Inhibitors of γ-secretase block in vivo and in vitro T helper type 1 polarization by preventing Notch upregulation of Tbx21 (original) (raw)

• Baron, M. An overview of the Notch signaling pathway. Semin. Cell Dev. Biol. 14, 113–119 (2003).
  CAS PubMed Google Scholar
• De Strooper, B. et al. A presenilin-1-dependent γ-secretase-like protease mediates release of Notch intracellular domain. Nature 398, 518–522 (1999).
  CAS PubMed Google Scholar
• Struhl, G. & Adachi, A. Nuclear access and action of notch in vivo . Cell 93, 649–660 (1998).
  CAS PubMed Google Scholar
• Kopan, R. & Ilagan, M.X. γ-secretase: proteasome of the membrane? Nat. Rev. Mol. Cell Biol. 5, 499–504 (2004).
  CAS PubMed Google Scholar
• Radtke, F., Wilson, A., Mancini, S.J.C. & MacDonald, R. Notch regulation of lymphocyte development and function. Nat. Immunol. 5, 247–253 (2004).
  CAS PubMed Google Scholar
• Adler, S.H. et al. Notch signaling augments T cell responsiveness by enhancing CD25 expression. J. Immunol. 171, 2896–2903 (2003).
  CAS PubMed Google Scholar
• Palaga, T., Miele, L., Golde, T.E. & Osborne, B.A. TCR-mediated Notch signaling regulates proliferation and IFN-γ production in peripheral T cells. J. Immunol. 171, 3019–3024 (2003).
  CAS PubMed Google Scholar
• Murphy, K.M. & Reiner, S.L. The lineage decisions of helper T cells. Nat. Rev. Immunol. 2, 933–944 (2002).
  CAS PubMed Google Scholar
• Maekawa, Y. et al. Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells. Immunity 19, 549–559 (2003).
  CAS PubMed Google Scholar
• Amsen, D. et al. Instruction of distinct CD4 T helper cell fates by different notch ligands on antigen-presenting cells. Cell 117, 515–526 (2004).
  CAS PubMed Google Scholar
• Szabo, S. et al. A novel transcription factor, t-bet, directs Th1 lineage commitment. Cell 100, 655–669 (2000).
  CAS PubMed Google Scholar
• Szabo, S. et al. Distinct effects of T-bet in Th1 lineage commitment and IFN-γ production in CD4 and CD8 T cells. Science 295, 338–342 (2002).
  CAS PubMed Google Scholar
• Afkarian, M. et al. T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells. Nat. Immunol. 3, 549–557 (2001).
  Google Scholar
• Mullen, A.C. et al. Role of T-bet in commitment of TH1 cells before IL-12-dependent selection. Science 292, 1907–1910 (2001).
  CAS PubMed Google Scholar
• Gavrilescu, L.C., Butcher, B.A., Del Rio, L., Taylor, G.A. & Denkers, E.Y. STAT1 is essential for antimicrobial effector function but dispensable for γ interferon production during Toxoplasma gondii infection. Infect. Immun. 72, 1257–1264 (2004).
  CAS PubMed PubMed Central Google Scholar
• Lovett-Racke, A.E. et al. Silencing t-bet defines a critical role in the differentiation of autoreactive T lymphocytes. Immunity 21, 719–731 (2004).
  CAS PubMed Google Scholar
• Bettelli, E. et al. Loss of t-bet but not STAT1 prevents the development of experimental autoimmune encephalomyelitis. J. Exp. Med. 200, 79–87 (2004).
  CAS PubMed PubMed Central Google Scholar
• Dal Canto, M.C., Melvold, R.V., Kim, B.S. & Miller, S.D. Two models of multiple sclerosis: experimental allergic encephalomyelitis (EAE) and Theiler's murine encephalomyelitis virus (TMEV) infection. A pathological and immunological comparison. Microsc. Res. Tech. 32, 215–229 (1995).
  CAS PubMed PubMed Central Google Scholar
• Szabo, S.J., Dighe, A.S., Gubler, U. & Murphy, K.M. Regulation of the interleukin (IL)-12R beta 2 subunit expression in developing T helper 1 (Th1) and Th2 cells. J. Exp. Med. 185, 817–824 (1997).
  CAS PubMed PubMed Central Google Scholar
• Cheng, P. et al. Notch-1 regulates NF-κB activity in hemopoietic progenitor cells. J. Immunol. 167, 4458–4467 (2001).
  CAS PubMed Google Scholar
• Tacchini-Cottier, F., Allenbach, C., Otten, L.A. & Radtke, F. Notch1 expression is not required for CD4+ T helper differentiation. Eur. J. Immunol. 34, 1588–1596 (2004).
  CAS PubMed Google Scholar
• Bird, J.J. et al. Helper T cell differentiation is controlled by the cell cycle. Immunity 9, 229–237 (1998).
  CAS PubMed Google Scholar
• Agarwal, S. & Rao, A. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9, 765–775 (1998).
  CAS PubMed Google Scholar
• Mullen, A.C. et al. Cell cycle controlling the silencing and functioning of mammalian activators. Curr. Biol. 11, 1695–1699 (2001).
  CAS PubMed Google Scholar
• Seki, N. et al. IL-4-induced GATA-3 expression is a time-restricted instruction switch for Th2 cell differentiation. J. Immunol. 172, 6158–6166 (2004).
  CAS PubMed Google Scholar
• Shuai, K. & Liu, B. Regulation of JAK-STAT signaling in the immune system. Nat. Rev. Immunol. 3, 900–911 (2003).
  CAS PubMed Google Scholar
• Sekimoto, T., Nakajima, K., Tachibana, T., Hirano, T. & Yoneda, Y. Interferon-γ-dependent nuclear import of Stat1 is mediated by the GTPase activity of Ran/TC4. J. Biol. Chem. 271, 31017–31020 (1996).
  CAS PubMed Google Scholar
• Thierfelder, W.E. et al. Requirement for Stat4 in interleukin-12-mediated responses of natural killer and T cells. Nature 382, 171–174 (1996).
  CAS PubMed Google Scholar
• Kaplan, M.H., Sun, Y.L., Hoey, T. & Grusby, M.J. Impaired IL-12 responses and enhanced development of Th2 cells in Stat4-deficient mice. Nature 382, 174–177 (1996).
  CAS PubMed Google Scholar
• Takeda, K. et al. Essential role of Stat6 in IL-4 signaling. Nature 380, 627–630 (1996).
  CAS PubMed Google Scholar
• Deftos, M.L., He, Y.-W., Ojala, E.W. & Bevan, M.J. Correlating Notch signaling with thymocyte maturation. Immunity 9, 777–786 (1998).
  CAS PubMed PubMed Central Google Scholar
• Lammich, S. et al. Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Aβ-like peptide. J. Biol. Chem. 277, 44754–44759 (2002).
  CAS PubMed Google Scholar
• Zhou, S. & Hayward, D. Nuclear localization of CBF1 is regulated by interactions with the SMRT corepressor complex. Mol. Cell. Biol. 21, 6222–6232 (2001).
  CAS PubMed PubMed Central Google Scholar
• Nam, Y., Weng, A.P., Aster, J.C. & Blacklow, S.C. Structural requirements for assembly of the CSL-intracellular Notch1-Mastermind-like1 transcriptional activation complex. J. Biol. Chem. 278, 21232–21239 (2003).
  CAS PubMed Google Scholar
• Weinmann, A.S. Novel ChIP-based strategies to uncover transcription factor target genes in the immune system. Nat. Rev. Immunol. 4, 381–386 (2004).
  CAS PubMed Google Scholar
• Barth, H. et al. Analysis of immunoregulatory T-helper cell subsets in patients with multiple sclerosis: relapsing-progressive course correlates with enhanced Th1, relapsing-remitting course with enhanced Th0 reactivity. J. Neuroimmunol. 133, 175–183 (2002).
  CAS PubMed Google Scholar
• Parronchi, P. et al. Type 1 T-helper cell predominance and interleukin-12 expression in the gut of patients with Crohn's disease. Am. J. Pathol. 150, 823–832 (1997).
  CAS PubMed PubMed Central Google Scholar
• Hartung, A.D. et al. Th-2 mediated atopic disease protection in Th1-mediated rheumatoid arthritis. Clin. Exp. Rheumatol. 21, 481–484 (2003).
  CAS PubMed Google Scholar
• Larche, M., Robinson, D.S. & Kay, A.B. The role of T lymphocytes in the pathogenesis of asthma. J. Allergy Clin. Immunol. 111, 450–463 (2003).
  CAS PubMed Google Scholar
• Tanigaki, K. et al. Regulation of αβ/γδ T cell lineage commitment and peripheral T cell responses by Notch/RBP-J signaling. Immunity 20, 611–622 (2004).
  CAS PubMed Google Scholar
• Zhang, Z. et al. Presenilins are required for γ-secretase cleavage of β-APP and transmembrane cleavage of Notch-1. Nat. Cell Biol. 2, 463–465 (2000).
  CAS PubMed Google Scholar
• Berezovska, O. et al. Notch1 and amyloid precursor protein are competitive substrates for presenilin1-dependent gamma-secretase cleavage. J. Biol. Chem. 276, 30018–30023 (2001).
  CAS PubMed Google Scholar
• Kipnis, A., Basaraba, R.J., Turner, J. & Orme, I.M. Increased neutrophil influx but no impairment of protective immunity to tuberclosis in mice lacking the CD44 molecule. J. Leukoc. Biol. 74, 992–997 (2003).
  CAS PubMed Google Scholar
• Wong, K.K. et al. Notch ligation by Delta1 inhibits peripheral immune responses to transplantation antigens by a CD8+ cell-dependent mechanism. J. Clin. Invest. 112, 1741–1750 (2003).
  CAS PubMed PubMed Central Google Scholar
• Mizutani, T., Taniguchi, Y., Aoki, T., Hashimoto, N. & Honjo, T. Conservation of the biochemical mechanisms of signal transduction among mammalian Notch family members. Proc. Natl. Acad. Sci. USA 98, 9026–9031 (2001).
  CAS PubMed PubMed Central Google Scholar
• Siemers, E. et al. Effect of LY450139, a functional γ-secretase inhibitor, on plasma and cerebrospinal fluid concentrations of A-β and cognitive functioning in patients with mild to moderate Alzheimer's disease. Neurology 62, A174 Abstract S17.001 (2004).
  Google Scholar
• Lanz, T.A., Hosley, J.D., Adams, W.J. & Merchant, K.M. Studies of Aβ pharmacodynamics in the brain, cerebrospinal fluid, and plasma in young (plaque-free) Tg2576 mice using the gamma-secretase inhibitor N2-[(2S)-2-(3,5-difluorophenyl)-2-hydroxyethanoyl]-N1-[(7S)-5-methyl-6-oxo-6,7-dihydro-5H-dibenzo[b,d]azepin-7-yl]-L-alaninamide (LY-411575). J. Pharmacol. Exp. Ther. 309, 49–55 (2004).
  CAS PubMed Google Scholar
• Anderson, G., Pongracz, J., Parnell, S. & Jenkinson, E.J. Notch ligand-bearing thymic epithelial cells initiate and sustain Notch signaling in thymocytes independently of T cell receptor signaling. Eur. J. Immunol. 31, 3349–3354 (2001).
  CAS PubMed Google Scholar