Signaling via LTβR on the lamina propria stromal cells of the gut is required for IgA production (original) (raw)

• Brandtzaeg, P. et al. The B-cell system of human mucosae and exocrine glands. Immunol. Rev. 171, 45–87 (1999).
  Article CAS Google Scholar
• Weiner, H. et al. Oral tolerance: immunologic mechanisms and treatment of animal and human organ-specific autoimmune diseases by oral administration of autoantigens. Annu. Rev. Immunol. 12, 809–837 (1994).
  Article CAS Google Scholar
• Staats, H.F. et al. Mucosal immunity to infection with implications for vaccine development. Curr. Opin. Immunol. 6, 572–583 (1994).
  Article CAS Google Scholar
• Burrows, P.D. & Cooper, M.D. IgA deficiency. Adv. Immunol. 65, 245–276 (1997).
  Article CAS Google Scholar
• Macpherson, A.J. et al. A primitive T cell-independent mechanism of intestinal mucosal IgA responses to commensal bacteria. Science 288, 2222–2226 (2000).
  Article CAS Google Scholar
• Sandler, S.G., Mallory, D., Malamut, D. & Eckrich, R. IgA anaphylactic transfusion reactions. Transfus. Med. Rev. 9, 1–8 (1995).
  Article CAS Google Scholar
• Craig, S.W. & Cebra, J.J. Peyer's patches: an enriched source of precursors for IgA-producing immunocytes in the rabbit. J. Exp. Med. 134, 188–200 (1971).
  Article CAS Google Scholar
• Husband, A.J. & Gowans, J.L. The origin and antigen-dependent distribution of IgA-containing cells in the intestine. J. Exp. Med. 148, 1146–1160 (1978).
  Article CAS Google Scholar
• Yamamoto, M. et al. Alternate mucosal immune system: organized Peyer's patches are not required for IgA responses in the gastrointestinal tract. J. Immunol. 164, 5184–5191 (2000).
  Article CAS Google Scholar
• Spahn, T.W. et al. Induction of oral tolerance to cellular immune responses in the absence of Peyer's patches. Eur. J. Immunol. 31, 1278–1287 (2001).
  Article CAS Google Scholar
• Fagarasan, S., Kinoshita, K., Muramatsu, M., Ikuta, K. & Honjo, T. In situ class switching and differentiation to IgA-producing cells in the gut lamina propria. Nature 413, 639–643 (2001).
  Article CAS Google Scholar
• Brandtzaeg, P., Baekkevold, E.S. & Morton, H.C. From B to A the mucosal way. Nature Immunol. 2, 1093–1094 (2001).
  Article CAS Google Scholar
• Berland, R. & Wortis, H.H. Origins and functions of B-1 cells with notes on the role of CD5. Annu. Rev. Immunol. 20, 253–300 (2002).
  Article CAS Google Scholar
• Mowat, A.M. & Viney, J.L. The anatomical basis of intestinal immunity. Immunol. Rev. 156, 145–166 (1997).
  Article CAS Google Scholar
• Griebel, P.J. & Hein, W.R. Expanding the role of Peyer's patches in B-cell ontogeny. Immunol. Today 17, 30–39 (1996).
  Article CAS Google Scholar
• Husband, A.J., Bao, S. & Beagley, K.W. Analysis of the mucosal microenvironment: factors determining successful responses to mucosal vaccines. Vet. Immunol. Immunopathol. 72, 135–142 (1999).
  Article CAS Google Scholar
• Fujihashi, K. et al. Peyer's patches are required for oral tolerance to proteins. Proc. Natl. Acad. Sci. USA 98, 3310–3315 (2001).
  Article CAS Google Scholar
• Fagarasan, S. et al. Mechanism of B1 cell differentiation and migration in GALT. Curr. Top. Microbiol. Immunol. 252, 221–229 (2000).
  CAS PubMed Google Scholar
• Kroese, F.G., de Waard, R. & Bos, N. A. B-1 cells and their reactivity with the murine intestinal microflora. Semin. Immunol. 8, 11–18 (1996).
  Article CAS Google Scholar
• Auci, D.L., Chice, S.M., Heusser, C., Athanassiades, T.J. & Durkin, H.G. Origin and fate of IgE-bearing lymphocytes. II. Gut-associated lymphoid tissue as sites of first appearance of IgE-bearing B lymphocytes and hapten-specific IgE antibody-forming cells in mice immunized with benzylpenicilloyl-keyhole limpet hemocyanin by various routes: relation to asialo GM1 ganglioside+ cells and IgE/CD23 immune complexes. J. Immunol. 149, 2241–2248 (1992).
  CAS PubMed Google Scholar
• Fagarasan, S. et al. Alymphoplasia (aly)-type nuclear factor κB-inducing kinase (NIK) causes defects in secondary lymphoid tissue chemokine receptor signaling and homing of peritoneal cells to the gut-associated lymphatic tissue system. J. Exp. Med. 191, 1477–1486 (2000).
  Article CAS Google Scholar
• De Togni, P. et al. Abnormal development of peripheral lymphoid organs in mice deficient in lymphotoxin. Science 264, 703–707 (1994).
  Article CAS Google Scholar
• Banks, T.A. et al. Lymphotoxin-α-deficient mice: effects on secondary lymphoid organ development and humoral immune responsiveness. J. Immunol. 155, 1685–1693 (1995).
  CAS PubMed Google Scholar
• Fu, Y.X. & Chaplin, D.D. Development and maturation of secondary lymphoid tissues. Annu. Rev. Immunol. 17, 399–433 (1999).
  Article CAS Google Scholar
• Davis, I.A., Knight, K.A. & Rouse, B.T. The spleen and organized lymph nodes are not essential for the development of gut-induced mucosal immune responses in lymphotoxin- alpha deficient mice. Clin. Immunol. Immunopathol. 89, 150–159 (1998).
  Article CAS Google Scholar
• Ware, C., VanArsdale, T., Crowe, P. & Browning, J. The ligands and receptors of the lymphotoxin system. Curr. Top. Microbiol. Immunol. 198, 175–218 (1995).
  CAS PubMed Google Scholar
• Pasparakis, M. et al. Peyers patch organogenesis is intact yet formation of B lymphocyte follicles is defective in peripheral lymphoid organs of mice deficient for tumor necrosis factor and its 55-kDa receptor. Proc. Natl. Acad. Sci. USA 94, 6319–6323 (1997).
  Article CAS Google Scholar
• Ryffel, B., Le Hir, M., Muller, M. & Eugster, H.P. Correction of the TNF-LTα-deficient phenotype by bone marrow transplantation. Dev. Immunol. 6, 253–260 (1998).
  Article CAS Google Scholar
• Davis, I.A. & Rouse, B.T. Immune responsiveness of lymphotoxin-α-deficient mice: two reconstitution models. Cell. Immunol. 189, 116–124 (1998).
  Article CAS Google Scholar
• Ansel, K.M., Harris, R.B. & Cyster, J.G. CXCL13 is required for B1 cell homing, natural antibody production, and body cavity immunity. Immunity 16, 67–76 (2002).
  Article CAS Google Scholar
• Hamada, H. et al. Identification of multiple isolated lymphoid follicles on the antimesenteric wall of the mouse small intestine. J. Immunol. 168, 57–64 (2002).
  Article CAS Google Scholar
• Ngo, V.N. et al. Lymphotoxin α/β and tumor necrosis factor are required for stromal cell expression of homing chemokines in B and T cell areas of the spleen. J. Exp. Med. 189, 403–412 (1999).
  Article CAS Google Scholar
• Gunn, M.D. et al. A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1. Nature 391, 799–803 (1998).
  Article CAS Google Scholar
• Kunkel, E.J. & Butcher, E.C. Chemokines and the tissue-specific migration of lymphocytes. Immunity 16, 1–4 (2002).
  Article CAS Google Scholar
• Butcher, E.C. & Picker, L.J. Lymphocyte homing and homeostasis. Science 272, 60–66 (1996).
  Article CAS Google Scholar
• Mackay, F., Majeau, G.R., Lawton, P., Hochman, P.S. & Browning, J.L. Lymphotoxin but not tumor necrosis factor functions to maintain splenic architecture and humoral responsiveness in adult mice. Eur. J. Immunol. 27, 2033–2042 (1997).
  Article CAS Google Scholar
• Macpherson, A.J. et al. IgA production without μ or δ chain expression in developing B cells. Nature Immunol. 2, 625–631 (2001).
  Article CAS Google Scholar
• Futterer, A., Mink, K., Luz, A., Kosco-Vilbois, M.H. & Pfeffer, K. The lymphotoxin β receptor controls organogenesis and affinity maturation in peripheral lymphoid tissues. Immunity 9, 59–70 (1998).
  Article CAS Google Scholar
• Rennert, P.D., Browning, J.L., Mebius, R., Mackay, F. & Hochman, P.S. Surface lymphotoxinα/β complex is required for the development of peripheral lymphoid organs. J. Exp. Med. 184, 1999–2006 (1996).
  Article CAS Google Scholar
• Fu, Y.X. et al. Lymphotoxin-α (LTα) supports development of splenic follicular structure that is required for IgG responses. J. Exp. Med. 185, 2111–2120 (1997).
  Article CAS Google Scholar
• Wang, J. et al. The regulation of T cell homeostasis and autoimmunity by T cell derived LIGHT. J. Clin. Invest. 108,1771–1780 (2001).
  Article CAS Google Scholar
• Lefrancois, L. & Lycke, N. in Current Protocol Immunology Vol. 1 (ed. Coico, R.) 3.19.1–16 (John Wiley & Sons, New York, 1996).
  Google Scholar
• Guo, Z. et al. Cutting edge: membrane lymphotoxin regulates CD8+ T cell-mediated intestinal allograft rejection. J. Immunol. 167, 4796–4800 (2001).
  Article CAS Google Scholar