SOCS3 regulates the plasticity of gp130 signaling (original) (raw)
Kile, B.T. et al. The SOCS box: a tale of destruction and degradation. Trends Biochem. Sci.27, 235–241 (2002). ArticleCAS Google Scholar
Alexander, W.S. et al. Suppressors of cytokine signaling (SOCS): negative regulators of signal transduction. J. Leukoc. Biol.66, 588–592 (1999). ArticleCAS Google Scholar
Alexander, W.S. et al. SOCS1 is a critical inhibitor of interferon-γ signaling and prevents the potentially fatal neonatal actions of this cytokine. Cell98, 597–608 (1999). ArticleCAS Google Scholar
Marine, J.C. et al. SOCS1 deficiency causes a lymphocyte-dependent perinatal lethality. Cell98, 609–616 (1999). ArticleCAS Google Scholar
Metcalf, D. et al. Gigantism in mice lacking suppressor of cytokine signalling-2. Nature405, 1069–1073 (2000). ArticleCAS Google Scholar
Greenhalgh, C.J. et al. Biological evidence that SOCS-2 can act either as an enhancer or suppressor of growth hormone signaling. J. Biol. Chem.277, 40181–40184 (2002). ArticleCAS Google Scholar
Marine, J.C. et al. SOCS3 is essential in the regulation of fetal liver erythropoiesis. Cell98, 617–627 (1999). ArticleCAS Google Scholar
Takahashi, Y. et al. SOCS3: An essential regulator of LIF receptor signaling in trophoblast giant cell differentiation. EMBO J.22, 372–384 (2003). ArticleCAS Google Scholar
Roberts, A.W. et al. Placental defects and embryonic lethality in mice lacking suppressor of cytokine signaling 3. Proc. Natl. Acad. Sci. USA98, 9324–9329 (2001). ArticleCAS Google Scholar
De Souza, D. et al. SH2 domains from suppressor of cytokine signaling-3 and protein tyrosine phosphatase SHP-2 have similar binding specificities. Biochemistry41, 9229–9236 (2002). ArticleCAS Google Scholar
Schmitz, J. et al. SOCS3 exerts its inhibitory function on interleukin-6 signal transduction through the SHP2 recruitment site of gp130. J. Biol. Chem.275, 12848–12856 (2000). ArticleCAS Google Scholar
Nicholson, S.E. et al. Suppressor of cytokine signaling-3 preferentially binds to the SHP-2-binding site on the shared cytokine receptor subunit gp130. Proc. Natl. Acad. Sci. USA97, 6493–6498 (2000). ArticleCAS Google Scholar
Hortner, M. et al. Suppressor of cytokine signaling-3 is recruited to the activated granulocyte-colony stimulating factor receptor and modulates its signal transduction. J. Immunol.169, 1219–1227 (2002). ArticleCAS Google Scholar
Hortner, M. et al. A new high affinity binding site for suppressor of cytokine signaling-3 on the erythropoietin receptor. Eur. J. Biochem.269, 2516–2526 (2002). ArticleCAS Google Scholar
Auernhammer, C.J., Bousquet, C. & Melmed, S. Autoregulation of pituitary corticotroph SOCS-3 expression: characterization of the murine SOCS-3 promoter. Proc. Natl. Acad. Sci. USA96, 6964–6969 (1999). ArticleCAS Google Scholar
Cassatella, M.A. et al. Interleukin-10 (IL-10) selectively enhances CIS3/SOCS3 mRNA expression in human neutrophils: evidence for an IL-10-induced pathway that is independent of STAT protein activation. Blood94, 2880–2889 (1999). CASPubMed Google Scholar
Stoiber, D. et al. Lipopolysaccharide induces in macrophages the synthesis of the suppressor of cytokine signaling 3 and suppresses signal transduction in response to the activating factor IFN-γ. J. Immunol.163, 2640–2647 (1999). CASPubMed Google Scholar
Stoiber, D. et al. Listeria monocytogenes modulates macrophage cytokine responses through STAT serine phosphorylation and the induction of suppressor of cytokine signaling 3. J. Immunol.166, 466–472 (2001). ArticleCAS Google Scholar
Bode, J.G. et al. LPS and TNFα induce SOCS3 mRNA and inhibit IL-6-induced activation of STAT3 in macrophages. FEBS Lett.463, 365–370 (1999). ArticleCAS Google Scholar
Dalpke, A.H., Opper, S., Zimmermann, S. & Heeg, K. Suppressors of cytokine signaling (SOCS)-1 and SOCS-3 are induced by CpG-DNA and modulate cytokine responses in APCs. J. Immunol.166, 7082–7089 (2001). ArticleCAS Google Scholar
Shouda, T. et al. Induction of the cytokine signal regulator SOCS3/CIS3 as a therapeutic strategy for treating inflammatory arthritis. J. Clin. Invest.108, 1781–1788 (2001). ArticleCAS Google Scholar
Suzuki, A. et al. CIS3/SOCS3/SSI3 plays a negative regulatory role in STAT3 activation and intestinal inflammation. J. Exp. Med.193, 471–481 (2001). ArticleCAS Google Scholar
Berlato, C. et al. Involvement of suppressor of cytokine signaling-3 as a mediator of the inhibitory effects of IL-10 on lipopolysaccharide-induced macrophage activation. J. Immunol.168, 6404–6411 (2002). ArticleCAS Google Scholar
Donnelly, R.P., Dickensheets, H. & Finbloom, D.S. The interleukin-10 signal transduction pathway and regulation of gene expression in mononuclear phagocytes. J. Interferon Cytokine Res.19, 563–573 (1999). ArticleCAS Google Scholar
Heinrich, P.C. et al. Interleukin-6-type cytokine signalling through the gp130/Jak/STAT pathway. Biochem. J.334, 297–314 (1998). ArticleCAS Google Scholar
Takeda, K. et al. Enhanced Th1 activity and development of chronic enterocolitis in mice devoid of Stat3 in macrophages and neutrophils. Immunity10, 39–49 (1999). ArticleCAS Google Scholar
Lang, R. et al. Shaping gene expression in activated and resting primary macrophages by IL-10. J. Immunol.169, 2253–2263 (2002). ArticleCAS Google Scholar
de Veer, M.J. et al. Functional classification of interferon-stimulated genes identified using microarrays. J. Leukoc. Biol.69, 912–920 (2001). CASPubMed Google Scholar
Friederichs, K. et al. Interleukin-6-induced proliferation of pre-B cells mediated by receptor complexes lacking the SHP2/SOCS3 recruitment sites revisited. Eur. J. Biochem.268, 6401–6407 (2001). ArticleCAS Google Scholar
Ohtani, T. et al. Dissection of signaling cascades through gp130 in vivo: reciprocal roles for STAT3- and SHP2-mediated signals in immune responses. Immunity12, 95–105 (2000). ArticleCAS Google Scholar
Tebbutt, N.C. et al. Reciprocal regulation of gastrointestinal homeostasis by SHP2 and STAT-mediated trefoil gene activation in gp130 mutant mice. Nat. Med.8, 1089–1097 (2002). ArticleCAS Google Scholar
Cacalano, N.A., Sanden, D. & Johnson, J.A. Tyrosine-phosphorylated SOCS-3 inhibits STAT activation but binds to p120 rasGAP and activates Ras. Nat. Cell Biol.3, 460–465 (2001). ArticleCAS Google Scholar
Costa-Pereira, A.P. et al. Mutational switch of an IL-6 response to an interferon-γ-like response. Proc. Natl. Acad. Sci. USA99, 8043–8047 (2002). ArticleCAS Google Scholar
Park, C., Li, E., Cha, E. & Schindler, C. Immune response in Stat2 knockout mice. Immunity13, 795–804 (2000). ArticleCAS Google Scholar
Croker, B.A. et al. SOCS3 negatively regulates IL-6 signaling in vivo. Nat. Immunol advance online publication, 18 May 2003 (doi:10.1038/ni931).