Coevolution in the tumor microenvironment (original) (raw)

Nature Genetics volume 40, pages 494–495 (2008)Cite this article

The progression of carcinomas to high-grade malignancies is accompanied by profound histological changes in the tumor-associated stroma. Although previous studies have suggested that mesenchymal cells of the stroma undergo genetic alterations during this progression, a new study now provides evidence that strongly contradicts this theory of stromal cell coevolution.

This is a preview of subscription content, access via your institution

Relevant articles

Open Access articles citing this article.

Access options

Subscribe to this journal

Receive 12 print issues and online access

$259.00 per year

only $21.58 per issue

Buy this article

USD 39.95

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Figure 1: Islands of neoplastic epithelial cells (light blue nuclei) are surrounded by a myofibroblast-rich stroma (dark brown).

References

  1. Qiu, W. et al. Nat. Genet. 40, 650–655 (2008).
    Article CAS Google Scholar
  2. Dvorak, H.F. N. Engl. J. Med. 315, 1650–1659 (1986).
    Article CAS Google Scholar
  3. Lakhani, S.R. et al. J. Pathol. 189, 496–503 (1999).
    Article CAS Google Scholar
  4. Moinfar, F. et al. Cancer Res. 60, 2562–2566 (2000).
    CAS PubMed Google Scholar
  5. Wernert, N., Locherbach, C., Wellmann, A., Behrens, P. & Hugel, A. Anticancer Res. 21, 2259–2264 (2001).
    CAS PubMed Google Scholar
  6. Kurose, K. et al. Nat. Genet. 32, 355–357 (2002).
    Article CAS Google Scholar
  7. Patocs, A. et al. N. Engl. J. Med. 357, 2543–2551 (2007).
    Article CAS Google Scholar
  8. Fukino, K., Shen, L., Patocs, A., Mutter, G.L. & Eng, C. J. Am. Med. Assoc. 297, 2103–2111 (2007).
    Article CAS Google Scholar
  9. Weber, F. et al. J. Am. Med. Assoc. 297, 187–195 (2007).
    Article CAS Google Scholar
  10. Moinfar, F. et al. Mod. Pathol. doi:10.1038/modpathol.2008.28 (8 February 2008).
    Article CAS Google Scholar
  11. Allinen, M. et al. Cancer Cell 6, 17–32 (2004).
    Google Scholar

Download references

Author information

Authors and Affiliations

  1. Massachusetts Institute of Technology Department of Biology, Robert A. Weinberg is at the Whitehead Institute for Biomedical Research, Ludwig Center for Molecular Oncology, Cambridge, Massachusetts 02142, USA. weinberg@wi.mit.edu,
    Robert A Weinberg

Rights and permissions

About this article

Cite this article

Weinberg, R. Coevolution in the tumor microenvironment.Nat Genet 40, 494–495 (2008). https://doi.org/10.1038/ng0508-494

Download citation

This article is cited by