Resting dendritic cells induce peripheral CD8+ T cell tolerance through PD-1 and CTLA-4 (original) (raw)
Mondino, A., Khoruts, A. & Jenkins, M.K. The anatomy of T-cell activation and tolerance. Proc. Natl. Acad. Sci. USA93, 2245–2252 (1996). ArticleCASPubMedPubMed Central Google Scholar
Derbinski, J., Schulte, A., Kyewski, B. & Klein, L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol.2, 1032–1039 (2001). ArticleCASPubMed Google Scholar
Kyewski, B., Derbinski, J., Gotter, J. & Klein, L. Promiscuous gene expression and central T-cell tolerance: more than meets the eye. Trends Immunol.23, 364–371 (2002). ArticleCASPubMed Google Scholar
Bjorses, P., Aaltonen, J., Horelli-Kuitunen, N., Yaspo, M.L. & Peltonen, L. Gene defect behind APECED: a new clue to autoimmunity. Hum. Mol. Genet.7, 1547–1553 (1998). ArticleCASPubMed Google Scholar
Anderson, M.S. et al. Projection of an immunological self shadow within the thymus by the aire protein. Science298, 1395–1401 (2002). ArticleCASPubMed Google Scholar
Bouneaud, C., Kourilsky, P. & Bousso, P. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity13, 829–840 (2000). ArticleCASPubMed Google Scholar
Walker, L.S. & Abbas, A.K. The enemy within: keeping self-reactive T cells at bay in the periphery. Nat. Rev. Immunol.2, 11–19 (2002). ArticleCASPubMed Google Scholar
Steinman, R.M. et al. Dendritic cell function in vivo during the steady state: a role in peripheral tolerance. Ann. NY Acad. Sci.987, 15–25 (2003). ArticleCASPubMed Google Scholar
Steinman, R.M., Hawiger, D. & Nussenzweig, M.C. Tolerogenic dendritic cells. Annu. Rev. Immunol.21, 685–711 (2003). ArticleCASPubMed Google Scholar
Sakaguchi, S. Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses. Annu. Rev. Immunol.22, 531–562 (2004). ArticleCASPubMed Google Scholar
Tivol, E.A. et al. Loss of CTLA-4 leads to massive lymphoproliferation and fatal multiorgan tissue destruction, revealing a critical negative regulatory role of CTLA-4. Immunity3, 541–547 (1995). ArticleCASPubMed Google Scholar
Waterhouse, P. et al. Lymphoproliferative disorders with early lethality in mice deficient in Ctla-4. Science270, 985–988 (1995). ArticleCASPubMed Google Scholar
Perez, V.L. et al. Induction of peripheral T cell tolerance in vivo requires CTLA-4 engagement. Immunity6, 411–417 (1997). ArticleCASPubMed Google Scholar
Walunas, T.L. & Bluestone, J.A. CTLA-4 regulates tolerance induction and T cell differentiation in vivo. J. Immunol.160, 3855–3860 (1998). CASPubMed Google Scholar
Lindsten, T. et al. Characterization of CTLA-4 structure and expression on human T cells. J. Immunol.151, 3489–3499 (1993). CASPubMed Google Scholar
Brunner, M.C. et al. CTLA-4-mediated inhibition of early events of T cell proliferation. J. Immunol.162, 5813–5820 (1999). CASPubMed Google Scholar
Ishida, Y., Agata, Y., Shibahara, K. & Honjo, T. Induced expression of PD-1, a novel member of the immunoglobulin gene superfamily, upon programmed cell death. EMBO J.11, 3887–3895 (1992). ArticleCASPubMedPubMed Central Google Scholar
Agata, Y. et al. Expression of the PD-1 antigen on the surface of stimulated mouse T and B lymphocytes. Int. Immunol.8, 765–772 (1996). ArticleCASPubMed Google Scholar
Nishimura, H., Nose, M., Hiai, H., Minato, N. & Honjo, T. Development of lupus-like autoimmune diseases by disruption of the PD-1 gene encoding an ITIM motif-carrying immunoreceptor. Immunity11, 141–151 (1999). ArticleCASPubMed Google Scholar
Nishimura, H. et al. Autoimmune dilated cardiomyopathy in PD-1 receptor-deficient mice. Science291, 319–322 (2001). ArticleCASPubMed Google Scholar
Freeman, G.J. et al. Engagement of the PD-1 immunoinhibitory receptor by a novel B7 family member leads to negative regulation of lymphocyte activation. J. Exp. Med.192, 1027–1034 (2000). ArticleCASPubMedPubMed Central Google Scholar
Latchman, Y. et al. PD-L2 is a second ligand for PD-1 and inhibits T cell activation. Nat. Immunol.2, 261–268 (2001). ArticleCASPubMed Google Scholar
Okazaki, T., Iwai, Y. & Honjo, T. New regulatory co-receptors: inducible co-stimulator and PD-1. Curr. Opin. Immunol.14, 779–782 (2002). ArticleCASPubMed Google Scholar
Chen, L. Co-inhibitory molecules of the B7–CD28 family in the control of T-cell immunity. Nat. Rev. Immunol.4, 336–347 (2004). ArticleCASPubMed Google Scholar
Probst, H.C., Lagnel, J., Kollias, G. & van den Broek, M. Inducible transgenic mice reveal resting dendritic cells as potent inducers of CD8+ T cell tolerance. Immunity18, 713–720 (2003). ArticleCASPubMed Google Scholar
Moser, M. Dendritic cells in immunity and tolerance-do they display opposite functions? Immunity19, 5–8 (2003). ArticleCASPubMed Google Scholar
Guermonprez, P., Valladeau, J., Zitvogel, L., Thery, C. & Amigorena, S. Antigen presentation and T cell stimulation by dendritic cells. Annu. Rev. Immunol.20, 621–667 (2002). ArticleCASPubMed Google Scholar
Scheinecker, C., McHugh, R., Shevach, E.M. & Germain, R.N. Constitutive presentation of a natural tissue autoantigen exclusively by dendritic cells in the draining lymph node. J. Exp. Med.196, 1079–1090 (2002). ArticleCASPubMedPubMed Central Google Scholar
Belz, G.T. et al. The CD8α+ dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens. J. Exp. Med.196, 1099–1104 (2002). ArticleCASPubMedPubMed Central Google Scholar
Lin, Y., Roberts, T.J., Sriram, V., Cho, S. & Brutkiewicz, R.R. Myeloid marker expression on antiviral CD8+ T cells following an acute virus infection. Eur. J. Immunol.33, 2736–2743 (2003). ArticleCASPubMed Google Scholar
Probst, H.C. et al. Immunodominance of an antiviral cytotoxic T cell response is shaped by the kinetics of viral protein expression. J. Immunol.171, 5415–5422 (2003). ArticleCASPubMed Google Scholar
Hou, W.S. & Van Parijs, L. A Bcl-2-dependent molecular timer regulates the lifespan and immunogenicity of dendritic cells. Nat. Immunol.5, 583–589 (2004). ArticleCASPubMed Google Scholar
Ingulli, E., Mondino, A., Khoruts, A. & Jenkins, M.K. In vivo detection of dendritic cell antigen presentation to CD4+ T cells. J. Exp. Med.185, 2133–2141 (1997). ArticleCASPubMedPubMed Central Google Scholar
Robinson, S.P., Langan-Fahey, S.M., Johnson, D.A. & Jordan, V.C. Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient. Drug Metab. Dispos.19, 36–43 (1991). CASPubMed Google Scholar
Krummel, M.F. & Allison, J.P. CD28 and CTLA-4 have opposing effects on the response of T cells to stimulation. J. Exp. Med.182, 459–465 (1995). ArticleCASPubMed Google Scholar
Dhodapkar, M.V. & Steinman, R.M. Antigen-bearing immature dendritic cells induce peptide-specific CD8+ regulatory T cells in vivo in humans. Blood100, 174–177 (2002). ArticleCASPubMed Google Scholar
Jonuleit, H., Schmitt, E., Schuler, G., Knop, J. & Enk, A.H. Induction of interleukin 10-producing, nonproliferating CD4+ T cells with regulatory properties by repetitive stimulation with allogeneic immature human dendritic cells. J. Exp. Med.192, 1213–1222 (2000). ArticleCASPubMedPubMed Central Google Scholar
Mahnke, K., Qian, Y., Knop, J. & Enk, A.H. Induction of CD4+/CD25+ regulatory T cells by targeting of antigens to immature dendritic cells. Blood101, 4862–4869 (2003). ArticleCASPubMed Google Scholar
Groux, H. et al. A transgenic model to analyze the immunoregulatory role of IL-10 secreted by antigen-presenting cells. J. Immunol.162, 1723–1729 (1999). CASPubMed Google Scholar
Bonifaz, L. et al. Efficient targeting of protein antigen to the dendritic cell receptor DEC-205 in the steady state leads to antigen presentation on major histocompatibility complex class I products and peripheral CD8+ T cell tolerance. J. Exp. Med.196, 1627–1638 (2002). ArticleCASPubMedPubMed Central Google Scholar
Hawiger, D. et al. Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo. J. Exp. Med.194, 769–779 (2001). ArticleCASPubMedPubMed Central Google Scholar
Misra, N., Bayry, J., Lacroix-Desmazes, S., Kazatchkine, M.D. & Kaveri, S.V. Cutting edge: human CD4+CD25+ T cells restrain the maturation and antigen-presenting function of dendritic cells. J. Immunol.172, 4676–4680 (2004). ArticleCASPubMed Google Scholar
Albert, M.L. Death-defying immunity: do apoptotic cells influence antigen processing and presentation? Nat. Rev. Immunol.4, 223–231 (2004). ArticleCASPubMed Google Scholar
Hernandez, J., Aung, S., Redmond, W.L. & Sherman, L.A. Phenotypic and functional analysis of CD8+ T cells undergoing peripheral deletion in response to cross-presentation of self-antigen. J. Exp. Med.194, 707–717 (2001). ArticleCASPubMedPubMed Central Google Scholar
Hugues, S. et al. Tolerance to islet antigens and prevention from diabetes induced by limited apoptosis of pancreatic beta cells. Immunity16, 169–181 (2002). ArticleCASPubMed Google Scholar
Kurts, C., Kosaka, H., Carbone, F.R., Miller, J.F. & Heath, W.R. Class I-restricted cross-presentation of exogenous self-antigens leads to deletion of autoreactive CD8+ T cells. J. Exp. Med.186, 239–245 (1997). ArticleCASPubMedPubMed Central Google Scholar
Morgan, D.J., Kreuwel, H.T. & Sherman, L.A. Antigen concentration and precursor frequency determine the rate of CD8+ T cell tolerance to peripherally expressed antigens. J. Immunol.163, 723–727 (1999). CASPubMed Google Scholar
Lo, D. et al. Peripheral tolerance to an islet cell-specific hemagglutinin transgene affects both CD4+ and CD8+ T cells. Eur. J. Immunol.22, 1013–1022 (1992). ArticleCASPubMed Google Scholar
McCoy, K.D., Hermans, I.F., Fraser, J.H., Le Gros, G. & Ronchese, F. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) can regulate dendritic cell-induced activation and cytotoxicity of CD8+ T cells independently of CD4+ T cell help. J. Exp. Med.189, 1157–1162 (1999). ArticleCASPubMedPubMed Central Google Scholar
Nishimura, H., Honjo, T. & Minato, N. Facilitation of beta selection and modification of positive selection in the thymus of PD-1-deficient mice. J. Exp. Med.191, 891–898 (2000). ArticleCASPubMedPubMed Central Google Scholar
Blank, C. et al. Absence of programmed death receptor 1 alters thymic development and enhances generation of CD4/CD8 double-negative TCR-transgenic T cells. J. Immunol.171, 4574–4581 (2003). ArticleCASPubMed Google Scholar
Walunas, T.L. et al. CTLA-4 can function as a negative regulator of T cell activation. Immunity1, 405–413 (1994). ArticleCASPubMed Google Scholar
Lehmann-Grube, F. Lymphocytic Choriomeningitis Virus. Virol. Monogr.10, 1–173 (1971). Google Scholar
Gallimore, A. et al. Induction and exhaustion of lymphocytic choriomeningitis virus-specific cytotoxic T lymphocytes visualized using soluble tetrameric major histocompatibility complex class I-peptide complexes. J. Exp. Med.187, 1383–1393 (1998). ArticleCASPubMedPubMed Central Google Scholar
Probst, H.C., Dumrese, T. & van den Broek, M.F. Cutting edge: competition for APC by CTLs of different specificities is not functionally important during induction of antiviral responses. J. Immunol.168, 5387–5391 (2002). ArticleCASPubMed Google Scholar
Battegay, M. et al. Quantification of lymphocytic choriomeningitis virus with an immunological focus assay in 24- or 96-well plates. J. Virol. Methods33, 191–198 (1991). ArticleCASPubMed Google Scholar