Friendly and dangerous signals: is the tissue in control? (original) (raw)

Nature Immunology volume 8, pages 11–13 (2007)Cite this article

In their own defense, tissues send a panoply of signals that initiate immunity and guide the choice of effector class. TH1-TH2 and Treg is far too simple a representation of the breathtaking variety of the resulting responses.

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References

  1. Janeway, C.A. Jr., Immunol. Today 13, 11–16 (1992).
    Article CAS Google Scholar
  2. Matzinger, P. Annu. Rev. Immunol. 12, 991–1045 (1994).
    Article CAS Google Scholar
  3. Matzinger, P. Science 296, 301–305 (2002).
    Article CAS Google Scholar
  4. Seong, S. & Matzinger, P. Nat. Rev. Immunol. 4, 469–478 (2004).
    Article CAS Google Scholar
  5. Takabayshi, K. et al. Immunity 24, 475–487 (2006).
    Article CAS Google Scholar
  6. Johansson, C. & Kelsall, B.L. Semin. Immunol. 17, 284–294 (2005).
    Article CAS Google Scholar
  7. Zamiri, P., Masli, S., Streilein, J.W. & Taylor, A.W. Invest. Ophthalmol. Vis. Sci. 47, 3912–3918 (2006).
    Article Google Scholar
  8. Havran, W.L., Jameson, J.M. & Witherden, D.A. Am. J. Physiol. Gastrointest. Liver Physiol. 289, G627–G630 (2005).
    Article CAS Google Scholar
  9. Hayday, A., Theodoridis, E., Ramsburg, E. & Shires, J. Nat. Immunol. 2, 997–1003 (2001).
    Article CAS Google Scholar
  10. Bendelac, A., Bonneville, M. & Kearney, J.F. Nat. Rev. Immunol. 1, 177–186 (2001).
    Article CAS Google Scholar
  11. Moffett, A. & Loke, C. Nat. Rev. Immunol. 6, 584–594 (2006).
    Article CAS Google Scholar

Download references

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  1. The Ghost Lab, Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, 20892, Maryland, USA
    Polly Matzinger

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  1. Polly Matzinger
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Matzinger, P. Friendly and dangerous signals: is the tissue in control?.Nat Immunol 8, 11–13 (2007). https://doi.org/10.1038/ni0107-11

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