Intracellular localization of Toll-like receptor 9 prevents recognition of self DNA but facilitates access to viral DNA (original) (raw)
Akira, S., Takeda, K. & Kaisho, T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nat. Immunol.2, 675–680 (2001). ArticleCAS Google Scholar
Janeway, C.A., Jr. Approaching the asymptote? Evolution and revolution in immunology. Cold Spring Harb. Symp. Quant. Biol.54, 1–13 (1989). ArticleCAS Google Scholar
Funami, K. et al. The cytoplasmic 'linker region' in Toll-like receptor 3 controls receptor localization and signaling. Int. Immunol.16, 1143–1154 (2004). ArticleCAS Google Scholar
Latz, E. et al. TLR9 signals after translocating from the ER to CpG DNA in the lysosome. Nat. Immunol.5, 190–198 (2004). ArticleCAS Google Scholar
Leifer, C.A. et al. TLR9 is localized in the endoplasmic reticulum prior to stimulation. J. Immunol.173, 1179–1183 (2004). ArticleCAS Google Scholar
Matsumoto, M. et al. Subcellular localization of Toll-like receptor 3 in human dendritic cells. J. Immunol.171, 3154–3162 (2003). ArticleCAS Google Scholar
Nagai, Y. et al. Essential role of MD-2 in LPS responsiveness and TLR4 distribution. Nat. Immunol.3, 667–672 (2002). ArticleCAS Google Scholar
Underhill, D.M. et al. The Toll-like receptor 2 is recruited to macrophage phagosomes and discriminates between pathogens. Nature401, 811–815 (1999). ArticleCAS Google Scholar
Ahmad-Nejad, P. et al. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol.32, 1958–1968 (2002). ArticleCAS Google Scholar
Hemmi, H. et al. A Toll-like receptor recognizes bacterial DNA. Nature408, 740–745 (2000). CAS Google Scholar
Hacker, H. et al. CpG-DNA-specific activation of antigen-presenting cells requires stress kinase activity and is preceded by non-specific endocytosis and endosomal maturation. EMBO J.17, 6230–6240 (1998). ArticleCAS Google Scholar
Leadbetter, E.A. et al. Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors. Nature416, 603–607 (2002). ArticleCAS Google Scholar
Viglianti, G.A. et al. Activation of autoreactive B cells by CpG dsDNA. Immunity19, 837–847 (2003). ArticleCAS Google Scholar
Poltorak, A. et al. Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in Tlr4 gene. Science282, 2085–2088 (1998). ArticleCAS Google Scholar
Qureshi, S.T. et al. Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (Tlr4). J. Exp. Med.189, 615–625 (1999). ArticleCAS Google Scholar
Krieg, A.M. et al. CpG motifs in bacterial DNA trigger direct B-cell activation. Nature374, 546–549 (1995). ArticleCAS Google Scholar
Nishiya, T. & DeFranco, A.L. Ligand-regulated chimeric receptor approach reveals distinctive subcellular localization and signaling properties of the Toll-like receptors. J. Biol. Chem.279, 19008–19017 (2004). ArticleCAS Google Scholar
Lund, J., Sato, A., Akira, S., Medzhitov, R. & Iwasaki, A. Toll-like receptor 9-mediated recognition of herpes simplex virus-2 by plasmacytoid dendritic cells. J. Exp. Med.198, 513–520 (2003). ArticleCAS Google Scholar
Krug, A. et al. Herpes simplex virus type 1 activates murine natural interferon-producing cells through Toll-like receptor 9. Blood103, 1433–1437 (2004). ArticleCAS Google Scholar
Krug, A. et al. TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function. Immunity21, 107–119 (2004). ArticleCAS Google Scholar
Tabeta, K. et al. Toll-like receptors 9 and 3 as essential components of innate immune defense against mouse cytomegalovirus infection. Proc. Natl. Acad. Sci. USA101, 3516–3521 (2004). ArticleCAS Google Scholar
Gilliet, M. et al. The development of murine plasmacytoid dendritic cell precursors is differentially regulated by FLT3-ligand and granulocyte/macrophage colony-stimulating factor. J. Exp. Med.195, 953–958 (2002). ArticleCAS Google Scholar
Honda, K. et al. Spatiotemporal regulation of MyD88-IRF-7 signalling for robust type-I interferon induction. Nature434, 1035–1040 (2005). ArticleCAS Google Scholar
Krieg, A.M. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol.20, 709–760 (2002). ArticleCAS Google Scholar
Shlomchik, M.J., Craft, J.E. & Mamula, M.J. From T to B and back again: positive feedback in systemic autoimmune disease. Nat. Rev. Immunol.1, 147–153 (2001). ArticleCAS Google Scholar
Boule, M.W. et al. Toll-like receptor 9-dependent and -independent dendritic cell activation by chromatin-immunoglobulin G complexes. J. Exp. Med.199, 1631–1640 (2004). ArticleCAS Google Scholar
Spitzer, S. & Eckstein, F. Inhibition of deoxyribonucleases by phosphorothioate groups in oligodeoxyribonucleotides. Nucleic Acids Res.16, 11691–11704 (1988). ArticleCAS Google Scholar
Napirei, M. et al. Features of systemic lupus erythematosus in DNase1-deficient mice. Nat. Genet.25, 177–181 (2000). ArticleCAS Google Scholar
Yasutomo, K. et al. Mutation of DNASE1 in people with systemic lupus erythematosus. Nat. Genet.28, 313–314 (2001). ArticleCAS Google Scholar
Reggiori, F. & Pelham, H.R. A transmembrane ubiquitin ligase required to sort membrane proteins into multivesicular bodies. Nat. Cell Biol.4, 117–123 (2002). ArticleCAS Google Scholar
Diebold, S.S., Kaisho, T., Hemmi, H., Akira, S. & Reis e Sousa, C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science303, 1529–1531 (2004). ArticleCAS Google Scholar
Lund, J.M. et al. Recognition of single-stranded RNA viruses by Toll-like receptor 7. Proc. Natl. Acad. Sci. USA101, 5598–5603 (2004). ArticleCAS Google Scholar
Horng, T., Barton, G.M. & Medzhitov, R. TIRAP: an adapter molecule in the Toll signaling pathway. Nat. Immunol.2, 835–841 (2001). ArticleCAS Google Scholar
Barton, G.M. & Medzhitov, R. Retroviral delivery of small interfering RNA into primary cells. Proc. Natl. Acad. Sci. USA99, 14943–14945 (2002). ArticleCAS Google Scholar