A structural basis for complement inhibition by Staphylococcus aureus (original) (raw)

References

  1. Therapeutic Intervention in the Complement System (eds. Lambris, J.D. & Holers, V.M.) (Humana, Totowa, New Jersey, 2000).
  2. Morikis, D. & Lambris, J.D. Structural Biology of the Complement System (eds. Morikis, D. & Lambris, J.D.) (Taylor & Francis, Boca Raton, Florida, 2005).
    Book Google Scholar
  3. The Human Complement System in Health and Diseases (eds. Volanakis, J.E. & Frank, M.) (Marcel Dekker, New York 1998).
  4. Patti, J.M., Allen, B.L., McGavin, M.J. & Hook, M. MSCRAMM mediated adherence of microorganisms to host tissues. Annu. Rev. Microbiol. 48, 585–617 (1994).
    Article CAS Google Scholar
  5. Chavakis, T. et al. Staphylococcus aureus extracellular adherence protein serves as anti-inflammatory factor by inhibiting the recruitment of host leukocytes. Nat. Med. 8, 687–693 (2002).
    Article CAS Google Scholar
  6. Lee, L.Y. et al. The Staphylococcus aureus Map protein is an immunomodulator that interferes with T cell-mediated responses. J. Clin. Invest. 110, 1461–1471 (2002).
    Article CAS Google Scholar
  7. Lee, L.Y.L. et al. Inhibition of complement activation by a secreted Staphylococcus aureus protein. J. Infect. Dis. 190, 571–579 (2004).
    Article CAS Google Scholar
  8. Lee, L.Y.L., Liang, X., Hook, M. & Brown, E.L. Identification and characterization of the C3 binding domain of the Staphylococcus aureus extracellular fibrinogen-binding protein (Efb). J. Biol. Chem. 279, 50710–50716 (2004).
    Article CAS Google Scholar
  9. Rooijakkers, S.H. et al. Immune evasion by a staphylococcal complement inhibitor that acts on C3 convertases. Nat. Immunol. 6, 920–927 (2005).
    Article CAS Google Scholar
  10. Hornef, M.W., Wick, M.J., Rhen, M. & Normark, S. Bacterial strategies for overcoming host innate and adaptive immune response. Nat. Immunol. 3, 1033–1040 (2002).
    Article CAS Google Scholar
  11. Sahu, A. & Lambris, J.D. Structure and biology of complement protein 3, a connecting link between innate and acquired immunity. Immunol. Rev. 180, 35–48 (2001).
    Article CAS Google Scholar
  12. Neth, O., Jack, D.L., Johnson, M., Klein, N.J. & Turner, M.W. Enhancement of complement activation and opsonophagocytosis by complexes of mannose-binding lectin with mannose-binding lectin-associated serine protease after binding to Staphylococcus aureus. J. Immunol. 169, 4430–4436 (2002).
    Article CAS Google Scholar
  13. Kawasaki, A. et al. Activation of the human complement cascade by bacterial cell walls, peptidoglycans, water-soluble peptidoglycan components, and synthetic muramylpeptides - studies on active components and structural requirements. Microbiol. Immunol. 31, 551–569 (1987).
    Article CAS Google Scholar
  14. Bredius, R.G., Driedijk, P.C., Schouten, M.F., Weening, R.S. & Out, T.A. Complement activation by polyclonal immunoglobulin G1 and G2 antibodies against Staphylococcus aureus, Haemophilus influenzae type B, and tetanus toxoid. Infect. Immun. 60, 4838–4847 (1992).
    CAS PubMed PubMed Central Google Scholar
  15. Verbrugh, H.A., Van Dijk, W.C., Peters, R., Van Der Tol, M.E. & Verhoef, J. The role of Staphylococcus aureus cell-wall peptidoglycan, teichoic acid, and protein A in the processes of complement activation and opsonization. Immunology 37, 615–621 (1979).
    CAS PubMed PubMed Central Google Scholar
  16. Wilkinson, B.J., Kim, Y., Peterson, P.K., Quie, P.G. & Michael, A.F. Activation of complement by cell surface components of Staphylococcus aureus. Infect. Immun. 20, 388–392 (1978).
    CAS PubMed PubMed Central Google Scholar
  17. Sakiniene, E., Bremell, T. & Tarkowski, A. Complement depletion aggravates Staphylococcus aureus septicaemia and septic arthritis. Clin. Exp. Immunol. 115, 95–102 (1999).
    Article CAS Google Scholar
  18. Palma, M., Nozohoor, S., Schennings, T., Heimdahl, A. & Flock, J.-I. Lack of the extracellular 19-kilodalton fibrinogen-binding protein from Staphylococcus aureus decreases virulence in experimental wound infection. Infect. Immun. 64, 5284–5289 (1996).
    CAS PubMed PubMed Central Google Scholar
  19. Nagar, B., Jones, R.G., Diefenbach, R.J., Isenman, D.E. & Rini, J.M. X-ray crystal structure of C3d: aC3 fragment and ligand for complement receptor 2. Science 280, 1277–1281 (1998).
    Article CAS Google Scholar
  20. Harboe, M., Ulvund, G., Vien, L., Fung, M. & Mollnes, T.E. The quantitative role of alternative pathway amplification in classical pathway induced terminal complement activation. Clin. Exp. Immunol. 138, 439–446 (2004).
    Article CAS Google Scholar
  21. Hack, C.E. et al. Disruption of the internal thioester bond in the third component of complement, (C3) which results in the exposure of neodeterminants also present on activation products of C3. An analysis with monoclonal antibodies. J. Immunol. 141, 1602–1609 (1988).
    CAS PubMed Google Scholar
  22. Nishida, N., Walz, T. & Springer, T.A. Structural transitions of complement component C3 and its activation products. Proc. Natl. Acad. Sci. USA 103, 19737–19742 (2006).
    Article CAS Google Scholar
  23. Janssen, B.J.C. et al. Structures of complement component C3 provide insights into the function and evolution of immunity. Nature 437, 505–511 (2005).
    Article CAS Google Scholar
  24. Janssen, B.J., Christodoulidou, A., McCarthy, A., Lambris, J.D. & Gros, P. Structure of C3b reveals conformational changes that underlie complement activity. Nature 444, 213–216 (2006).
    Article CAS Google Scholar
  25. Isenman, D.E. & Cooper, N.R. The structure and function of the third component of human complement 1. The nature and extent of conformational changes accompanying C3 activation. Mol. Immunol. 18, 331–339 (1981).
    Article CAS Google Scholar
  26. Isenman, D.E., Kells, D.I.C., Cooper, N.R., Muller-Eberhard, H.J. & Pangburn, M.K. Nucleophilic modification of human complement component protein C3: correlation of conformational changes with acquisition of C3b-like functional properties. Biochemistry 20, 4458–4467 (1981).
    Article CAS Google Scholar
  27. Isenman, D.E. Conformational changes accompanying proteolytic cleavage of human complement protein C3b by the regulatory enzyme factor I and its cofactor H. Spectroscopic and enzymological studies. J. Biol. Chem. 258, 4238–4244 (1983).
    CAS PubMed Google Scholar
  28. Nilsson, B. et al. Confomational differences between surface-bound and fluid-phase complement component-C3 fragments. Epitope mapping by cDNA expression. Biochem. J. 282, 715–721 (1992).
    Article CAS Google Scholar
  29. Winters, M.S., Spellman, D.S. & Lambris, J.D. Solvent accessibility of native and hydrolyzed human complement component 3 analyzed by hydrogen/deuterium exchange and mass spectrometry. J. Immunol. 174, 3469–3474 (2005).
    Article CAS Google Scholar
  30. Lindahl, G., Sjobring, U. & Johnsson, E. Human complement regulators: a major target for pathogenic microorganisms. Curr. Opin. Immunol. 12, 44–51 (2000).
    Article CAS Google Scholar
  31. Zipfel, P.F. et al. Factor H family proteins: on complement, microbes and human diseases. Biochem. Soc. Trans. 30, 971–978 (2002).
    Article CAS Google Scholar
  32. Hammel, M., Ramyar, K.X., Spencer, C.T. & Geisbrecht, B.V. Crystallization and X-ray diffraction analysis of the complement component-3 (C3) inhibitory domain of Efb from Staphylococcus aureus. Acta. Cryst. F. 62, 285–288 (2006).
    Article CAS Google Scholar
  33. Terwilliger, T.C. & Berendzen, J. Automated MAD and MIR structure solution. Acta Crystallogr. D Biol. Crystallogr. 55, 849–861 (1999).
    Article CAS Google Scholar
  34. Terwilliger, T.C. Maximum likelihood density modification. Acta Crystallogr. D Biol. Crystallogr. 56, 965–972 (2000).
    Article CAS Google Scholar
  35. Terwilliger, T.C. Automated main-chain model-building by template-matching and interative fragment extension. Acta Crystallogr. D Biol. Crystallogr. 59, 34–44 (2002).
    Google Scholar
  36. Jones, T.A., Zou, J.-Y., Cowan, S.W. & Kjeldgaard, M. Improved methods for the building of protein models in electron density maps and the location of errors in the models. Acta Crystallogr. D Biol. Crystallogr. 47, 110–119 (1991).
    Article Google Scholar
  37. Brunger, A.T. et al. Crystallography & NMR system: a new software suite for macromolecular structure determination. Acta Crystallogr. D Biol. Crystallogr. 54, 905–921 (1998).
    Article CAS Google Scholar
  38. Murshudov, G.N., Lebedev, A., Vagin, A.A., Wilson, K.S. & Dodson, E.J. Efficient anisotropic refinement of macromolecular structures using FFT. Acta Crystallogr. D Biol. Crystallogr. 55, 247–255 (1999).
    Article CAS Google Scholar
  39. Winn, M., Isupov, M. & Murshudov, G.N. Use of TLS parameters to model anisotropic displacments in macromolecular refinement. Acta Crystallogr. D Biol. Crystallogr. 57, 122–133 (2001).
    Article CAS Google Scholar
  40. The Collaborative Computational Crystallography Project 4. The CCP4 suite: programs for protein crystallography. Acta Cryst. D 50, 760–763 (1994).
  41. Nicholls, A., Sharp, K.A. & Honig, B. Protein folding and association: insights from the interfacial and thermodynamic properties of hydrocarbons. Proteins 11, 281–296 (1991).
    Article CAS Google Scholar
  42. Zemla, A. LGA: a method for finding 3D similarities in protein structures. Nucleic Acids Res. 31, 3370–3374 (2003).
    Article CAS Google Scholar
  43. Kraus, D., Medof, D.E. & Mold, C. Complementary recognition of alternative pathway activators by decay-accelerating factor and factor H. Infect. Immun. 66, 399–405 (1998).
    CAS PubMed PubMed Central Google Scholar
  44. Sfyroera, G., Katragadda, M., Morikis, D., Isaacs, S.N. & Lambris, J.D. Electrostatic modeling predicts the activities of orthopoxvirus complement control proteins. J. Immunol. 174, 2143–2151 (2005).
    Article CAS Google Scholar
  45. Becherer, J.D., Alsenz, J., Esparza, I., Hack, C.E. & Lambris, J.D. A segment spanning residues 727–768 of the complement C3 sequence contains a neoantigenic site and accomodates the binding of CR1, factor H, and factor B. Biochemistry 31, 1787–1794 (1992).
    Article CAS Google Scholar

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