Positional cloning moves from perditional to traditional (original) (raw)

Nature Genetics volume 9, pages 347–350 (1995)Cite this article

A Correction to this article was published on 01 September 1995

Abstract

The technique of positional cloning has become a familiar component of modern human genetics research. After a halting start in the mid–1980s, the number of disease genes succumbing to cloning efforts based solely on pinpointing their position in the genome is growing exponentially. More than 40 genes have been identified so far. But the positional candidate approach, which combines knowledge of map position with the increasingly dense human transcript map, greatly expedites the search process and will soon become the predominant method of disease gene discovery. The challenge ahead is to apply such methods to identifying genes involved in complex polygenic disorders.

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Authors and Affiliations

  1. National Center for Human Genome Research, National Institutes of Health, Building 31, Room 4B09, Bethesda, Maryland, 20892, USA
    Francis S. Collins

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  1. Francis S. Collins
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Collins, F. Positional cloning moves from perditional to traditional.Nat Genet 9, 347–350 (1995). https://doi.org/10.1038/ng0495-347

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