Homozygous Tsix mutant mice reveal a sex-ratio distortion and revert to random X-inactivation (original) (raw)
Lee, J.T., Davidow, L.S. & Warshawsky, D. Tsix, a gene antisense to Xist at the X-inactivation center. Nature Genet.21, 400–404 (1999). ArticleCAS Google Scholar
Brown, C.J. et al. A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature349, 38–44 (1991). ArticleCAS Google Scholar
Brown, C.J. et al. The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell71, 527–542 (1992). ArticleCAS Google Scholar
Brockdorff, N. et al. The product of the mouse Xist gene is a 15 kb inactive X-specific transcript containing no conserved ORF and located in the nucleus. Cell71, 515–526 (1992). ArticleCAS Google Scholar
Lee, J.T. & Lu, N. Targeted mutagenesis of Tsix leads to nonrandom X-inactivation. Cell99, 47–57 (1999). ArticleCAS Google Scholar
Stavropoulos, N., Lu, N. & Lee, J.T. A functional role for Tsix transcription in blocking Xist RNA accumulation but not in X-chromosome choice. Proc. Natl Acad. Sci. USA98, 10232–10237 (2001). ArticleCAS Google Scholar
Luikenhuis, S., Wutz, A. & Jaenisch, R. Antisense transcription through the Xist locus mediates Tsix function in embryonic stem cells. Mol. Cell. Biol.21, 8512–8520 (2001). ArticleCAS Google Scholar
Lyon, M.F. Gene action in the X-chromosome of the mouse (Mus musculus L.). Nature190, 372–373 (1961). ArticleCAS Google Scholar
Avner, P. & Heard, E. X-chromosome inactivation: counting, choice, and initiation. Nature Rev. Genet.2, 59–67 (2001). ArticleCAS Google Scholar
Boumil, R.M. & Lee, J.T. 40 years of decoding the silence in X-chromosome inactivation. Hum. Mol. Genet.10, 2225–2232 (2001). ArticleCAS Google Scholar
Takagi, N. & Sasaki, M. Preferential inactivation of the paternally derived X-chromosome in the extraembryonic membranes of the mouse. Nature256, 640–642 (1975). ArticleCAS Google Scholar
Huynh, K.D. & Lee, J.T. Imprinted X inactivation in eutherians: a model of gametic execution and zygotic relaxation. Curr. Opin. Cell. Biol.13, 690–697 (2001). ArticleCAS Google Scholar
Penny, G.D., Kay, G.F., Sheardown, S.A., Rastan, S. & Brockdorff, N. Requirement for Xist in X chromosome inactivation. Nature379, 131–137 (1996). ArticleCAS Google Scholar
Lee, J.T. Disruption of imprinted X inactivation by parent-of-origin effects at Tsix. Cell103, 17–27 (2000). ArticleCAS Google Scholar
Sado, T., Wang, Z., Sasaki, H. & Li, E. Regulation of imprinted X-chromosome inactivation in mice by Tsix. Development128, 1275–1286 (2001). CASPubMed Google Scholar
Okamoto, I., Tan, S.S. & Takagi, N. X-chromosome inactivation in XX androgenetic mouse embryos surviving implantation. Development127, 4137–4145 (2000). CASPubMed Google Scholar
Bell, A.C., West, A.G. & Felsenfeld, G. The protein CTCF is required for the enhancer blocking activity of vertebrate insulators. Cell98, 387–396 (1999). ArticleCAS Google Scholar
Bell, A. & Felsenfeld, G. Methylation of a CTCF-dependent boundary controls imprinted expression of the Igf2 gene. Nature405, 482–485 (2000). ArticleCAS Google Scholar
Hark, A.T. et al. CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. Nature405, 486–489 (2000). ArticleCAS Google Scholar
Kanduri, C. et al. Functional association of CTCF with the insulator upstream of the H19 gene is parent of origin-specific and methylation-sensitive. Curr. Biol.10, 853–856 (2000). ArticleCAS Google Scholar
Chao, W., Huynh, K.D., Spencer, R.J., Davidow, L.S. & Lee, J.T. CTCF, a candidate trans-acting factor for X-inactivation choice. Science295, 345–347 (2002). ArticleCAS Google Scholar
Percec, I., Plenge, R.M., Nadeau, J.H., Bartolomei, M.S. & Willard, H.F. Autosomal dominant mutations affecting X inactivation choice in the mouse. Science296, 1136–1139 (2002). ArticleCAS Google Scholar
Carrel, L. et al. X inactivation analysis and DNA methylation studies of the ubiquitin activating enzyme E1 and PCTAIRE-1 genes in human and mouse. Hum. Mol. Genet.5, 391–401 (1996). ArticleCAS Google Scholar
Charlier, C. et al. The callipyge mutation enhances the expression of coregulated imprinted genes in cis without affecting their imprinting status. Nature Genet.27, 367–369 (2001). ArticleCAS Google Scholar
Pardo-Manuel de Villena, F., Naumova, A.K., Verner, A.E., Jin, W.H. & Sapienza, C. Confirmation of maternal transmission ratio distortion at Om and direct evidence that the maternal and paternal 'DDK syndrome' genes are linked. Mamm. Genome8, 642–646 (1997). ArticleCAS Google Scholar
Cattanach, B.M. & Papworth, D. Controlling elements in the mouse. V. Linkage tests with X-linked genes. Genet. Res.38, 57–70 (1981). ArticleCAS Google Scholar
Marahrens, Y., Loring, J. & Jaenisch, R. Role of the Xist gene in X chromosome choosing. Cell92, 657–664 (1998). ArticleCAS Google Scholar
Plenge, R.M. et al. A promoter mutation in the XIST gene in two unrelated families with skewed X-chromosome inactivation. Nature Genet.17, 353–356 (1997). ArticleCAS Google Scholar
Marahrens, Y. X-inactivation by chromosomal pairing events. Genes Dev.13, 2624–2632 (1999). ArticleCAS Google Scholar
Kay, G.F. et al. Expression of Xist during mouse development suggests a role in the initiation of X chromosome inactivation. Cell72, 171–182 (1993). ArticleCAS Google Scholar