Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats (original) (raw)
- Article
- Published: 01 April 1993
- Madeleine Vincent2,
- Nilesh J. Samani3,
- Pascale Hilbert1,4,
- Michael A. Kaiser3,
- Jean-Paul Beressi1,
- Yuri Kotelevtsev5,
- Jacques S. Beckmann1,
- Florent Soubrier5,
- Jean Sassard2 &
- …
- G. Mark Lathrop1
Nature Genetics volume 3, pages 354–357 (1993)Cite this article
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Abstract
Several genetic loci involved in blood pressure regulation have recently been localized in experimental models of hypertension, but the manner in which they influence blood pressure remains unknown. Here, we report a study of the Lyon hypertensive rat strain showing that different loci are involved in the regulation of steady-state (diastolic pressure) and pulsatile (systolic – diastolic, or pulse pressure) components of blood pressure. Significant linkage was established between diastolic blood pressure and a microsatellite marker of the renin gene (REN) on rat chromosome 13, and between pulse pressure and the carboxypeptidase B gene (CPB) on chromosome 2. These findings show that two independent loci influence different haemodynamic components of blood pressure, and that pulse pressure has a specific genetic determination.
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Authors and Affiliations
- INSERM U. 358, Centre d'Etude du Polymorphisme Humain, 75010, Paris, France
Christopher Dubay, Pascale Hilbert, Jean-Paul Beressi, Jacques S. Beckmann & G. Mark Lathrop - URA CNRS 1483, Département de Physiologie et de la Pharmacologie Clinique, Faculté de Pharmacie, 8 avenue Rockefeller, 69373, Lyon, France
Madeleine Vincent & Jean Sassard - Department of Medicine, University of Leicester, Leicester Royal Infirmary, PO Box 65, Leicester, LE27LX, UK
Nilesh J. Samani & Michael A. Kaiser - IRIBNH, Campuse Erasme, Brussels, 1070, Belgium
Pascale Hilbert - INSERM U. 36, Collège de France, 3 rue d'Ulm, 75005, Paris, France
Yuri Kotelevtsev & Florent Soubrier
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Dubay, C., Vincent, M., Samani, N. et al. Genetic determinants of diastolic and pulse pressure map to different loci in Lyon hypertensive rats.Nat Genet 3, 354–357 (1993). https://doi.org/10.1038/ng0493-354
- Received: 20 October 1992
- Accepted: 18 November 1992
- Issue Date: 01 April 1993
- DOI: https://doi.org/10.1038/ng0493-354