High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease (original) (raw)

Nature Genetics volume 38, pages 515–517 (2006)Cite this article

Abstract

Here we show that in substantia nigra neurons from both aged controls and individuals with Parkinson disease, there is a high level of deleted mitochondrial DNA (mtDNA) (controls, 43.3% ± 9.3%; individuals with Parkinson disease, 52.3% ± 9.3%). These mtDNA mutations are somatic, with different clonally expanded deletions in individual cells, and high levels of these mutations are associated with respiratory chain deficiency. Our studies suggest that somatic mtDNA deletions are important in the selective neuronal loss observed in brain aging and in Parkinson disease.

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Acknowledgements

This work has been supported by Alzheimer's Research Trust, Wellcome Trust, Medical Research Council UK and European Neurological Society.

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Author notes

  1. Andreas Bender and Kim J Krishnan: These authors contributed equally to this work.

Authors and Affiliations

  1. Mitochondrial Research Group, School of Neurology, Neurobiology and Psychiatry, The Medical School, University of Newcastle upon Tyne, Newcastle upon Tyne, NE2 4HH, UK
    Andreas Bender, Kim J Krishnan, Geoffrey A Taylor, Amy K Reeve, Joshua S Hersheson, Joanne Betts, Robert W Taylor & Douglass M Turnbull
  2. MRC Building, Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    Christopher M Morris
  3. Department of Neuropathology, Institute for the Health of the Elderly, Newcastle General Hospital, Newcastle upon Tyne, NE4 6BE, UK
    Robert H Perry & Evelyn Jaros
  4. Department of Neurology, University of Munich, Klinikum Grosshadern, Marchioninistr. 15, Munich, 81377, Germany
    Andreas Bender & Thomas Klopstock

Authors

  1. Andreas Bender
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  2. Kim J Krishnan
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  3. Christopher M Morris
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  4. Geoffrey A Taylor
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  5. Amy K Reeve
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  6. Robert H Perry
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  7. Evelyn Jaros
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  8. Joshua S Hersheson
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  9. Joanne Betts
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  10. Thomas Klopstock
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  11. Robert W Taylor
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  12. Douglass M Turnbull
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Correspondence toDouglass M Turnbull.

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The authors declare no competing financial interests.

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Bender, A., Krishnan, K., Morris, C. et al. High levels of mitochondrial DNA deletions in substantia nigra neurons in aging and Parkinson disease.Nat Genet 38, 515–517 (2006). https://doi.org/10.1038/ng1769

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