Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma (original) (raw)
Boring, C.C., Squires, T.S. & Tong, T. Cancer statistics, 1993. CA Cancer J. Clin.43, 7–26 (1993). ArticleCASPubMed Google Scholar
Almoguerra, C. et al. Most human carcinomas of the exocrine pancreas contain mutant c-K-ras genes. Cell53, 549–554 (1988). Article Google Scholar
Hruban, R.H. et al. K-ras oncogene activation in adenocarcinomas of the human pancreas: a study of 82 carcinomas using a combination of mutant-enriched polymerase chain reaction analysis and allele-specific oligonucleotlde hybridization. Am. J. Pathol.143, 545–554 (1993). CASPubMedPubMed Central Google Scholar
Pellegata, S. et al. K-ras and p53 gene mutations in pancreatic cancer: ductal and nonductal tumors progress through different genetic lesions. Cancer Res.54, 1556–1560 (1994). CASPubMed Google Scholar
Redston, M.S. et al. p53 mutations in pancreatic carcinoma and evidence of common involvement of homocopoiymer tracts in DNA microdeletions. Cancer Res.54, 3025–3033 (1994). CASPubMed Google Scholar
Seymour, A.B. et al. Allelotype of pancreatic adenocarcinoma. Cancer Res.54, 2761–2764 (1994). CASPubMed Google Scholar
El-Deiry, W. et al. WAF1, a potential mediator of p53 tumor suppression. Cell75, 817–825 (1993). ArticleCASPubMed Google Scholar
Noda, A., Ning, Y., Venable, S.F., Pereira-Smith, O.M. & Smith, J.R. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp. Cell Res.211, 90–98 (1994). ArticleCASPubMed Google Scholar
Harper, J.W., Adami, G.R., Wei, N., Keyomarsi, K. & Elledge, S.J. The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyciin-dependent kinases. Cell75, 805–816 (1993). ArticleCASPubMed Google Scholar
Serrano, M., Hannon, G.J. & Beach, D. A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4. Nature366, 704–707 (1993). ArticleCASPubMed Google Scholar
Kamb, A. et al. A cell cycle regulator potentially involved in genesis of many tumor types. Science264, 436–440 (1994). ArticleCASPubMed Google Scholar
Nobori, T. et al. Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers. Nature368, 753–756 (1994). ArticleCASPubMed Google Scholar
Cannon-Albright, L.A. et al. Assignment of a locus for familial melanoma, MLM, to chromosome 9p13–p22. Science258, 1148–1152 (1992). ArticleCASPubMed Google Scholar
Bos, J.L. et al. Prevalence of ras gene mutations in human colorectal cancers. Nature327, 293–297 (1987). ArticleCASPubMed Google Scholar
Weber, J.L. & May, P.E. Abundant class of human DNA polymorphisms which can be typed using the polymerase chain reaction. Am. J. hum. Genet.44, 388–396 (1989). CASPubMedPubMed Central Google Scholar
Kwaitkowski, K.W., Armour, J., Bale, A.E., Fountain, J.W. & Goudie, D. Report on the second international workshop on hyman chromosome 9. Cytogenet. Cell Genet.64, 94–103 (1993). Google Scholar
Okamoto, A. et al. Mutations and altered expression of p16INK4 in human cancer. Proc. natn. Acad. Sci. U.S.A. (in the press).
Cairns, P. et al. Rates of p16 (MTS1) mutations in primary tumors with 9p loss. Science265, 415–416 (1994). ArticleCASPubMed Google Scholar
Yanagisawa, A. et al. Frequent c-Ki-ras oncogene activation in mucous cell hyperplasias of pancreas suffering from chronic inflammation. Cancer Res.53, 953–956 (1993). CASPubMed Google Scholar
Caldas, C. et al. Detection of K-ras mutations in the stool of patients with pancreatic adenocarcinoma and pancreatic ductal hyperplasia. Cancer Res.54, 3568–3573 (1994). CASPubMed Google Scholar
Cameron, J.L. et al. Factors influencing survival after pancreaticoduodenectomy for pancreatic cancer. Am. J. Surg.161, 120–125 (1991). ArticleCASPubMed Google Scholar
Feinberg, A.P. & Vogelstein, B. A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal. Biochem.137, 266–267 (1984). ArticleCASPubMed Google Scholar
Ruggeri, B. et al. Human pancreatic carcinomas and cell lines reveal frequent and multiple alterations in the p53 and Rb-1 tumor-suppressor genes. Oncogene7, 1503–1511 (1992). CASPubMed Google Scholar