Genome-wide association study of prostate cancer identifies a second risk locus at 8q24 (original) (raw)
References
- Crawford, E.D. Epidemiology of prostate cancer. Urology 62, 3–12 (2003).
Article Google Scholar - Parkin, D.M. et al. Cancer Incidence in Five Continents (IARC Scientific Publications, Lyon, 2002).
Google Scholar - Steinberg, G.D., Carter, B.S., Beaty, T.H., Childs, B. & Walsh, P.C. Family history and the risk of prostate cancer. Prostate 17, 337–347 (1990).
Article CAS Google Scholar - Freedman, M.L. et al. Admixture mapping identifies 8q24 as a prostate cancer risk locus in African-American men. Proc. Natl. Acad. Sci. USA 103, 14068–14073 (2006).
Article CAS Google Scholar - Amundadottir, L.T. et al. A common variant associated with prostate cancer in European and African populations. Nat. Genet. 38, 652–658 (2006).
Article CAS Google Scholar - Schumacher, F.R. et al. Prostate cancer risk and 8q24. Cancer Res. (in the press).
- Gohagan, J.K., Prorok, P.C., Hayes, R.B. & Kramer, B.S. The Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial of the National Cancer Institute: history, organization, and status. Control. Clin. Trials 21, 251S–272S (2000).
Article CAS Google Scholar - Prorok, P.C. et al. Design of the Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial. Control. Clin. Trials 21, 273S–309S (2000).
Article CAS Google Scholar - Phillips, M.S. et al. Chromosome-wide distribution of haplotype blocks and the role of recombination hot spots. Nat. Genet. 33, 382–387 (2003).
Article CAS Google Scholar - Calle, E.E. et al. The American Cancer Society Cancer Prevention Study II Nutrition Cohort: rationale, study design, and baseline characteristics. Cancer 94, 2490–2501 (2002).
Article Google Scholar - Chen, Y.C. et al. Sequence variants of Toll-like receptor 4 and susceptibility to prostate cancer. Cancer Res. 65, 11771–11778 (2005).
Article CAS Google Scholar - Valeri, A. et al. Segregation analysis of prostate cancer in France: evidence for autosomal dominant inheritance and residual brother-brother dependence. Ann. Hum. Genet. 67, 125–137 (2003).
Article CAS Google Scholar - The ATBC Cancer Prevention Study Group. The alpha-tocopherol, beta-carotene lung cancer prevention study: design, methods, participant characteristics and compliance. Ann. Epidemiol. 4, 1–10 (1994).
- Fearnhead, P. SequenceLDhot: detecting recombination hotspots. Bioinformatics 22, 3061–3066 (2006).
Article CAS Google Scholar - Myers, S., Bottolo, L., Freeman, C., McVean, G. & Donnelly, P. A fine-scale map of recombination rates and hotspots across the human genome. Science 310, 321–324 (2005).
Article CAS Google Scholar - The International HapMap Consortium. A haplotype map of the human genome. Nature 437, 1299–1320 (2005).
- Minichiello, M.J. & Durbin, R. Mapping trait loci by use of inferred ancestral recombination graphs. Am. J. Hum. Genet. 79, 910–922 (2006).
Article CAS Google Scholar - Stephens, M., Smith, N.J. & Donnelly, P. A new statistical method for haplotype reconstruction from population data. Am. J. Hum. Genet. 68, 978–989 (2001).
Article CAS Google Scholar - Stephens, M. & Scheet, P. Accounting for decay of linkage disequilibrium in haplotype inference and missing-data imputation. Am. J. Hum. Genet. 76, 449–462 (2005).
Article CAS Google Scholar - Nupponen, N.N., Kakkola, L., Koivisto, P. & Visakorpi, T. Genetic alterations in hormone-refractory recurrent prostate carcinomas. Am. J. Pathol. 153, 141–148 (1998).
Article CAS Google Scholar - Cher, M.L. et al. Genetic alterations in untreated metastases and androgen-independent prostate cancer detected by comparative genomic hybridization and allelotyping. Cancer Res. 56, 3091–3102 (1996).
CAS PubMed Google Scholar - Bruzzi, P., Green, S.B., Byar, D.P., Brinton, L.A. & Schairer, C. Estimating the population attributable risk for multiple risk factors using case-control data. Am. J. Epidemiol. 122, 904–914 (1985).
Article CAS Google Scholar - Wacholder, S., Benichou, J., Heineman, E.F., Hartge, P. & Hoover, R.N. Attributable risk: advantages of a broad definition of exposure. Am. J. Epidemiol. 140, 303–309 (1994).
Article CAS Google Scholar - Seldin, M.F. et al. European population substructure: clustering of northern and southern populations. PLoS Genet. 2, e143 (2006).
Article Google Scholar - Saarela, J. et al. PRKCA and multiple sclerosis: association in two independent populations. PLoS Genet. 2, e42 (2006).
Article Google Scholar - Willer, C.J. et al. Tag SNP selection for Finnish individuals based on the CEPH Utah HapMap database. Genet. Epidemiol. 30, 180–190 (2006).
Article Google Scholar
Acknowledgements
The HPFS study is supported by NIH grants CA CA55075 and 5U01CA098233-04. The ACS study is supported by U01 CA098710. The ATBC study is supported by NIH contracts N01-CN-45165, N01-RC-45035 and N01-RC-37004. F.R.S. is supported by an NRSA training grant (T32 CA 09001). P.F. is supported by a UK Engineering and Physical Sciences Research Council Grant (GR/S18786). M.M. is supported by the Wellcome Trust. N.O., R.B.H., S.W., K.Y., N.C., M.T., J.F.F., R.H., S.J.C. and G.T. are supported by the Intramural Research Program of the National Cancer Institute (US National Institutes of Health, Department of Health and Human Services).
Author information
Authors and Affiliations
- SAIC-Frederick, National Cancer Institute (NCI)-Frederick Cancer Research and Development Center, Frederick, 21702, Maryland, USA
Meredith Yeager, Zhaoming Wang, Robert Welch & Brian J Staats - Division of Cancer Epidemiology and Genetics, Department of Health and Human Services (DHHS), Center for Cancer Research, NCI, US National Institutes of Health (NIH), Bethesda, 20892, Maryland, USA
Meredith Yeager, Richard B Hayes, Sholom Wacholder, Kai Yu, Nilanjan Chatterjee, Zhaoming Wang, Robert Welch, Brian J Staats, Demetrius Albanes, Stephanie Weinstein, Margaret Tucker, Joseph F Fraumeni Jr, Robert Hoover, David J Hunter, Stephen J Chanock & Gilles Thomas - Department of Health and Human Services (DHHS), Pediatric Oncology Branch, Center for Cancer Research, NCI, US National Institutes of Health (NIH), Bethesda, 20892, Maryland, USA
Nick Orr & Stephen J Chanock - Bioinformed Consulting Services, Gaithersburg, 20877, Maryland, USA
Kevin B Jacobs - Department of Epidemiology, Program in Molecular and Genetic Epidemiology, Harvard School of Public Health, Boston, 02115, Massachusetts, USA
Peter Kraft, Fredrick R Schumacher & David J Hunter - Wellcome Trust Sanger Institute, Wellcome Trust Genome Campus, Cambridge, CB10 1SA, UK
Mark J Minichiello - Department of Mathematics and Statistics, Lancaster University, Lancaster, LA1 4YF, UK
Paul Fearnhead - Department of Epidemiology and Surveillance Research, American Cancer Society, Atlanta, 30329, Georgia, USA
Eugenia E Calle, Heather Spencer Feigelson, Michael J Thun & Carmen Rodriguez - Department of Health Promotion and Chronic Disease Prevention, National Public Health Institute, Helsinki, FIN-00300, Finland
Jarmo Virtamo - Department of Nutrition, Harvard School of Public Health, Boston, 02115, Massachusetts, USA
Edward Giovannucci & Walter C Willett - Centre de Recherche pour les Pathologies Prostatiques (CeRePP), Hôpital Tenon, Assistance Publique-Hôpitaux de Paris, Paris, 75970, France
Geraldine Cancel-Tassin, Olivier Cussenot & Antoine Valeri - Division of Urologic Surgery, Washington University School of Medicine, St. Louis, 63108, Missouri, USA
Gerald L Andriole - Division of Hematology and Oncology, Columbia University, New York, 10032, New York, USA
Edward P Gelmann - Office of Cancer Genomics, NCI, NIH, DHHS, Bethesda, 20892, Maryland, USA
Daniela S Gerhard
Authors
- Meredith Yeager
You can also search for this author inPubMed Google Scholar - Nick Orr
You can also search for this author inPubMed Google Scholar - Richard B Hayes
You can also search for this author inPubMed Google Scholar - Kevin B Jacobs
You can also search for this author inPubMed Google Scholar - Peter Kraft
You can also search for this author inPubMed Google Scholar - Sholom Wacholder
You can also search for this author inPubMed Google Scholar - Mark J Minichiello
You can also search for this author inPubMed Google Scholar - Paul Fearnhead
You can also search for this author inPubMed Google Scholar - Kai Yu
You can also search for this author inPubMed Google Scholar - Nilanjan Chatterjee
You can also search for this author inPubMed Google Scholar - Zhaoming Wang
You can also search for this author inPubMed Google Scholar - Robert Welch
You can also search for this author inPubMed Google Scholar - Brian J Staats
You can also search for this author inPubMed Google Scholar - Eugenia E Calle
You can also search for this author inPubMed Google Scholar - Heather Spencer Feigelson
You can also search for this author inPubMed Google Scholar - Michael J Thun
You can also search for this author inPubMed Google Scholar - Carmen Rodriguez
You can also search for this author inPubMed Google Scholar - Demetrius Albanes
You can also search for this author inPubMed Google Scholar - Jarmo Virtamo
You can also search for this author inPubMed Google Scholar - Stephanie Weinstein
You can also search for this author inPubMed Google Scholar - Fredrick R Schumacher
You can also search for this author inPubMed Google Scholar - Edward Giovannucci
You can also search for this author inPubMed Google Scholar - Walter C Willett
You can also search for this author inPubMed Google Scholar - Geraldine Cancel-Tassin
You can also search for this author inPubMed Google Scholar - Olivier Cussenot
You can also search for this author inPubMed Google Scholar - Antoine Valeri
You can also search for this author inPubMed Google Scholar - Gerald L Andriole
You can also search for this author inPubMed Google Scholar - Edward P Gelmann
You can also search for this author inPubMed Google Scholar - Margaret Tucker
You can also search for this author inPubMed Google Scholar - Daniela S Gerhard
You can also search for this author inPubMed Google Scholar - Joseph F Fraumeni Jr
You can also search for this author inPubMed Google Scholar - Robert Hoover
You can also search for this author inPubMed Google Scholar - David J Hunter
You can also search for this author inPubMed Google Scholar - Stephen J Chanock
You can also search for this author inPubMed Google Scholar - Gilles Thomas
You can also search for this author inPubMed Google Scholar
Corresponding author
Correspondence toStephen J Chanock.
Ethics declarations
Competing interests
The authors declare no competing financial interests.
Supplementary information
Rights and permissions
About this article
Cite this article
Yeager, M., Orr, N., Hayes, R. et al. Genome-wide association study of prostate cancer identifies a second risk locus at 8q24.Nat Genet 39, 645–649 (2007). https://doi.org/10.1038/ng2022
- Received: 16 January 2006
- Accepted: 07 March 2007
- Published: 01 April 2007
- Issue Date: May 2007
- DOI: https://doi.org/10.1038/ng2022