Linkage disequilibrium mapping of a type 1 diabetes susceptibility gene (IDDM7) to chromosome 2q31–q33 (original) (raw)
Singal, D.P. & Blajchman, A., Histocompatibility antigens, lymphocytotoxic antibodies and tissue antibodies in patients with diabetes mellitus. Diabetes22, 429–432 (1973). ArticleCASPubMed Google Scholar
Nerup, J. et al. HL-A antigens and diabetes mellitus. Lancet II 864–866 (1974). Article Google Scholar
Cudworth, A. & Woodrow, J. HL-A system and diabetes mellitus. Diabetes24, 345–349 (1974). Article Google Scholar
Morton, N.E. et al. Heterozygous expression of insulin-dependent diabetes mellitus (IDDM) determinants in the HLA system. Am. J. hum. Genet.35, 201–213 (1983). CASPubMedPubMed Central Google Scholar
Bell, G.I., Horita, S. & Karam, J.H. A polymorphic locus near the human insulin gene is associated with insulin-dependent diabetes mellitus. Diabetes33, 176–183 (1984). ArticleCASPubMed Google Scholar
Thomson, G., Robinson, W.P., Kuhner, M.K., Joe, S. & Klitz, W. HLA and insulin gene associations with IDDM. Genet. Epidemiol.6, 155–160 (1989). ArticleCASPubMed Google Scholar
Spielman, R.S., McGinnis, R.E. & Ewens, W.J. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus. Am. J. hum. Genet.52, 506–516 (1993). CASPubMedPubMed Central Google Scholar
Julier, C. et al. Insulin-IGF2 region on chromosome 11p encodes a gene implicated In HLA-DR4-dependent diabetes susceptibility. Nature354, 155–159 (1991). ArticleCASPubMed Google Scholar
Bain, S.C. et al. Insulin gene region-encoded susceptibility to type 1 diabetes is not restricted to HLA-DR4-positive individuals. Nature Genet.2, 212–215 (1992). ArticleCASPubMed Google Scholar
Davles, J.L. et al. A genome-wide search for human type 1 diabetes susceptibility genes. Nature371, 130–136 (1994). Article Google Scholar
Hashimoto, L. et al. Genetic mapping of a susceptibility locus for insulin-dependent diabetes mellitus on chromosome 11q. Nature371, 161–164 (1994). ArticleCASPubMed Google Scholar
Field, L.L., Tobias, R. & Magnus, T. A locus on chromosome 15q26 (IDDM3) produces susceptibility to Insulin-dependent diabetes mellitus. Nature Genet.8, 189–194 (1994). ArticleCASPubMed Google Scholar
Bowcock, A.M. et al. Refining the position of Wilson disease by linkage disequillbrium with polymorphic microsatellites. Am. J. hum. Genet.54, 79–87 (1994). CASPubMedPubMed Central Google Scholar
Hastbacka, J. et al. Linkage disequilibrium mapping in isolated founder populations: diastrophlc dysplasia in Finland. Nature Genet.2, 204–211 (1992). ArticleCASPubMed Google Scholar
Lerner, T.J. et al. Linkage disequilibrium between the juvenile neuronal ceroid llpofuscinosis gene and marker loci on chromosome 16p12.1. Am. J. hum. Genet.54, 88–94 (1994). CASPubMedPubMed Central Google Scholar
Morral, N. et al. The origin of the major cystic fibrosis mutation (DF508) in European populations. Nature Genet.7, 169–175 (1994). ArticleCASPubMed Google Scholar
Puffenberger, E.G. et al. Identity-by-descent and association mapping of a recessive gene for Hirschsprung disease on human chromosome 13q22. Hum. molec. Genet.3, 1217–1225 (1994). ArticleCASPubMed Google Scholar
Snarey, A. et al. Linkage disequilibrium in the region of the autosomal dominant polycystic kidney disease gene (PKD1). Am. J. hum. Genet.55, 365–371 (1994). CASPubMedPubMed Central Google Scholar
Reed, P.W. et al. Chromosome-specific microsatellite sets for fluorescence-based, semi-automated genome mapping. Nature Genet.7, 390–395 (1994). ArticleCASPubMed Google Scholar
Pritchard, L.E. et al. Analysis of the CD3 gene region and type 1 diabetes: application of fluorescence-based technology to linkage disequilibrium mapping. Hum. molec. Genet, (in the press).
Cornall, R.J. et al. Type 1 diabetes in mice is linked to the interleukin-1 receptor and Lsh/Ity/Bcg genes on chromosome 1. Nature353, 262–265 (1991). ArticleCASPubMed Google Scholar
Schurr, E., Skamene, E., Morgan, K., Chu, M.-L. & Gros, P. Mapping of Col3a1 and Col6a3 to proximal murine chromosome 1 identifies conserved linkage of structural protein genes between murine chromosome 1 and human chromosome 2q. Genomics8, 477–486 (1990). ArticleCASPubMed Google Scholar
Tiller, G.E., Polumbo, P.A. & Sumnar, M.L. Linkage mapping of the gene for type III collagen (COL3A1) to human chromosome 2q using a VNTR polymorphism. Genomics20, 275–277 (1994). ArticleCASPubMed Google Scholar
Gyapay, G. et al. The 1993–94 Généthon human genetic linkage map. Nature Genet.7, 246–339 (1994). ArticleCASPubMed Google Scholar
Mølvig, J. A model of the pathogenesls of insulin-dependent diabetes mellitus. Dan. med. Bull.39, 509–541 (1992). PubMed Google Scholar
Pociot, P., Johannesen, J. & Nerup, J. Non-HLA markers may differentiate between familial and sporadic IDDM cases. J. Autoimm. (in the press).
Bergholdt, R. et al. Possible association of an interleukin-1 receptor type 1 gene polymorphism with IDDM. Eur. J. Endocrinol.130 (suppl), 17 (1994). Google Scholar
Vidal, S.M., Malo, D., Vogan, K., Skamene, E. & Gros, P. Natural resistance to infection with intracellular parasites: isolation of a candidate for Bcg. Cell73, 469–485 (1993). ArticleCASPubMed Google Scholar
Todd, S. & Naylor, S.L. Dinucleotide repeat polymorphism in the human interleukin 1, alpha gene (IL1 A). Nucl. Acids Res.19, 3756 (1991). PubMedPubMed Central Google Scholar
Risch, N. Linkage strategies for genetically complex traits. III. The effect of marker polymorphism on analysis of affected relative pairs. Am. J. hum. Genet.46, 242–253 (1990). CASPubMedPubMed Central Google Scholar
Schaid, D.J. & Sommer, S.S. Comparison of statistics for candidate-gene association studies using cases and parents. Am. J. hum. Genet.55, 402–409 (1994). CASPubMedPubMed Central Google Scholar
Pociot, F., Mølvig, J., Wogensen, L., Worsaae, H. & Nerup, J. A Taql polymorphism in the human interleukln-1β (IL-1β) gene correlates with IL-1β secretion in vitro. Eur. J. clin. Invest.22, 396–402 (1992). ArticleCASPubMed Google Scholar
Tarlow, J.K. et al. Polymorphism in the human IL-1 receptor antagonist gene intron 2 is caused by variable numbers of an 86-bp tandem repeat. Hum. Genet.91, 403–404 (1993). ArticleCASPubMed Google Scholar
Mandrup-Poulsen, T. et al. Monokine antagonism is reduced in patients with IDDM. Diabetes43, 1242–1247 (1994). ArticleCASPubMed Google Scholar
Nicklin, M.J.H., Weith, A. & Duff, G.W. A physical map of the region encompassing the human interleukin-1α, interleukin-1β, and interleukin-1 receptor antagonist genes. Genomics19, 382–384 (1994). ArticleCASPubMed Google Scholar
McDowell, T.L., Symons, J.A., Ploski, R., Førre, Ø. & Duff, G.W. A polymorphism in the 5′ region of the interleukin-1 alpha gene is associated with juvenile chronic arthritis (JCA). Br. J. Rheumatol.32 (Suppl1), 162 (1993). Article Google Scholar
di Giovine, F.S., Takhsh, E., Blakemore, A.I.F. & Duff, G.W. Single base polymorphism at −511 in the human Interleukin-1β gene (IL1 β). Hum. molec. Genet.1, 450 (1992). ArticleCASPubMed Google Scholar
White, J.K. et al. Genetic and physical mapping of 2q35 in the region of NRAMP and IL8R genes: identification of a polymorphic repeat in exon 2 of NRAMP. Genomics (in the press).
Olson, J.M. & Wijsman, E.M. Design and sample-size considerations in the detection of linkage disequilibrium with a disease locus. Am. J. hum. Genet.55, 574–580 (1994). CASPubMedPubMed Central Google Scholar
Watkins, W.S. et al. Linkage disequilibrium patterns vary with chromosomal location: a case study from the von Willebrand Factor region. Am. J. hum. Genet.55, 348–355 (1994). CASPubMedPubMed Central Google Scholar
Jorde, L.B., Watkins, W.S., Viskochil, D., O'Connell, P. & Ward, K. Linkage, disequilibrium in the neurofibromatosis 1 (NF1) region; implications for gene mapping. Am. J. hum. Genet.53, 1038–1050 (1993). CASPubMedPubMed Central Google Scholar
Jorde, L.B. et al. Linkage disequilibrium predicts physical distance in the adenomatous polyposis coli region. Am. J. hum. Genet.54, 884–898 (1994). CASPubMedPubMed Central Google Scholar
Todd, J.A., Bell, J.I. & McDevitt, H.O. HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature329, 599–604 (1987). ArticleCASPubMed Google Scholar
Lucassen, A.M. et al. Susceptibility to insulin-dependent diabetes mellitus maps to a 4.1 kb segment of DNA spanning the insulin gene and associated VNTR. Nature Genet.4, 305–310 (1993). ArticleCASPubMed Google Scholar
Risch, N. Assessing the role of HLA-linked and unlinked determinants of disease. Am. J. hum. Genet.40, 1–14 (1987). CASPubMedPubMed Central Google Scholar
Suarez, B.K., Hampe, C.L. & Eerdewegh, P.V. in Genetic approaches to mental disorders (eds Gershon, E.S. & Cloninger, C.R.) 23–46 (American Psychiatric Press, Washington, DC, 1994). Google Scholar
Bain, S.C., Todd, J.A. & Bamett, A.H. . The British Diabetic Association — Warren Repository. Autoimmunity7, 83–85 (1990). ArticleCASPubMed Google Scholar
Pociot, F. et al. A nationwide population-based study of the familial aggregation of Type 1 (insulin-dependent) diabetes mellitus in Denmark. Dlabetologia36, 870–875 (1993). ArticleCAS Google Scholar
Larin, Z., Monaco, A.P. & Lehrach, H. Yeast artificial chromosome libraries containing large inserts from mouse and human DNA. Proc. natn. Acad. Sci. U.S.A88, 4123–4127 (1991). ArticleCAS Google Scholar
Albertsen, H.M. et al. Construction and characterisation of a yeast artifcial chromosome library containing seven haploid human genome equivalents. Proc. natn. Acad. Sci. U.S.A.87, 4256–4260 (1990). ArticleCAS Google Scholar
Church, G.M. & Gilbert, W. Genomic sequencing. Proc. natn. Acad. Sci. U.S.A81, 1991–1995 (1984). ArticleCAS Google Scholar
Feinberg, A.P. & Vogelsteln, B. A technique for radiolabelling DNA restriction endonuclease fragments to a high specific activity. Anal. Biochem.137, 6–13 (1983). Article Google Scholar
Matise, T.C., Perlin, M. & Chakravarti, A. Automated construction of genetic linkage maps using an expert system (MultiMap): a human genome linkage map. Nature Genet.6, 384–390 (1994). ArticleCASPubMed Google Scholar
Buetow, K.H. et al. Integrated human genome-wide maps constructed using the CEPH reference panel. Nature Genet.6, 391–393 (1994). ArticleCASPubMed Google Scholar