Leukotriene B4 receptor BLT1 mediates early effector T cell recruitment (original) (raw)

References

  1. Butcher, E.C. & Picker, L.J. Lymphocyte homing and homeostasis. Science 272, 60–66 (1996).
    Article CAS Google Scholar
  2. Banchereau, J. & Steinman, R.M. Dendritic cells and the control of immunity. Nature 392, 245–252 (1998).
    Article CAS Google Scholar
  3. Abbas, A.K., Murphy, K.M. & Sher, A. Functional diversity of helper T lymphocytes. Nature 383, 787–793 (1996).
    Article CAS Google Scholar
  4. von Andrian, U.H. & Mackay, C.R. T-cell function and migration. Two sides of the same coin. N. Engl. J. Med. 343, 1020–1034 (2000).
    Article CAS Google Scholar
  5. Campbell, J.J. & Butcher, E.C. Chemokines in tissue-specific and microenvironment-specific lymphocyte homing. Curr. Opin. Immunol. 12, 336–341 (2000).
    Article CAS Google Scholar
  6. Weninger, W., Manjunath, N. & von Andrian, U.H. Migration and differentiation of CD8+ T cells. Immunol. Rev. 186, 221–233 (2002).
    Article CAS Google Scholar
  7. Mathew, A. et al. Signal transducer and activator of transcription 6 controls chemokine production and T helper cell type 2 cell trafficking in allergic pulmonary inflammation. J. Exp. Med. 193, 1087–1096 (2001).
    Article CAS Google Scholar
  8. Mathew, A., Medoff, B.D., Carafone, A.D. & Luster, A.D. Cutting edge: Th2 cell trafficking into the allergic lung is dependent on chemoattractant receptor signaling. J. Immunol. 169, 651–655 (2002).
    Article CAS Google Scholar
  9. Murphy, P.M. The molecular biology of leukocyte chemoattractant receptors. Annu. Rev. Immunol. 12, 593–633 (1994).
    Article CAS Google Scholar
  10. Haeggstrom, J.Z. & Wetterholm, A. Enzymes and receptors in the leukotriene cascade. Cell. Mol. Life. Sci. 59, 742–753 (2002).
    Article CAS Google Scholar
  11. Paterson, N.A., Wasserman, S.I., Said, J.W. & Austen, K.F. Release of chemical mediators from partially purified human lung mast cells. J. Immunol. 117, 1356–1362 (1976).
    CAS PubMed Google Scholar
  12. Heavey, D.J. et al. Generation of leukotriene C4, leukotriene B4, and prostaglandin D2 by immunologically activated rat intestinal mucosa mast cells. J. Immunol. 140, 1953–1957 (1988).
    CAS PubMed Google Scholar
  13. Huang, W.W. et al. Molecular and biological characterization of the murine leukotriene B4 receptor expressed on eosinophils. J. Exp. Med. 188, 1063–1074 (1998).
    Article CAS Google Scholar
  14. Yokomizo, T., Kato, K., Terawaki, K., Izumi, T. & Shimizu, T. A second leukotriene B4 receptor, BLT2: A new therapeutic target in inflammation and immunological disorders. J. Exp. Med. 192, 421–432 (2000).
    Article CAS Google Scholar
  15. Tager, A.M. et al. BLTR mediates leukotriene B4-induced chemotaxis and adhesion and plays a dominant role in eosinophil accumulation in a murine model of peritonitis. J. Exp. Med. 192, 439–446 (2000).
    Article CAS Google Scholar
  16. Bleul, C.C., Fuhlbrigge, R.C., Casasnovas, J.M., Aiuti, A. & Springer, T.A. A highly efficacious lymphocyte chemoattractant, stromal cell-derived factor 1 (SDF-1). J. Exp. Med. 184, 1101–1109 (1996).
    Article CAS Google Scholar
  17. Gerszten, R.E. et al. MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature 398, 718–723 (1999).
    Article CAS Google Scholar
  18. Barnden, M.J., Allison, J., Heath, W.R. & Carbone, F.R. Defective TCR expression in transgenic mice constructed using cDNA-based α- and β-chain genes under the control of heterologous regulatory elements. Immunol. Cell. Biol. 76, 34–40 (1998).
    Article CAS Google Scholar
  19. Reinhardt, R.L., Khoruts, A., Merica, R., Zell, T. & Jenkins, M.K. Visualizing the generation of memory CD4 T cells in the whole body. Nature 410, 101–105 (2001).
    Article CAS Google Scholar
  20. Shindo, K., Fukumura, M. & Miyakawa, K. Leukotriene B4 levels in the arterial blood of asthmatic patients and the effects of prednisolone. Eur. Respir. J. 8, 605–610 (1995).
    CAS PubMed Google Scholar
  21. Sampson, A.P., Castling, D.P., Green, C.P. & Price, J.F. Persistent increase in plasma and urinary leukotrienes after acute asthma. Arch. Dis. Child. 73, 221–225 (1995).
    Article CAS Google Scholar
  22. Wenzel, S.E. et al. Effect of 5-lipoxygenase inhibition on bronchoconstriction and airway inflammation in nocturnal asthma. Am. J. Respir. Crit. Care Med. 152, 897–905 (1995).
    Article CAS Google Scholar
  23. Csoma, Z. et al. Increased leukotrienes in exhaled breath condensate in childhood asthma. Am. J. Respir. Crit. Care Med. 166, 1345–9 (2002).
    Article Google Scholar
  24. Turner, C.R. et al. In vitro and in vivo effects of leukotriene B4 antagonism in a primate model of asthma. J. Clin. Invest. 97, 381–387 (1996).
    Article CAS Google Scholar
  25. Henderson, W.R., Jr. et al. The importance of leukotrienes in airway inflammation in a mouse model of asthma. J. Exp. Med. 184, 1483–1494 (1996).
    Article CAS Google Scholar
  26. Goodarzi, K., Goodarzi, M., Tager, A.M., Luster, A.D. & von Andrian, U.H. Leukotriene B4 and BLT1 control cytotoxic effector T cell recruitment to inflamed tissues. Nat. Immunol. Published online 31 August 2003; doi:10.1038/ni972.
  27. MacLean, J.A., Sauty, A., Luster, A.D., Drazen, J.M. & De Sanctis, G.T. Antigen-induced airway hyperresponsiveness, pulmonary eosinophilia, and chemokine expression in B cell-deficient mice. Am. J. Resp. Cell Mol. Biol. 20, 379–387 (1999).
    Article CAS Google Scholar
  28. Oshiba, A. et al. Passive transfer of immediate hypersensitivity and airway hyperresponsiveness by allergen-specific immunoglobulin (Ig) E and IgG1 in mice. J. Clin. Invest. 97, 1398–1408 (1996).
    Article CAS Google Scholar
  29. al-Laith, M. et al. Immunoglobulin-G-dependent stimulation of guinea pig lung mast cells and macrophages. Allergy 48, 608–614 (1993).
    Article CAS Google Scholar
  30. Cohn, L., Homer, R.J., Marinov, A., Rankin, J. & Bottomly, K. Induction of airway mucus production by T helper 2 (Th2) cells: a critical role for interleukin 4 in cell recruitment but not mucus production. J. Exp. Med. 186, 1737–1747 (1997).
    Article CAS Google Scholar
  31. Katz, H.R. et al. Secretory granule mediator release and generation of oxidative metabolites of arachidonic acid via Fc-IgG receptor bridging in mouse mast cells. J. Immunol. 148, 868–671 (1992).
    CAS PubMed Google Scholar
  32. Hsueh, W., Gonzalez-Crussi, F. & Henderson, S. LTB4 production and lysosomal enzyme release by rat alveolar macrophages: effects of phagocytosis, receptor binding, and ionophore stimulation. Exp. Lung Res. 13, 385–399 (1987).
    Article CAS Google Scholar
  33. Rankin, J.A., Schrader, C.E., Smith, S.M., Lewis, R.A. & Lewis, C.R. Recombinant interferon-γ primes alveolar macrophages cultured in vitro for the release of leukotriene B4 in response to IgG stimulation. J. Clin. Invest. 83, 1691–1700 (1989).
    Article CAS Google Scholar
  34. Borgeat, P. & Samuelsson, B. Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid. J. Biol. Chem. 254, 2643–2646 (1979).
    CAS PubMed Google Scholar
  35. Ford-Hutchinson, A.W., Bray, M.A., Doig, M.V., Shipley, M.E. & Smith, M.J. Leukotriene B, a potent chemokinetic and aggregating substance released from polymorphonuclear leukocytes. Nature 286, 264–265 (1980).
    Article CAS Google Scholar
  36. Smith, M.J., Ford-Hutchinson, A.W. & Bray, M.A. Leukotriene B: a potential mediator of inflammation. J. Pharm. Pharmacol. 32, 517–518 (1980).
    Article CAS Google Scholar
  37. Yokomizo, T., Izumi, T., Chang, K., Takuwa, Y. & Shimizu, T. A G-protein-coupled receptor for leukotriene B4 that mediates chemotaxis. Nature 387, 620–624 (1997).
    Article CAS Google Scholar
  38. Arcoleo, F., Milano, S., D'Agostino, P. & Cillari, E. Effect of exogenous leukotriene B4 (LTB4) on BALB/c mice splenocyte production of Th1 and Th2 lymphokines. Int. J. Immunopharmacol. 17, 457–463 (1995).
    Article CAS Google Scholar
  39. Yamaoka, K.A. & Kolb, J.P. Leukotriene B4 induces interleukin 5 generation from human T lymphocytes. Eur. J. Immunol. 23, 2392–2398 (1993).
    Article CAS Google Scholar
  40. de Jong, E.M., van Erp, P.E., van Vlijmen, I.M. & van de Kerkhof, P.C. The inter-relation between inflammation and epidermal proliferation in normal skin following epicutaneous application of leukotriene-B4—an immunohistochemical study. Clin. Exp. Dermatol. 17, 413–420 (1992).
    Article CAS Google Scholar
  41. Hamid, Q., Tulic, M.K., Liu, M.C. & Moqbel, R. Inflammatory cells in asthma: mechanisms and implications for therapy. J. Allergy & Clin. Immunol. 111, S5–S17 (2003).
    Article CAS Google Scholar
  42. Krump, E. & Borgeat, P. Kinetics of 5-lipoxygenase activation, arachidonic acid release, and leukotriene synthesis in human neutrophils: effects of granulocyte-macrophage colony-stimulating factor. Biochim. Biophys. Acta. 1213, 135–139 (1994).
    Article CAS Google Scholar
  43. Reinhardt, R.L., Bullard, D.C., Weaver, C.T. & Jenkins, M.K. Preferential accumulation of antigen-specific effector CD4 T cells at an antigen injection site involves CD62E-dependent migration but not local proliferation. J. Exp. Med. 197, 751–762 (2003).
    Article CAS Google Scholar
  44. Sallusto, F., Lenig, D., Mackay, C.R. & Lanzavecchia, A. Flexible programs of chemokine receptor expression on human polarized T helper 1 and 2 lymphocytes. J. Exp. Med. 187, 875–883 (1998).
    Article CAS Google Scholar
  45. Kim, C.H. et al. Rules of chemokine receptor association with T cell polarization in vivo. J. Clin. Invest. 108, 1331–1339 (2001).
    Article CAS Google Scholar
  46. Colantonio, L., Recalde, H., Sinigaglia, F. & D'Ambrosio, D. Modulation of chemokine receptor expression and chemotactic responsiveness during differentiation of human naive T cells into Th1 or Th2 cells. Eur. J. Immunol. 32, 1264–1273 (2002).
    Article CAS Google Scholar
  47. Weninger, W., Crowley, M.A., Manjunath, N. & von Andrian, U.H. Migratory properties of naive, effector, and memory CD8+ T cells. J. Exp. Med. 194, 953–966 (2001).
    Article CAS Google Scholar
  48. Means, T.K., Hayashi, F., Smith, K.D., Aderem, A. & Luster, A.D. The Toll-like receptor 5 stimulus bacterial flagellin induces maturation and chemokine production in human dendritic cells. J. Immunol. 170, 5165–5175 (2003).
    Article CAS Google Scholar
  49. Allport, J.R. et al. Neutrophils from MMP-9- or neutrophil elastase-deficient mice show no defect in transendothelial migration under flow in vitro. J. Leukoc. Biol. 71, 821–828 (2002).
    CAS PubMed Google Scholar
  50. Medoff, B.D. et al. IFN-γ-inducible protein 10 (CXCL10) contributes to airway hyperreactivity and airway inflammation in a mouse model of asthma. J. Immunol. 168, 5278–5286 (2002).
    Article CAS Google Scholar
  51. Openshaw, P. et al. Heterogeneity of intracellular cytokine synthesis at the single-cell level in polarized T helper 1 and T helper 2 populations. J. Exp. Med. 182, 1357–1367 (1995).
    Article CAS Google Scholar
  52. Bird, J.J. et al. Helper T cell differentiation is controlled by the cell cycle. Immunity 9, 229–237 (1998).
    Article CAS Google Scholar
  53. MacLean, J.A., Ownbey, R. & Luster, A.D. T cell-dependent regulation of eotaxin in antigen-induced pulmonary eosinophila. J. Exp. Med. 184, 1461–1469 (1996).
    Article CAS Google Scholar

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