Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2 (original) (raw)

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Acknowledgements

We thank all individuals with psoriasis who participated in this study, their families and their physicians for their cooperation. We acknowledge the cooperation of Genizon Biosciences. We wish to thank T. Wesse, T. Henke, C. Fürstenau, S. Ehlers, M. Davids and R. Vogler for expert technical help. We thank J.R. Hov for helpful discussions. This study was supported by the German Ministry of Education and Research (BMBF) through the National Genome Research Network (NGFN), the PopGen biobank and the KORA (Cooperative Research in the Region of Augsburg) research platform. KORA was initiated and financed by the Helmholtz Zentrum München-National Research Center for Environmental Health, which is funded by the German Federal Ministry of Education, Science, Research and Technology and by the State of Bavaria and the Munich Center of Health Sciences (MC Health) as part of LMUinnovativ. The project received infrastructure support through the Deutsche Forschungsgemeinschaft (DFG) clusters of excellence 'Multimodal Computing and Interaction' and 'Inflammation at Interfaces'. This research was also supported by grants R01-AR42742, R01-AR050511 and R01-AR054966 from the US National Institutes of Health.

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Author notes

1. Michael Weichenthal and Andre Franke: These authors contributed equally to this work.

Authors and Affiliations

1. Institute of Clinical Molecular Biology, Christian-Albrechts-University, Kiel, Germany
   Eva Ellinghaus, David Ellinghaus, Stefan Schreiber & Andre Franke
2. Department of Dermatology, University of Michigan, Ann Arbor, Michigan, USA
   Philip E Stuart, Rajan P Nair, Trilokraj Tejasvi, Johann Gudjonsson, Stefan W Stoll, John J Voorhees, Sylviane Lambert & James T Elder
3. Genizon BioSciences, Inc., St. Laurent, Quebec, Canada
   Sophie Debrus, John V Raelson, Majid Belouchi, Hélène Fournier & Claudia Reinhard
4. Department of Biostatistics, Center for Statistical Genetics, University of Michigan, Ann Arbor, Michigan, USA
   Jun Ding, Yun Li & Gonçalo R Abecasis
5. Department of Dermatology and Allergy, Technische Universität München, Munich, Germany
   Stephan Weidinger & Bernadette Eberlein
6. Department of Dermatology, University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany
   Stephan Weidinger, Ulrich Mrowietz & Michael Weichenthal
7. Comprehensive Center for Inflammation Medicine, University of Lübeck, Lübeck, Germany
   Manfred Kunz
8. Department of Medicine, Memorial University, St. John's, Newfoundland, Canada
   Proton Rahman
9. Division of Rheumatology, University of Toronto, Psoriatic Arthritis Program, University Health Network, Toronto, Ontario, Canada
   Dafna D Gladman
10. Institute of Epidemiology, Helmholtz Centre Munich, German Research Center for Environmental Health, Neuherberg, Germany
    Christian Gieger & H Erich Wichmann
11. Institute of Medical Informatics, Biometry and Epidemiology, Ludwig-Maximilians-University, Munich, Germany
    H Erich Wichmann
12. Klinikum Grosshadern, Munich, Germany
    H Erich Wichmann
13. Clinic for Specialized Medicine and Surgery, Oslo University Hospital Rikshospitalet, Oslo, Norway
    Tom H Karlsen
14. Max Planck Institute for Informatics, Saarbrücken, Germany
    Gabriele Mayr & Mario Albrecht
15. Institute for Immunology, University Hospital Schleswig-Holstein, Christian-Albrechts-University, Kiel, Germany
    Dieter Kabelitz
16. Ann Arbor Veterans Affairs Hospital, Ann Arbor, Michigan, USA
    James T Elder

Authors

1. Eva Ellinghaus
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2. David Ellinghaus
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3. Philip E Stuart
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4. Rajan P Nair
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5. Sophie Debrus
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6. John V Raelson
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7. Majid Belouchi
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8. Hélène Fournier
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9. Claudia Reinhard
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10. Jun Ding
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11. Yun Li
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12. Trilokraj Tejasvi
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13. Johann Gudjonsson
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14. Stefan W Stoll
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15. John J Voorhees
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16. Sylviane Lambert
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17. Stephan Weidinger
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18. Bernadette Eberlein
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19. Manfred Kunz
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20. Proton Rahman
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21. Dafna D Gladman
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22. Christian Gieger
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23. H Erich Wichmann
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24. Tom H Karlsen
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25. Gabriele Mayr
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26. Mario Albrecht
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27. Dieter Kabelitz
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28. Ulrich Mrowietz
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29. Gonçalo R Abecasis
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30. James T Elder
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31. Stefan Schreiber
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32. Michael Weichenthal
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33. Andre Franke
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Contributions

E.E. performed SNP selection, genotyping, data analysis and prepared the figures and tables. A.F. helped with data analysis. D.E. performed imputation, data analysis and generated the regional plots. P.E.S., J.G., J.D. and Y.L. performed the expression and expression quantitative trait loci analyses. S.W.S. and S.L. performed small hairpin RNA (shRNA) experiments. G.R.A. helped with statistical analyses and interpretation of the results. M.A. and G.M. performed in silico protein analyses. M.W., U.M., S.W., B.E. and M.K. coordinated the recruitment and collected phenotype data of panels A and B. C.G. and H.E.W. provided the KORA control samples. J.T.E., J.J.V., R.P.N., T.T., S.D., J.V.R., M.B., H.F., C.R., P.R. and D.D.G. provided the replication samples C through F and the respective genotypes and phenotypes. T.H.K., R.P.N. and D.K. helped with genotyping. E.E. and A.F. drafted the manuscript. D.E., M.W., J.T.E., T.H.K. and S.S. edited the manuscript. A.F. planned and supervised the study. All authors approved the final draft.

Corresponding authors

Correspondence toMichael Weichenthal or Andre Franke.

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The authors declare no competing financial interests.

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Ellinghaus, E., Ellinghaus, D., Stuart, P. et al. Genome-wide association study identifies a psoriasis susceptibility locus at TRAF3IP2.Nat Genet 42, 991–995 (2010). https://doi.org/10.1038/ng.689

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• Received: 25 February 2010
• Accepted: 26 July 2010
• Published: 17 October 2010
• Issue Date: November 2010
• DOI: https://doi.org/10.1038/ng.689