Gain of function mutations in p53 (original) (raw)

References

  1. Johnson, P. & Benchimol, S. Friend virus induced murine erythroleukaemia: The p53 locus, in Cancer Surveys 12, (ed. A.J. Levine) 137–151 (Cold Spring Harbor Press, New York, 1992).
    Google Scholar
  2. Baker, S.J. et al. Chromosome 17 deletions and p53 gene mutations in colorectal carcinoma. Science 244, 217–221 (1989).
    Article CAS Google Scholar
  3. Baker, S.J., Markowitz, S., Fearon, E.R., Willson, J.K.U. & Vogelstein, B. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249, 912–915 (1990).
    Article CAS Google Scholar
  4. Finlay, C.A., Hinds, P.W. & Levine, A.J. The p53 proto-oncogene can act as a suppressor of transformation. Cell 57, 1083–1093 (1989).
    Article CAS Google Scholar
  5. Chen, P.-L., Chen, Y., Bookstein, R. & Lee, W.-H. Genetic mechanisms of tumour suppression by the human p53 gene. Science 250, 1576–1579 (1990).
    Article CAS Google Scholar
  6. Farmer, G.E. et al. Wild-type p53 activates transcription in vitro. Nature 358, 83–86 (1992).
    Article CAS Google Scholar
  7. Kern, S. et al. Oncogenic forms of p53 inhibit p53-regulated gene expression. Science 256, 827–32 (1992).
    Article CAS Google Scholar
  8. Zambetti, G.P., Bargonetti, J., Walker, K., Prives, C. & Levine, A.J. Wild-type p53 mediates positive regulation of gene expression through a specific DNA sequence element. Genes Dev. 6, 1143–1152 (1992).
    Article CAS Google Scholar
  9. Bargonetti, J., Friedman, P.N., Kern, S.E., Vogelstein, B. & Prives, C. Wild-type but not mutant p53 immunopurified proteins bind to sequences adjacent to the SV40 origin of replication. Cell 65, 1083–1091 (1991).
    Article CAS Google Scholar
  10. El-Deiry, W.S., Kern, S.E., Pietenpol, J.A., Kinzler, K.W. & Vogelstein, B. Definition of a consensus binding site for p53. Nature Genet. 1, 45–49 (1992).
    Article CAS Google Scholar
  11. Funk, W.D. et al. A transcriptionally active DNA-binding site for human p53 protein complexes. Molec. cell. Biol. 12, 2866–2871 (1992).
    Article CAS Google Scholar
  12. Kern, S.E. et al. Identification of p53 as a sequence-specific DNA-binding protein. Science 252, 1708–1711 (1991).
    Article CAS Google Scholar
  13. Barnonetti, J. et al. Site-specific binding of wild-type p53 to cellular DMA is inhibited by SV40 T antigen and mutant p53. Genes Dev. 6, 1886–1898 (1992).
    Article Google Scholar
  14. Levine, A.J., Momand, J. & Finlay, C.A. The p53 tumour suppressor gene. Nature 351, 453–456 (1991).
    Article CAS Google Scholar
  15. Hollstein, M., Sidransky, D., Vogelstein, B. & Harris, C.C. p53 mutations in human cancers. Science 253, 49–53 (1991).
    Article CAS Google Scholar
  16. Kern, S.E. et al. Mutant p53 proteins bind DNA abnormally in vitro. Oncogene 6, 131–136 (1991).
    CAS Google Scholar
  17. Mietz, J.A., Unger, T., Huibregtse, J.M. & Howley, P.M. The transcriptional transactivation function of wild-type p53 is inhibited by SV40 large T-antigen and by HPV-16 E6 oncoprotein. EMBO J. 11, 5013–5020 (1992).
    Article CAS Google Scholar
  18. Yew, P.R. & Berk, A.J. Inhibition of p53 transactivat ion required for transformation by adenovirus E1B 55 Kd protein. Nature 357, 82–85 (1992).
    Article CAS Google Scholar
  19. Momand, J., Zambetti, G.P., Olson, D.C., George, D. & Levine, A.J. The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53 mediated transactivation. Cell 69, 1237–1245 (1992).
    Article CAS Google Scholar
  20. Zambetti, G.P., Olson, D., Labow, M. & Levine, A.J. A mutant p53 protein is required for the maintenance of the transformed cell phenotype in p53 plus ras transformed cells. Proc. natn. Acad. Sci. U.S.A. 89, 3952–3956 (1992).
    Article CAS Google Scholar
  21. Martinez, J., Georgoff, I., Martinez, J. & Levine, A.J. Cellular localization and cell cycle regulation by a temperature sensitive p53 protein. Genes Dev. 5, 151–159 (1991).
    Article CAS Google Scholar
  22. Eliyahu, D., Raz, A., Gruss, P., Givol, D. & Oren, M. Participation of p53 cellular tumour antigen in transformation of normal embryonic cells. Nature 312, 646–649 (1984).
    Article CAS Google Scholar
  23. Parada, L.F., Land, H., Weinberg, R.A., Wolf, D. & Rotter, V. Cooperation between gene encoding p53 tumour antigen and ras in cellular transformation. Nature 312, 649–651 (1984).
    Article CAS Google Scholar
  24. Jenkins, J.R., Rudge, K. & Currie, G.A. Cellular immortalization by a cDNA clone encoding the transformation–associated phosphoprotein p53. Nature 312, 651–654 (1984).
    Article CAS Google Scholar
  25. Wolf, D., Admon, S., Oren, M. & Rotter, V. Abelson murine leukemia virus-transformed cells that lack p53 protein synthesis express aberrant p53 mRNA species. Molec. cell. Biol. 4, 552–558 (1984).
    Article CAS Google Scholar
  26. Shaulsky, G., Goldfinger, N. & Rotter, V. Alterations in tumour development in vivo mediated by expression of wild-type or mutant p53 proteins. Cancer Res. 51, 5232–5237 (1991).
    CAS PubMed Google Scholar
  27. Harvey, D. & Levine, A.J. p53 alteration is a common event in the spontaneous immortalization of primary BALB/C murine embryo fibroblasts. Genes Dev. 5, 2375–2385 (1991).
    Article CAS Google Scholar
  28. Masuda, H., Miller, C., Koeffler, H.P., Battifora, H. & Cline, M.J. Rearrangement of the p53 gene in human osteogenic sarcomas. Proc. natn. Acad. Sci. U.S.A. 84, 7716–7719 (1987).
    Article CAS Google Scholar
  29. Hinds, P.W. et al. Mutant p53 cDNAs from human colorectal carcinomas can cooperate with ras in transformation of primary rat cells: A comparison of the “hot spot” mutant phenotypes. Cell Growth Diff. 1, 571–580 (1990).
    CAS Google Scholar
  30. Baker, S.J., Markowitz, S., Fearon, E.R., Willson, J.K.U. & Vogelstein, B. Suppression of human colorectal carcinoma cell growth by wild-type p53. Science 249, 912–915 (1990).
    Article CAS Google Scholar
  31. Diller, L. et al. p53 functions as a cell cycle control protein in osteosarcomas. Molec. cell. Biol. 10, 5772–5781 (1990).
    Article CAS Google Scholar
  32. Johnson, P., Gray, D., Mowat, M. & Benchimol, S. Expression of wild-type p53 is not compatible with continued growth of p53-negative tumour cells. Molec. cell. Biol. 11, 1–11 (1991).
    Article CAS Google Scholar
  33. Mercer, W.E. et al. Negative growth regulation in a glioblastoma tumour cell line that conditionally expresses human wild-type p53. Proc. natn. Acad. Sci. U.S.A. 87, 6166–6170 (1990).
    Article CAS Google Scholar
  34. Eliyahu, D., Michalovitz, D. & Oren, M. Overproduction of p53 antigen makes established cells highly tumorigenic. Nature 316, 158–160 (1985).
    Article CAS Google Scholar
  35. Chin, K.V., Ueda, K., Pastan, I. & Gottesman, M.M. Modulation of activity of the promoter of the human MDR1 gene by ras and p53. Science, 255, 459–462 (1992).
    Article CAS Google Scholar
  36. Werness, B.A., Levine, A.J. & Howley, P.M. Association of human papillomavirus types 16 and 18 E6 proteins with p53. Science 248, 76–79 (1990).
    Article CAS Google Scholar
  37. Scheffner, M., Werness, B.A., Huibregtse, J.M., Levine, A.J. & Howley, P.M. The E6 oncoprotein encoded by human papillomavirus 16 or 18 promotes the degradation of p53. Cell 63, 1129–1136 (1990).
    Article CAS Google Scholar
  38. Riou, G. et al. Association between poor prognosis in early stage invasive cervical carcinomas and nondetection of HPV DNA. Lancet 335, 1171–1174 (1990).
    Article CAS Google Scholar
  39. Tan, T.-H., Wallis, J. & Levine, A.J. Identification of the p53 protein domain involved in formation of the simian virus 40 large T antigen-p53 protein complex. J. Virol. 59, 574–583 (1986).
    CAS PubMed PubMed Central Google Scholar
  40. Reich, N.C. & Levine, A.J. Growth regulation of a cellular tumour antigen, p53, in nontransformed cells. Nature 308, 199–201 (1984).
    Article CAS Google Scholar
  41. Thor, A.D. et al. Accumulation of p53 tumour suppressor gene protein: an independent marker of prognosis in breast cancer. J. natn. Cancer Inst. 84, 845–855 (1992).
    Article CAS Google Scholar
  42. Martin, H.M., Filipe, M.I., Morris, R.W., Lane, D.P. & Silvestre, F. p53 expression and prognosis in gastric carcinoma. Int. J. Cancer 50, 859–862 (1992).
    Article CAS Google Scholar

Download references