VEGF is a modifier of amyotrophic lateral sclerosis in mice and humans and protects motoneurons against ischemic death (original) (raw)

• Shaw, C.E., Al-Chalabi, A. & Leigh, N. Progress in the pathogenesis of amyotrophic lateral sclerosis. Curr. Neurol. Neurosci. Rep. 1, 69–76 (2001).
  Article CAS Google Scholar
• Brown, R.H. Jr. & Robberecht, W. Amyotrophic lateral sclerosis: pathogenesis. Semin. Neurol. 21, 131–139 (2001).
  Article Google Scholar
• Rowland, L.P. & Shneider, N.A. Amyotrophic lateral sclerosis. N. Engl. J. Med. 344, 1688–1700 (2001).
  Article CAS Google Scholar
• Cleveland, D.W. & Rothstein, J.D. From Charcot to Lou Gehrig: deciphering selective motor neuron death in ALS. Nat. Rev. Neurosci. 2, 806–819 (2001).
  Article CAS Google Scholar
• Turner, M.R., Parton, M.J. & Leigh, P.N. Clinical trials in ALS: an overview. Semin. Neurol. 21, 167–175 (2001).
  Article CAS Google Scholar
• Siddique, T. & Lalani, I. Genetic aspects of amyotrophic lateral sclerosis. Adv. Neurol. 88, 21–32 (2002).
  CAS PubMed Google Scholar
• Andersen, P.M. Genetics of sporadic ALS. Amyotroph. Lateral. Scler. Other Motor Neuron Disord. 2 Suppl 1, S37–S41 (2001).
  Article CAS Google Scholar
• Hand, C.K. & Rouleau, G.A. Familial amyotrophic lateral sclerosis. Muscle Nerve 25, 135–159 (2002).
  Article CAS Google Scholar
• Yang, Y. et al. The gene encoding alsin, a protein with three guanine-nucleotide exchange factor domains, is mutated in a form of recessive amyotrophic lateral sclerosis. Nat. Genet. 29, 160–165 (2001).
  Article CAS Google Scholar
• Julien, J.P. Amyotrophic lateral sclerosis. unfolding the toxicity of the misfolded. Cell 104, 581–591 (2001).
  Article CAS Google Scholar
• Figlewicz, D.A. et al. Variants of the heavy neurofilament subunit are associated with the development of amyotrophic lateral sclerosis. Hum. Mol. Genet. 3, 1757–1761 (1994).
  Article CAS Google Scholar
• Al-Chalabi, A. et al. Deletions of the heavy neurofilament subunit tail in amyotrophic lateral sclerosis. Hum. Mol. Genet. 8, 157–164 (1999).
  Article CAS Google Scholar
• Panas, M. et al. Genotyping of presenilin-1 polymorphism in amyotrophic lateral sclerosis. J. Neurol. 247, 940–942 (2000).
  Article CAS Google Scholar
• Veldink, J.H. et al. Homozygous deletion of the survival motor neuron 2 gene is a prognostic factor in sporadic ALS. Neurology 56, 749–752 (2001).
  Article CAS Google Scholar
• Siddique, T. et al. Lack of association between apolipoprotein E genotype and sporadic amyotrophic lateral sclerosis. Neurogenetics 1, 213–216 (1998).
  Article CAS Google Scholar
• Lacomblez, L. et al. APOE: a potential marker of disease progression in ALS. Neurology 58, 1112–1114 (2002).
  Article CAS Google Scholar
• Oosthuyse, B. et al. Deletion of the hypoxia-response element in the vascular endothelial growth factor promoter causes motor neuron degeneration. Nat. Genet. 28, 131–138 (2001).
  Article CAS Google Scholar
• Skene, J.P. & Cleveland, D.W. Hypoxia and Lou Gehrig. Nat. Genet. 28, 107–108 (2001).
  Article CAS Google Scholar
• Shahbazi, M. et al. Vascular endothelial growth factor gene polymorphisms are associated with acute renal allograft rejection. J. Am. Soc. Nephrol. 13, 260–264 (2002).
  CAS PubMed Google Scholar
• Awata, T. et al. A common polymorphism in the 5′-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes. Diabetes 51, 1635–1639 (2002).
  Article CAS Google Scholar
• Huez, I. et al. Two independent internal ribosome entry sites are involved in translation initiation of vascular endothelial growth factor mRNA. Mol. Cell. Biol. 18, 6178–6190 (1998).
  Article CAS Google Scholar
• Huez, I., Bornes, S., Bresson, D., Creancier, L. & Prats, H. New vascular endothelial growth factor isoform generated by internal ribosome entry site-driven CUG translation initiation. Mol. Endocrinol. 15, 2197–2210 (2001).
  Article CAS Google Scholar
• Mathews, D.H., Sabina, J., Zuker, M. & Turner, D.H. Expanded sequence dependence of thermodynamic parameters improves prediction of RNA secondary structure. J. Mol. Biol. 288, 911–940 (1999).
  Article CAS Google Scholar
• Altshuler, D. et al. The common PPARγ Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat. Genet. 26, 76–80 (2000).
  Article CAS Google Scholar
• Gurney, M.E. The use of transgenic mouse models of amyotrophic lateral sclerosis in preclinical drug studies. J. Neurol. Sci. 152 Suppl 1, S67–S73 (1997).
  Article CAS Google Scholar
• Lang-Lazdunski, L. et al. Ischemic spinal cord injury induced by aortic cross-clamping: prevention by riluzole. Eur. J. Cardiothorac. Surg. 18, 174–181 (2000).
  Article CAS Google Scholar
• Lang-Lazdunski, L. et al. Spinal cord ischemia. Development of a model in the mouse. Stroke 31, 208–213 (2000).
  Article CAS Google Scholar
• McCarron, S.L. et al. Influence of cytokine gene polymorphisms on the development of prostate cancer. Cancer Res. 62, 3369–3372 (2002).
  CAS PubMed Google Scholar
• Hudder, A. & Werner, R. Analysis of a Charcot–Marie–Tooth disease mutation reveals an essential internal ribosome entry site element in the connexin-32 gene. J. Biol. Chem. 275, 34586–34591 (2000).
  Article CAS Google Scholar
• Lazaris-Karatzas, A., Montine, K.S. & Sonenberg, N. Malignant transformation by a eukaryotic initiation factor subunit that binds to mRNA 5′ cap. Nature 345, 544–547 (1990).
  Article CAS Google Scholar
• West, M.J., Sullivan, N.F. & Willis, A.E. Translational upregulation of the c-myc oncogene in Bloom's syndrome cell lines. Oncogene 11, 2515–2524 (1995).
  CAS PubMed Google Scholar
• Prats, A.C. & Prats, H. Translational control of gene expression: role of IRESs and consequences for cell transformation and angiogenesis. Prog. Nucleic Acid Res. Mol. Biol. 72, 367–413 (2002).
  Article CAS Google Scholar
• Ferrara, N. Role of vascular endothelial growth factor in regulation of physiological angiogenesis. Am J. Physiol. Cell Physiol. 280, C1358–C1366 (2001).
  Article CAS Google Scholar
• Ioannidis, J.P., Ntzani, E.E., Trikalinos, T.A. & Contopoulos-Ioannidis, D.G. Replication validity of genetic association studies. Nat. Genet. 29, 306–309 (2001).
  Article CAS Google Scholar
• Lohmueller, K.E., Pearce, C.L., Pike, M., Lander, E.S. & Hirschhorn, J.N. Meta-analysis of genetic association studies supports a contribution of common variants to susceptibility to common disease. Nat. Genet. 33, 177–182 (2003).
  Article CAS Google Scholar
• Landeghem, G.F., Tabatabaie, P., Beckman, L., Beckman, G. & Andersen, P.M. Mn-SOD signal sequence mutation associated with sporadic motor neuron disease. Eur. J. Neurol. 6, 639–644 (1999).
  Article Google Scholar
• Giess, R. et al. Early onset of severe familial amyotrophic lateral sclerosis with a SOD- 1 mutation: potential impact of CNTF as a candidate modifier gene. Am. J. Hum. Genet. 70, 1277–1286 (2002).
  Article CAS Google Scholar
• Giess, R. et al. Potential role of LIF as a modifier gene in the pathogenesis of amyotrophic lateral sclerosis. Neurology 54, 1003–1005 (2000).
  Article CAS Google Scholar
• Yang, Z.J. et al. Role of vascular endothelial growth factor in neuronal DNA damage and repair in rat brain following a transient cerebral ischemia. J. Neurosci. Res. 70, 140–149 (2002).
  Article CAS Google Scholar
• Svensson, B. et al. Vascular endothelial growth factor protects cultured rat hippocampal neurons against hypoxic injury via an antiexcitotoxic, caspase-independent mechanism. J. Cereb. Blood Flow Metab. 22, 1170–1175 (2002).
  Article CAS Google Scholar
• Wick, A. et al. Neuroprotection by hypoxic preconditioning requires sequential activation of vascular endothelial growth factor receptor and Akt. J. Neurosci. 22, 6401–6407 (2002).
  Article CAS Google Scholar
• Facchiano, F. et al. Promotion of regeneration of corticospinal tract axons in rats with recombinant vascular endothelial growth factor alone and combined with adenovirus coding for this factor. J Neurosurg. 97, 161–168 (2002).
  Article CAS Google Scholar
• Matsuzaki, H. et al. Vascular endothelial growth factor rescues hippocampal neurons from glutamate-induced toxicity: signal transduction cascades. FASEB J. 15, 1218–1220 (2001).
  Article CAS Google Scholar
• Jin, K. et al. Vascular endothelial growth factor (VEGF) stimulates neurogenesis in vitro and in vivo. Proc. Natl. Acad. Sci. USA 99, 11946–11950 (2002).
  Article CAS Google Scholar
• Carmeliet, P. & Storkebaum, E. Vascular and neuronal effects of VEGF in the nervous system: implications for neurological disorders. Semin. Cell Dev. Biol. 13, 39–53 (2002).
  Article CAS Google Scholar
• Sondell, M., Sundler, F. & Kanje, M. Vascular endothelial growth factor is a neurotrophic factor which stimulates axonal outgrowth through the flk-1 receptor. Eur. J. Neurosci. 12, 4243–4254 (2000).
  Article CAS Google Scholar
• Li, B., Xu, W., Luo, C., Gozal, D. & Liu, R. VEGF-induced activation of the PI3-K/Akt pathway reduces mutant SOD1-mediated motor neuron cell death. Brain Res. Mol. Brain Res. 111, 155–164 (2003).
  Article CAS Google Scholar
• Nilsson, L.G. et al. The betula prospective cohort study: memory, health and aging. Aging Neuropsychol. Cogn. 4, 1–32 (1996).
  Article Google Scholar
• Thijs, V., Peeters, E., Theys, P., Matthijs, G. & Robberecht, W. Demographic characteristics and prognosis in a Flemish amyotrophic lateral sclerosis population. Acta Neurol. Belg. 100, 84–90 (2000).
  CAS PubMed Google Scholar
• Terwilliger, J.D. & Ott, J. Handbook for Human Genetic Linkage (Johns Hopkins University Press, Baltimore, 1994).
  Google Scholar