Ciliary signaling goes down the tubes (original) (raw)

Nature Genetics volume 33, pages 113–114 (2003)Cite this article

The focus of research on polycystic kidney disease (PKD) has recently shifted to the primary cilia of renal epithelial cells. A new study shows that the protein products of the genes mutated in PKD mediate mechanosensory calcium mobilization, suggesting that a disruption of fluid-flow sensing triggers abnormal cell proliferation and cyst growth.

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References

  1. Igarashi, P. & Somlo, S. J. Am. Soc. Nephrol. 13, 2384–2398 (2002).
    Article CAS Google Scholar
  2. Nauli, S.M. et al. Nat. Genet. 33 (2003); advance online publication, 6 January 2003 (doi:10.1038/ng1076).
  3. Murcia, N.S. et al. Development 127, 2347–2355 (2000).
    CAS PubMed Google Scholar
  4. Yoder, B.K. et al. Am. J. Physiol. Renal Physiol. 282, F541–552 (2002).
    Article CAS Google Scholar
  5. Hou, X. et al. J. Clin. Invest. 109, 533–540 (2002).
    Article CAS Google Scholar
  6. Barr, M.M. & Sternberg, P.W. Nature 401, 386–389 (1999).
    CAS PubMed Google Scholar
  7. Qin, H., Rosenbaum, J.L. & Barr, M.M. Curr. Biol. 11, 457–461 (2001).
    Article CAS Google Scholar
  8. Haycraft, C.J. et al. Development 128, 1493–1505 (2001).
    CAS Google Scholar
  9. Pazour, G.J. et al. Curr. Biol. 12, R378–380 (2002).
    Article CAS Google Scholar
  10. Yoder, B.K., Hou, X. & Guay-Woodford, L.M. J. Am. Soc. Nephrol. 13, 2508–2516 (2002).
    Article CAS Google Scholar
  11. Bhunia, A.K. et al. Cell 109, 157–168 (2002).
    Article CAS Google Scholar
  12. Scheffers, M.S. et al. Hum. Mol. Genet. 11, 59–67 (2002).
    Article CAS Google Scholar
  13. Koulen, P. et al. Nat. Cell Biol. 4, 191–197 (2002).
    Article CAS Google Scholar
  14. Delmas, P. et al. J. Biol. Chem. 277, 11276–11283 (2002).
    Article CAS Google Scholar
  15. Schrier, R.W. & Gottschalk, C.W. (eds.) Diseases of the Kidney 6th edn. vol. I. 529 (Little Brown and Co., Boston, 1997).
    Google Scholar

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Authors and Affiliations

  1. Department of Biochemistry and Molecular Biology and the Kidney Institute, University of Kansas Medical Center, Kansas City, 66160, Kansas, USA
    James P. Calvet

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  1. James P. Calvet
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Calvet, J. Ciliary signaling goes down the tubes.Nat Genet 33, 113–114 (2003). https://doi.org/10.1038/ng1078

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