The genetics of variation in gene expression (original) (raw)

• Brem, R.B., Yvert, G., Clinton, R. & Kruglyak, L. Genetic dissection of transcriptional regulation in budding yeast. Science 296, 752–755 (2002).
  Article CAS Google Scholar
• Cavalieri, D., Townsend, J.P. & Hartl, D.L. Manifold anomalies in gene expression in a vineyard isolate of Saccharomyces cerevisiae revealed by DNA microarray analysis. Proc. Natl Acad. Sci. USA 97, 12369–12374 (2000).
  Article CAS Google Scholar
• Steinmetz, L.M. et al. Dissecting the architecture of a quantitative trait locus in yeast. Nature 416, 326–330 (2002).
  Article CAS Google Scholar
• Jin, W. et al. The contributions of sex, genotype and age to transcriptional variance in Drosophila melanogaster. Nature Genet. 29, 389–395 (2001).
  Article CAS Google Scholar
• Sandberg, R. et al. Regional and strain-specific gene expression mapping in the adult mouse brain. Proc. Natl Acad. Sci. USA 97, 11038–11043 (2000).
  Article CAS Google Scholar
• Oleksiak, M.F., Churchill, G.A. & Crawford, D.L. Variation in gene expression within and among natural populations. Nature Genet. 32, 261–266 (2002).
  Article CAS Google Scholar
• Enard, W. et al. Intra- and interspecific variation in primate gene expression patterns. Science 296, 340–343 (2002).
  Article CAS Google Scholar
• Watts, J.A. et al. Gene expression phenotype in heterozygous carriers of ataxia telangiectasia. Am. J. Hum. Genet. 71, 791–800 (2002).
  Article Google Scholar
• Concannon, P. ATM heterozygosity and cancer risk. Nature Genet. 32, 89–90 (2002).
  Article CAS Google Scholar
• Spring, K. et al. Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer. Nature Genet. 32, 185–190 (2002).
  Article CAS Google Scholar
• Cargill, M. et al. Characterization of single-nucleotide polymorphisms in coding regions of human genes. Nature Genet. 22, 231–238 (1999).
  Article CAS Google Scholar
• Halushka, M.K. et al. Patterns of single-nucleotide polymorphisms in candidate genes for blood-pressure homeostasis. Nature Genet. 22, 239–247 (1999).
  Article CAS Google Scholar
• Kruglyak, L. & Nickerson, D. Variation is the spice of life. Nature Genet. 27, 234–236 (2001).
  Article CAS Google Scholar
• Gabriel, S.B. et al. The structure of haplotype blocks in the human genome. Science 296, 2225–2229 (2002).
  Article CAS Google Scholar
• Dawson, E. et al. First-generation linkage disequilibrium map of human chromosome 22. Nature 418, 544–548 (2002).
  Article CAS Google Scholar
• Daly, M.J., Rioux, J.D., Schaffner, S.F., Hudson, T.J. & Lander, E.S. High-resolution haplotype structure in the human genome. Nature Genet. 29, 229–232 (2001).
  Article CAS Google Scholar
• Patil, N. et al. Blocks of limited haplotype diversity revealed by high-resolution scanning of human chromosome 21. Science 294, 1719–1723 (2001).
  Article CAS Google Scholar
• Couzin, J. New mapping project splits the community. Science 296, 1391–1392 (2002).
  Article CAS Google Scholar
• Ewens, W.J. & Spielman, R.S. Locating genes by linkage and association. Theor. Pop. Biol. 60, 135–139 (2001).
  Article CAS Google Scholar
• Jorde, L.B. Linkage disequilibrium and the search for complex disease genes. Genome Res. 10, 1435–1444 (2000).
  Article CAS Google Scholar
• Spielman, R.S., McGinnis, R.E. & Ewens, W.J. Transmission test for linkage disequilibrium: the insulin gene region and insulin-dependent diabetes mellitus. Am. J. Hum. Genet. 52, 506–516 (1993).
  CAS Google Scholar
• Thomson, G. Mapping disease genes: family-based association studies. Am. J. Hum. Genet. 57, 487–498 (1995).
  CAS Google Scholar
• Devlin, B. & Roeder, K. Genomic control for association studies. Biometrics 55, 997–1004 (1999).
  Article CAS Google Scholar
• Pritchard, J.K., Stephens, M., Rosenberg, N.A. & Donnelly, P. Association mapping in structured populations. Am. J. Hum. Genet. 67, 170–181 (2000).
  Article CAS Google Scholar
• Chen, X. & Kwok, P.Y. Template-directed dye-terminator incorporation (TDI) assay: a homogeneous DNA diagnostic method based on fluorescence resonance energy-transfer. Nucleic Acid Res. 25, 347–353 (1997).
  Article Google Scholar
• Wang, D.G. et al. Large-scale identification, mapping, and genotyping of single-nucleotide polymorphisms in the human genome. Science 280, 1077–1082 (1998).
  Article CAS Google Scholar
• Chen, X., Levine, L. & Kwok, P.Y. Fluorescence polarization in homogeneous nucleic acid analysis. Genome Res. 9, 492–498 (1999).
  CAS Google Scholar
• Howell, W.M., Jobs, M., Gyllensten, U. & Brookes, A.J. Dynamic allele-specific hybridization. A new method for scoring single nucleotide polymorphisms. Nat. Biotechnol. 17, 87–88 (1999).
  Article CAS Google Scholar
• Griffin, T.J., Hall, J.G., Prudent, J.R. & Smith, L.M. Direct genetic analysis by matrix-assisted laser desorption/ ionization mass spectrometry. Proc. Natl Acad. Sci. USA 96, 6301–6306 (1999).
  Article CAS Google Scholar
• Lindblad-Toh, K. et al. Large-scale discovery and genotyping of single-nucleotide polymorphisms in the mouse. Nature Genet. 24, 381–386 (2000).
  Article CAS Google Scholar
• Fan, J.B. et al. Parallel genotyping of human SNPs using generic high-density oligonucleotide tag arrays. Genome Res. 10, 853–860 (2000).
  Article CAS Google Scholar
• Oliphant, A., Barker, D.L., Stuelpnagel, J.R. & Chee, M.S. BeadArray Technology: enabling an accurate, cost-effective approach to high-throughput genotyping. Biotechniques 32, S56–S61 (2002).
  Article Google Scholar