LAB: A new membrane-associated adaptor molecule in B cell activation (original) (raw)

References

  1. Reth, M. & Wienands, J. Initiation and processing of signals from the B cell antigen receptor. Annu. Rev. Immunol. 15, 453–479 (1997).
    Article CAS Google Scholar
  2. DeFranco, A.L. The complexity of signaling pathways activated by the BCR. Curr. Opin. Immunol. 9, 296–308 (1997).
    Article CAS Google Scholar
  3. Tamir, I. & Cambier, J.C. Antigen receptor signaling: integration of protein tyrosine kinase functions. Oncogene 17, 1353–1364 (1998).
    Article CAS Google Scholar
  4. Schaeffer, E.M. & Schwartzberg, P.L. Tec family kinases in lymphocyte signaling and function. Curr. Opin. Immunol. 12, 282–288 (2000).
    Article CAS Google Scholar
  5. Kurosaki, T. Functional dissection of BCR signaling pathways. Curr. Opin. Immunol. 12, 276–281 (2000).
    Article CAS Google Scholar
  6. Conley, M.E., Rohrer, J., Rapalus, L., Boylin, E.C. & Minegishi, Y. Defects in early B-cell development: comparing the consequences of abnormalities in pre-BCR signaling in the human and the mouse. Immunol. Rev. 178, 75–90 (2000).
    Article CAS Google Scholar
  7. Zhang, W., Sloan-Lancaster, J., Kitchen, J., Trible, R.P. & Samelson, L.E. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell 92, 83–92 (1998).
    Article CAS Google Scholar
  8. Finco, T.S., Kadlecek, T., Zhang, W., Samelson, L.E. & Weiss, A. LAT is required for TCR-mediated activation of PLCγ1 and the Ras pathway. Immunity 9, 617–626 (1998).
    Article CAS Google Scholar
  9. Zhang, W., Irvin, B.J., Trible, R.P., Abraham, R.T. & Samelson, L.E. Functional analysis of LAT in TCR-mediated signaling pathways using a LAT-deficient Jurkat cell line. Int. Immunol. 11, 943–950 (1999).
    Article CAS Google Scholar
  10. Zhang, W. et al. Essential role of LAT in T cell development. Immunity 10, 323–332 (1999).
    Article CAS Google Scholar
  11. Fu, C., Turck, C.W., Kurosaki, T. & Chan, A.C. BLNK: a central linker protein in B cell activation. Immunity 9, 93–103 (1998).
    Article CAS Google Scholar
  12. Wienands, J. et al. SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation. J. Exp. Med. 188, 791–795 (1998).
    Article CAS Google Scholar
  13. Goitsuka, R. et al. BASH, a novel signaling molecule preferentially expressed in B cells of the bursa of Fabricius. J. Immunol. 161, 5804–5808 (1998).
    CAS PubMed Google Scholar
  14. Pappu, R. et al. Requirement for B cell linker protein (BLNK) in B cell development. Science 286, 1949–1954 (1999).
    Article CAS Google Scholar
  15. Ishiai, M. et al. BLNK required for coupling Syk to PLC γ 2 and Rac1-JNK in B cells. Immunity 10, 117–125 (1999).
    Article CAS Google Scholar
  16. Minegishi, Y. et al. An essential role for BLNK in human B cell development. Science 286, 1954–1957 (1999).
    Article CAS Google Scholar
  17. Zhang, W., Trible, R.P. & Samelson, L.E. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity 9, 239–246 (1998).
    Article CAS Google Scholar
  18. Doyle, J.L., DeSilva, U., Miller, W. & Green, E.D. Divergent human and mouse orthologs of a novel gene (WBSCR15/Wbscr15) reside within the genomic interval commonly deleted in Williams syndrome. Cytogenet. Cell Genet. 90, 285–290 (2000).
    Article CAS Google Scholar
  19. Zhang, W. et al. Association of Grb2, Gads, and phospholipase C-γ 1 with phosphorylated LAT tyrosine residues: effect of LAT tyrosine mutations on T cell antigen receptor-mediated signaling. J. Biol. Chem. 275, 23355–23361 (2000).
    Article CAS Google Scholar
  20. Liu, S.K., Fang, N., Koretzky, G.A. & McGlade, C.J. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr. Biol. 9, 67–75 (1999).
    Article CAS Google Scholar
  21. Chan, A.C. et al. Activation of ZAP-70 kinase activity by phosphorylation of tyrosine 493 is required for lymphocyte antigen receptor function. EMBO J. 14, 2499–2508 (1995).
    Article CAS Google Scholar
  22. Sharp, P.A. RNAi and double-strand RNA. Genes Dev. 13, 139–141 (1999).
    Article CAS Google Scholar
  23. Elbashir, S.M., Lendeckel, W. & Tuschl, T. RNA interference is mediated by 21- and 22-nucleotide RNAs. Genes Dev. 15, 188–200 (2001).
    Article CAS Google Scholar
  24. Elbashir, S.M. et al. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 411, 494–498 (2001).
    Article CAS Google Scholar
  25. Yu, J.Y., DeRuiter, S.L. & Turner, D.L. RNA interference by expression of short-interfering RNAs and hairpin RNAs in mammalian cells. Proc. Natl. Acad. Sci. USA 99, 6047–6052 (2002).
    Article CAS Google Scholar
  26. Pierce, S.K. Lipid rafts and B-cell activation. Nat. Rev. Immunol. 2, 96–105 (2002).
    Article CAS Google Scholar
  27. Cheng, P.C., Dykstra, M.L., Mitchell, R.N. & Pierce, S.K. A role for lipid rafts in B cell antigen receptor signaling and antigen targeting. J. Exp. Med. 190, 1549–1560 (1999).
    Article CAS Google Scholar
  28. Fujimoto, M., Poe, J.C., Inaoki, M. & Tedder, T.F. CD19 regulates B lymphocyte responses to transmembrane signals. Semin. Immunol. 10, 267–277 (1998).
    Article CAS Google Scholar
  29. Cherukuri, A., Dykstra, M. & Pierce, S.K. Floating the raft hypothesis: Lipid rafts play a role in immune cell activation. Immunity 14, 657–660. (2001).
    Article CAS Google Scholar
  30. Zipfel, P.A. et al. The c-Abl tyrosine kinase is regulated downstream of the B cell antigen receptor and interacts with CD19. J. Immunol. 165, 6872–6879 (2000).
    Article CAS Google Scholar
  31. Engels, N., Wollscheid, B. & Wienands, J. Association of SLP-65/BLNK with the B cell antigen receptor through a non-ITAM tyrosine of Ig-α. Eur. J. Immunol. 31, 2126–2134 (2001).
    Article CAS Google Scholar
  32. Wong, J., Ishiai, M., Kurosaki, T. & Chan, A.C. Functional complementation of BLNK by SLP-76 and LAT linker proteins. J. Biol. Chem. 275, 33116–33122 (2000).
    Article CAS Google Scholar
  33. Zhu, M., Janssen, E. & Zhang, W. Minimal requirement of tyrosine residues of LAT (linker for activation of T cells) in TCR signaling and thymocyte development. J. Immunol. 17, 325–333 (2003).
    Article Google Scholar

Download references