High-throughput oncogene mutation profiling in human cancer (original) (raw)

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• 14 March 2007

NOTE: In the version of this article initially published, the name of an author was spelled incorrectly as Laura MacConnaill. The correct spelling is Laura MacConaill. The error has been corrected in the HTML and PDF versions of the article.

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Acknowledgements

We thank E. Lander and G. Getz for comments and advice. R.K.T. is a Mildred-Scheel fellow of the Deutsche Krebshilfe. R.K.T. is supported by the International Association for the Study of Lung Cancer (IASLC). R.M.D. is supported by the Swiss national science foundation (no: 3100A0-103671/1). A.G and J.M. are supported by the National Cancer Institute through SPORE grant P50CA70907. G.D.D. is supported by the Virginia and Daniel K. Ludwig Trust for Cancer Research, the Quick Family Fund for Cancer Research and the Ronald O. Perelman Fund for Cancer Research at Dana-Farber. I.K.M. and P.S.M. are supported by Accelerate Brain Tumor Cure. I.K.M., L.M.L, T.F.C., and P.S.M. are supported by the Henry E. Singleton Brain Tumor Program. I.K.M., L.M.L, T.F.C., S.F.N., M.M., W.R.S. and P.S.M. are supported by the Brain Tumor Funders' Collaborative. M.M. and L.A.G. are supported by a grant from Genentech, Inc. M.M. is supported by the American Cancer Society. L.A.G is supported by the National Cancer Institute, the Prostate Cancer Foundation, the Burroughs-Wellcome Fund, the Robert Wood Johnson Foundation and the Novartis Institute for Biomedical Research.

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Author notes

1. Roman K Thomas, Alissa C Baker and Ralph M DeBiasi: These authors contributed equally to this work.

Authors and Affiliations

1. Department of Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, 02115, Massachusetts, USA
   Roman K Thomas, Alissa C Baker, Ralph M DeBiasi, Wendy Winckler, Thomas LaFramboise, William M Lin, Meng Wang, Whei Feng, Laura E MacConaill, Jeffrey C Lee, Rick Nicoletti, Charlie Hatton, Kwok-Kin Wong, Rameen Beroukhim, Jordi Barretina, Amit Dutt, Caroline Emery, Heidi Greulich, Kinjal Shah, F Stephen Hodi, Glenn Dranoff, Massimo Loda, Jonathan Fletcher, Sabina Signoretti, Kenneth C Anderson, George D Demetri, William R Sellers, Matthew Meyerson & Levi A Garraway
2. The Broad Institute of M.I.T. and Harvard, 7 Cambridge Center, Cambridge, 02142, Massachusetts, USA
   Roman K Thomas, Ralph M DeBiasi, Wendy Winckler, Thomas LaFramboise, William M Lin, Meng Wang, Whei Feng, Laura E MacConaill, Jeffrey C Lee, Rick Nicoletti, Charlie Hatton, Mary Goyette, Liuda Ziaugra, Stacey Gabriel, Rameen Beroukhim, Jordi Barretina, Amit Dutt, Heidi Greulich, Kinjal Shah, Matthew Meyerson & Levi A Garraway
3. Hamon Center for Therapeutic Oncology Research, University of Texas Southwestern Medical Center at Dallas, 6000 Harry Hines Boulevard, Dallas, 75390-8593, Texas, USA
   Luc Girard, Kuntal Majmudar, Michael Peyton, Adi Gazdar & John Minna
4. Department of Surgery 2, Nagoya City University Medical School, Nagoya, 467-8601, Japan
   Hidefumi Sasaki
5. Department of Pathology, University of Texas Southwestern Medical Center, Dallas, 75390, Texas, USA
   Adi Gazdar
6. Departments of Internal Medicine and Pharmacology, University of Texas Southwestern Medical Center, Dallas, 75390, Texas, USA
   John Minna
7. Department of Pediatric Oncology, Dana-Farber Cancer Institute, Harvard Medical School, Boston, 02115, Massachusetts, USA
   Scott A Armstrong
8. Department of Molecular and Medical Pharmacology and Medicine, David Geffen School of Medicine at the University of California, Los Angeles, 90095-1732, Los Angeles, California, USA
   Ingo K Mellinghoff
9. Department of Pathology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, 90095-1732, California, USA
   Paul S Mischel
10. Department of Neurology, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, 90095-1732, California, USA
    Tim F Cloughesy
11. Department of Human Genetics, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, 90095-1732, California, USA
    Stan F Nelson
12. Department of Neurosurgery, David Geffen School of Medicine at the University of California, Los Angeles, Los Angeles, 90095-1732, California, USA
    Linda M Liau
13. Department of Pathology, Brigham and Women's Hospital, Harvard Medical School, 75 Francis Street, Boston, 02115, Massachusetts, USA
    Kirsten Mertz, Mark A Rubin, Massimo Loda, Jonathan Fletcher & Sabina Signoretti
14. Institute of Surgical Pathology, University Hospital Zürich, Zürich, 8091, Switzerland
    Kirsten Mertz & Holger Moch
15. Department of Urology, Northwestern University Feinberg School of Medicine, Chicago, 60637, Illinois, USA
    William Catalona
16. Genetics Branch, Center for Cancer Research, National Cancer Institute and National Naval Medical Center, Bethesda, Maryland, USA
    Frederic Kaye
17. Ludwig Center for Cancer Research at Dana-Farber Cancer Institute, Boston, 02115, Massachusetts, USA
    George D Demetri
18. Department of Dermatology, University Hospital Zürich, Zürich, 8091, Switzerland
    Reinhard Dummer
19. Division of Immunology, Department of Dermatology, Allergy and Infectious Diseases, Medical University of Vienna, and Center of Molecular Medicine, Austrian Academy of Sciences, Wahringer Gurtel 18-20, Vienna, A-1090, Austria
    Stephan Wagner
20. The Wistar Institute, 3601 Spruce Street, Philadelphia, 19104, Pennsylvania, USA
    Meenhard Herlyn
21. Novartis Institutes for BioMedical Research, 250 Massachusetts Avenue, Cambridge, 02139, Massachusetts, USA
    William R Sellers
22. Department of Pathology, Harvard Medical School, 77 Avenue Louis Pasteur, Boston, 02115, Massachusetts, USA
    Matthew Meyerson
23. Center for Cancer Genome Discovery, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, 02115, Massachusetts, USA
    Matthew Meyerson & Levi A Garraway
24. Melanoma Program in Medical Oncology, Dana-Farber Cancer Institute, Harvard Medical School, 44 Binney Street, Boston, 02115, Massachusetts, USA
    Levi A Garraway
25. Max Planck Institute for Neurological Research with Klaus Joachim Zülch Laboratories of the Max Planck Society and the Medical Faculty of the University of Cologne, Gleueler Str. 50, 50931, Cologne, Germany
    Roman K Thomas
26. Center for Integrated Oncology and Department I for Internal Medicine, University of Cologne, Cologne, 50931, Germany
    Roman K Thomas & Thomas Zander

Authors

1. Roman K Thomas
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2. Alissa C Baker
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3. Ralph M DeBiasi
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4. Wendy Winckler
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5. Thomas LaFramboise
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6. William M Lin
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7. Meng Wang
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8. Whei Feng
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9. Thomas Zander
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10. Laura E MacConaill
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11. Jeffrey C Lee
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12. Rick Nicoletti
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13. Charlie Hatton
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14. Mary Goyette
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15. Luc Girard
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16. Kuntal Majmudar
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17. Liuda Ziaugra
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18. Kwok-Kin Wong
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19. Stacey Gabriel
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20. Rameen Beroukhim
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21. Michael Peyton
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22. Jordi Barretina
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23. Amit Dutt
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24. Caroline Emery
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25. Heidi Greulich
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26. Kinjal Shah
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27. Hidefumi Sasaki
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28. Adi Gazdar
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29. John Minna
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30. Scott A Armstrong
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31. Ingo K Mellinghoff
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32. F Stephen Hodi
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33. Glenn Dranoff
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34. Paul S Mischel
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35. Tim F Cloughesy
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36. Stan F Nelson
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37. Linda M Liau
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38. Kirsten Mertz
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39. Mark A Rubin
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40. Holger Moch
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41. Massimo Loda
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42. William Catalona
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43. Jonathan Fletcher
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44. Sabina Signoretti
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45. Frederic Kaye
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46. Kenneth C Anderson
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47. George D Demetri
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48. Reinhard Dummer
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49. Stephan Wagner
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50. Meenhard Herlyn
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51. William R Sellers
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52. Matthew Meyerson
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53. Levi A Garraway
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Corresponding author

Correspondence toLevi A Garraway.

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The authors declare no competing financial interests.

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Thomas, R., Baker, A., DeBiasi, R. et al. High-throughput oncogene mutation profiling in human cancer.Nat Genet 39, 347–351 (2007). https://doi.org/10.1038/ng1975

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• Received: 04 August 2006
• Accepted: 11 January 2007
• Published: 11 February 2007
• Issue Date: March 2007
• DOI: https://doi.org/10.1038/ng1975