N-domain–dependent nonphosphorylated STAT4 dimers required for cytokine-driven activation (original) (raw)
Jacobson, N.G. et al. Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J. Exp. Med.181, 1755–1762 (1995). ArticleCAS Google Scholar
Bacon, C.M. et al. Interleukin 12 induces tyrosine phosphorylation and activation of STAT4 in human lymphocytes. Proc. Natl. Acad. Sci. USA92, 7307–7311 (1995). ArticleCAS Google Scholar
Kaplan, M.H. et al. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature382, 174–177 (1996). ArticleCAS Google Scholar
Horvath, C.M., Wen, Z. & Darnell, J.E. Jr. A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev.9, 984–994 (1995). ArticleCAS Google Scholar
Seidel, H.M. et al. Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc. Natl. Acad. Sci. USA92, 3041–3045 (1995). ArticleCAS Google Scholar
Ihle, J.N. STATs: signal transducers and activators of transcription. Cell84, 331–334 (1996). ArticleCAS Google Scholar
Xu, X., Sun, Y.L. & Hoey, T. Cooperative DNA binding and sequence-selective recognition conferred by the STAT amino-terminal domain. Science273, 794–797 (1996). ArticleCAS Google Scholar
Symes, A. et al. STAT proteins participate in the regulation of the vasoactive intestinal peptide gene by the ciliary neurotrophic factor family of cytokines. Mol. Endocrinol.8, 1750–1763 (1994). CASPubMed Google Scholar
Dajee, M. et al. Prolactin induction of the α2-Macroglobulin gene in rat ovarian granulosa cells: stat 5 activation and binding to the interleukin-6 response element. Mol. Endocrinol.10, 171–184 (1996). CASPubMed Google Scholar
Chatterjee-Kishore, M. et al. How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene. EMBO J.19, 4111–4122 (2000). ArticleCAS Google Scholar
Meyer, T., Gavenis, K. & Vinkemeier, U. Cell type-specific and tyrosine phosphorylation-independent nuclear presence of STAT1 and STAT3. Exp. Cell Res.272, 45–55 (2002). ArticleCAS Google Scholar
Darnell, J.E. Jr. STATs and gene regulation. Science277, 1630–1635 (1997). ArticleCAS Google Scholar
Leaman, D.W. et al. Regulation of STAT-dependent pathways by growth factors and cytokines. FASEB J.10, 1578–1588 (1996). ArticleCAS Google Scholar
Schindler, C. & Darnell, J.E. Jr. Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu. Rev. Biochem.64, 621–651 (1995). ArticleCAS Google Scholar
Kisseleva, T. et al. Signaling through the JAK/STAT pathway, recent advances and future challenges. Gene285, 1–24 (2002). ArticleCAS Google Scholar
Ndubuisi, M.I. et al. Cellular physiology of STAT3: where's the cytoplasmic monomer? J. Biol. Chem.274, 25499–25509 (1999). ArticleCAS Google Scholar
Haan, S. et al. Cytoplasmic STAT proteins associate prior to activation. Biochem. J.345, 417–421 (2000). ArticleCAS Google Scholar
Shah, M. et al. Interactions of STAT3 with caveolin-1 and heat shock protein 90 in plasma membrane raft and cytosolic complexes. Preservation of cytokine signaling during fever. J. Biol. Chem.277, 45662–45669 (2002). ArticleCAS Google Scholar
Guo, G.G. et al. Association of the chaperone glucose-regulated protein 58 (GRP58/ER-60/ERp57) with Stat3 in cytosol and plasma membrane complexes. J. Interferon Cytokine Res.22, 555–563 (2002). ArticleCAS Google Scholar
Braunstein, J. et al. STATs dimerize in the absence of phosphorylation. J. Biol. Chem. (2003).
Chen, X. et al. Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell93, 827–839 (1998). ArticleCAS Google Scholar
Vinkemeier, U. et al. Structure of the amino-terminal protein interaction domain of STAT-4. Science279, 1048–1052 (1998). ArticleCAS Google Scholar
Murphy, T.L. et al. Role of the Stat4 N domain in receptor proximal tyrosine phosphorylation. Mol. Cell Biol.20, 7121–7131 (2000). ArticleCAS Google Scholar
Chang, H.C. et al. Stat4 requires the N-terminal domain for efficient phosphorylation. J. Biol. Chem. (2003).
Chen, X. et al. A reinterpretation of the dimerization interface of the N-terminal domains of STATs. Protein Sci.12, 361–365 (2003). ArticleCAS Google Scholar
Jones, S. & Thornton, J.M. Principles of protein-protein interactions. Proc. Natl. Acad. Sci. USA93, 13–20 (1996). ArticleCAS Google Scholar
Lawrence, M.C. & Colman, P.M. Shape complementarity at protein/protein interfaces. J. Mol. Biol.234, 946–950 (1993). ArticleCAS Google Scholar
Lo Conte, L., Chothia, C. & Janin, J. The atomic structure of protein-protein recognition sites. J. Mol. Biol.285, 2177–2198 (1999). ArticleCAS Google Scholar
Beranger, F. et al. Getting more from the two-hybrid system: N-terminal fusions to LexA are efficient and sensitive baits for two-hybrid studies. Nucleic Acids Res.25, 2035–2036 (1997). ArticleCAS Google Scholar
Farrar, J.D. et al. Selective loss of type I interferon–induced STAT4 activation caused by a minisatellite insertion in mouse STAT2. Nat. Immunol.1, 65–69 (2000). ArticleCAS Google Scholar
Farrar, J.D. & Murphy, K.M. Type I interferons and T helper development. Immunol. Today21, 484–489 (2000). ArticleCAS Google Scholar
Yang, J. et al. Induction of interferon-γ production in Th1 CD4+ T cells: evidence for two distinct pathways for promoter activation. Eur. J. Immunol.29, 548–555 (1999). ArticleCAS Google Scholar
Yang, J. et al. IL-18-stimulated GADD45β required in cytokine-induced, but not TCR-induced, IFN-γ production. Nat. Immunol.2, 157–164 (2001). ArticleCAS Google Scholar
Afkarian, M. et al. T-bet is a STAT1-induced regulator of IL-12R expression in naive CD4+ T cells. Nat. Immunol.3, 549–557 (2002). ArticleCAS Google Scholar
Meraz, M.A. et al. Targeted disruption of the Stat1 gene in mice reveals unexpected physiologic specificity in the JAK-STAT signaling pathway. Cell84, 431–442 (1996). ArticleCAS Google Scholar
John, S. et al. The significance of tetramerization in promoter recruitment by Stat5. Mol. Cell Biol.19, 1910–1918 (1999). ArticleCAS Google Scholar
Soldaini, E. et al. DNA binding site selection of dimeric and tetrameric Stat5 proteins reveals a large repertoire of divergent tetrameric Stat5a binding sites. Mol. Cell Biol.20, 389–401 (2000). ArticleCAS Google Scholar
Farrar, J.D. et al. Recruitment of Stat4 to the human interferon-α/β receptor requires activated Stat2. J. Biol. Chem.275, 2693–2697 (2000). ArticleCAS Google Scholar
Ihle, J.N. & Kerr, I.M. Jaks and Stats in signaling by the cytokine receptor superfamily. Trends Genet.11, 69–74 (1995). ArticleCAS Google Scholar
Cho, S.S. et al. Activation of STAT4 by IL-12 and IFN-α: evidence for the involvement of ligand-induced tyrosine and serine phosphorylation. J. Immunol.157, 4781–4789 (1996). CASPubMed Google Scholar
Hubbard, S.J., Campbell, S.F. & Thornton, J.M. Molecular recognition. Conformational analysis of limited proteolytic sites and serine proteinase protein inhibitors. J. Mol. Biol.220, 507–530 (1991). ArticleCAS Google Scholar
Evan, G.I. et al. Isolation of monoclonal antibodies specific for human c-myc proto-oncogene product. Mol. Cell Biol.5, 3610–3616 (1985). ArticleCAS Google Scholar
Ranganath, S. et al. GATA-3-dependent enhancer activity in IL-4 gene regulation. J. Immunol.161, 3822–3826 (1998). CAS Google Scholar
Ouyang, W. et al. The Ets transcription factor ERM is Th1-specific and induced by IL-12 through a Stat4-dependent pathway. Proc. Natl. Acad. Sci. USA96, 3888–3893 (1999). ArticleCAS Google Scholar
Morinobu, A. et al. STAT4 serine phosphorylation is critical for IL-12-induced IFN-γ production but not for cell proliferation. Proc. Natl. Acad. Sci. USA99, 12281–12286 (2002). ArticleCAS Google Scholar
Ouyang, W. et al. Inhibition of Th1 development mediated by GATA-3 through an IL-4-independent mechanism. Immunity9, 745–755 (1998). ArticleCAS Google Scholar