Many hypotheses but no replication for the association between PDE4D and stroke (original) (raw)

Nature Genetics volume 38, pages 1091–1092 (2006)Cite this article

To the Editor:

Stroke is the second-leading cause of death and a major cause of long-term disability throughout the world. Accumulated evidence suggests that inherited genetic variation plays a role in its pathogenesis. The need for identifying culprit genetic variants is great, since they may provide novel targets for the preventative therapeutics that are desperately needed.

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Figure 1: Pairwise _r_2 plot for 11 associated SNPs and allele 0 of microsatellite AC008818-1 in the HapMap CEU panel.

References

  1. Gretarsdottir, S. et al. Nat. Genet. 35, 131–138 (2003).
    Article CAS Google Scholar
  2. Meschia, J.F. et al. Ann. Neurol. 58, 351–361 (2005).
    Article CAS Google Scholar
  3. Saleheen, D. et al. Stroke 36, 2275–2277 (2005).
    Article CAS Google Scholar
  4. Woo, D. et al. Stroke 37, 371–376 (2006).
    Article CAS Google Scholar
  5. van Rijn, M.J.E. et al. Neurology 65, 1203–1209 (2005).
    Article CAS Google Scholar
  6. Nakayama, T., Asai, S., Sato, N. & Soma, M. Stroke 37, 69–76 (2006).
    Article CAS Google Scholar
  7. Lohmussaar, E. et al. Stroke 36, 731–736 (2005).
    Article CAS Google Scholar
  8. Bevan, S., Porteous, L., Sitzer, M. & Markus, H.S. Stroke 36, 949–953 (2005).
    Article CAS Google Scholar
  9. Nilsson-Ardnor, S. et al. Stroke 36, 1666–1671 (2005).
    Article CAS Google Scholar
  10. Kuhlenbaumer, G. et al. J. Neurol. Neurosurg. Psychiatry 77, 521–524 (2006).
    Article CAS Google Scholar

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Authors and Affiliations

  1. Vascular and Critical Care Neurology, Massachusetts General Hospital, Boston, 02114, Massachusetts, USA
    Jonathan Rosand & Natalia Rost
  2. Center for Human Genetic Research, Massachusetts General Hospital, Boston, 02114, Massachusetts, USA
    Jonathan Rosand, Nick Bayley, Natalia Rost & Paul I W de Bakker
  3. Program in Medical and Population Genetics, Broad Institute of Harvard and MIT, Cambridge, 02142, Massachusetts, USA
    Jonathan Rosand, Nick Bayley, Natalia Rost & Paul I W de Bakker

Authors

  1. Jonathan Rosand
  2. Nick Bayley
  3. Natalia Rost
  4. Paul I W de Bakker

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Rosand, J., Bayley, N., Rost, N. et al. Many hypotheses but no replication for the association between PDE4D and stroke.Nat Genet 38, 1091–1092 (2006). https://doi.org/10.1038/ng1006-1091

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