A deletion in the bovine myostatin gene causes the double–muscled phenotype in cattle (original) (raw)
- Letter
- Published: 01 September 1997
- Luis José Royo Martin2,
- Dominique Poncelet1,
- Dimitri Pirottin1,
- Benoit Brouwers1,
- Juliette Riquet1,
- Andreina Schoeberlein1,
- Susana Dunner2,
- François Ménissier3,
- Julio Massabanda4,
- Ruedi Fries4,
- Roger Hanset1 &
- …
- Michel Georges1
Nature Genetics volume 17, pages 71–74 (1997)Cite this article
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Abstract
An exceptional muscle development commonly referred to as ‘double-muscled’ (Fig. 1) has been seen in several cattle breeds and has attracted considerable attention from beef producers. Double-muscled animals are characterized by an increase in muscle mass of about 20%, due to general skeletal-muscle hyperplasia—that is, an increase in the number of muscle fibers rather than in their individual diameter1. Although the hereditary nature of the double-muscled condition was recognized early on, the precise mode of inheritance has remained controversial; monogenic (dominant and recessive), oligogenic and polygenic models have been proposed2. In the Belgian Blue cattle breed (BBCB)4, segregation analysis performed both in experimental crosses3 and in the outbred population suggested an autosomal recessive inheritance. This was confirmed when the muscular hypertrophy (mh) locus was mapped 3.1 cM from microsatellite TGLA44 on the centromeric end of bovine chromosome 2 (ref. 5). We used a positional candidate approach to demonstrate that a mutation in bovine MSTN, which encodes myostatin, a member of the TGFβ superfamily, is responsible for the double-muscled phenotype. We report an 11-bp deletion in the coding sequence for the bioactive carboxy-termihal domain of the protein causing the muscular hypertrophy observed in Belgian Blue cattle.
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Authors and Affiliations
- Department of Genetics, Faculty of Veterinary Medicine, University of Liège (B43), 20 Bd de Colonster, 4000, Liège, Belgium
Luc Grobet, Dominique Poncelet, Dimitri Pirottin, Benoit Brouwers, Juliette Riquet, Andreina Schoeberlein, Roger Hanset & Michel Georges - Laboratorio de Genética, Dpto. de Produción Animal, Universidad Complutense, 28040, Madrid, Spain
Luis José Royo Martin & Susana Dunner - Station de Génétique Quantitative et Appliquée, I.N.R.A., 78352, Jouy-en-Josas, France
François Ménissier - Technische Universität München, D-85350, Freising-Weihenstephan, Germany
Julio Massabanda & Ruedi Fries
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- Luc Grobet
You can also search for this author inPubMed Google Scholar - Luis José Royo Martin
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Correspondence toMichel Georges.
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Grobet, L., Royo Martin, L., Poncelet, D. et al. A deletion in the bovine myostatin gene causes the double–muscled phenotype in cattle.Nat Genet 17, 71–74 (1997). https://doi.org/10.1038/ng0997-71
- Received: 02 July 1997
- Accepted: 04 July 1997
- Issue Date: 01 September 1997
- DOI: https://doi.org/10.1038/ng0997-71