foundation; Science Funding programme (UK); Social Insurance Institution of Finland; Söderberg's Foundation; South Tyrol Ministry of Health; South Tyrolean Sparkasse Foundation; State of Bavaria; Stockholm County Council (560183); Susan G. Komen Breast Cancer Foundation; Swedish Cancer Society; Swedish Cultural Foundation in Finland; Swedish Foundation for Strategic Research; Swedish Heart-Lung Foundation; Swedish Medical Research Council (8691, K2007-66X-20270-01-3, K2010-54X-09894-19-3, K2010-54X-09894-19-3 and 2006-3832); Swedish Research Council; Swedish Society of Medicine; Swiss National Science Foundation (33CSCO-122661, 310000-112552 and 3100AO-116323/1); Torsten and Ragnar Söderberg's Foundation; Université Henri Poincaré-Nancy 1, Région Lorraine, Communauté Urbaine du Grand Nancy; University Hospital Medical funds to Tampere; University Hospital Oulu, Finland; University of Oulu, Finland (75617); Västra Götaland Foundation; Walter E. Nichols, M.D., and Eleanor Nichols endowments; Wellcome Trust (068545, 072960, 075491, 076113, 077016, 079557, 079895, 081682, 083270, 085301 and 086596); Western Australian DNA Bank; Western Australian Genetic Epidemiology Resource; and Yrjö Jahnsson Foundation.
Author information
Author notes
- Elizabeth K Speliotes, Cristen J Willer, Sonja I Berndt, Keri L Monda, Gudmar Thorleifsson, Michael Boehnke, Kari Stefansson, Kari E North, Mark I McCarthy, Joel N Hirschhorn, Erik Ingelsson and Ruth J F Loos: These authors contributed equally to this work.
Authors and Affiliations
- Metabolism Initiative and Program in Medical and Population Genetics, Broad Institute, Cambridge, Massachusetts, USA
Elizabeth K Speliotes, Sailaja Vedantam, Candace Guiducci, Brian Thomson & Joel N Hirschhorn - Division of Gastroenterology, Massachusetts General Hospital, Boston, Massachusetts, USA
Elizabeth K Speliotes & Lee M Kaplan - Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
Cristen J Willer, Anne U Jackson, Heather M Stringham, Robert J Weyant, Ryan Welch, Laura J Scott, Elizabeth Jewell, Tanya M Teslovich, Gonçalo R Abecasis & Michael Boehnke - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services, National Cancer Institute, National Institutes of Health, Bethesda, Maryland, USA
Sonja I Berndt, Ju-Hyun Park, Jianxin Shi, Stephen J Chanock & Nilanjan Chatterjee - Department of Epidemiology, School of Public Health, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA
Keri L Monda & Kari E North - deCODE Genetics, Reykjavik, Iceland
Gudmar Thorleifsson, Valgerdur Steinthorsdottir, G Bragi Walters, Unnur Thorsteinsdottir & Kari Stefansson - Genetics of Complex Traits, Peninsula College of Medicine and Dentistry, University of Exeter, Exeter, UK
Hana Lango Allen, Michael N Weedon, Andrew R Wood, John R B Perry, Andrew T Hattersley & Timothy M Frayling - Wellcome Trust Centre for Human Genetics, University of Oxford, Oxford, UK
Cecilia M Lindgren, Reedik Mägi, Joshua C Randall, Teresa Ferreira, Inga Prokopenko, Anuj Goel, Andrew P Morris, Nigel W Rayner, Neil R Robertson, Hugh Watkins & Mark I McCarthy - Oxford Centre for Diabetes, Endocrinology and Metabolism, University of Oxford, Oxford, UK
Cecilia M Lindgren, Inga Prokopenko, Amanda J Bennett, Christopher J Groves, Neelam Hassanali, Matt J Neville, Nigel W Rayner, Neil R Robertson, Fredrik Karpe & Mark I McCarthy - Medical Research Council (MRC) Epidemiology Unit, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
Jian'an Luan, Tuomas O Kilpeläinen, Jing Hua Zhao, Shengxu Li, Ken K Ong, Manjinder S Sandhu, Nicholas J Wareham & Ruth J F Loos - Divisions of Genetics and Endocrinology and Program in Genomics, Children's Hospital, Boston, Massachusetts, USA
Sailaja Vedantam & Joel N Hirschhorn - Department of Epidemiology and Preventive Medicine, Regensburg University Medical Center, Regensburg, Germany
Thomas W Winkler & Iris M Heid - Department of Nutrition, Harvard School of Public Health, Boston, Massachusetts, USA
Lu Qi, Tsegaselassie Workalemahu, Frank B Hu & David J Hunter - Department of Medicine, Channing Laboratory, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts, USA
Lu Qi, Frank B Hu & David J Hunter - Institute of Epidemiology, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany
Iris M Heid, Claudia Lamina, Elisabeth Thiering, Chih-Mei Chen, Christian Gieger, Harald Grallert, Peter Rzehak, Joachim Heinrich, Thomas Illig, Annette Peters & H-Erich Wichmann - Wellcome Trust Sanger Institute, Hinxton, Cambridge, UK
Eleanor Wheeler, Manjinder S Sandhu, Nicole Soranzo, Willem H Ouwehand, Panos Deloukas, Leena Peltonen & Inês Barroso - Center for Human Genetic Research, Massachusetts General Hospital, Boston, Massachusetts, USA
Ayellet V Segrè, Sekar Kathiresan, Benjamin F Voight, Steven A McCarroll & Shaun Purcell - Program in Medical and Population Genetics, Broad Institute of Harvard and Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Ayellet V Segrè, James Nemesh, Soumya Raychaudhuri, Sekar Kathiresan, Benjamin F Voight & Steven A McCarroll - Department of Molecular Biology, Massachusetts General Hospital, Boston, Massachusetts, USA
Ayellet V Segrè, Benjamin F Voight & Steven A McCarroll - Department of Epidemiology, Erasmus Medical Center (MC), Rotterdam, The Netherlands
Karol Estrada, Najaf Amin, Fernando Rivadeneira, Sophie van Wingerden, Albert Hofman, Joyce B J van Meurs, Jacqueline C Witteman, André Uitterlinden & Cornelia M van Duijn - Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands
Karol Estrada, Marjolein J Peters, Fernando Rivadeneira, Joyce B J van Meurs, André Uitterlinden & M Carola Zillikens - Netherlands Genomics Initiative (NGI)-sponsored Netherlands Consortium for Healthy Aging (NCHA), Rotterdam, The Netherlands
Karol Estrada, Marjolein J Peters, Fernando Rivadeneira, Albert Hofman, Joyce B J van Meurs, Jacqueline C Witteman, André Uitterlinden, M Carola Zillikens & Cornelia M van Duijn - Department of Epidemiology, Harvard School of Public Health, Boston, Massachusetts, USA
Liming Liang, Peter Kraft, Frank B Hu & David J Hunter - Department of Biostatistics, Harvard School of Public Health, Boston, Massachusetts, USA
Liming Liang & Peter Kraft - Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
Stefan Gustafsson, Fredrik Wiklund, Henrik Grönberg, Per Hall & Erik Ingelsson - Queensland Statistical Genetics Laboratory, Queensland Institute of Medical Research, Queensland, Australia
Jian Yang & Peter M Visscher - Centre National de la Recherche Scientifique (CNRS) UMR8199-IBL-Institut Pasteur de Lille, Lille, France
Nabila Bouatia-Naji, Christine Cavalcanti-Proença, Stefan Gaget, Cecile Lecoeur, David Meyre, Vincent Vatin & Philippe Froguel - University Lille Nord de France, Lille, France
Nabila Bouatia-Naji, Christine Cavalcanti-Proença, Stefan Gaget, Cecile Lecoeur, David Meyre, Vincent Vatin & Philippe Froguel - Estonian Genome Center, University of Tartu, Tartu, Estonia
Tõnu Esko, Tõnu Esko, Helene Alavere, Mari Nelis, Mari-Liis Tammesoo & Andres Metspalu - Estonian Biocenter, Tartu, Estonia
Tõnu Esko, Tõnu Esko, Mari Nelis, Maris Teder-Laving & Andres Metspalu - Institute of Molecular and Cell Biology, University of Tartu, Tartu, Estonia
Tõnu Esko, Tõnu Esko, Mari Nelis, Maris Teder-Laving & Andres Metspalu - Department of Genetics, Washington University School of Medicine, St. Louis, Missouri, USA.,
Mary F Feitosa, Shamika Ketkar, Qunyuan Zhang & Ingrid B Borecki - Department of Medical Genetics, University of Lausanne, Lausanne, Switzerland
Zoltán Kutalik, Toby Johnson, Sven Bergmann, Diana Marek & Jacques S Beckmann - Swiss Institute of Bioinformatics, Lausanne, Switzerland
Zoltán Kutalik, Toby Johnson, Sven Bergmann & Diana Marek - Department of Twin Research and Genetic Epidemiology, King's College London, London, UK
Massimo Mangino, Nicole Soranzo & Timothy D Spector - Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts, USA
Soumya Raychaudhuri - Institute for Medical Informatics, Biometry and Epidemiology, University of Duisburg-Essen, Essen, Germany
Andre Scherag & Tanja Boes - Icelandic Heart Association, Kopavogur, Iceland
Albert Vernon Smith, Thor Aspelund, Gudny Eiriksdottir & Vilmundur Gudnason - University of Iceland, Reykjavik, Iceland
Albert Vernon Smith, Thor Aspelund & Vilmundur Gudnason - Comprehensive Cancer Center East, Nijmegen, The Netherlands
Katja K Aben & Lambertus A Kiemeney - Hudson Alpha Institute for Biotechnology, Huntsville, Alabama, USA
Devin M Absher & Lindsay L Waite - Department of Pharmacy and Pharmacology, University of Bath, Bath, UK
Anna L Dixon - Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbruecke, Nuthetal, Germany
Eva Fisher & Heiner Boeing - Department of Medicine, University of Washington, Seattle, Washington, USA
Nicole L Glazer - Cardiovascular Health Research Unit, University of Washington, Seattle, Washington, USA
Nicole L Glazer & David S Siscovick - University of Melbourne, Parkville, Australia
Michael E Goddard - Department of Primary Industries, Melbourne, Victoria, Australia.,
Michael E Goddard - Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
Nancy L Heard-Costa & Larry D Atwood - Technical University Munich, Chair of Biomathematics, Garching, Germany
Volker Hoesel - Department of Biological Psychology, Vrije Universiteit (VU) University Amsterdam, Amsterdam, The Netherlands
Jouke-Jan Hottenga, Eco J C Geus, Gonneke Willemsen & Dorret I Boomsma - Department of Genetics and Pathology, Rudbeck Laboratory, University of Uppsala, Uppsala, Sweden
Åsa Johansson, Wilmar Igl & Ulf Gyllensten - Department of Cancer Research and Molecular Medicine, Faculty of Medicine, Norwegian University of Science and Technology (NTNU), Trondheim, Norway
Åsa Johansson - Clinical Pharmacology, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary, University of London, London, UK
Toby Johnson - Clinical Pharmacology and Barts and The London Genome Centre, William Harvey Research Institute, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, Charterhouse Square, London, UK
Toby Johnson, Mark J Caulfield & Patricia B Munroe - Division of Genetic Epidemiology, Department of Medical Genetics, Molecular and Clinical Pharmacology, Innsbruck Medical University, Innsbruck, Austria
Claudia Lamina - National Heart and Lung Institute, Imperial College London, London, UK
Miriam F Moffatt - Department of Neurology, Boston University School of Medicine, Boston, Massachusetts, USA
Richard H Myers - National Human Genome Research Institute, National Institutes of Health, Bethesda, Maryland, USA
Narisu Narisu, Lori L Bonnycastle, Peter S Chines, Michael R Erdos, Mario A Morken, Amy J Swift & Francis S Collins - Institut für Medizinische Biometrie und Statistik, Universität zu Lübeck, Universitätsklinikum Schleswig-Holstein, Campus Lübeck, Lübeck, Germany
Michael Preuss, Inke R König & Andreas Ziegler - Institute for Molecular Medicine Finland (FIMM), University of Helsinki, Helsinki, Finland
Samuli Ripatti, Niina Pellikka, Johannes Kettunen, Markus Perola, Kaisa Silander, Ida Surakka, Elisabeth Widen, Jaakko Kaprio & Leena Peltonen - Department of Chronic Disease Prevention, National Institute for Health and Welfare, Unit of Public Health Genomics, Helsinki, Finland
Samuli Ripatti, Niina Pellikka, Johannes Kettunen, Markus Perola, Kaisa Silander, Ida Surakka & Leena Peltonen - Hagedorn Research Institute, Gentofte, Denmark
Camilla Sandholt, Anette P Gjesing, Torben Hansen & Oluf Pedersen - Department of Social Medicine, MRC Centre for Causal Analyses in Translational Epidemiology, Oakfield House, Bristol, UK
Nicholas J Timpson, Ian N M Day, George Davey Smith & Debbie A Lawlor - Department of Oncology, University of Cambridge, Cambridge, UK
Jonathan P Tyrer - Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Richard M Watanabe - Department of Physiology and Biophysics, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Richard M Watanabe, Richard N Bergman & Thomas A Buchanan - Department of Biostatistics, Boston University School of Public Health, Boston, Massachusetts, USA
Charles C White, Julius S Ngwa & L Adrienne Cupples - Department of Medicine, University of Milan, Surgery and Dentistry, Milano, Italy
Christina Barlassina & Fabio Macciardi - Division of Preventive Medicine, Brigham and Women's Hospital, Boston, Massachusetts, USA
Daniel I Chasman & Paul M Ridker - Harvard Medical School, Boston, Massachusetts, USA
Daniel I Chasman, Lee M Kaplan & Paul M Ridker - Centre for Genetic Epidemiology and Biostatistics, University of Western Australia, Crawley, Western Australia, Australia
Matthew N Cooper, Robert W Lawrence, Jennie Hui & Lyle J Palmer - Department of Physiology, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
John-Olov Jansson - Division of Nephrology and Dialysis, University Vita-Salute San Raffaele, Milan, Italy
Maria T S Alibrandi, Chiara Lanzani & Paolo Manunta - Department of Clinical Sciences, Lund University Diabetes Centre, Lund University, Malmö, Sweden
Peter Almgren & Leif C Groop - Department of Biostatistics, University of Washington, Seattle, Washington, USA
Alice M Arnold & Barbara McKnight - Collaborative Health Studies Coordinating Center, Seattle, Washington, USA
Alice M Arnold - INSERM Centre de recherche en Epidémiologie et Santé des Populations (CESP) Centre for Research in Epidemiology and Public Health U1018, Villejuif, France
Beverley Balkau - University Paris Sud 11, Unité Mixte de Recherche en Santé (UMRS) 1018, Villejuif, France
Beverley Balkau - Multidisciplinary Cardiovascular Research Centre (MCRC), Leeds Institute of Genetics, Health and Therapeutics (LIGHT), University of Leeds, Leeds, UK
Anthony J Balmforth & Alistair S Hall - Department of Social Medicine, University of Bristol, Bristol, UK
Yoav Ben-Shlomo - Institute of Experimental Paediatric Endocrinology, Charité Universitätsmedizin Berlin, Berlin, Germany
Heike Biebermann, Susanna Wiegand & Heiko Krude - Department of Genomics of Common Disease, School of Public Health, Imperial College London, London, UK
Alexandra I F Blakemore & Philippe Froguel - Department of Medicine III, University of Dresden, Dresden, Germany
Stefan R Bornstein & Barbara Ludwig - Clinical Pharmacology Unit, University of Cambridge, Addenbrooke's Hospital, Cambridge, UK
Morris J Brown - Division of Endocrinology, Keck School of Medicine, University of Southern California, Los Angeles, California, USA
Thomas A Buchanan - Istituto di Neurogenetica e Neurofarmacologia del Consiglio Nazionale delle Ricerche (CNR), Monserrato, Cagliari, Italy
Fabio Busonero, Serena Sanna & Manuela Uda - Centre for Population Health Sciences, University of Edinburgh, Teviot Place, Edinburgh, Scotland, UK
Harry Campbell, Sarah H Wild, Igor Rudan & James F Wilson - University of Warwick, Warwick Medical School, Coventry, UK
Francesco P Cappuccio - Medical Genetics Institute, Cedars-Sinai Medical Center, Los Angeles, California, USA
Yii-Der Ida Chen & Talin Haritunians - Clinical Trial Service Unit, Oxford, UK
Robert Clarke - Department of Epidemiology and Biostatistics, School of Public Health, Faculty of Medicine, Imperial College London, London, UK
Lachlan Coin, Paul Elliott, Ulla Sovio & Marjo-Riitta Jarvelin - University of Dundee, Ninewells Hospital and Medical School, Dundee, UK
John Connell - Department of Epidemiology, Biostatistics and HTA, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Martin den Heijer & Lambertus A Kiemeney - Department of Endocrinology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Martin den Heijer - Northshore University Healthsystem, Evanston, Illinois, USA
Jubao Duan, Pablo V Gejman & Alan R Sanders - The London School of Hygiene and Tropical Medicine, London, UK
Shah Ebrahim - South Asia Network for Chronic Disease, New Dehli, India
Shah Ebrahim - MRC-Health Protection Agency (HPA) Centre for Environment and Health, London, UK
Paul Elliott - Cardiovascular Epidemiology and Genetics, Institut Municipal D'investigacio Medica and Centro de Investigación Biomédica en Red CIBER Epidemiología y Salud Pública, Barcelona, Spain
Roberto Elosua - Department of General Practice and Primary Health Care, University of Helsinki, Helsinki, Finland
Johan G Eriksson - National Institute for Health and Welfare, Helsinki, Finland
Johan G Eriksson & Eero Kajantie - Helsinki University Central Hospital, Unit of General Practice, Helsinki, Finland
Johan G Eriksson - Folkhalsan Research Centre, Helsinki, Finland
Johan G Eriksson, Bo Isomaa & Tiinamaija Tuomi - Vasa Central Hospital, Vasa, Finland
Johan G Eriksson - Institute of Genetic Medicine, European Academy Bozen-Bolzano (EURAC), Bolzano-Bozen, Italy, Affiliated Institute of the University of Lübeck, Lübeck, Germany
Maurizio F Facheris, Andrew A Hicks, Irene Pichler & Peter P Pramstaller - Department of Neurology, General Central Hospital, Bolzano, Italy
Maurizio F Facheris & Peter P Pramstaller - Department of Internal Medicine B, Ernst-Moritz-Arndt University, Greifswald, Germany
Stephan B Felix - Department of Pediatrics and Adolescent Medicine, Pediatric Endocrinology, Diabetes and Obesity Unit, Ulm, Germany
Pamela Fischer-Posovszky & Martin Wabitsch - Division of Epidemiology and Community Health, School of Public Health, University of Minnesota, Minneapolis, Minnesota, USA
Aaron R Folsom - Institut für Klinische Chemie und Laboratoriumsmedizin, Universität Greifswald, Greifswald, Germany
Nele Friedrich, Sabine Schipf & Henri Wallaschofski - Center for Neurobehavioral Genetics, University of California, Los Angeles, California, USA
Nelson B Freimer - Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland, USA
Mao Fu, Alan R Shuldiner & Jeffrey R O'Connell - Department of Cardiovascular Medicine, University of Oxford, John Radcliffe Hospital, Headington, Oxford, UK
Anuj Goel & Hugh Watkins - Montreal Heart Institute, Montreal, Quebec, Canada
Philippe Goyette, Guillaume Lettre & Jean-Claude Tardif - Department of Medicine III, Pathobiochemistry, University of Dresden, Dresden, Germany
Jürgen Gräßler - Merck Research Laboratories, Merck and Co., Inc., Boston, Massachusetts, USA
Danielle M Greenawalt - Department of Clinical Sciences, Obstetrics and Gynecology, University of Oulu, Oulu, Finland
Anna-Liisa Hartikainen & Anneli Pouta - Department of Chronic Disease Prevention, National Institute for Health and Welfare, Chronic Disease Epidemiology and Prevention Unit, Helsinki, Finland
Aki S Havulinna, Pekka Jousilahti, Seppo Koskinen & Veikko Salomaa - MRC Human Genetics Unit, Institute for Genetics and Molecular Medicine, Western General Hospital, Edinburgh, Scotland, UK
Caroline Hayward, Veronique Vitart & Alan F Wright - Department of Psychiatry and Midwest Alcoholism Research Center, Washington University School of Medicine, St. Louis, Missouri, USA
Andrew C Heath - Klinik und Poliklinik für Innere Medizin II, Universität Regensburg, Regensburg, Germany
Christian Hengstenberg - Regensburg University Medical Center, Innere Medizin II, Regensburg, Germany
Christian Hengstenberg - Department of Child and Adolescent Psychiatry, University of Duisburg-Essen, Essen, Germany
Anke Hinney, Susann Scherag, Carla I G Vogel & Johannes Hebebrand - Interfaculty Institute for Genetics and Functional Genomics, Ernst-Moritz-Arndt-University Greifswald, Greifswald, Germany
Georg Homuth - Department of Molecular Genetics, PathWest Laboratory of Western Australia, J Block, QEII Medical Centre, Nedlands, Western Australia, Australia
Jennie Hui & John P Beilby - Busselton Population Medical Research Foundation Inc., Sir Charles Gairdner Hospital, Nedlands, Western Australia, Australia
Jennie Hui, John P Beilby, Alan L James & Lyle J Palmer - Division of Research, Kaiser Permanente Northern California, Oakland, California, USA
Carlos Iribarren - Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, California, USA
Carlos Iribarren - Department of Social Services and Health Care, Jakobstad, Finland
Bo Isomaa - Core Genotyping Facility, SAIC-Frederick, Inc., National Cancer Institute (NCI)-Frederick, Frederick, Maryland, USA
Kevin B Jacobs - Institute of Medical Biometry and Epidemiology, University of Marburg, Marburg, Germany
Ivonne Jarick - Institut für Epidemiologie und Sozialmedizin, Universität Greifswald, Greifswald, Germany
Ulrich John - Research Centre for Prevention and Health, Glostrup University Hospital, Glostrup, Denmark
Torben Jørgensen - Faculty of Health Science, University of Copenhagen, Copenhagen, Denmark
Torben Jørgensen - Department of Chronic Disease Prevention, National Institute for Health and Welfare, Population Studies Unit, Turku, Finland
Antti Jula - Institute of Health Sciences, University of Oulu, Oulu, Finland
Marika Kaakinen & Marjo-Riitta Jarvelin - Biocenter Oulu, University of Oulu, Oulu, Finland
Marika Kaakinen & Marjo-Riitta Jarvelin - Hospital for Children and Adolescents, Helsinki University Central Hospital and University of Helsinki, Hospital District of Helsinki and Uusimaa (HUS), Helsinki, Finland
Eero Kajantie - Massachusetts General Hospital (MGH) Weight Center, Massachusetts General Hospital, Boston, Massachusetts, USA
Lee M Kaplan - Cardiovascular Research Center and Cardiology Division, Massachusetts General Hospital, Boston, Massachusetts, USA
Sekar Kathiresan - Framingham Heart Study of the National, Heart, Lung, and Blood Institute and Boston University, Framingham, Massachusetts, USA
Sekar Kathiresan & Christopher J O'Donnell - Department of Medicine, Harvard Medical School, Boston, Massachusetts, USA
Sekar Kathiresan - National Institute for Health and Welfare, Diabetes Prevention Unit, Helsinki, Finland
Leena Kinnunen, Jaakko Tuomilehto & Timo T Valle - Department of Medicine, Stanford University School of Medicine, Stanford, California, USA
Joshua W Knowles, Thomas Quertermous & Themistocles L Assimes - Andrija Stampar School of Public Health, Medical School, University of Zagreb, Zagreb, Croatia
Ivana Kolcic, Ozren Polasek & Lina Zgaga - Interdisciplinary Centre for Clinical Research, University of Leipzig, Leipzig, Germany
Peter Kovacs - Department of Medicine, University of Kuopio and Kuopio University Hospital, Kuopio, Finland
Johanna Kuusisto & Markku Laakso - Department of Public Health and General Practice, Nord-Trøndelag Health Study (HUNT) Research Centre, Norwegian University of Science and Technology, Levanger, Norway
Kirsti Kvaløy, Kristian Midthjell, Carl G P Platou & Kristian Hveem - Finnish Institute of Occupational Health, Oulu, Finland
Jaana Laitinen - Institut inter-regional pour la santé (IRSA), La Riche, France
Olivier Lantieri - Laboratory of Epidemiology, Demography, Biometry, National Institute on Aging, National Institutes of Health, Bethesda, Maryland, USA
Lenore J Launer & Tamara B Harris - Department of Clinical Chemistry, University of Tampere and Tampere University Hospital, Tampere, Finland
Terho Lehtimäki - Department of Medicine, Université de Montréal, Montreal, Quebec, Canada
Guillaume Lettre & Jean-Claude Tardif - Human Genetics, Genome Institute of Singapore, Singapore, Singapore
Jianjun Liu - Transplantation Laboratory, Haartman Institute, University of Helsinki, Helsinki, Finland
Marja-Liisa Lokki - Department of Internal Medicine, Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden
Mattias Lorentzon & Claes Ohlsson - Department of Public Health and Primary Care, Institute of Public Health, University of Cambridge, Cambridge, UK
Robert N Luben, Manjinder S Sandhu & Kay-Tee Khaw - Department of Endocrinology, Diabetology and Nutrition, Bichat-Claude Bernard University Hospital, Assistance Publique des Hôpitaux de Paris, Paris, France
Michel Marre - Cardiovascular Genetics Research Unit, Université Henri Poincaré-Nancy 1, Nancy, France
Michel Marre - Genetic Epidemiology Laboratory, Queensland Institute of Medical Research, Queensland, Australia
Nicholas G Martin - Department of Social Medicine, Avon Longitudinal Study of Parents and Children (ALSPAC) Laboratory, University of Bristol, Bristol, UK
Wendy L McArdle - Division of Health, Research Board, An Bord Taighde Sláinte, Dublin, Ireland
Anne McCarthy - Institute of Human Genetics, Klinikum rechts der Isar der Technischen Universität München, Munich, Germany
Thomas Meitinger - Institute of Human Genetics, Helmholtz Zentrum München-German Research Center for Environmental Health, Neuherberg, Germany
Thomas Meitinger - Department of Clinical Sciences, Lund University, Malmö, Sweden
Olle Melander & Martin Ridderstråle - Molecular Epidemiology Laboratory, Queensland Institute of Medical Research, Queensland, Australia
Grant W Montgomery - Croatian Centre for Global Health, School of Medicine, University of Split, Split, Croatia
Rosanda Mulic & Igor Rudan - Neurogenetics Laboratory, Queensland Institute of Medical Research, Queensland, Australia
Dale R Nyholt - National Heart, Lung, and Blood Institute, National Institutes of Health, Framingham, Massachusetts, USA
Christopher J O'Donnell - University of Cambridge Metabolic Research Laboratories, Institute of Metabolic Science, Addenbrooke's Hospital, Cambridge, UK
Stephen O'Rahilly & I Sadaf Farooqi - Department of Clinical Genetics, Erasmus MC, Rotterdam, The Netherlands
Ben Oostra - Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario, Canada
Guillaume Paré - Amgen, Cambridge, Massachusetts, USA
Alex N Parker - Department of Public Health, Finnish Twin Cohort Study, University of Helsinki, Helsinki, Finland
Kirsi H Pietiläinen & Jaakko Kaprio - Department of Psychiatry, Obesity Research Unit, Helsinki University Central Hospital, Helsinki, Finland
Kirsi H Pietiläinen & Aila Rissanen - Department of Medicine, Levanger Hospital, The Nord-Trøndelag Health Trust, Levanger, Norway
Carl G P Platou - Gen-Info Ltd, Zagreb, Croatia
Ozren Polasek - National Institute for Health and Welfare, Oulu, Finland
Anneli Pouta & Marjo-Riitta Jarvelin - Department of Cardiovascular Sciences, University of Leicester, Glenfield Hospital, Leicester, UK
Suzanne Rafelt & Nilesh J Samani - Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku, Finland
Olli Raitakari - The Department of Clinical Physiology, Turku University Hospital, Turku, Finland
Olli Raitakari - Clinical Psychology and Psychotherapy, University of Marburg, Marburg, Germany
Winfried Rief - Department of Clinical Sciences and Clinical Chemistry, University of Oulu, Oulu, Finland
Aimo Ruokonen - Ludwig-Maximilians-Universität, Institute of Medical Informatics, Biometry and Epidemiology, Chair of Epidemiology, Munich, Germany,
Peter Rzehak & H-Erich Wichmann - South Karelia Central Hospital, Lappeenranta, Finland
Jouko Saramies - Department of Clinical Sciences and Internal Medicine, University of Oulu, Oulu, Finland
Markku J Savolainen - Institut für Community Medicine, Greifswald, Germany
Sabine Schipf - Institute for Clinical Molecular Biology and Department of Internal Medicine I, Christian-Albrechts-University, University Hospital Schleswig-Holstein, Kiel, Germany
Stefan Schreiber - Universität zu Lübeck, Medizinische Klinik II, Lübeck, Germany
Heribert Schunkert & Jeanette Erdmann - Division of Cardiology, Cardiovascular Laboratory, Helsinki University Central Hospital, Helsinki, Finland
Juha Sinisalo & Markku S Nieminen - Departments of Medicine and Epidemiology, University of Washington, Seattle, Washington, USA
David S Siscovick - Department of Psychiatry, Instituut voor Extramuraal Geneeskundig Onderzoek (EMGO) Institute, VU University Medical Center, Amsterdam, The Netherlands
Jan H Smit & Brenda W Penninx - Department of Haematology, University of Cambridge, Cambridge, UK
Jonathan Stephens & Willem H Ouwehand - National Health Service (NHS) Blood and Transplant, Cambridge Centre, Cambridge, UK
Jonathan Stephens & Willem H Ouwehand - Leicester NIHR Biomedical Research Unit in Cardiovascular Disease, Glenfield Hospital, Leicester, UK
John R Thompson & Nilesh J Samani - Department of Health Sciences, University of Leicester, University Road, Leicester, UK
John R Thompson - Department of Medicine, University of Leipzig, Leipzig, Germany
Anke Tönjes & Michael Stumvoll - Coordination Centre for Clinical Trials, University of Leipzig, Leipzig, Germany
Anke Tönjes - Department of Medicine, Helsinki University Central Hospital, Helsinki, Finland
Tiinamaija Tuomi - Research Program of Molecular Medicine, University of Helsinki, Helsinki, Finland
Tiinamaija Tuomi - Department of Human Genetics, Leiden University Medical Center, Leiden, The Netherlands
Gert-Jan van Ommen - Center of Medical Systems Biology, Leiden University Medical Center, Leiden, The Netherlands
Gert-Jan van Ommen - Department of Medicine, University of Turku and Turku University Hospital, Turku, Finland
Jorma Viikari - INSERM Cardiovascular Genetics team, Centre Investigation Clinique (CIC) 9501, Nancy, France
Sophie Visvikis-Siest - Steno Diabetes Center, Gentofte, Denmark
Daniel R Witte - Center for Human Genomics, Wake Forest University, Winston-Salem, North Carolina, USA
Jianfeng Xu - Department of Physiatrics, Lapland Central Hospital, Rovaniemi, Finland
Paavo Zitting - School of Pathology and Laboratory Medicine, University of Western Australia, Nedlands, Western Australia, Australia
John P Beilby - Department of Internal Medicine, University of Oulu, Oulu, Finland
Heikki V Huikuri - School of Medicine and Pharmacology, University of Western Australia, Perth, Western Australia, Australia
Alan L James - Department of Clinical Physiology, University of Tampere and Tampere University Hospital, Tampere, Finland
Mika Kähönen - Stanford University School of Medicine, Stanford, California, USA
Douglas F Levinson - Department of Psychiatry and Human Behavior, University of California, Irvine (UCI), Irvine, California, USA
Fabio Macciardi - Leipziger Interdisziplinärer Forschungs-komplex zu molekularen Ursachen umwelt- und lebensstilassoziierter Erkrankungen (LIFE) Study Centre, University of Leipzig, Leipzig, Germany
Michael Stumvoll - Service of Medical Genetics, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, Lausanne, Switzerland
Jacques S Beckmann - Human Genetics Center and Institute of Molecular Medicine, University of Texas Health Science Center, Houston, Texas, USA
Eric Boerwinkle - Faculty of Health Science, University of Southern Denmark, Odense, Denmark
Torben Hansen - New York University Medical Center, New York, New York, USA
Richard B Hayes - Department of Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Unit for Child and Adolescent Mental Health, Helsinki, Finland
Jaakko Kaprio - NIHR Oxford Biomedical Research Centre, Churchill Hospital, Oxford, UK
Fredrik Karpe & Mark I McCarthy - Department of Urology, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands
Lambertus A Kiemeney - Institute of Biomedical Sciences, University of Copenhagen, Copenhagen, Denmark
Oluf Pedersen - Faculty of Health Science, University of Aarhus, Aarhus, Denmark
Oluf Pedersen - Department of Psychiatry, Leiden University Medical Centre, Leiden, The Netherlands
Brenda W Penninx - Department of Psychiatry, University Medical Centre Groningen, Groningen, The Netherlands
Brenda W Penninx - Department of Neurology, University of Lübeck, Lübeck, Germany
Peter P Pramstaller - Institute for Paediatric Nutrition Medicine, Vestische Hospital for Children and Adolescents, University of Witten-Herdecke, Datteln, Germany
Thomas Reinehr - Department of Medicine III, Prevention and Care of Diabetes, University of Dresden, Dresden, Germany
Peter E H Schwarz - Geriatrics Research and Education Clinical Center, Baltimore Veterans Administration Medical Center, Baltimore, Maryland, USA
Alan R Shuldiner - Department of Public Health, Hjelt Institute, University of Helsinki, Helsinki, Finland
Jaakko Tuomilehto - South Ostrobothnia Central Hospital, Seinajoki, Finland
Jaakko Tuomilehto - Department of Internal Medicine, Centre Hospitalier Universitaire Vaudois (CHUV) University Hospital, Lausanne, Switzerland
Gérard Waeber - The Broad Institute of Harvard and Massachusetts Institute of Technology (MIT), Cambridge, Massachusetts, USA
Shaun Purcell & Leena Peltonen - Department of Psychiatry, Harvard Medical School, Boston, Massachusetts, USA
Shaun Purcell - Pacific Biosciences, Menlo Park, California, USA
Eric E Schadt - Sage Bionetworks, Seattle, Washington, USA
Eric E Schadt - Division of Biostatistics, Washington University School of Medicine, St. Louis, Missouri, USA
Ingrid B Borecki - Division of Intramural Research, National Heart, Lung, and Blood Institute, Framingham Heart Study, Framingham, Massachusetts, USA
Caroline S Fox - Department of Epidemiology and Population Health, Albert Einstein College of Medicine, New York, New York, USA
Robert C Kaplan - Department of Genetics, University of North Carolina, Chapel Hill, North Carolina, USA
Karen L Mohlke - Department of Medical Genetics, University of Helsinki, Helsinki, Finland
Leena Peltonen - Laboratory of Genetics, National Institute on Aging, Baltimore, Maryland, USA
David Schlessinger - Division of Community Health Sciences, St. George's, University of London, London, UK
David P Strachan - Klinikum Grosshadern, Munich, Germany
H-Erich Wichmann - Faculty of Medicine, University of Iceland, Reykjavík, Iceland
Unnur Thorsteinsdottir & Kari Stefansson - University of Cambridge Metabolic Research Labs, Institute of Metabolic Science Addenbrooke's Hospital, Cambridge, UK
Inês Barroso - Carolina Center for Genome Sciences, School of Public Health, University of North Carolina Chapel Hill, Chapel Hill, North Carolina, USA
Kari E North - Department of Genetics, Harvard Medical School, Boston, Massachusetts, USA
Joel N Hirschhorn
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Consortia
MAGIC
on behalf of Procardis Consortium
Contributions
A full list of author contributions appears in the Supplementary Note.
Corresponding authors
Correspondence toMichael Boehnke, Kari Stefansson, Kari E North, Mark I McCarthy, Joel N Hirschhorn, Erik Ingelsson or Ruth J F Loos.
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Competing interests
I.B. and spouse own stock in Incyte Ltd and GlaxoSmithKline. J.N.H. is a member of the Scientific Advisory Board, Correlagen, Inc. V.H. has received consultancy fees from GlaxoSmithKline, Lilly and Takeda. A.P. is employed by Amgen. K.S., V.S., G.T., U.T. and G.B.W. are employed by deCODE Genetics.
Additional information
On behalf of the MAGIC (Meta-Analyses of Glucose and Insulin-Related Traits Consortium) investigators.
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Speliotes, E., Willer, C., Berndt, S. et al. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index.Nat Genet 42, 937–948 (2010). https://doi.org/10.1038/ng.686
- Received: 13 May 2010
- Accepted: 15 September 2010
- Published: 10 October 2010
- Issue Date: November 2010
- DOI: https://doi.org/10.1038/ng.686