Ciliary signaling goes down the tubes (original) (raw)
- News & Views
- Published: 06 January 2003
Nature Genetics volume 33, pages 113–114 (2003)Cite this article
The focus of research on polycystic kidney disease (PKD) has recently shifted to the primary cilia of renal epithelial cells. A new study shows that the protein products of the genes mutated in PKD mediate mechanosensory calcium mobilization, suggesting that a disruption of fluid-flow sensing triggers abnormal cell proliferation and cyst growth.
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Authors and Affiliations
- Department of Biochemistry and Molecular Biology and the Kidney Institute, University of Kansas Medical Center, Kansas City, 66160, Kansas, USA
James P. Calvet
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- James P. Calvet
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Calvet, J. Ciliary signaling goes down the tubes.Nat Genet 33, 113–114 (2003). https://doi.org/10.1038/ng1078
- Published: 06 January 2003
- Issue Date: February 2003
- DOI: https://doi.org/10.1038/ng1078