A mouse model for Down syndrome exhibits learning and behaviour deficits (original) (raw)
References
Hook, E.B. in Trisomy 21 (Down Syndrome): Research Perspectives (eds. Cruz, F.F.d.l. & Gerald, P.S.) 3–68 (Universwity Park Press, Baltimore, 1981). Google Scholar
Coyle, J.T., Oster-Granite, M.L. & Gearhart, J.D. The neurobiologic consequences of Down Syndrome. Brain Res. Bull.16, 773–787 (1986). ArticleCASPubMed Google Scholar
Crome, R., Cowie, V. & Slater, E. A statistical note on cerebellar and brain-stem weight in Down Syndrome. J. ment. Def. Res.10, 69–72 (1966). Google Scholar
Solitaire, G. & Lamarche, J. Alzheimer's disease and senile dementia as seen in Mongoloids: neuropathological observations. Am. J. ment. Def.70, 840–848 (1966). Google Scholar
Haberland, C. Alzheimer's disease in Down syndrome. Acta Neurol. Belgium69, 369–380 (1969). CAS Google Scholar
Ellis, W.G., McCulloch, J.R. & Corley, C.L. Presenile dementia in Down syndrome. Ultrastructural identity with Alzheimer's disease. Neurology24, 101–106 (1974). ArticleCASPubMed Google Scholar
Burger, P.C. & Vogel, F.S. The development of the pathologic changes of Alzheimer's disease and senile dementia in patients with Down's syndrome. Am. J. Path.73, 457–476 (1973). CASPubMedPubMed Central Google Scholar
Weisnewski, K.E., Weisnewski, M.H. & Wen, G.Y. Occurence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome. Ann. Neurol.17, 278–282 (1985). Article Google Scholar
Korenberg, J. et al. Down syndrome phenotypes: The consequences of chromosomal imbalance. Proc. natn. Acad. Sci. U.S.A.91, 4997–5001 (1994). ArticleCAS Google Scholar
McCormick, M.K. et al. Molecular approach to the characterization of the Down syndrome region of chromosome 21. Genomics5, 325–331 (1989). ArticleCASPubMed Google Scholar
Rahmani, Z. et al. Critical role of the D21S55 region on chromosome 21 inthe pathogenesis of Down Syndrome. Proc. natn. Acad. Sci. U.S.A.86, 5958–5962 (1989). ArticleCAS Google Scholar
Epstein, C.J., Cox, D.R. & Epstein, L.B. Mouse trisomy 16: An animal model for human trisomy 21 (Down's syndrome). Ann. N. Y. Acad. Sci.450, 157–177 (1985). ArticleCASPubMed Google Scholar
Davisson, M.T., Schmidt, C. & Akeson, E. Segmental trisomy of murine chromosome 16: A new model system for studying Down Syndrome. Prog. clin. biol. Res.360, 263–280 (1990). CASPubMed Google Scholar
Davisson, M.T. et al. Segmental trisomy as a mouse model for Down Syndrome. Prog. clin. biol. Res.384, 117–133 (1993). CASPubMed Google Scholar
Dietrich, W.F. et al. A genetic map of the mouse with 4,006 simple sequence length polymorphisms. Nature Genet.7, 220–225 (1994). ArticleCASPubMed Google Scholar
Bendotti, C. et al. Neuroanatomical localization and quantification of cerebrovascular amyloid peptide RNA following in situ hybridization in the brains of normal, aneuploid, and experimentally lesioned mice. Proc. natn. Acad. Sci. U.S.A.85, 3628–3632 (1988). ArticleCAS Google Scholar
Gearhart, J. et al. Mouse chimeras composed of trisomy 16 and normal (2N) cells: Preliminary studies. Brain Res. Bull.16, 815–824 (1986). ArticleCASPubMed Google Scholar
Sanberg, P., Moran, T. & Coyle, J. in Experimental models of dementing disorders: A synaptic neurochemicalperspective (ed. Coyle, J.) 253–278 (AlanLiss, Inc., 1987). Google Scholar
Guilarte, T., Miceli, R. & Moran, T. Developmental effects of vitamin B-6 restriction on the locomotor behavior of rats. Brain Res. Bull.34, 31–40 (1991). Google Scholar
Bautista, J., Schwartz, G., dela Torre, D., Moran, T. & Carbone, K. Early and persistent abnormalities in rats with neonatally acquired Borna disease virus infection. Brain Res. Bull.34, 31–40 (1994). ArticleCASPubMed Google Scholar
Delaber, J.-M. et al. Report of the fourth international workshop on human chromosome 21. Genomics18, 735–744 (1993). Article Google Scholar
Cox, D.R., Burmeister, M., Price, E.R., Kim, S. & Myers, R.M. Radiation hybrid mapping: A somatic cell genetic method for constructing high resolution maps of mammalian chromosomes. Science250, 245–250 (1990). ArticleCASPubMed Google Scholar
Cheng, S.V. et al. Comparative mapping of DNA markers from the familial Alzheimer disease and Down syndrome regions of chromosome 21 to mouse chromosomes 16 and 17. Proc. natn. Acad. Sci. U.S.A.85, 6032–6036 (1988). ArticleCAS Google Scholar
Miyabara, S., Gropp, A. & Winking, H. Trisomy 16 in the mouse fetus associated with generalized edema and cardiovascular and urinary tract anomalies. J. exp. Zool.228, 253–269 (1983). Article Google Scholar
Bucan, M. et al. Comparative mapping of 9 human chromosome 22q loci in the laboratory mouse. Hum. molec. Genet.2, 1245–1252 (1993). ArticleCASPubMed Google Scholar
Goldmuntz, E. et al. Microdeletions of chromosomal region 22q11 in patients with congenital conotruncal cardiac defects. J. med. Genet.30, 807–812 (1993). ArticleCASPubMedPubMed Central Google Scholar
Wisniewski, K.E., Dalton, A.J., Crapper-McLachlan, D.R., Wen, G.Y. & Wisniewski, H.M. Alzheimer's disease in Down syndrome: clinicopathologic studies. Neurology35, 957–961 (1985). ArticleCASPubMed Google Scholar
Goldgaber, D., Lerman, M.I., McBride, W.O., Saffiotti, U. & Gajdusek, D.C. Characterization and chromosomal location of a cDNA encoding brain amyloid of Alzheimer's disease. Science235, 877–880 (1987). ArticleCASPubMed Google Scholar
Tanzi, R.E. et al. Amyloid beta protein gene: cDNA, mRNA distribution and genetic linkage near the Alzheimer locus. Science235, 880–884 (1987). ArticleCASPubMed Google Scholar
Goate, A. et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzhemers disease. Nature349, 704–706 (1991). ArticleCASPubMed Google Scholar
Mullan, M. et al. A pathogenic mutation for probable Alzheimer's disease in the APP gene at the N-terminus of B-amyloid. Nature Genet.1, 345–347 (1992). ArticleCASPubMed Google Scholar
Lamb, B.T. et al. Introduction and expression of the 400 kilobase amyloid precursor protein gene in transgenic mice. Nature Genet.5, 22–30 (1993). ArticleCASPubMed Google Scholar
Games, D. et al. Alzheimer-type neuropathology in transgenic mice overexpressing V717F b-amyloid precursor protein. Nature373, 523–527 (1995). ArticleCASPubMed Google Scholar
Morris, R., Garrud, P., Rawlins, J. & O'Keefe, J. Place navigation impaired in rats with hippocampal lesions. Nature297, 681–683 (1982). ArticleCASPubMed Google Scholar
Wishart, J. in The Psychobiology of Down Syndrome (ed. Nadel, L) 7–50 (M.I.T. Press, Cambridge, 1988). Google Scholar
Pueschel, S. in The Psy chobiology of Down Syndrome (ed. Nadel, L.) 199–216 (M.I.T. Press, Cambridge, 1988). Google Scholar
Marcel, M. & Armstrong, V. Auditory and visual sequential memory of Down Syndrome and nonretarded children. Am. J. ment. Def.87, 86–95 (1982). Google Scholar
Cabin, D.E., Hawkins, A., Griffin, C. & Reeves, R. HYAC transgenic mice in the study of the genetic basis of Down syndrome. Progr. cin. biol. Res.393, 213–226 (1995). CAS Google Scholar
Davisson, M.T. & Akeson, E.C. An improved method for preparing G-banded chromosomes from mouse peripheral blood. Cytogenet. Cell Genet.45, 70–74 (1987). ArticleCASPubMed Google Scholar
Pittler, S. & Baehr, W. Identification of a nonsense mutation in the rod photoreceptor cGMP phosphodiesterase b-subunit of the rd mouse. Proc. natn. Acad. Sci. U.S.A.88, 8322–8326 (1991). ArticleCAS Google Scholar
Kao, F.T. & Puck, K.T. Genetics of somatic mammalina cells, VII. Induction and isolation of nutritional mutants in Chinese hamster cells. Proc. natn. Acad. Sci. U.S.A.60, 1275–1281 (1975). Article Google Scholar
Reeves, R.H. et al. Genetic linkage in the mouse of genes involved in Down syndrome and Alzheimers disease in man. Molec. Brain Res.2, 215–221 (1987). ArticleCAS Google Scholar
O'Hara, B.F., Fisher, S., Oster-Granite, M.L., Gearhart, J.D. & Reeves, R.H. Developmental expression of the amyloid precursor protein, growth-associated protein 43, and somatostatin in normal and trisomy 16 mice. Dev. Brain Res.49, 300–304 (1989). ArticleCAS Google Scholar
O'Hara, B.F. et al. Genetic mapping and analysis of somatostatin expression in snell dwarf mice. Molec. Brain Res.4, 283–292 (1988). ArticleCAS Google Scholar
Camper, S.A., Saunders, T.L., Katz, R.W. & Reeves, R.H. The Pit-1 transcription factor gene is a candidate for the murine Snell dwarf mutation. Genomics8, 586–590 (1990). ArticleCASPubMed Google Scholar
Mjaatvedt, A., Citron, M.P. & Reeves, R.H. High resolution mapping of D16Led1, Gart, Gas-4, Cbr, Pcp-4, and Erg on mouse chromosome 16. Genomics17, 382–386 (1993). ArticleCASPubMed Google Scholar
Irving, N.G., Hardy, J.A. & Brown, S.D.M. The multipoint genetic mapping of mouse chromosome 16. Genomics9, 386–389 (1991). ArticleCASPubMed Google Scholar
Gregor, P. et al. Chromosomal localization of glutamate receptor genes: relationship to familial amyotrophic lateral sclerosis and other neurological disorders of mice and man. Proc. natn. Acad. Sci. U.S.A.90, 3053–3057 (1993). ArticleCAS Google Scholar
Epstein, C.J. et al. Transgenic mice with increased Cu/Zn-superoxide dismutase activity: Animal model of dosage effects in Down Syndrome. Proc. natn. Acad. Sci. U.S.A.84, 8044–8048 (1987). ArticleCAS Google Scholar
Watson, D.K. et al. Conserved chromosomal positions of dual domains of the ets protooncogene in cats, mice and humans. Proc. natn. Acad. Sci. U.S.A.83, 1792–1796 (1986). ArticleCAS Google Scholar
Staehli, P. et al. MX protein: Constitutive expression in 3T3 cells transformed with cloned MX cDNA confers selective resistance to influenza virus. Cell44, 147–158 (1986). Article Google Scholar
Dietrich, W. et al. A genetic map of the mouse suitable for typing intraspecific crosses. Genetics131, 423–447. (1992). CASPubMedPubMed Central Google Scholar
Irving, N.G., Citron, M.P. & Reeves, R.H. The positions of twelve simple sequence repeat markers relative to reference markers on mouse chromosome 16. Mamm. Genome4, 364–367 (1993). ArticleCASPubMed Google Scholar
Sisodia, S.S., Koo, E.H., Hoffman, P.M., Perry, G. & Price, D.L. Identification and transport of full-length amyloid precursor proteins in rat peripheral nervous system. J. Neurosci.13, 3136–42 (1993). ArticleCASPubMedPubMed Central Google Scholar
Elstner, E.F. & Heupel, A. Inhibition of nitrite formation from hydroxylammonium chloride: A simple assay for Superoxide dismutase. Analyt. Biochem.70, 616–620 (1976). ArticleCASPubMed Google Scholar
Elroy-Stein, O., Bernstein, Y. & Groner, Y. Overproduction of human Cu/Zn-superoxide dismutase in transfected cells: extenuation of paraquat-mediated cytotoxicity and enhancement of lipid peroxidation. EMBO J.5, 615–622 (1986). ArticleCASPubMedPubMed Central Google Scholar