Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies (original) (raw)

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Acknowledgements

We thank all of the study participants; the Center of Medical Systems Biology (CMSB); D. Ruano (Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal); M.J. Soares, J. Valente and M.H. Azevedo (Instituto de Psicologia Médica, Faculdade de Medicina, Coimbra, Portugal); C. Pato and M.T. Pato (Center for Psychiatric and Molecular Genetics, and Department of Psychiatry, State University of New York, Syracuse, New York, and the Veterans Administration Medical Center, Washington, D.C.); A. Gabbas (Haematology Division and Bone Marrow Transplantation Unit, San Francesco Hospital, Nuoro, Italy); R. van Wyk, C. Botha and G. Valencia (Universidad de Antioquia) and P. Snijders for recruitment of subjects; M. Almonte and E. Slaten for genotyping assistance; R. Ophoff for comments on the manuscript and M. Levinson for assistance with graphics. We acknowledge funding from the Biotechnology and Biological Sciences Research Council (A.C.), the US National Institutes of Health (N.F., M.K., A.R.-L.), Newfound Genomics (P.R.), Colciencias (A.R.-L.), the Universidad de Antioquia (A.R.-L.), the National Alliance for Research in Schizophrenia and Depression (A.R.-L.), the Wellcome Trust (A.R.-L.), the Netherlands Organisation for Scientific Research (C. van D.), the Netherlands Diabetes Fund (C. van D.), the Netherlands Kidney Fund (C. van D.), the Netherlands Heart Foundation (C. van D.), the International Alzheimer Organisation (C. van D.), the Netherlands Brain Fund (C. van D.), the Center of Excellence of the Academy of Finland (L.P.), Nordic Center of Excellence in Disease Genetics (L.P.) and Biocentrum Helsinki, Finland (L.P.).

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Authors and Affiliations

1. Center for Neurobehavioral Genetics, University of California, Los Angeles, 90095, California, USA
   Susan Service & Nelson Freimer
2. Southern California Genotyping Consortium, University of California, Los Angeles, 90095, California, USA
   Joseph DeYoung
3. Rockefeller University, New York, 10021, New York, USA
   Maria Karayiorgou
4. Department of Psychiatry & Weskoppies Hospital, University of Pretoria, Pretoria, 0001, Republic of South Africa
   J Louw Roos & Herman Pretorious
5. Laboratory of Molecular Genetics, University of Antioquia, Medellin, Colombia
   Gabriel Bedoya & Andres Ruiz-Linares
6. Department of Psychiatry, University of Antioquia, Medellin, Colombia
   Jorge Ospina
7. Department of Biology (Wolfson House), The Galton Laboratory, University College London, London, NW1 2HE, UK
   Andres Ruiz-Linares
8. Institute of Medical Psychology, Faculty of Medicine, University of Coimbra, Coimbra, 3000-033, Portugal
   António Macedo
9. Life and Health Sciences Research Institute (ICVS), School of Health Sciences, University of Minho, Braga, 4704-553, Portugal
   Joana Almeida Palha
10. Department of Human Genetics, Section of Medical Genomics, Vrije University and Vrije University Medical Center, Amsterdam, 1081 BT, The Netherlands
    Peter Heutink
11. Center for Neurogenomics and Cognitive Research, Vrije University and Vrije University Medical Center, Amsterdam, 1081 BT, The Netherlands
    Peter Heutink
12. Departments of Epidemiology & Biostatistics and Clinical Genetics, Genetic Epidemiology Unit, Erasmus Medical Center, Rotterdam, 3000 DR, The Netherlands
    Yurii Aulchenko, Ben Oostra & Cornelia van Duijn
13. Department of Public Health Science and General Practice, University of Oulu, Oulu, 90220, Finland
    Marjo-Riitta Jarvelin
14. Department of Epidemiology and Public Health, Imperial College London, London, W2 1PG, UK
    Marjo-Riitta Jarvelin
15. Department of Medical Genetics, University of Helsinki, Helsinki, Finland, 00290
    Teppo Varilo & Leena Peltonen
16. Department of Molecular Medicine, National Public Health Institute, Biomedicum Helsinki, Helsinki, 00290, Finland
    Teppo Varilo & Leena Peltonen
17. Newfound Genomics, 187 Lemarchant Road, St. John's, A1C 2H5, Newfoundland, Canada
    Lynette Peddle
18. Memorial University of Newfoundland, St. John's, A1C 5S7, Newfoundland, Canada
    Proton Rahman
19. Division of Haematology, 'San Francesco' Hospital, Nuoro, ASL3, Italy
    Giovanna Piras & Maria Monne
20. Illumina, Inc., 9885 Towne Centre Dr., San Diego, 92121, California, USA
    Sarah Murray & Luana Galver
21. Department of Human Genetics, University of California, Los Angeles, 90095, California, USA
    Chiara Sabatti
22. Department of Statistics, University of California, Los Angeles, 90095, California, USA
    Chiara Sabatti
23. Human Genetics Research Division, University of Southampton, Southampton General Hospital, Tremona Road, SO16 6YA, Southampton, UK
    Andrew Collins
24. The Jane and Terry Semel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, 90095, California, USA
    Nelson Freimer
25. Department of Psychiatry, University of California, Los Angeles, 90095, California, USA
    Nelson Freimer

Authors

1. Susan Service
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2. Joseph DeYoung
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3. Maria Karayiorgou
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4. J Louw Roos
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5. Herman Pretorious
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6. Gabriel Bedoya
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7. Jorge Ospina
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8. Andres Ruiz-Linares
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9. António Macedo
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10. Joana Almeida Palha
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11. Peter Heutink
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12. Yurii Aulchenko
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13. Ben Oostra
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14. Cornelia van Duijn
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15. Marjo-Riitta Jarvelin
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16. Teppo Varilo
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17. Lynette Peddle
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18. Proton Rahman
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19. Giovanna Piras
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20. Maria Monne
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21. Sarah Murray
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22. Luana Galver
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23. Leena Peltonen
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24. Chiara Sabatti
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25. Andrew Collins
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26. Nelson Freimer
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Corresponding author

Correspondence toNelson Freimer.

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Competing interests

S.M. and L.G. are employed by Illumina, Inc.

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Service, S., DeYoung, J., Karayiorgou, M. et al. Magnitude and distribution of linkage disequilibrium in population isolates and implications for genome-wide association studies.Nat Genet 38, 556–560 (2006). https://doi.org/10.1038/ng1770

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• Received: 08 November 2005
• Accepted: 28 February 2006
• Published: 02 April 2006
• Issue Date: 01 May 2006
• DOI: https://doi.org/10.1038/ng1770