Epigenetic silencing of retinoblastoma gene regulates pathologic differentiation of myeloid cells in cancer (original) (raw)

• Gabrilovich, D.I. et al. The terminology issue for myeloid-derived suppressor cells. Cancer Res. 67, 425 (2007).
  CAS PubMed PubMed Central Google Scholar
• Gabrilovich, D.I. & Nagaraj, S. Myeloid-derived suppressor cells as regulators of the immune system. Nat. Rev. Immunol. 9, 162–174 (2009).
  CAS PubMed PubMed Central Google Scholar
• Gabrilovich, D.I., Ostrand-Rosenberg, S. & Bronte, V. Coordinated regulation of myeloid cells by tumours. Nat. Rev. Immunol. 12, 253–268 (2012).
  Article CAS PubMed PubMed Central Google Scholar
• Ostrand-Rosenberg, S. & Sinha, P. Myeloid-derived suppressor cells: linking inflammation and cancer. J. Immunol. 182, 4499–4506 (2009).
  CAS PubMed Google Scholar
• Cuenca, A.G. et al. A paradoxical role for myeloid-derived suppressor cells in sepsis and trauma. Mol. Med. 17, 281–292 (2011).
  CAS PubMed Google Scholar
• Highfill, S.L. et al. Bone marrow myeloid-derived suppressor cells (MDSCs) inhibit graft-versus-host disease (GVHD) via an arginase-1-dependent mechanism that is up-regulated by interleukin-13. Blood 116, 5738–5747 (2010).
  CAS PubMed PubMed Central Google Scholar
• Jeisy-Scott, V. et al. Increased MDSC accumulation and Th2 biased response to influenza A virus infection in the absence of TLR7 in mice. PLoS ONE 6, e25242 (2011).
  CAS PubMed PubMed Central Google Scholar
• Chen, S., Akbar, S.M., Abe, M., Hiasa, Y. & Onji, M. Immunosuppressive functions of hepatic myeloid-derived suppressor cells of normal mice and in a murine model of chronic hepatitis B virus. Clin. Exp. Immunol. 166, 134–142 (2011).
  CAS PubMed PubMed Central Google Scholar
• Zhu, X., Herrera, G. & Ochoa, J.B. Immunosupression and infection after major surgery: a nutritional deficiency. Crit. Care Clin. 26, 491–500 (2010).
  PubMed Google Scholar
• Sander, L.E. et al. Hepatic acute-phase proteins control innate immune responses during infection by promoting myeloid-derived suppressor cell function. J. Exp. Med. 207, 1453–1464 (2010).
  CAS PubMed PubMed Central Google Scholar
• Youn, J.I., Nagaraj, S., Collazo, M. & Gabrilovich, D.I. Subsets of myeloid-derived suppressor cells in tumor-bearing mice. J. Immunol. 181, 5791–5802 (2008).
  CAS PubMed Google Scholar
• Movahedi, K. et al. Identification of discrete tumor-induced myeloid-derived suppressor cell subpopulations with distinct T-cell suppressive activity. Blood 111, 4233–4244 (2008).
  CAS PubMed Google Scholar
• Dolcetti, L. et al. Hierarchy of immunosuppressive strength among myeloid-derived suppressor cell subsets is determined by GM-CSF. Eur. J. Immunol. 40, 22–35 (2010).
  CAS PubMed Google Scholar
• Peranzoni, E. et al. Myeloid-derived suppressor cell heterogeneity and subset definition. Curr. Opin. Immunol. 22, 238–244 (2010).
  CAS PubMed Google Scholar
• Auffray, C., Sieweke, M.H. & Geissmann, F. Blood monocytes: development, heterogeneity, and relationship with dendritic cells. Annu. Rev. Immunol. 27, 669–692 (2009).
  CAS PubMed Google Scholar
• Youn, J.-I., Collazo, M., Shalova, I., Biswas, S. & Gabrilovich, D. Characterization of the nature of granulocytic myeloid-derived suppressor cells in tumor-bearing mice. J. Leukoc. Biol. 91, 167–181 (2012).
  CAS PubMed PubMed Central Google Scholar
• Brandau, S. et al. Myeloid-derived suppressor cells in the peripheral blood of cancer patients contain a subset of immature neutrophils with impaired migratory properties. J. Leukoc. Biol. 89, 311–317 (2011).
  CAS PubMed Google Scholar
• Nagaraj, S. & Gabrilovich, D.I. Myeloid-derived suppressor cells in human cancer. Cancer J. 16, 348–353 (2010).
• Sonda, N., Chioda, M., Zilio, S., Simonato, F. & Bronte, V. Transcription factors in myeloid-derived suppressor cell generation. Curr. Opin. Immunol. 23, 279–285 (2011).
  CAS PubMed Google Scholar
• Condamine, T. & Gabrilovich, D.I. Molecular mechanisms regulating myeloid-derived suppressor cell differentiation and function. Trends Immunol. 32, 19–25 (2011).
  CAS PubMed Google Scholar
• Nagaraj, S. et al. Anti-inflammatory triterpenoid blocks immune suppressive function of myeloid-derived suppressor cells and improves immune response in cancer. Clin. Cancer Res. 16, 1812–1823 (2010).
  CAS PubMed PubMed Central Google Scholar
• Solito, S. et al. A human promyelocytic-like population is responsible for the immune suppression mediated by myeloid-derived suppressor cells. Blood 118, 2254–2265 (2011).
  CAS PubMed PubMed Central Google Scholar
• Zea, A.H. et al. Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. Cancer Res. 65, 3044–3048 (2005).
  CAS PubMed Google Scholar
• Filipazzi, P. et al. Identification of a new subset of myeloid suppressor cells in peripheral blood of melanoma patients with modulation by a granulocyte-macrophage colony-stimulation factor-based antitumor vaccine. J. Clin. Oncol. 25, 2546–2553 (2007).
  CAS PubMed Google Scholar
• Poschke, I., Mougiakakos, D., Hansson, J., Masucci, G.V. & Kiessling, R. Immature immunosuppressive CD14+HLA-DR-/low cells in melanoma patients are Stat3hi and overexpress CD80, CD83, and DC-sign. Cancer Res. 70, 4335–4345 (2010).
  CAS PubMed Google Scholar
• Walkley, C.R., Shea, J.M., Sims, N.A., Purton, L.E. & Orkin, S.H. Rb regulates interactions between hematopoietic stem cells and their bone marrow microenvironment. Cell 129, 1081–1095 (2007).
  CAS PubMed PubMed Central Google Scholar
• Geissmann, F. et al. Development of monocytes, macrophages, and dendritic cells. Science 327, 656–661 (2010).
  CAS PubMed PubMed Central Google Scholar
• Borregaard, N. & Cowland, J.B. Granules of the human neutrophilic polymorphonuclear leukocyte. Blood 89, 3503–3521 (1997).
  CAS PubMed Google Scholar
• Varol, C. et al. Monocytes give rise to mucosal, but not splenic, conventional dendritic cells. J. Exp. Med. 204, 171–180 (2007).
  CAS PubMed PubMed Central Google Scholar
• Sasmono, R.T. et al. Mouse neutrophilic granulocytes express mRNA encoding the macrophage colony-stimulating factor receptor (CSF-1R) as well as many other macrophage-specific transcripts and can transdifferentiate into macrophages in vitro in response to CSF-1. J. Leukoc. Biol. 82, 111–123 (2007).
  CAS PubMed Google Scholar
• Burkhart, D.L. & Sage, J. Cellular mechanisms of tumour suppression by the retinoblastoma gene. Nat. Rev. Cancer 8, 671–682 (2008).
  CAS PubMed PubMed Central Google Scholar
• Giacinti, C. & Giordano, A. RB and cell cycle progression. Oncogene 25, 5220–5227 (2006).
  CAS PubMed Google Scholar
• Calo, E. et al. Rb regulates fate choice and lineage commitment in vivo. Nature 466, 1110–1114 (2010).
  PubMed PubMed Central Google Scholar
• Macleod, K.F. The role of the RB tumour suppressor pathway in oxidative stress responses in the haematopoietic system. Nat. Rev. Cancer 8, 769–781 (2008).
  CAS PubMed PubMed Central Google Scholar
• Traore, K. et al. Signal transduction of phorbol 12-myristate 13-acetate (PMA)-induced growth inhibition of human monocytic leukemia THP-1 cells is reactive oxygen dependent. Leuk. Res. 29, 863–879 (2005).
  CAS PubMed Google Scholar
• Bergh, G., Ehinger, M., Olsson, I., Jacobsen, S.E. & Gullberg, U. Involvement of the retinoblastoma protein in monocytic and neutrophilic lineage commitment of human bone marrow progenitor cells. Blood 94, 1971–1978 (1999).
  CAS PubMed Google Scholar
• Daria, D. et al. The retinoblastoma tumor suppressor is a critical intrinsic regulator for hematopoietic stem and progenitor cells under stress. Blood 111, 1894–1902 (2008).
  CAS PubMed PubMed Central Google Scholar
• Walkley, C.R. & Orkin, S.H. Rb is dispensable for self-renewal and multilineage differentiation of adult hematopoietic stem cells. Proc. Natl. Acad. Sci. USA 103, 9057–9062 (2006).
  CAS PubMed PubMed Central Google Scholar
• Viatour, P. et al. Hematopoietic stem cell quiescence is maintained by compound contributions of the retinoblastoma gene family. Cell Stem Cell 3, 416–428 (2008).
  CAS PubMed PubMed Central Google Scholar
• Fajas, L. et al. The retinoblastoma-histone deacetylase 3 complex inhibits PPARgamma and adipocyte differentiation. Dev. Cell 3, 903–910 (2002).
  CAS PubMed Google Scholar
• Zhang, H.S. et al. Exit from G1 and S phase of the cell cycle is regulated by repressor complexes containing HDAC-Rb-hSWI/SNF and Rb-hSWI/SNF. Cell 101, 79–89 (2000).
  CAS PubMed Google Scholar
• Takaki, T., Fukasawa, K., Suzuki-Takahashi, I. & Hirai, H. Cdk-mediated phosphorylation of pRB regulates HDAC binding in vitro. Biochem. Biophys. Res. Commun. 316, 252–255 (2004).
  CAS PubMed Google Scholar
• Fan, L.X., Li, X., Magenheimer, B., Calvet, J.P. & Li, X. Inhibition of histone deacetylases targets the transcription regulator Id2 to attenuate cystic epithelial cell proliferation. Kidney Int. 81, 76–85 (2012).
  CAS PubMed Google Scholar
• Gutsch, R. et al. CCAAT/enhancer-binding protein beta inhibits proliferation in monocytic cells by affecting the retinoblastoma protein/E2F/cyclin E pathway but is not directly required for macrophage morphology. J. Biol. Chem. 286, 22716–22729 (2011).
  CAS PubMed PubMed Central Google Scholar
• Lasorella, A., Rothschild, G., Yokota, Y., Russell, R.G. & Iavarone, A. Id2 mediates tumor initiation, proliferation, and angiogenesis in Rb mutant mice. Mol. Cell. Biol. 25, 3563–3574 (2005).
  CAS PubMed PubMed Central Google Scholar
• Ji, H. et al. Kras activation generates an inflammatory response in lung tumors. Oncogene 25, 2105–2112 (2006).
  CAS PubMed Google Scholar
• Pickard, A., Wong, P.P. & McCance, D.J. Acetylation of Rb by PCAF is required for nuclear localization and keratinocyte differentiation. J. Cell Sci. 123, 3718–3726 (2010).
  CAS PubMed PubMed Central Google Scholar