Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity (original) (raw)

Nature Genetics volume 36, pages 1255–1257 (2004)Cite this article

A Corrigendum to this article was published on 01 January 2005

Abstract

Splice acceptors with the genomic NAGNAG motif may cause NAG insertion-deletions in transcripts, occur in 30% of human genes and are functional in at least 5% of human genes. We found five significant biases indicating that their distribution is nonrandom and that they are evolutionarily conserved and tissue-specific. Because of their subtle effects on mRNA and protein structures, these splice acceptors are often overlooked or underestimated, but they may have a great impact on biology and disease.

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Figure 1: Alternative splicing at NAGNAG acceptors.

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Acknowledgements

We thank I. Görlich and M.-L. Schmidt for technical assistance. This work was supported by grants from the German Ministry of Education and Research to S.S. and to M.P. as well as from the Deutsche Forschungsgemeinschaft to M.P.

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Author notes

  1. Michael Hiller and Klaus Huse: These authors contributed equally to this work.

Authors and Affiliations

  1. Institute of Computer Science, Friedrich-Schiller-University Jena, Chair for Bioinformatics, Ernst-Abbe-Platz 2, Jena, 07743, Germany
    Michael Hiller & Rolf Backofen
  2. Genome Analysis, Institute of Molecular Biotechnology, Beutenbergstr. 11, Jena, 07745, Germany
    Klaus Huse, Karol Szafranski, Niels Jahn & Matthias Platzer
  3. Institute for Clinical Molecular Biology, Christian-Albrechts-University Kiel, Schittenhelmstr. 12, Kiel, 24105, Germany
    Jochen Hampe & Stefan Schreiber

Authors

  1. Michael Hiller
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  2. Klaus Huse
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  3. Karol Szafranski
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  4. Niels Jahn
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  5. Jochen Hampe
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  6. Stefan Schreiber
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  7. Rolf Backofen
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  8. Matthias Platzer
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Correspondence toMatthias Platzer.

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The authors declare no competing financial interests.

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Hiller, M., Huse, K., Szafranski, K. et al. Widespread occurrence of alternative splicing at NAGNAG acceptors contributes to proteome plasticity.Nat Genet 36, 1255–1257 (2004). https://doi.org/10.1038/ng1469

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