Self-reactivity in thymic double-positive cells commits cells to a CD8αα lineage with characteristics of innate immune cells (original) (raw)
Germain, R.N. T-cell development and the CD4-CD8 lineage decision. Nat. Rev. Immunol.2, 309–322 (2002). ArticleCAS Google Scholar
Sebzda, E. et al. Positive and negative thymocyte selection induced by different concentrations of a single peptide. Science263, 1615–1618 (1994). ArticleCAS Google Scholar
Ashton-Rickardt, P.G. et al. Evidence for a differential avidity model of T cell selection in the thymus. Cell76, 651–663 (1994). ArticleCAS Google Scholar
Hogquist, K.A., Jameson, S.C. & Bevan, M.J. Strong agonist ligands for the T cell receptor do not mediate positive selection of functional CD8+ T cells. Immunity3, 79–86 (1995). ArticleCAS Google Scholar
Kawai, K. & Ohashi, P.S. Immunological function of a defined T-cell population tolerized to low-affinity self antigens. Nature374, 68–69 (1995). ArticleCAS Google Scholar
Girao, C., Hu, Q., Sun, J. & Ashton-Rickardt, P.G. Limits to the differential avidity model of T cell selection in the thymus. J. Immunol.159, 4205–4211 (1997). CASPubMed Google Scholar
Wang, R., Nelson, A., Kimachi, K., Grey, H.M. & Farr, A.G. The role of peptides in thymic positive selection of class II major histocompatibility complex-restricted T cells. Proc. Natl. Acad. Sci. USA95, 3804–3809 (1998). ArticleCAS Google Scholar
Kraj, P. et al. Positive selection of CD4+ T cells is induced in vivo by agonist and inhibited by antagonist peptides. J. Exp. Med.194, 407–416 (2001). ArticleCAS Google Scholar
Jordan, M.S. et al. Thymic selection of CD4+CD25+ regulatory T cells induced by an agonist self-peptide. Nat. Immunol.2, 283–284 (2001). Article Google Scholar
Apostolou, I., Sarukhan, A., Klein, L. & von Boehmer, H. Origin of regulatory T cells with known specificity for antigen. Nat. Immunol.3, 756–763 (2002). ArticleCAS Google Scholar
Park, S.H. et al. The mouse CD1d-restricted repertoire is dominated by a few autoreactive T cell receptor families. J. Exp. Med.193, 893–904 (2001). ArticleCAS Google Scholar
Burnet, F.M. A modification of Jerne's theory of antibody production using the concept of clonal selection. C.A. Cancer J. Clin.26, 119–121 (1976). ArticleCAS Google Scholar
von Boehmer, H., Teh, H.S. & Kisielow, P. The thymus selects the useful, neglects the useless and destroys the harmful. Immunol. Today10, 57–61 (1989). ArticleCAS Google Scholar
Schwartz, R.H. in Fundamental Immunology (ed. Paul, W.E.) 701–739 (Lippincott-Raven, Philadelphia, 1999). Google Scholar
Anderson, M.S. et al. Projection of an immunological self-shadow within the thymus by the aire protein. Science298, 139–1401 (2002). Article Google Scholar
Anderson, G., Jenkinson, E.J., Moore, N.C. & Owen, J.J. MHC class II-positive epithelium and mesenchyme cells are both required for T-cell development in the thymus. Nature362, 70–73 (1993). ArticleCAS Google Scholar
Schulz, R.J., Parkes, A., Mizoguchi, E., Bhan, A.K. & Koyasu, S. Development of CD4−CD8− αβ TCR+NK1.1+ T lymphocytes: thymic selection by self antigen. J. Immunol.157, 4379–4389 (1996). CASPubMed Google Scholar
Yasutomo, K., Doyle, C., Miele, L. & Germain, R.N. The duration of antigen receptor signalling determines CD4+ versus CD8+ T-cell lineage fate. Nature404, 506–510 (2000). ArticleCAS Google Scholar
Rocha, B., von Boehmer, H. & Guy-Grand, D. Selection of intraepithelial lymphocytes with CD8α/α co-receptors by self-antigen in the murine gut. Proc. Natl. Acad. Sci. USA89, 5336–5340 (1992). ArticleCAS Google Scholar
Cruz, D. et al. An opposite pattern of selection of a single T cell antigen receptor in the thymus and among intraepithelial lymphocytes. J. Exp. Med.188, 255–265 (1998). ArticleCAS Google Scholar
Leishman, A.J. et al. Precursors of functional MHC class I- or class II-restricted CD8αα+ T cells are positively selected in the thymus by agonist self-peptides. Immunity16, 355–364 (2002). ArticleCAS Google Scholar
Chidgey, A. & Boyd, R. Agonist peptide modulates T cell selection thresholds through qualitative and quantitative shifts in CD8 co-receptor expression. Int. Immunol.9, 1527–1536 (1997). ArticleCAS Google Scholar
Barnden, M.J., Heath, W.R. & Carbone, F.R. Down-modulation of CD8 β-chain in response to an altered peptide ligand enables developing thymocytes to escape negative selection. Cell. Immunol.175, 111–119 (1997). ArticleCAS Google Scholar
Hogquist, K.A. & Bonnevier, J.L. Development of peptide-selected CD8 T cells in fetal thymic organ culture occurs via the conventional pathway. J. Immunol.161, 3896–3901 (1998). CASPubMed Google Scholar
Teh, H.S. et al. Early deletion and late positive selection of T cells expressing a male-specific receptor in T-cell receptor transgenic mice. Dev. Immunol.1, 1–10 (1990). ArticleCAS Google Scholar
Teh, H.S., Kishi, H., Scott, B. & von Boehmer, H. Deletion of autospecific T cells in T cell receptor (TCR) transgenic mice spares cells with normal TCR levels and low levels of CD8 molecules. J. Exp. Med.169, 795–806 (1989). ArticleCAS Google Scholar
Kisielow, P., Bluthmann, H., Staerz, U.D., Steinmetz, M. & von Boehmer, H. Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes. Nature333, 742–746 (1988). ArticleCAS Google Scholar
Berg, L.J., Frank, G.D. & Davis, M.M. The effects of MHC gene dosage and allelic variation on T cell receptor selection. Cell60, 1043–1053 (1990). ArticleCAS Google Scholar
Kersh, G.J., Engle, D.L., Williams, C.B. & Allen, P.M. Ligand-specific selection of MHC class II-restricted thymocytes in fetal thymic organ culture. J. Immunol.164, 5675–5682 (2000). ArticleCAS Google Scholar
Irizarry, R.A. et al. Summaries of Affymetrix GeneChip probe level data. Nucleic Acids Res.31, e15 (2003). Article Google Scholar
Moretta, A. et al. Activating receptors and coreceptors involved in human natural killer cell-mediated cytolysis. Annu. Rev. Immunol.19, 197–223 (2001). ArticleCAS Google Scholar
Yokota, Y. et al. Development of peripheral lymphoid organs and natural killer cells depends on the helix-loop-helix inhibitor Id2. Nature397, 702–706 (1999). ArticleCAS Google Scholar
Barton, K. et al. The Ets-1 transcription factor is required for the development of natural killer cells in mice. Immunity9, 555–563 (1998). ArticleCAS Google Scholar
Luster, A.D. The role of chemokines in linking innate and adaptive immunity. Curr. Opin. Immunol.14, 129–135 (2002). ArticleCAS Google Scholar
Vorbach, C., Harrison, R. & Capecchi, M.R. Xanthine oxidoreductase is central to the evolution and function of the innate immune system. Trends Immunol.24, 512–517 (2003). ArticleCAS Google Scholar
Hacker, C. et al. Transcriptional profiling identifies Id2 function in dendritic cell development. Nat. Immunol.4, 380–386 (2003). ArticleCAS Google Scholar
Bendelac, A., Bonneville, M. & Kearney, J.F. Autoreactivity by design: innate B and T lymphocytes. Nat. Rev. Immunol.1, 177–186 (2001). ArticleCAS Google Scholar
Teh, H.S. et al. Thymic major histocompatibility complex antigens and the αβ T-cell receptor determine the CD4/CD8 phenotype of T cells. Nature335, 229–233 (1988). ArticleCAS Google Scholar
Bruno, L., Fehling, H.J. & von Boehmer, H. The αβ T cell receptor can replace the γδ receptor in the development of γδ lineage cells. Immunity5, 343–352 (1996). ArticleCAS Google Scholar
Buch, T., Rieux-Laucat, F., Forster, I. & Rajewsky, K. Failure of HY-specific thymocytes to escape negative selection by receptor editing. Immunity16, 707–718 (2002). ArticleCAS Google Scholar
Gao, G.F., Rao, Z. & Bell, J.I. Molecular coordination of αβ T-cell receptors and coreceptors CD8 and CD4 in their recognition of peptide-MHC ligands. Trends Immunol.23, 408–413 (2002). Article Google Scholar
Bain, G. et al. E2A deficiency leads to abnormalities in αβ T-cell development and to rapid development of T-cell lymphomas. Mol. Cell. Biol.17, 4782–4791 (1997). ArticleCAS Google Scholar
Capone, M. et al. Selective absence of CD8+ TCRαβ+ intestinal epithelial cells in transgenic mice expressing β2-microglobulin-associated ligands exclusively on thymic cortical epithelium. Eur. J. Immunol.33, 1471–1477 (2003). ArticleCAS Google Scholar
Gleimer, M. & Parham, P. Stress management: MHC class I and class I-like molecules as reporters of cellular stress. Immunity19, 469–477 (2003). ArticleCAS Google Scholar
Natarajan, K., Dimasi, N., Wang, J., Mariuzza, R.A. & Margulies, D.H. Structure and function of natural killer cell receptors: multiple molecular solutions to self, nonself discrimination. Annu. Rev. Immunol.20, 853–885 (2002). ArticleCAS Google Scholar
McMahon, C.W. & Raulet, D.H. Expression and function of NK cell receptors in CD8+ T cells. Curr. Opin. Immunol.13, 465–470 (2001). ArticleCAS Google Scholar
Shires, J., Theodoridis, E. & Hayday, A.C. Biological insights into TCRγδ+ and TCRαβ+ intraepithelial lymphocytes provided by serial analysis of gene expression (SAGE). Immunity15, 419–434 (2001). ArticleCAS Google Scholar