Lysine methylation of the NF-κB subunit RelA by SETD6 couples activity of the histone methyltransferase GLP at chromatin to tonic repression of NF-κB signaling (original) (raw)
Kouzarides, T. Chromatin modifications and their function. Cell128, 693–705 (2007). ArticleCAS Google Scholar
Albert, M. & Helin, K. Histone methyltransferases in cancer. Semin. Cell Dev. Biol.2, 209–220 (2009). Google Scholar
Huang, J. & Berger, S.L. The emerging field of dynamic lysine methylation of non-histone proteins. Curr. Opin. Genet. Dev.18, 152–158 (2008). ArticleCAS Google Scholar
Hoffmann, A., Natoli, G. & Ghosh, G. Transcriptional regulation via the NF-κB signaling module. Oncogene25, 6706–6716 (2006). ArticleCAS Google Scholar
Natoli, G. Control of NF-κB-dependent transcriptional responses by chromatin organization. Cold Spring Harb Perspect Biol1, a000224 (2009). Article Google Scholar
Ghosh, S. & Hayden, M.S. New regulators of NF-κB in inflammation. Nat. Rev. Immunol.8, 837–848 (2008). ArticleCAS Google Scholar
Perkins, N.D. Post-translational modifications regulating the activity and function of the nuclear factor κB pathway. Oncogene25, 6717–6730 (2006). ArticleCAS Google Scholar
Grivennikov, S.I., Greten, F.R. & Karin, M. Immunity, inflammation, and cancer. Cell140, 883–899 (2010). ArticleCAS Google Scholar
Tachibana, M. et al. Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3–K9. Genes Dev.19, 815–826 (2005). ArticleCAS Google Scholar
Saccani, S. & Natoli, G. Dynamic changes in histone H3 Lys 9 methylation occurring at tightly regulated inducible inflammatory genes. Genes Dev.16, 2219–2224 (2002). ArticleCAS Google Scholar
Duran, A., Diaz-Meco, M.T. & Moscat, J. Essential role of RelA Ser311 phosphorylation by ζPKC in NF-κB transcriptional activation. EMBO J.22, 3910–3918 (2003). ArticleCAS Google Scholar
Ea, C.K. & Baltimore, D. Regulation of NF-κB activity through lysine monomethylation of p65. Proc. Natl. Acad. Sci. USA106, 18972–18977 (2009). ArticleCAS Google Scholar
Yang, X.D. et al. Negative regulation of NF-κB action by Set9-mediated lysine methylation of the RelA subunit. EMBO J.28, 1055–1066 (2009). ArticleCAS Google Scholar
Trievel, R.C., Flynn, E.M., Houtz, R.L. & Hurley, J.H. Mechanism of multiple lysine methylation by the SET domain enzyme Rubisco LSMT. Nat. Struct. Biol.10, 545–552 (2003). ArticleCAS Google Scholar
Dong, J., Jimi, E., Zeiss, C., Hayden, M.S. & Ghosh, S. Constitutively active NF-κB triggers systemic TNFα-dependent inflammation and localized TNFα-independent inflammatory disease. Genes Dev.24, 1709–1717 (2010). ArticleCAS Google Scholar
Chen, L., Fischle, W., Verdin, E. & Greene, W.C. Duration of nuclear NF-κB action regulated by reversible acetylation. Science293, 1653–1657 (2001). ArticleCAS Google Scholar
Tachibana, M., Sugimoto, K., Fukushima, T. & Shinkai, Y. Set domain-containing protein, G9a, is a novel lysine-preferring mammalian histone methyltransferase with hyperactivity and specific selectivity to lysines 9 and 27 of histone H3. J. Biol. Chem.276, 25309–25317 (2001). ArticleCAS Google Scholar
Buerki, C. et al. Functional relevance of novel p300-mediated lysine 314 and 315 acetylation of RelA/p65. Nucleic Acids Res.36, 1665–1680 (2008). ArticleCAS Google Scholar
Collins, R.E. et al. The ankyrin repeats of G9a and GLP histone methyltransferases are mono- and dimethyllysine binding modules. Nat. Struct. Mol. Biol.15, 245–250 (2008). ArticleCAS Google Scholar
Tachibana, M., Matsumura, Y., Fukuda, M., Kimura, H. & Shinkai, Y. G9a/GLP complexes independently mediate H3K9 and DNA methylation to silence transcription. EMBO J.27, 2681–2690 (2008). ArticleCAS Google Scholar
Smith, L. et al. Activation of atypical protein kinase C ζ by caspase processing and degradation by the ubiquitin-proteasome system. J. Biol. Chem.275, 40620–40627 (2000). ArticleCAS Google Scholar
Leitges, M. et al. Targeted disruption of the zetaPKC gene results in the impairment of the NF-κB pathway. Mol. Cell8, 771–780 (2001). ArticleCAS Google Scholar
Su, I.H. & Tarakhovsky, A. Lysine methylation and 'signaling memory'. Curr. Opin. Immunol.18, 152–157 (2006). ArticleCAS Google Scholar
Hirota, T., Lipp, J.J., Toh, B.H. & Peters, J.M. Histone H3 serine 10 phosphorylation by Aurora B causes HP1 dissociation from heterochromatin. Nature438, 1176–1180 (2005). ArticleCAS Google Scholar
Fischle, W. et al. Regulation of HP1-chromatin binding by histone H3 methylation and phosphorylation. Nature438, 1116–1122 (2005). ArticleCAS Google Scholar
Zhang, K. et al. The Set1 methyltransferase opposes Ipl1 aurora kinase functions in chromosome segregation. Cell122, 723–734 (2005). ArticleCAS Google Scholar
Toney, L.M. et al. BCL-6 regulates chemokine gene transcription in macrophages. Nat. Immunol.1, 214–220 (2000). ArticleCAS Google Scholar
Yasuda, K. et al. Murine dendritic cell type I IFN production induced by human IgG-RNA immune complexes is IFN regulatory factor (IRF)5 and IRF7 dependent and is required for IL-6 production. J. Immunol.178, 6876–6885 (2007). ArticleCAS Google Scholar
Michishita, E. et al. SIRT6 is a histone H3 lysine 9 deacetylase that modulates telomeric chromatin. Nature452, 492–496 (2008). ArticleCAS Google Scholar
Kattah, M.G., Coller, J., Cheung, R.K., Oshidary, N. & Utz, P.J. HIT: a versatile proteomics platform for multianalyte phenotyping of cytokines, intracellular proteins and surface molecules. Nat. Med.14, 1284–1289 (2008). ArticleCAS Google Scholar
van der Pouw Kraan, T.C. et al. Rheumatoid arthritis subtypes identified by genomic profiling of peripheral blood cells: assignment of a type I interferon signature in a subpopulation of patients. Ann. Rheum. Dis.66, 1008–1014 (2007). ArticleCAS Google Scholar
Julia, A. et al. An eight-gene blood expression profile predicts the response to infliximab in rheumatoid arthritis. PLoS One4, e7556 (2009). Article Google Scholar
Barnes, M.G. et al. Subtype-specific peripheral blood gene expression profiles in recent-onset juvenile idiopathic arthritis. Arthritis Rheum.60, 2102–2112 (2009). ArticleCAS Google Scholar
Wong, H.R. et al. Genome-level expression profiles in pediatric septic shock indicate a role for altered zinc homeostasis in poor outcome. Physiol. Genomics30, 146–155 (2007). ArticleCAS Google Scholar
Demeter, J. et al. The Stanford Microarray Database: implementation of new analysis tools and open source release of software. Nucleic Acids Res.35, D766–D770 (2007). ArticleCAS Google Scholar
Shanley, T.P. et al. Genome-level longitudinal expression of signaling pathways and gene networks in pediatric septic shock. Mol. Med.13, 495–508 (2007). ArticleCAS Google Scholar
Shi, X. et al. ING2 PHD domain links histone H3 lysine 4 methylation to active gene repression. Nature442, 96–99 (2006). ArticleCAS Google Scholar
Schnitzler, G.R. in Current Protocols in Molecular Biology Ch 21, 21.5.1–21.5.12 (John Wiley & Sons, Hoboken, New Jersey, 2001).
Rappsilber, J., Ishihama, Y. & Mann, M. Stop and go extraction tips for matrix-assisted laser desorption/ionization, nanoelectrospray, and LC/MS sample pretreatment in proteomics. Anal. Chem.75, 663–670 (2003). ArticleCAS Google Scholar
Mendez, J. & Stillman, B. Chromatin association of human origin recognition complex, cdc6, and minichromosome maintenance proteins during the cell cycle: assembly of prereplication complexes in late mitosis. Mol. Cell. Biol.20, 8602–8612 (2000). ArticleCAS Google Scholar
Michishita, E., Park, J.Y., Burneskis, J.M., Barrett, J.C. & Horikawa, I. Evolutionarily conserved and nonconserved cellular localizations and functions of human SIRT proteins. Mol. Biol. Cell16, 4623–4635 (2005). ArticleCAS Google Scholar
Ainbinder, E. et al. Mechanism of rapid transcriptional induction of tumor necrosis factor α-responsive genes by NF-κB. Mol. Cell. Biol.22, 6354–6362 (2002). ArticleCAS Google Scholar
Nelson, J.D., Denisenko, O. & Bomsztyk, K. Protocol for the fast chromatin immunoprecipitation (ChIP) method. Nat. Protocols1, 179–185 (2006). ArticleCAS Google Scholar
Kelley, L.A. & Sternberg, M.J. Protein structure prediction on the web: a case study using the Phyre server. Nat. Protocols4, 363–371 (2009). ArticleCAS Google Scholar
Couture, J.F., Hauk, G., Thompson, M.J., Blackburn, G.M. & Trievel, R.C. Catalytic roles for carbon-oxygen hydrogen bonding in SET domain lysine methyltransferases. J. Biol. Chem.281, 19280–19287 (2006). ArticleCAS Google Scholar
Bua, D.J. et al. Epigenome microarray platform for proteome-wide dissection of chromatin-signaling networks. PLoS One4, e6789 (2009). Article Google Scholar
Espejo, A., Cote, J., Bednarek, A., Richard, S. & Bedford, M.T. A protein-domain microarray identifies novel protein-protein interactions. Biochem. J.367, 697–702 (2002). ArticleCAS Google Scholar