Nonequivalent nuclear location of immunoglobulin alleles in B lymphocytes (original) (raw)

References

  1. Ohlsson, R., Tycko, B. & Sapienza, C. Monoallelic expression: 'there can only be one'. Trends Genet. 14, 435–438 (1998).
    Article CAS PubMed Google Scholar
  2. Honjo, T. & Alt, F. W. Immunoglobulin Genes (Academic Press, London, 1995).
    Google Scholar
  3. Rajewsky, K. Clonal selection and learning in the antibody system. Nature 381, 751–758 (1996).
    Article CAS PubMed Google Scholar
  4. Rolink, A. & Melchers, F. Generation and regeneration of cells of the B-lymphocyte lineage. Curr. Opin. Immunol. 5, 207–217 (1993).
    Article CAS PubMed Google Scholar
  5. Schatz, D. G., Oettinger, M. A. & Baltimore, D. The V(D)J recombination activating gene, RAG-1. Cell 59, 1035–1048 (1989).
    Article CAS PubMed Google Scholar
  6. Barreto, B. & Cumano, A. Frequency and characterization of phenotypic Ig heavy chain allelically included IgM-expressing B cells in mice. J. Immunol. 164, 893–899 (2000).
    Article CAS PubMed Google Scholar
  7. Dernburg, A. F. et al. Perturbation of nuclear architecture by long-distance chromosome interactions. Cell 85, 745–759 (1996).
    Article CAS PubMed Google Scholar
  8. Andrulis, E. D., Neiman, A. M., Zappulla, D. C. & Sternglanz, R. Perinuclear localization of chromatin facilitates transcriptional silencing. Nature 394, 592–595 (1998).
    Article CAS PubMed Google Scholar
  9. Brown, K. E., Baxter, J., Graf, D., Merkenschlager, M. & Fisher, A. G. Dynamic repositioning of genes in the nucleus of lymphocytes preparing for cell division. Mol. Cell 3, 207–217 (1999).
    Article CAS PubMed Google Scholar
  10. Brown, K. E. et al. Association of transcriptionally silent genes with Ikaros complexes at centromeric heterochromatin. Cell 91, 845–854 (1997).
    Article CAS PubMed Google Scholar
  11. Gasser, S. M. Positions of potential: nuclear organization and gene expression. Cell 104, 639–642 (2001).
    Article CAS PubMed Google Scholar
  12. Grogan, J. L. et al. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14, 205–215 (2001).
    Article CAS PubMed Google Scholar
  13. Francastel, C., Walters, M. C., Groudine, M. & Martin, D. I. K. A functional enhancer suppresses silencing of a transgene and prevents its localization close to centromeric heterochromatin. Cell 99, 259–269 (1999).
    Article CAS PubMed Google Scholar
  14. Schübeler, D. et al. Nuclear localization and histone acetylation: a pathway for chromatin opening and transcriptional activation of the human β-globin locus. Genes Dev. 14, 940–950 (2000).
    PubMed PubMed Central Google Scholar
  15. Lundgren, M. et al. Transcription factor dosage affects changes in higher order chromatin structure associated with activation of a heterochromatic gene. Cell 103, 733–743 (2000).
    Article CAS PubMed Google Scholar
  16. Georgopouos, K. et al. The Ikaros gene is required for the development of all lymphoid lineages. Cell. 79, 43–156 (1994).
    Google Scholar
  17. Sabbattini, P. et al. Binding of Ikaros to the λ5 promoter silences transcription through a mechanism that does not require heterochromatin formation. EMBO J. 20, 2812–2822 (2001).
    Article CAS PubMed PubMed Central Google Scholar
  18. Elenich, L. A., Ford, C. S., Collins, J. T. & Dunnick, W. A. γ 1 heavy chain transgenes are responsive to IFN-γ repression and CD40 ligation. J. Immunol. 158, 4564–4573 (1997).
    CAS PubMed Google Scholar
  19. Ratcliffe, M. J. & Julius, M. H. H-2 restricted T-B cell interactions involved in polyspecific B cell responses mediated by soluble antigen. Eur. J. Immunol. 12, 634–641 (1982).
    Article CAS PubMed Google Scholar
  20. Hood, L., Grant, J. A. & Sox, H. C. Jr in Developmental Aspects of Antibody Formation and Structure (eds. Sterzl, J. & Hiha, I.) vol. 1, 283–295 (Academic Press, New York, 1969).
    Google Scholar
  21. Bernier, G. M. & Cebra, J. J. Polypeptide chains of human γ-globulin: cellular localization by fluorescent antibody. Science 144, 1590–1591 (1964).
    Article CAS PubMed Google Scholar
  22. Zou, Y-R., Takeda, S. & Rajewsky, K. Gene targeting in the Igκ locus: efficient generation of λ chain-expressing B cells, independent of gene rearrangements in Igκ. EMBO J. 12, 811–820 (1993).
    Article CAS PubMed PubMed Central Google Scholar
  23. Esser, C. & Radbruch, A. Immunoglobulin class switching; molecular and cellular analysis. Annu. Rev. Immunol. 8, 717–735 (1990).
    Article CAS PubMed Google Scholar
  24. Fisher, A. G., Burdet, C., Bunce, C., Merkenschlager, M. & Ceredig, R. Lymphoproliferative disorders in IL-7 transgenic mice: expansion of immature B cells which retain macrophage potential. Int. Immunol. 7, 415–423 (1995).
    Article CAS PubMed Google Scholar
  25. Nelson, K. J., Haimovich, J. & Perry, R. P. Characterization of productive and sterile transcripts from the immunoglobulin heavy-chain locus: processing of μm and μs mRNA. Mol. Cell Biol. 3, 1317–1332 (1983).
    Article CAS PubMed PubMed Central Google Scholar
  26. Lennon, G. G. & Perry, R. P. Cμ-containing transcripts initiate heterogeneously within the IgH enhancer region and contain a novel 5′-nontranslatable exon. Nature 318, 475–478 (1985).
    Article CAS PubMed Google Scholar
  27. Lennon, G. G. & Perry, R. P. Identification of a defective mouse immunoglobulin D (diversity) element which can undergo DJH, but not VHD, recombination. Immunogenetics 30, 383–386 (1989).
    Article CAS PubMed Google Scholar
  28. Nelson, K. J., Mather, E. L. & Perry, R. P. Lipopolysaccharide-induced transcription of the κ immunoglobulin locus occurs on both alleles and is independent of methylation status. Nucleic Acids Res. 12, 1911–1923 (1984).
    Article CAS PubMed PubMed Central Google Scholar
  29. Bridger, J. M., Boyle, S., Kill, I. R. & Bickmore, W. A. Re-modelling of nuclear architecture in quiescent and senescent human fibroblasts. Curr. Biol. 10, 149–152 (2000).
    Article CAS PubMed Google Scholar
  30. Nemazee, D. Receptor selection in B and T Lymphocytes. Annu. Rev. Immunol. 18, 19–51 (2000).
    Article CAS PubMed Google Scholar
  31. Kelley, D. E. & Perry, R. P. Transcriptional and posttranscriptional control of immunoglobulin mRNA production during B lymphocyte development. Nucleic Acids Res. 14, 5431–5447 (1986).
    Article CAS PubMed PubMed Central Google Scholar
  32. Kim, K. J., Kanellopoulos-Langevin, C., Merwin, R. M., Sachs, D. H. & Asofsky, R. Establishment and characterization of BALB/c lymphoma lines with B cell properties. J. Immunol. 122, 549–554 (1979).
    CAS PubMed Google Scholar
  33. Weiss, S. & Wu, G. E. Somatic point mutations in unrearranged immunoglobulin gene segments encoding the variable region of λ light chains. EMBO J. 6, 927–932 (1987).
    Article CAS PubMed PubMed Central Google Scholar
  34. Shimizu, A., Takahashi, N., Yaoita, Y. & Honjo, T. Organisation of the constant-region gene family of the mouse immunoglobulin heavy chain. Cell 28, 499–506 (1982).
    Article CAS PubMed Google Scholar
  35. Mainville, C. A. et al. Deletion mapping of fifteen mouse VH gene families reveals a common organization for three Igh haplotypes. J. Immunol. 3, 1038–46 (1996).
    Google Scholar
  36. Liu, C. P., Tucker, P. W., Mushinski, J. F. & Blattner, F.R. Mapping of heavy chain genes for mouse immunoglobulins M and D. Science 209, 1348–1353 (1980).
    Article CAS PubMed Google Scholar
  37. Hahm, K. et al. The lymphoid transcription factor LyF-1 is encoded by specific, alternatively spliced mRNAs derived from the Ikaros gene. Mol. Cell. Biol. 14, 7111–7123 (1994).
    Article CAS PubMed PubMed Central Google Scholar
  38. Gu, H., Kitamura, D. & Rajewsky, K. B cell development regulated by gene rearrangement: arrest of maturation by membrane-bound Dμ protein and selection of DH element reading frames. Cell 65, 47–54 (1991).
    Article CAS PubMed Google Scholar

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