Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene (original) (raw)

Nature Genetics volume 34, pages 261–262 (2003)Cite this article

Abstract

MicroRNAs (miRNAs) are an abundant class of RNAs that are ∼21–25 nucleotides (nt) long, interact with mRNAs and trigger either translation repression or RNA cleavage (RNA interference, RNAi) depending on the degree of complementarity with their targets. Here we show that the imprinted mouse distal chromosome 12 locus encodes two miRNA genes expressed from the maternally inherited chromosome and antisense to a retrotransposon-like gene (Rtl1) expressed only from the paternal allele.

This is a preview of subscription content, access via your institution

Access options

Subscribe to this journal

Receive 12 print issues and online access

$209.00 per year

only $17.42 per issue

Buy this article

Prices may be subject to local taxes which are calculated during checkout

Additional access options:

Similar content being viewed by others

Accession codes

Accessions

GenBank/EMBL/DDBJ

References

  1. Lagos-Quintana, M. et al. Curr. Biol. 12, 735–739 (2002).
    Article CAS Google Scholar
  2. Cavaille, J., Seitz, H., Paulsen, M., Ferguson-Smith, A.C. & Bachellerie, J.P. Hum. Mol. Genet. 11, 1527–1538 (2002).
    Article CAS Google Scholar
  3. Llave, C., Xie, Z., Kasschau, K.D. & Carrington, J.C. Science 297, 2053–2056 (2002).
    Article CAS Google Scholar
  4. Hutvagner, G. & Zamore, P.D. Science 297, 2056–2060 (2002).
    Article CAS Google Scholar
  5. Reinhart, B.J. & Bartel, D.P. Science 297, 1831 (2002).
    Article CAS Google Scholar
  6. Volpe, T.A. et al. Science 297, 1833–1837 (2002).
    Article CAS Google Scholar
  7. Hall, I.M. et al. Science 297, 2232–2237 (2002).
    Article CAS Google Scholar
  8. Rougeulle, C. & Heard, E. Trends Genet. 18, 434–437 (2002).
    Article CAS Google Scholar
  9. Sleutels, F., Zwart, R. & Barlow, D.P. Nature 415, 810–813 (2002).
    Article CAS Google Scholar
  10. Rhoades, M.W. et al. Cell 110, 513–520 (2002).
    Article CAS Google Scholar
  11. Plasterk, R.H. Science 296, 1263–1265 (2002).
    Article CAS Google Scholar
  12. Neumann, B., Kubicka, P. & Barlow, D.P. Nat. Genet. 9, 12–13 (1995).
    Article CAS Google Scholar
  13. Yoder, J.A., Walsh, C.P. & Bestor, T.H. Trends Genet. 13, 335–340 (1997).
    Article CAS Google Scholar
  14. Charlier, C. et al. Genome Res. 11, 850–862 (2001).
    Article CAS Google Scholar

Download references

Acknowledgements

This work was supported by grants from the Toulouse Génopole, the Programme Interdisciplinaire du Centre National de la Recherche Scientifique Dynamique et Réactivité des Assemblages Biologiques and La Ligue contre le Cancer/Comité de Haute-Garonne (to J.C.) and by laboratory funds from the Centre National de la Recherche Scientifique and Université Paul-Sabatier, Toulouse (to J.-P.B.). Work in M.P.'s laboratory was supported by the Deutsche Forschungs Gemeinschaft. N.Y. is supported by a BBSRC studentship and S.-P. L. by a scholarship from the Taiwanese government. H.S. is supported by a PhD fellowship Allocation de Moniteur Normalien (Ministère de l'Education Nationale, de la Recherche et de la Technologie).

Author information

Authors and Affiliations

  1. LBME, Centre National de la Recherche Scientifique (UMR 5099), IFR 109, Université P. Sabatier, 118 route de Narbonne, Toulouse, 31062, Cedex, France
    Hervé Seitz, Jean-Pierre Bachellerie & Jérôme Cavaillé
  2. Department of Anatomy, University of Cambridge, Downing Street, Cambridge, CB2 3DY, UK
    Neil Youngson, Shau-Ping Lin & Anne C Ferguson-Smith
  3. Universität des Saarlandes, FR Genetik, Postfach 151150, Saarbrücken, D-66041, Germany
    Simone Dalbert & Martina Paulsen

Authors

  1. Hervé Seitz
    You can also search for this author inPubMed Google Scholar
  2. Neil Youngson
    You can also search for this author inPubMed Google Scholar
  3. Shau-Ping Lin
    You can also search for this author inPubMed Google Scholar
  4. Simone Dalbert
    You can also search for this author inPubMed Google Scholar
  5. Martina Paulsen
    You can also search for this author inPubMed Google Scholar
  6. Jean-Pierre Bachellerie
    You can also search for this author inPubMed Google Scholar
  7. Anne C Ferguson-Smith
    You can also search for this author inPubMed Google Scholar
  8. Jérôme Cavaillé
    You can also search for this author inPubMed Google Scholar

Corresponding author

Correspondence toJérôme Cavaillé.

Ethics declarations

Competing interests

The authors declare no competing financial interests.

Rights and permissions

About this article

Cite this article

Seitz, H., Youngson, N., Lin, SP. et al. Imprinted microRNA genes transcribed antisense to a reciprocally imprinted retrotransposon-like gene.Nat Genet 34, 261–262 (2003). https://doi.org/10.1038/ng1171

Download citation