Small changes in expression affect predisposition to tumorigenesis (original) (raw)
- Brief Communication
- Published: 17 December 2001
- Zuzana Dobbie3,
- Stephen B. Gruber4,
- Sanford Markowitz5,
- Kathy Romans1,2,
- Francis M. Giardiello1,2,
- Kenneth W. Kinzler1,2 &
- …
- Bert Vogelstein1,2
Nature Genetics volume 30, pages 25–26 (2002)Cite this article
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Abstract
We have used quantitative measures of gene expression to show that constitutional 50% decreases in expression of one adenomatous polyposis coli tumor suppressor gene (APC) allele can lead to the development of familial adenomatous polyposis.
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References
- Johnson, N.A. & Porter, A.H. J. Theor. Biol. 205, 527–542 (2000).
Article CAS Google Scholar - Antonarakis, S.E., Krawczak, M. & Cooper, D.N. The Metabolic and Molecular Bases of Inherited Disease . (eds Scriver, C.R. et al.) 356–358 (McGraw-Hill, Toronto, 2001).
Google Scholar - Kinzler, K.W. & Vogelstein, B. Cell 87, 159–170 (1996).
Article CAS Google Scholar - Laken, S.J. et al. Proc. Natl Acad. Sci. USA 96, 2322–2326 (1999).
Article CAS Google Scholar - Yan, H. et al. Nature 403, 723–724 (2000).
Article CAS Google Scholar - Zhou, W. et al. Nature Biotechnol. 19, 78–81 (2001).
Article CAS Google Scholar - Jaiswal, A.S. & Narayan, S. J. Cell Biochem. 81, 262–277 (2001).
Article CAS Google Scholar - Solomon, E. et al. Nature 328, 616–619 (1987).
Article CAS Google Scholar - Shih, I.M. et al. Cancer Res. 61, 818–822 (2001).
CAS Google Scholar - Royall, R. Statistical Evidence: A Likelihood Paradigm (Chapman and Hall, London, 1997).
Google Scholar
Acknowledgements
This work was supported by grants from the National Institutes of Health.
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Authors and Affiliations
- The Howard Hughes Medical Institute, The Oncology Center,
Hai Yan, Kathy Romans, Francis M. Giardiello, Kenneth W. Kinzler & Bert Vogelstein - The Department of Medicine, The Johns Hopkins Medical Institutions, Baltimore, 21231, Maryland, USA
Hai Yan, Kathy Romans, Francis M. Giardiello, Kenneth W. Kinzler & Bert Vogelstein - Department of Research, Research Group Human Genetics, University Hospital, Basel, 4031, Switzerland
Zuzana Dobbie - Division of Molecular Medicine and Genetics, University of Michigan Medical School and School of Public Health, Ann Arbor, 48109, Michigan, USA
Stephen B. Gruber - Department of Medicine and Ireland Cancer Center, Howard Hughes Medical Institute, Case Western Reserve University, University Hospitals of Cleveland and the Research Institute of University Hospitals of Cleveland, Cleveland, 44106, Ohio, USA
Sanford Markowitz
Authors
- Hai Yan
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Correspondence toBert Vogelstein.
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Yan, H., Dobbie, Z., Gruber, S. et al. Small changes in expression affect predisposition to tumorigenesis.Nat Genet 30, 25–26 (2002). https://doi.org/10.1038/ng799
- Received: 28 September 2001
- Accepted: 19 November 2001
- Published: 17 December 2001
- Issue Date: January 2002
- DOI: https://doi.org/10.1038/ng799