Unconventional topology of self peptide–major histocompatibility complex binding by a human autoimmune T cell receptor (original) (raw)
References
Steinman, L. Multiple sclerosis: a coordinated immunological attack against myelin in the central nervous system. Cell85, 299–302 (1996). CAS Google Scholar
Davis, M.M. & Chien, Y.-H. T-cell antigen receptors. in Fundamental Immunology (ed. Paul, W.E.) 227–258 (Lippincott Williams & Wilkins, Philadelphia, 2003). Google Scholar
Kisielow, P., Teh, H.S., von Bluthmann, H. & Boehmer, H. Positive selection of antigen-specific T cells in thymus by restricting MHC molecules. Nature335, 730–733 (1988). CAS Google Scholar
Kappler, J.W., Roehm, N. & Marrack, P. T cell tolerance by clonal elimination in the thymus. Cell49, 273–280 (1987). CAS Google Scholar
Alam, S.M. et al. T-cell-receptor affinity and thymocyte positive selection. Nature381, 616–620 (1996). CAS Google Scholar
Derbinski, J., Schulte, A., Kyewski, B. & Klein, L. Promiscuous gene expression in medullary thymic epithelial cells mirrors the peripheral self. Nat. Immunol.2, 1032–1039 (2001). CAS Google Scholar
The Finnish-German APECED Consortium. Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy. An autoimmune disease, APECED, caused by mutations in a novel gene featuring two PHD-type zinc-finger domains. Nat. Genet.17, 399–403 (1997).
Anderson, M.S. et al. Projection of an immunological self shadow within the thymus by the aire protein. Science298, 1395–1401 (2002). CAS Google Scholar
Harrington, C.J. et al. Differential tolerance is induced in T cells recognizing distinct epitopes of myelin basic protein. Immunity8, 571–580 (1998). CAS Google Scholar
Anderson, A.C. et al. High frequency of autoreactive myelin proteolipid protein-specific T cells in the periphery of naive mice: mechanisms of selection of the self-reactive repertoire. J. Exp. Med.191, 761–770 (2000). CAS Google Scholar
Wucherpfennig, K.W. et al. Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones. J. Exp. Med.179, 279–290 (1994). CAS Google Scholar
Pribyl, T.M., Campagnoni, C., Kampf, K., Handley, V.W. & Campagnoni, A.T. The major myelin protein genes are expressed in the human thymus. J. Neurosci. Res.45, 812–819 (1996). CAS Google Scholar
Sakaguchi, N. et al. Altered thymic T-cell selection due to a mutation of the ZAP-70 gene causes autoimmune arthritis in mice. Nature426, 454–460 (2003). CAS Google Scholar
Garboczi, D.N. et al. Structure of the complex between human T-cell receptor, viral peptide and HLA-A2. Nature384, 134–141 (1996). CAS Google Scholar
Garcia, K.C. et al. An αβ T cell receptor structure at 2.5 Å and its orientation in the TCR-MHC complex. Science274, 209–219 (1996). CAS Google Scholar
Garcia, K.C. et al. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science279, 1166–1172 (1998). CAS Google Scholar
Ding, Y.H. et al. Two human T cell receptors bind in a similar diagonal mode to the HLA-A2/Tax peptide complex using different TCR amino acids. Immunity8, 403–411 (1998). CAS Google Scholar
Stewart-Jones, G.B., McMichael, A.J., Bell, J.I., Stuart, D.I. & Jones, E.Y. A structural basis for immunodominant human T cell receptor recognition. Nat. Immunol.4, 657–663 (2003). CAS Google Scholar
Reinherz, E.L. et al. The crystal structure of a T cell receptor in complex with peptide and MHC class II. Science286, 1913–1921 (1999). CAS Google Scholar
Reiser, J.B. et al. A T cell receptor CDR3β loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex. Immunity16, 345–354 (2002). CAS Google Scholar
Reiser, J.B. et al. Crystal structure of a T cell receptor bound to an allogeneic MHC molecule. Nat. Immunol.1, 291–297 (2000). CAS Google Scholar
Sun, R. et al. Evidence that the antigen receptors of cytotoxic T lymphocytes interact with a common recognition pattern on the H-2Kb molecule. Immunity3, 573–582 (1995). CAS Google Scholar
Rudolph, M.G., Luz, J.G. & Wilson, I.A. Structural and thermodynamic correlates of T cell signaling. Annu. Rev. Biophys. Biomol. Struct.31, 121–149 (2002). CAS Google Scholar
Hennecke, J., Carfi, A. & Wiley, D.C. Structure of a covalently stabilized complex of a human αβ T- cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1. EMBO J.19, 5611–5624 (2000). CAS Google Scholar
Wucherpfennig, K.W. et al. Clonal expansion and persistence of human T cells specific for an immunodominant myelin basic protein peptide. J. Immunol.152, 5581–5592 (1994). CAS Google Scholar
Ota, K. et al. T-cell recognition of an immunodominant myelin basic protein epitope in multiple sclerosis. Nature346, 183–187 (1990). CAS Google Scholar
Pette, M. et al. Myelin autoreactivity in multiple sclerosis: recognition of myelin basic protein in the context of HLA-DR2 products by T lymphocytes of multiple-sclerosis patients and healthy donors. Proc. Natl. Acad. Sci. USA87, 7968–7972 (1990). CAS Google Scholar
Krogsgaard, M. et al. Visualization of myelin basic protein (MBP) T cell epitopes in multiple sclerosis lesions using a monoclonal antibody specific for the human histocompatibility leukocyte antigen (HLA)-DR2-MBP 85–99 complex. J. Exp. Med.191, 1395–1412 (2000). CAS Google Scholar
Madsen, L.S. et al. A humanized model for multiple sclerosis using HLA-DR2 and a human T-cell receptor. Nat. Genet.23, 343–347 (1999). CAS Google Scholar
Hausmann, S., Martin, M., Gauthier, L. & Wucherpfennig, K.W. Structural features of autoreactive TCR that determine the degree of degeneracy in peptide recognition. J. Immunol.162, 338–344 (1999). CAS Google Scholar
Nakagawa, T. et al. Cathepsin L: critical role in Ii degradation and CD4 T cell selection in the thymus. Science280, 450–453 (1998). CAS Google Scholar
Baker, B.M., Turner, R.V., Gagnon, S.J., Wiley, D.C. & Biddison, W.E. Identification of a crucial energetic footprint on the α1 helix of human histocompatibility leukocyte antigen (HLA)-A2 that provides functional interactions for recognition by tax peptide/HLA-A2-specific T cell receptors. J. Exp. Med.193, 551–562 (2001). CAS Google Scholar
Wang, J.H. et al. Crystal structure of the human CD4 N-terminal two-domain fragment complexed to a class II MHC molecule. Proc. Natl. Acad. Sci. USA98, 10799–10804 (2001). CAS Google Scholar
Sim, B.C., Zerva, L., Greene, M.I. & Gascoigne, N.R. Control of MHC restriction by TCR Vα CDR1 and CDR2. Science273, 963–966 (1996). CAS Google Scholar
Savage, P.A. & Davis, M.M. A kinetic window constricts the T cell receptor repertoire in the thymus. Immunity14, 243–252 (2001). CAS Google Scholar
Busch, D.H. & Pamer, E.G. T cell affinity maturation by selective expansion during infection. J. Exp. Med.189, 701–710 (1999). CAS Google Scholar
Appel, H., Gauthier, L., Pyrdol, J. & Wucherpfennig, K.W. Kinetics of T-cell receptor binding by bivalent HLA-DR peptide complexes that activate antigen-specific human T-cells. J. Biol. Chem.275, 312–321 (2000). CAS Google Scholar
Monks, C.R., Freiberg, B.A., Kupfer, H., Sciaky, N. & Kupfer, A. Three-dimensional segregation of supramolecular activation clusters in T cells. Nature395, 82–86 (1998). CAS Google Scholar
Grakoui, A. et al. The immunological synapse: a molecular machine controlling T cell activation. Science285, 221–227 (1999). CAS Google Scholar
Ehrlich, L.I., Ebert, P.J., Krummel, M.F., Weiss, A. & Davis, M.M. Dynamics of p56lck translocation to the T cell immunological synapse following agonist and antagonist stimulation. Immunity17, 809–822 (2002). CAS Google Scholar
Richie, L.I. et al. Imaging synapse formation during thymocyte selection: inability of CD3ζ to form a stable central accumulation during negative selection. Immunity16, 595–606 (2002). CAS Google Scholar
Wucherpfennig, K.W. & Strominger, J.L. Molecular mimicry in T cell-mediated autoimmunity: viral peptides activate human T cell clones specific for myelin basic protein. Cell80, 695–705 (1995). CAS Google Scholar
Maynard, J. et al. Structure of an autoimmune T cell receptor complexed with class II peptide-MHC; insights into MHC bias and antigen specificity. Immunity22, 81–92 (2005). CAS Google Scholar
Smith, K.J., Pyrdol, J., Gauthier, L., Wiley, D.C. & Wucherpfennig, K.W. Crystal structure of HLA-DR2 (DRA*0101, DRB1*1501) complexed with a peptide from human myelin basic protein. J. Exp. Med.188, 1511–1520 (1998). CAS Google Scholar
Otwinowski, Z. & Minor, W. Processing of X-ray diffraction data collected in oscillation mode. Meth. Enzymol.276, 307–326 (1997). CAS Google Scholar
Storoni, L.C., McCoy, A.J. & Read, R.J. Likelihood-enhanced fast rotation functions. Acta Crystallogr. D Biol. Crystallogr.60, 432–438 (2004). Google Scholar
Sundberg, E.J. et al. Structures of two streptococcal superantigens bound to TCR beta chains reveal diversity in the architecture of T cell signaling complexes. Structure (Camb.)10, 687–699 (2002). CAS Google Scholar
Brunger, A.T. et al. Crystallography & NMR system: A new software suite for macromolecular structure determination. Acta Crystallogr. D Biol. Crystallogr.54, 905–921 (1998). CAS Google Scholar
Jones, T.A., Zou, J.Y., Cowan, S.W. & Kjeldgaard . Improved methods for building protein models in electron density maps and the location of errors in these models. Acta Crystallogr. A47, 110–119 (1991). Google Scholar