The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease (original) (raw)

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Acknowledgements

The authors thank J. Ott for advice on the statistical analysis. The authors acknowledge the work of B. Tycko, M. Medarano, R. Lantigua, Y. Stern, A. Akomolafe, J. Browndyke, H. Chui, R. Go, A. Kurz, H. Petrovitch, N. Relkin, D. Sadovnick, P. Erlich, S. Sunyaev, L. Ma, J. Lok and S. Younkin. This work was supported by the Canadian Institutes of Health Research, the Howard Hughes Medical Institute, the Canadian Institutes of Health Research–Japan Science and Technology Trust, the Alzheimer Society of Ontario, the Canada Foundation for Innovation, the Ontario Research and Development Challenge Fund, the Ontario Mental Health Foundation, Genome Canada, the US National Institutes of Health and the National Institute on Aging (grants R37-AG15473 and P01-AG07232 (R.M.), R01-AG09029 (L.A.F.), RO1-HG/AG02213 (R.C.G.), P30-AG13846 (L.A.F., R.C.G.), R01-AG017173 (R.P.F., L.A.F.), P50-AG16574 (R.C.P., S.Y., N.G.R.) and U01-AG06786 (R.C.P.)), the Alzheimer Association, the Alzheimer Society of Canada, the Blanchett Hooker Rockefeller Foundation, the Charles S. Robertson Gift (R.M.), Fonds de la Recherche en Santé (Y.M.), Assessorato Regionale alla Sanità-Regione Calabria, Finalized Project of the Ministry of Health (2003–2005) (A.C.B.), Fondation pour la Recherche Médical, Robert and Clarice Smith and Abigail Van Buren, the Alzheimer Disease Research Program (R.P., S.Y.) and the W. Garfield Weston Fellowship (E.R., G.S.U.).

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Author notes

1. Ekaterina Rogaeva, Yan Meng, Joseph H Lee, Yongjun Gu, Toshitaka Kawarai and Fanggeng Zou: These authors contributed equally to this work.

Authors and Affiliations

1. Department of Medicine, Department of Laboratory Medicine and Pathobiology and Department of Medical Biophysics, Centre for Research in Neurodegenerative Diseases, University of Toronto, Toronto, Ontario, Canada
   Ekaterina Rogaeva, Yongjun Gu, Toshitaka Kawarai, Taiichi Katayama, Hiroshi Hasegawa, Fusheng Chen, Nobuto Shibata, Raphaelle Pardossi-Piquard, Christopher Bohm, Yosuke Wakutani, Sandy D Der, Paul E Fraser, Gerold Schmitt-Ulms & Peter St George-Hyslop
2. Toronto Western Hospital Research Institute, Toronto, M5S 3H2, Ontario, Canada
   Ekaterina Rogaeva, Yongjun Gu, Toshitaka Kawarai, Taiichi Katayama, Hiroshi Hasegawa, Fusheng Chen, Nobuto Shibata, Raphaelle Pardossi-Piquard, Christopher Bohm, Yosuke Wakutani, Sandy D Der, Paul E Fraser, Gerold Schmitt-Ulms & Peter St George-Hyslop
3. Department of Medicine (Genetics Program), Department of Neurology, Department of Genetics & Genomics, Department of Epidemiology and Department of Biostatistics, Boston University School of Medicine, Boston University School of Public Health, Boston, 02118, Massachusetts, USA
   Yan Meng, Clinton T Baldwin, Kathryn L Lunetta, L Adrienne Cupples, Karen T Cuenco, Robert C Green & Lindsay A Farrer
4. The Taub Institute on Alzheimer's Disease and the Aging Brain and The Gertrude H. Sergievsky Center, College of Physicians and Surgeons, Columbia University, New York, NY, USA
   Joseph H Lee, Rong Cheng & Richard Mayeux
5. Department of Epidemiology, Mailman School of Public Health, Columbia University, New York, 10032, New York, USA
   Joseph H Lee, Rong Cheng & Richard Mayeux
6. Department of Neuroscience and Department of Neurology, Mayo Clinic Jacksonville, 4500 San Pablo Road, Jacksonville, 32224, Florida, USA
   Fanggeng Zou, Neill Graff-Radford, Ronald C Petersen, Dennis Dickson & Steven Younkin
7. Department of Neurology, Mayo Clinic Rochester, 200 First Street SW, Rochester, 55905, Minnesota, USA
   Fanggeng Zou, Neill Graff-Radford, Ronald C Petersen, Dennis Dickson & Steven Younkin
8. Department of Neuroscience, University of Turin, Via Cherasco 15, Turin, 10126, Italy
   Lorenzo Pinessi & Innocenzo Rainero
9. Department of Neurological and Psychiatric Sciences, Centre for Research, Transfer, and High Education on Chronic, Inflammatory, Degenerative and Neoplastic Disorders, University of Florence, Viale Pieraccini 6, Florence, 50139, Italy
   Sandro Sorbi
10. Regional Center of Neurogenetics, AS6, Lamezia Terme (CZ), 88046, Italy
    Amalia Bruni
11. Wien Center for Alzheimer's Disease and Memory Disorders, Mount Sinai Medical Center, Miami Beach, 33140, Florida, USA
    Ranjan Duara
12. Department of Psychiatry and Department of Behavioral Sciences and Medicine, University of Miami School of Medicine, Miami, 33140, Florida, USA
    Ranjan Duara
13. Department of Neurology, Case Western Reserve University, Cleveland, 44106, Ohio, USA
    Robert P Friedland
14. Meir Hospital, Kfar Saba and Rappaport Faculty of Medicine, Technion, Haifa, 47441, Israel
    Rivka Inzelberg
15. Department of Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinstrasse 52, Hamburg, 20246, Germany
    Wolfgang Hampe
16. Department of Genome Research and Clinical Application (M6), Graduate School of Medicine, Chiba University, 1-8-1 Inohana, Chuo-ku, Chiba, 260-8670, Japan
    Hideaki Bujo
17. Department of Biochemistry, Department of Orthopaedic Surgery and The Genome Research Centre, University of Hong Kong, Hong Kong
    You-Qiang Song
18. Department of Molecular Cardiovascular Research, Max Delbrueck Center for Molecular Medicine, Robert Roessle Str. 10, Berlin, D-13125, Germany
    Olav M Andersen & Thomas E Willnow

Authors

1. Ekaterina Rogaeva
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2. Yan Meng
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3. Joseph H Lee
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4. Yongjun Gu
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5. Toshitaka Kawarai
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6. Fanggeng Zou
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7. Taiichi Katayama
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8. Clinton T Baldwin
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9. Rong Cheng
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10. Hiroshi Hasegawa
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11. Fusheng Chen
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12. Nobuto Shibata
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13. Kathryn L Lunetta
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14. Raphaelle Pardossi-Piquard
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15. Christopher Bohm
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16. Yosuke Wakutani
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17. L Adrienne Cupples
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18. Karen T Cuenco
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19. Robert C Green
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20. Lorenzo Pinessi
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21. Innocenzo Rainero
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22. Sandro Sorbi
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23. Amalia Bruni
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24. Ranjan Duara
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25. Robert P Friedland
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26. Rivka Inzelberg
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27. Wolfgang Hampe
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28. Hideaki Bujo
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29. You-Qiang Song
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30. Olav M Andersen
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31. Thomas E Willnow
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32. Neill Graff-Radford
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33. Ronald C Petersen
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34. Dennis Dickson
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35. Sandy D Der
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36. Paul E Fraser
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37. Gerold Schmitt-Ulms
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38. Steven Younkin
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39. Richard Mayeux
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40. Lindsay A Farrer
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41. Peter St George-Hyslop
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Contributions

The authors' roles are described in Supplementary Table 11 online.

Corresponding authors

Correspondence toRichard Mayeux, Lindsay A Farrer or Peter St George-Hyslop.

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The authors declare no competing financial interests.

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Rogaeva, E., Meng, Y., Lee, J. et al. The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease.Nat Genet 39, 168–177 (2007). https://doi.org/10.1038/ng1943

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• Received: 16 October 2006
• Accepted: 20 November 2006
• Published: 14 January 2007
• Issue Date: 01 February 2007
• DOI: https://doi.org/10.1038/ng1943