CD45 links the B cell receptor with cell survival and is required for the persistence of germinal centers (original) (raw)

• Cyster, J.G. Chemokines, sphingosine-1-phosphate, and cell migration in secondary lymphoid organs. Annu. Rev. Immunol. 23, 127–159 (2005).
  Article CAS Google Scholar
• van Kooten, C. & Banchereau, J. CD40–CD40 ligand. J. Leukoc. Biol. 67, 2–17 (2000).
  Article CAS Google Scholar
• Tarlinton, D. Germinal centers: form and function. Curr. Opin. Immunol. 10, 245–251 (1998).
  Article CAS Google Scholar
• Wolniak, K.L., Shinall, S.M. & Waldschmidt, T.J. The germinal center response. Crit. Rev. Immunol. 24, 39–65 (2004).
  Article CAS Google Scholar
• Liu, Y.J. et al. Mechanism of antigen-driven selection in germinal centres. Nature 342, 929–931 (1989).
  Article CAS Google Scholar
• Lane, P. et al. Soluble CD40 ligand can replace the normal T cell–derived CD40 ligand signal to B cells in T cell–dependent activation. J. Exp. Med. 177, 1209–1213 (1993).
  Article CAS Google Scholar
• Grillot, D.A. et al. Bcl-x exhibits regulated expression during B cell development and activation and modulates lymphocyte survival in transgenic mice. J. Exp. Med. 183, 381–391 (1996).
  Article CAS Google Scholar
• Lanzavecchia, A. & Sallusto, F. Progressive differentiation and selection of the fittest in the immune response. Nat. Rev. Immunol. 2, 982–987 (2002).
  Article CAS Google Scholar
• Thomas, M.L. The regulation of B- and T-lymphocyte activation by the transmembrane protein tyrosine phosphatase CD45. Curr. Opin. Cell Biol. 6, 247–252 (1994).
  Article CAS Google Scholar
• Huntington, N.D. & Tarlinton, D.M. CD45: direct and indirect government of immune regulation. Immunol. Lett. 94, 167–174 (2004).
  Article CAS Google Scholar
• Pani, G., Siminovitch, K.A. & Paige, C.J. The motheaten mutation rescues B cell signaling and development in CD45-deficient mice. J. Exp. Med. 186, 581–588 (1997).
  Article CAS Google Scholar
• Kishihara, K. et al. Normal B lymphocyte development but impaired T cell maturation in CD45-exon6 protein tyrosine phosphatase-deficient mice. Cell 74, 143–156 (1993).
  Article CAS Google Scholar
• Benatar, T. et al. Immunoglobulin-mediated signal transduction in B cells from CD45-deficient mice. J. Exp. Med. 183, 329–334 (1996).
  Article CAS Google Scholar
• Cyster, J.G. et al. Regulation of B-lymphocyte negative and positive selection by tyrosine phosphatase CD45. Nature 381, 325–328 (1996).
  Article CAS Google Scholar
• Byth, K.F. et al. CD45-null transgenic mice reveal a positive regulatory role for CD45 in early thymocyte development, in the selection of CD4+CD8+ thymocytes, and B cell maturation. J. Exp. Med. 183, 1707–1718 (1996).
  Article CAS Google Scholar
• Kong, Y.Y. et al. Differential requirements of CD45 for lymphocyte development and function. Eur. J. Immunol. 25, 3431–3436 (1995).
  Article CAS Google Scholar
• Mee, P.J. et al. Greatly reduced efficiency of both positive and negative selection of thymocytes in CD45 tyrosine phosphatase-deficient mice. Eur. J. Immunol. 29, 2923–2933 (1999).
  Article CAS Google Scholar
• Niiro, H. & Clark, E.A. Regulation of B-cell fate by antigen-receptor signals. Nat. Rev. Immunol. 2, 945–956 (2002).
  Article CAS Google Scholar
• Baeuerle, P.A. & Baltimore, D. NF-κB: ten years after. Cell 87, 13–20 (1996).
  Article CAS Google Scholar
• Grumont, R.J., Rourke, I.J. & Gerondakis, S. Rel-dependent induction of A1 transcription is required to protect B cells from antigen receptor ligation-induced apoptosis. Genes Dev. 13, 400–411 (1999).
  Article CAS Google Scholar
• Allen, D. et al. Timing, genetic requirements and functional consequences of somatic hypermutation during B-cell development. Immunol. Rev. 96, 5–22 (1987).
  Article CAS Google Scholar
• Rahman, Z.S., Rao, S.P., Kalled, S.L. & Manser, T. Normal induction but attenuated progression of germinal center responses in BAFF and BAFF-R signaling-deficient mice. J. Exp. Med. 198, 1157–1169 (2003).
  Article CAS Google Scholar
• Kitamura, D., Roes, J., Kuhn, R. & Rajewsky, K.A. B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene. Nature 350, 423–426 (1991).
  Article CAS Google Scholar
• MacLennan, I.C. Germinal centers. Annu. Rev. Immunol. 12, 117–139 (1994).
  Article CAS Google Scholar
• Van Parijs, L., Refaeli, Y., Abbas, A.K. & Baltimore, D. Autoimmunity as a consequence of retrovirus-mediated expression of C-FLIP in lymphocytes. Immunity 11, 763–770 (1999).
  Article CAS Google Scholar
• Rickert, R.C., Rajewsky, K. & Roes, J. Impairment of T cell–dependent B cell responses and B-1 cell development in CD19-deficient mice. Nature 376, 352–355 (1995).
  Article CAS Google Scholar
• Ridderstad, A. & Tarlinton, D.M. Kinetics of establishing the memory B cell population as revealed by CD38 expression. J. Immunol. 160, 4688–4695 (1998).
  CAS PubMed Google Scholar
• Xu, Y., Beavitt, S.J., Harder, K.W., Hibbs, M.L. & Tarlinton, D.M. The activation and subsequent regulatory roles of Lyn and CD19 after B cell receptor ligation are independent. J. Immunol. 169, 6910–6918 (2002).
  Article CAS Google Scholar
• Smith, K.G., Tarlinton, D.M., Doody, G.M., Hibbs, M.L. & Fearon, D.T. Inhibition of the B cell by CD22: a requirement for Lyn. J. Exp. Med. 187, 807–811 (1998).
  Article CAS Google Scholar
• Cornall, R.J. et al. Polygenic autoimmune traits: Lyn, CD22, and SHP-1 are limiting elements of a biochemical pathway regulating BCR signaling and selection. Immunity 8, 497–508 (1998).
  Article CAS Google Scholar
• Trowbridge, I.S. & Thomas, M.L. CD45: an emerging role as a protein tyrosine phosphatase required for lymphocyte activation and development. Annu. Rev. Immunol. 12, 85–116 (1994).
  Article CAS Google Scholar
• Shrivastava, P., Katagiri, T., Ogimoto, M., Mizuno, K. & Yakura, H. Dynamic regulation of Src-family kinases by CD45 in B cells. Blood 103, 1425–1432 (2004).
  Article CAS Google Scholar
• Odom, S. et al. Negative regulation of immunoglobulin E-dependent allergic responses by Lyn kinase. J. Exp. Med. 199, 1491–1502 (2004).
  Article CAS Google Scholar
• Datta, S.R. et al. Akt phosphorylation of BAD couples survival signals to the cell-intrinsic death machinery. Cell 91, 231–241 (1997).
  Article CAS Google Scholar
• Han, S. et al. Cellular interaction in germinal centers. Roles of CD40 ligand and B7-2 in established germinal centers. J. Immunol. 155, 556–567 (1995).
  CAS PubMed Google Scholar
• Ghia, P. et al. Unbalanced expression of bcl-2 family proteins in follicular lymphoma: contribution of CD40 signaling in promoting survival. Blood 91, 244–251 (1998).
  CAS PubMed Google Scholar
• Tuscano, J.M. et al. Bcl-x rather than Bcl-2 mediates CD40-dependent centrocyte survival in the germinal center. Blood 88, 1359–1364 (1996).
  CAS PubMed Google Scholar
• Basso, K. et al. Tracking CD40 signaling during germinal center development. Blood 104, 4088–4096 (2004).
  Article CAS Google Scholar
• Foy, T.M. et al. gp39–CD40 interactions are essential for germinal center formation and the development of B cell memory. J. Exp. Med. 180, 157–163 (1994).
  Article CAS Google Scholar
• Ridderstad, A., Nossal, G.J. & Tarlinton, D.M. The xid mutation diminishes memory B cell generation but does not affect somatic hypermutation and selection. J. Immunol. 157, 3357–3365 (1996).
  CAS PubMed Google Scholar
• Kim, N., Martin, T.E., Simon, M.C. & Storb, U. The transcription factor Spi-B is not required for somatic hypermutation. Mol. Immunol. 39, 577–583 (2003).
  Article CAS Google Scholar
• Wang, J.H. et al. Aiolos regulates B cell activation and maturation to effector state. Immunity 9, 543–553 (1998).
  Article CAS Google Scholar
• Cortes, M. & Georgopoulos, K. Aiolos is required for the generation of high-affinity bone marrow plasma cells responsible for long-term immunity. J. Exp. Med. 199, 209–219 (2004).
  Article CAS Google Scholar
• Smith, K.G., Light, A., Nossal, G.J. & Tarlinton, D.M. The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response. EMBO J. 16, 2996–3006 (1997).
  Article CAS Google Scholar
• Ng, L.G. et al. B cell-activating factor belonging to the TNF family (BAFF)-R is the principal BAFF receptor facilitating BAFF costimulation of circulating T and B cells. J. Immunol. 173, 807–817 (2004).
  Article CAS Google Scholar
• McHeyzer-Williams, M.G., Nossal, G.J. & Lalor, P.A. Molecular characterization of single memory B cells. Nature 350, 502–505 (1991).
  Article CAS Google Scholar
• Janas, M.L., Hodgkin, P., Hibbs, M. & Tarlinton, D. Genetic evidence for Lyn as a negative regulator of IL-4 signaling. J. Immunol. 163, 4192–4198 (1999).
  CAS PubMed Google Scholar
• Hasbold, J. et al. Quantitative analysis of lymphocyte differentiation and proliferation in vitro using carboxyfluorescein diacetate succinimidyl ester. Immunol. Cell Biol. 77, 516–522 (1999).
  Article CAS Google Scholar
• Lalor, P.A., Nossal, G.J., Sanderson, R.D. & McHeyzer-Williams, M.G. Functional and molecular characterization of single, (4-hydroxy-3-nitrophenyl)acetyl (NP)-specific, IgG1+ B cells from antibody-secreting and memory B cell pathways in the C57BL/6 immune response to NP. Eur. J. Immunol. 22, 3001–3011 (1992).
  Article CAS Google Scholar
• Pulendran, B., Karvelas, M. & Nossal, G.J. A form of immunologic tolerance through impairment of germinal center development. Proc. Natl. Acad. Sci. USA 91, 2639–2643 (1994).
  Article CAS Google Scholar
• Nossal, G.J., Karvelas, M. & Pulendran, B. Soluble antigen profoundly reduces memory B-cell numbers even when given after challenge immunization. Proc. Natl. Acad. Sci. USA 90, 3088–3092 (1993).
  Article CAS Google Scholar
• Huang, D.C., Cory, S. & Strasser, A. Bcl-2, Bcl-xL and adenovirus protein E1B19kD are functionally equivalent in their ability to inhibit cell death. Oncogene 14, 405–414 (1997).
  Article CAS Google Scholar
• Kinsella, T.M. & Nolan, G.P. Episomal vectors rapidly and stably produce high-titer recombinant retrovirus. Hum. Gene Ther. 7, 1405–1413 (1996).
  Article CAS Google Scholar
• Chen, L. et al. Differential targeting of prosurvival Bcl-2 proteins by their BH3-only ligands allows complementary apoptotic function. Mol. Cell 17, 393–403 (2005).
  Article CAS Google Scholar