Inhibition of lipoprotein-associated phospholipase A2 reduces complex coronary atherosclerotic plaque development (original) (raw)

• Ross, R. Atherosclerosis—an inflammatory disease. N. Engl. J. Med. 340, 115–126 (1999).
  Article PubMed CAS Google Scholar
• Hansson, G.K. & Libby, P. The immune response in atherosclerosis: a double-edged sword. Nat. Rev. Immunol. 6, 508–519 (2006).
  Article PubMed CAS Google Scholar
• Steinberg, D. Thematic review series: the pathogenesis of atherosclerosis. An interpretive history of the cholesterol controversy, part V: the discovery of the statins and the end of the controversy. J. Lipid Res. 47, 1339–1351 (2006).
  Article CAS PubMed Google Scholar
• Witztum, J.L. The oxidation hypothesis of atherosclerosis. Lancet 344, 793–795 (1994).
  Article PubMed CAS Google Scholar
• Shah, P.K. Molecular mechanisms of plaque instability. Curr. Opin. Lipidol. 18, 492–499 (2007).
  Article CAS PubMed Google Scholar
• Kolodgie, F.D. et al. Intraplaque hemorrhage and progression of coronary atheroma. N. Engl. J. Med. 349, 2316–2325 (2003).
  Article PubMed CAS Google Scholar
• Virmani, R. et al. Lessons from sudden coronary death: a comprehensive morphological classification scheme for atherosclerotic lesions. Arterioscler. Thromb. Vasc. Biol. 20, 1262–1275 (2000).
  Article PubMed CAS Google Scholar
• Spagnoli, L.G. et al. Extracranial thrombotically active carotid plaque as a risk factor for ischemic stroke. J. Am. Med. Assoc. 292, 1845–1852 (2004).
  Article CAS Google Scholar
• McIntyre, T.M. et al. Biologically active oxidized phospholipids. J. Biol. Chem. 274, 25189–25192 (1999).
  Article PubMed CAS Google Scholar
• Prescott, S.M. et al. Platelet-activating factor and related lipid mediators. Annu. Rev. Biochem. 69, 419–445 (2000).
  Article PubMed CAS Google Scholar
• Macphee, C.H., Nelson, J.J. & Zalewski, A. Lipoprotein-associated phospholipase A2 as a target of therapy. Curr. Opin. Lipidol. 16, 442–446 (2005).
  Article PubMed CAS Google Scholar
• Zalewski, A. & Macphee, C. Role of lipoprotein-associated phospholipase A2 in atherosclerosis: biology, epidemiology, and possible therapeutic target. Arterioscler. Thromb. Vasc. Biol. 25, 923–931 (2005).
  Article CAS PubMed Google Scholar
• Tsimikas, S., Tsironis, L.D. & Tselepis, A.D. New insights into the role of lipoprotein(a)-associated lipoprotein-associated phospholipase A2 in atherosclerosis and cardiovascular disease. Arterioscler. Thromb. Vasc. Biol. 27, 2094–2099 (2007).
  Article PubMed CAS Google Scholar
• Garza, C.A. et al. Association between lipoprotein-associated phospholipase A2 and cardiovascular disease: a systematic review. Mayo Clin. Proc. 82, 159–165 (2007).
  Article CAS PubMed Google Scholar
• Macphee, C.H. et al. Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase, generates two bioactive products during the oxidation of low-density lipoprotein: use of a novel inhibitor. Biochem. J. 338, 479–487 (1999).
  Article PubMed PubMed Central CAS Google Scholar
• Davis, B. et al. Electrospray ionization mass spectrometry identifies substrates and products of lipoprotein-associated phospholipase A2 in oxidized human low density lipoprotein. J. Biol. Chem. 283, 6428–6437 (2008).
  Article PubMed CAS Google Scholar
• Kougias, P. et al. Lysophosphatidylcholine and secretory phospholipase A2 in vascular disease: mediators of endothelial dysfunction and atherosclerosis. Med. Sci. Monit. 12, RA5–RA16 (2006).
  PubMed CAS Google Scholar
• Shi, Y. et al. Role of lipoprotein-associated phospholipase A2 in leukocyte activation and inflammatory responses. Atherosclerosis 191, 54–62 (2007).
  Article PubMed CAS Google Scholar
• Carpenter, K.L. et al. Mildly oxidised LDL induces more macrophage death than moderately oxidised LDL: roles of peroxidation, lipoprotein-associated phospholipase A2 and PPARγ. FEBS Lett. 553, 145–150 (2003).
  Article PubMed CAS Google Scholar
• Perez, R. et al. Involvement of group VIA calcium-independent phospholipase A2 in macrophage engulfment of hydrogen peroxide–treated U937 cells. J. Immunol. 176, 2555–2561 (2006).
  Article PubMed CAS Google Scholar
• Aprahamian, T. et al. Impaired clearance of apoptotic cells promotes synergy between atherogenesis and autoimmune disease. J. Exp. Med. 199, 1121–1131 (2004).
  Article PubMed PubMed Central CAS Google Scholar
• Kolodgie, F.D. et al. Lipoprotein-associated phospholipase A2 protein expression in the natural progression of human coronary atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 26, 2523–2529 (2006).
  Article CAS PubMed Google Scholar
• Blackie, J.A. et al. The identification of clinical candidate SB-480848: a potent inhibitor of lipoprotein-associated phospholipase A2 . Bioorg. Med. Chem. Lett. 13, 1067–1070 (2003).
  Article PubMed CAS Google Scholar
• Gerrity, R.G. et al. Diabetes-induced accelerated atherosclerosis in swine. Diabetes 50, 1654–1665 (2001).
  Article PubMed CAS Google Scholar
• Mohler, E.R., III et al. Site-specific atherogenic gene expression correlates with subsequent variable lesion development in coronary and peripheral vasculature. Arterioscler. Thromb. Vasc. Biol. 28, 850–855 (2008).
  Article PubMed CAS Google Scholar
• Chatzizisis, Y.S. et al. Role of endothelial shear stress in the natural history of coronary atherosclerosis and vascular remodeling: molecular, cellular and vascular behavior. J. Am. Coll. Cardiol. 49, 2379–2393 (2007).
  Article PubMed CAS Google Scholar
• Jo, H. et al. Role of NADPH oxidases in disturbed flow- and BMP4- induced inflammation and atherosclerosis. Antioxid. Redox Signal. 8, 1609–1619 (2006).
  Article PubMed CAS Google Scholar
• Schaloske, R.H. & Dennis, E.A. The phospholipase A2 superfamily and its group numbering system. Biochim. Biophys. Acta 1761, 1246–1259 (2006).
  Article PubMed CAS Google Scholar
• Gardner, A.A., Reichert, E.C., Topham, M.K. & Stafforini, D.M. Identification of a domain that mediates association of platelet-activating factor acetylhydrolase with high-density lipoprotein. J. Biol. Chem. 283, 17099–17106 (2008).
  Article PubMed PubMed Central CAS Google Scholar
• Stafforini, D.M. et al. Molecular basis of the interaction between plasma platelet-activating factor acetylhydrolase and low density lipoprotein. J. Biol. Chem. 274, 7018–7024 (1999).
  Article PubMed CAS Google Scholar
• Heller, E.A. et al. Chemokine CXCL10 promotes atherogenesis by modulating the local balance of effector and regulatory T cells. Circulation 113, 2301–2312 (2006).
  Article PubMed CAS Google Scholar
• Swirski, F.K. et al. Ly-6Chi monocytes dominate hypercholesterolemia-associated monocytosis and give rise to macrophages in atheromata. J. Clin. Invest. 117, 195–205 (2007).
  Article PubMed PubMed Central CAS Google Scholar
• Papaspyridonos, M. et al. Novel candidate genes in unstable areas of human atherosclerotic plaques. Arterioscler. Thromb. Vasc. Biol. 26, 1837–1844 (2006).
  Article PubMed CAS Google Scholar
• Reddy, V.y., Zhang, Z.-Y. & Weiss, S.J. Pericellular mobilization of the tissue-destructive cysteine proteinases, cathepsins B, L and S by human monocyte-derived macrophages. Proc. Natl. Acad. Sci. USA 92, 3849–3853 (1995).
  Article PubMed CAS PubMed Central Google Scholar
• Heart Protection Study Collaborative Group. MRC/BHF Heart Protection Study of cholesterol-lowering with simvastatin in 5693 people with diabetes: a randomized placebo-controlled trial. Lancet 361, 2005–2013 (2003).
• Moreno, P.R. et al. Coronary composition and macrophage infiltration in atherectomy specimens from patients with diabetes mellitus. Circulation 102, 2180–2184 (2000).
  Article PubMed CAS Google Scholar
• Burke, A.P. et al. Morphologic findings of coronary atherosclerotic plaques in diabetics: a postmortem study. Arterioscler. Thromb. Vasc. Biol. 24, 1266–1271 (2004).
  Article PubMed CAS Google Scholar
• Pennathur, S. & Heinecke, J.W. Mechanisms for oxidative stress in diabetic cardiovascular disease. Antioxid. Redox Signal. 9, 955–969 (2007).
  Article PubMed CAS Google Scholar
• Tacke, F. et al. Monocyte subsets differentially employ CCR2, CCR5 and CX3CR1 to accumulate within atherosclerotic plaques. J. Clin. Invest. 117, 185–194 (2007).
  Article PubMed PubMed Central CAS Google Scholar
• Navab, M. et al. The oxidation hypothesis of atherogenesis: the role of oxidized phospholipids and HDL. J. Lipid Res. 45, 993–1007 (2004).
  Article PubMed CAS Google Scholar
• Sangvanich, P., Mackness, B., Gaskell, S.J., Durrington, P. & Mackness, M. The effect of high-density lipoproteins on the formation of lipid/protein conjugates during in vitro oxidation of low-density lipoprotein. Biochem. Biophys. Res. Commun. 300, 501–506 (2003).
  Article PubMed CAS Google Scholar
• Getz, G.S. & Reardon, C.A. Diet and murine atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 26, 242–249 (2006).
  Article PubMed CAS Google Scholar
• Caslake, M.J. et al. Lipoprotein-associated phospholipase A2, platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease. Atherosclerosis 150, 413–419 (2000).
  Article PubMed CAS Google Scholar
• Van Eck, M. et al. Bone marrow transplantation in apolipoprotein E–deficient mice. Effect of ApoE gene dosage on serum lipid concentrations, βVLDL catabolism, and atherosclerosis. Arterioscler. Thromb. Vasc. Biol. 17, 3117–3126 (1997).
  Article PubMed CAS Google Scholar
• Singer, A.G. et al. Interfacial kinetic and binding properties of the complete set of human and mouse groups I, II, V, X and XII secreted phospholipases A2 . J. Biol. Chem. 277, 48535–48549 (2002).
  Article PubMed CAS Google Scholar
• Smart, B.P. et al. Inhibition of the complete set of mammalian secreted phospholipases A2 by indole analogues: a structure-guided study. Bioorg. Med. Chem. 12, 1737–1749 (2004).
  Article PubMed CAS Google Scholar