TCRs with high affinity for foreign pMHC show self-reactivity (original) (raw)

References

  1. Davis, M.M. & Bjorkman, P.J. T-cell antigen receptor genes and T-cell recognition. Nature 334, 395–402 (1988).
    CAS PubMed Google Scholar
  2. Goldrath, A.W. & Bevan, M.J. Selecting and maintaining a diverse T-cell repertoire. Nature 402, 255–262 (1999).
    CAS PubMed Google Scholar
  3. Sherman, L.A. et al. Self-tolerance and the composition of T cell repertoire. Immunol. Res. 21, 305–313 (2000).
    CAS PubMed Google Scholar
  4. Zerrahn, J., Held, W. & Raulet, D.H. The MHC reactivity of the T cell repertoire prior to positive and negative selection. Cell 88, 627–636 (1997).
    CAS PubMed Google Scholar
  5. Alam, S.M. et al. T cell receptor affinity and thymocyte positive selection. Nature 381, 616–620 (1996).
    CAS Google Scholar
  6. Evavold, B.D., Sloan-Lancaster, J., Wilson, K.J., Rothbard, J.B. & Allen, P.M. Specific T cell recognition of minimally homologous peptides: Evidence for multiple endogenous ligands. Immunity 2, 655–663 (1995).
    CAS PubMed Google Scholar
  7. Mason, D. A very high level of crossreactivity is an essential feature of the T-cell receptor. Immunol. Today 19, 395–404 (1998).
    CAS PubMed Google Scholar
  8. Garcia, K.C. et al. Structural basis of plasticity in T cell receptor recognition of a self peptide-MHC antigen. Science 279, 1166–1172 (1998).
    CAS PubMed Google Scholar
  9. Reiser, J.B. et al. A T cell receptor CDR3β loop undergoes conformational changes of unprecedented magnitude upon binding to a peptide/MHC class I complex. Immunity 16, 345–354 (2002).
    CAS PubMed Google Scholar
  10. Hare, B.J. et al. Structure, specificity and CDR mobility of a class II restricted single-chain T-cell receptor. Nat. Struct. Biol. 6, 574–581 (1999).
    CAS PubMed Google Scholar
  11. Garcia, K.C., Degano, M., Speir, J.A. & Wilson, I.A. Emerging principles for T cell receptor recognition of antigen in cellular immunity. Rev. Immunogenet. 1, 75–90 (1999).
    CAS PubMed Google Scholar
  12. Willcox, B.E. et al. TCR binding to peptide-MHC stabilizes a flexible recognition interface. Immunity 10, 357–365 (1999).
    CAS PubMed Google Scholar
  13. Boniface, J.J., Reich, Z., Lyons, D.S. & Davis, M.M. Thermodynamics of T cell receptor binding to peptide-MHC: Evidence for a general mechanism of molecular scanning. Proc. Natl. Acad. Sci. USA 96, 11446–11451 (1999).
    CAS PubMed Google Scholar
  14. van der Merwe, P.A. The TCR triggering puzzle. Immunity 14, 665–668 (2001).
    CAS PubMed Google Scholar
  15. Savage, P.A., Boniface, J.J. & Davis, M.M. A kinetic basis for T cell receptor repertoire selection during an immune response. Immunity 10, 485–492 (1999).
    CAS PubMed Google Scholar
  16. Savage, P.A. & Davis, M.M. A kinetic window constricts the T cell receptor repertoire in the thymus. Immunity 14, 243–252 (2001).
    CAS PubMed Google Scholar
  17. Holler, P.D., Lim, A.R., Cho, B.K., Rund, L.A. & Kranz, D.M. CD8− T cell transfectants that express a high affinity T cell receptor exhibit enhanced peptide-dependent activation. J. Exp. Med. 194, 1043–1052 (2001).
    CAS PubMed PubMed Central Google Scholar
  18. Holler, P.D. et al. In vitro evolution of a T cell receptor with high affinity for peptide/MHC. Proc. Natl. Acad. Sci. USA 97, 5387–5392 (2000).
    CAS PubMed Google Scholar
  19. Boder, E.T. & Wittrup, K.D. Yeast surface display for screening combinatorial polypeptide libraries. Nat. Biotech. 15, 553–557 (1997).
    CAS Google Scholar
  20. Kieke, M.C., Cho, B.K., Boder, E.T., Kranz, D.M. & Wittrup, K.D. Isolation of anti-T cell receptor scFv mutants by yeast surface display. Protein Engineer. 10, 1303–1310 (1997).
    CAS Google Scholar
  21. Shusta, E.V., Holler, P.D., Kieke, M.C., Kranz, D.M. & Wittrup, K.D. Directed evolution of a stable scaffold for T-cell receptor engineering. Nat. Biotechnol. 18, 754–759 (2000).
    CAS PubMed Google Scholar
  22. Kieke, M.C. et al. Selection of functional T cell receptor mutants from a yeast surface-display library. Proc. Natl. Acad. Sci. USA 96, 5651–5656 (1999).
    CAS PubMed Google Scholar
  23. Garcia, K.C. et al. αβ T cell receptor interactions with syngeneic and allogeneic ligands: affinity measurements and crystallization. Proc. Natl. Acad. Sci. USA 94, 13838–13843 (1997).
    CAS PubMed Google Scholar
  24. Speir, J.A. et al. Structural basis of the 2C TCR allorecognition of H-2Ld peptide complexes. Immunity 8, 553–562 (1998).
    CAS PubMed Google Scholar
  25. Schlueter, C.J., Manning, T.C., Schodin, B.A. & Kranz, D.M. A residue in the center of peptide QL9 affects binding to both Ld and the T cell receptor. J. Immunol. 157, 4478–4485 (1996).
    CAS PubMed Google Scholar
  26. Schodin, B.A., Tsomides, T.J. & Kranz, D.M. Correlation between the number of T cell receptors required for T cell activation and TCR-ligand affinity. Immunity 5, 137–146 (1996).
    CAS PubMed Google Scholar
  27. Manning, T.C., Schodin, B.A. & Kranz, D.M. A strategy for the synthesis and screening of thiol-modified peptide variants recognized by T cells. J. Immunol. Meth. 192, 125–132 (1996).
    CAS Google Scholar
  28. Davis, M.M. et al. Ligand recognition by αβ T cell receptors. Annu. Rev. Immunol. 16, 523–544 (1998).
    CAS PubMed Google Scholar
  29. Gascoigne, N.R.J., Zai, T. & Alam, S.M. T-cell receptor binding kinetics in T-cell development and activation. Exp. Rev. Mol. Med. (12 February 2001), http://www-ermm.cbcu.cam.ac.uk/01002502h.htm.
  30. Sha, W.C. et al. Positive selection of transgenic receptor-bearing thymocytes by Kb antigen is altered by Kb mutations that involve peptide binding. Proc. Natl. Acad. Sci. USA 87, 6186–6191 (1990).
    CAS PubMed Google Scholar
  31. Manning, T.C., Parke, E.A., Teyton, L. & Kranz, D.M. Effects of complementarity determining region mutations on the affinity of an αβ T cell receptor: measuring the energy associated with CD4/CD8 repertoire skewing. J. Exp. Med. 189, 461–470 (1999).
    CAS PubMed PubMed Central Google Scholar
  32. Lee, P.U., Churchill, H.R., Daniels, M., Jameson, S.C. & Kranz, D.M. Role of 2C T cell receptor residues in the binding of self- and allo-major histocompatibility complexes. J. Exp. Med. 191, 1355–1364 (2000).
    CAS PubMed PubMed Central Google Scholar
  33. Eisen, H.N. Specificity and degeneracy in antigen recognition: yin and yang in the immune system. Annu. Rev. Immunol. 19, 1–21 (2001).
    CAS PubMed Google Scholar
  34. Degano, M. et al. A functional hot spot for antigen recognition in a superagonist TCR/MHC complex. Immunity 12, 251–261 (2000).
    CAS PubMed Google Scholar
  35. Ostrov, D.A., Shi, W., Schwartz, J.C., Almo, S.C. & Nathenson, S.G. Structure of murine CTLA-4 and its role in modulating T cell responsiveness. Science 290, 816–819 (2000).
    CAS PubMed Google Scholar
  36. Manivel, V., Sahoo, N.C., Salunke, D.M. & Rao, K.V. Maturation of an antibody response is governed by modulations in flexibility of the antigen-combining site. Immunity 13, 611–620 (2000).
    CAS PubMed Google Scholar
  37. Eisen, H.N., Sykulev, Y. & Tsomides, T.J. Antigen-specific T-cell receptors and their reactions with complexes formed by peptides with major histocompatibility complex (MHC) proteins. Adv. Protein Chem. 49, 1–56 (1996).
    CAS PubMed Google Scholar
  38. Valitutti, S., Muller, S., Cella, M., Padovan, E. & Lanzavecchia, A. Serial triggering of many T-cell receptors by a few peptide-MHC complexes. Nature 375, 148–151 (1995).
    CAS PubMed Google Scholar
  39. Kalergis, A.M. et al. Efficient T cell activation requires an optimal dwell-time of interaction between the TCR and the pMHC complex. Nat. Immunol. 2, 229–234 (2001).
    CAS PubMed Google Scholar
  40. Andersen, P.S., Geisler, C., Buus, S., Mariuzza, R.A. & Karjalainen, K. Role of TCR-ligand affinity in T cell activation by bacterial superantigens. J. Biol. Chem. 276, 33452–33457 (2001).
    CAS PubMed Google Scholar
  41. Bouneaud, C., Kourilsky, P. & Bousso, P. Impact of negative selection on the T cell repertoire reactive to a self-peptide: a large fraction of T cell clones escapes clonal deletion. Immunity 13, 829–840 (2000).
    CAS PubMed Google Scholar
  42. Correia-Neves, M., Waltzinger, C., Mathis, D. & Benoist, C. The shaping of the T cell repertoire. Immunity 14, 21–32 (2001).
    CAS PubMed Google Scholar
  43. O'Herrin, S.M. et al. Analysis of the expression of peptide-major histocompatibility complexes using high affinity soluble divalent T cell receptors. J. Exp. Med. 186, 1333–1345 (1997).
    CAS PubMed PubMed Central Google Scholar
  44. Garboczi, D.N. et al. Assembly, specific binding, and crystallization of a human TCR-αβ with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2. J. Immunol. 157, 5403–5410 (1996).
    CAS PubMed Google Scholar
  45. Geitz, R.D., Schiestl, R.H., Willems, A. & Woods, R.A. Studies on the mechanism of high efficiency transformations of intact yeast cells. Yeast 11, 355–360 (1995).
    Google Scholar
  46. Alexander, J., Payne, J.A., Murray, R., Frelinger, J.A. & Cresswell, P. Differential transport requirements of HLA and H-2 class I glycoproteins. Immunogenetics 29, 380–399 (1989).
    CAS PubMed Google Scholar
  47. Kranz, D.M., Sherman, D.H., Sitkovsky, M.V., Pasternack, M.S. & Eisen, H.N. Immunoprecipitation of cell surface structure of cloned cytotoxic T lymphocytes by clone-specific antisera. Proc. Natl. Acad. Sci. USA 81, 573–577 (1984).
    CAS PubMed Google Scholar

Download references