Somatic mutations in the BRCA1 gene in sporadic ovarian tumours (original) (raw)

References

  1. Miki, Y. et al. A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1. Science 266, 66–71 (1994).
    Article CAS PubMed Google Scholar
  2. Futreal, P.A. et al. BRCA1 mutations on primary breast and ovarian carcinomas. Science 266, 120–122 (1994).
    Article CAS PubMed Google Scholar
  3. Hall, J.M. et al. Linkage of early onset breast cancer to chromosome 17q21. Science 250, 1684–1689 (1990).
    Article CAS PubMed Google Scholar
  4. Castilla, L.H. et al. Mutations in the BRCA1 gene in families with early-onset breast and ovarian cancer. Nature Genet. 8, 387–391 (1994).
    Article CAS PubMed Google Scholar
  5. Simard, J. et al. Common origins of BRCA1 mutations in Canadian breast and ovarian cancer families. Nature Genet. 8, 392–398 (1994).
    Article CAS PubMed Google Scholar
  6. Friedman, L.S. et al. Confirmation of BRCA1 by analysis of germline mutations linked to breast and ovarian cancer In 10 families. Nature Genet. 8, 399–404 (1994).
    Article CAS PubMed Google Scholar
  7. Shattuck-Eidens, D. et al. A collaborative survey of 80 mutations in the BRCA1 breast and ovarian cancer susceptibility gene. J. Am. med. Assoc. 273, 535–541 (1995).
    Article CAS Google Scholar
  8. Easton, D.F., Bishop, D.T., Ford, D. & Crockford, G.P. The Breast Cancer Linkage Consortium. Genetic linkage analysis in familial breast and ovarian cancer. Results from 214 families. Am. J. hum. Genet. 52, 678–701 (1993).
    CAS PubMed PubMed Central Google Scholar
  9. Ford, D. et al. Risks of cancer in BRCA1 mutation carriers. Lancet 343, 692–695 (1994).
    Article CAS PubMed Google Scholar
  10. Kelsell, D.P., Black, D.M., Bishop, D.T. & Spurr, N.K. Genetic analysis of the BRCA1 region in a large breast/ovarian family: Refinement of the minimal region containing BRCA1. Hum. molec. Genet. 2, 1823–1828 (1993).
    Article CAS PubMed Google Scholar
  11. Smith, S.A., Easton, D.F., Evans, D.G.R. & Ponder, B.A.J. Allele losses in the region 17q12–21 in familial breast and ovarian cancer involve the wild-type chromosome. Nature Genet. 2, 128–131 (1992).
    Article CAS PubMed Google Scholar
  12. Sato, T. et al. Allelotype of human ovarian cancer. Cancer Res. 51, 5118–5122 (1991).
    CAS PubMed Google Scholar
  13. Lee, J.H., Kavanagh, J.J., Wildrick, D.M., Wharton, J.T. & Blick, M. Frequent loss of heterozygosity on chromosomes 6q, 11, and 17 in human ovarian carcinomas. Cancer Res. 50, 2724–2728 (1990).
    CAS PubMed Google Scholar
  14. Eccles, D.M., Cranston, G., Steel, C.M., Nakamura, Y. & Leonard, R.C.F. Allele losses on chromosome 17 in human epithelial ovarian carcinomas. Oncogene 5, 1599–1601 (1990).
    CAS PubMed Google Scholar
  15. Jacobs, I.J. et al. A deletion unit on chromosome 17q in epithelial ovarian tumors distal to the familial breast/ovarian cancer locus. Cancer Res. 53, 1218–1221 (1993).
    CAS PubMed Google Scholar
  16. Cropp, C.S. et al. Evidence for involvement of BRCA1 in sporadic breast carcinomas. Cancer Res. 55, 2548–2551 (1994).
    Google Scholar
  17. Merajver, S.D. et al. Germline BRCA1 mutations and loss of the wild-type allele in early-onset breast/ovarian families. Clin. Cancer Res. (in the press).
  18. Young, R.H. & Scully, R.E. Pathology of epithelial tumors. Hem. /Onc. Clin. N. Am. 6, 739–760 (1992).
    Article CAS Google Scholar
  19. Orita, M., Suzuki, Y., Sekiya, T.S. & Hayashi, K. Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction. Genomics 5, 874–879 (1989).
    Article CAS PubMed Google Scholar
  20. Knudson, A.G. Antioncogenes and human cancer. Proc. natn. Acad. Sci. U.S.A. 90, 10914–10921 (1993).
    Article CAS Google Scholar
  21. Frank, T.S. et al. Loss of heterozygosity and overexpression of the p53 gene in ovarian carcinoma. Mod. Pathol. 7, 3–8 (1994).
    CAS PubMed Google Scholar
  22. Beaudet, A.L. & Tsui, L.-C. A suggested nomenclature for designating mutations. Hum. Mut. 2, 245–248 (1993).
    Article CAS PubMed Google Scholar

Download references